|
Affiliation |
Frontier Science Research Center Life science field of inquiry physiology activator search condition analysis field |
|
Title |
Associate Professor |
|
External Link |
|
IDA Takanori
|
|
|
Research Areas 【 display / non-display 】
-
Life Science / Veterinary medical science
Papers 【 display / non-display 】
-
Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats. Reviewed
Jiang D, Matsuzaki M, Ida T, Kitamura K, Kato J
Hypertension research : official journal of the Japanese Society of Hypertension 2024.2
Language：English Publishing type：Research paper (scientific journal)
-
Izumi T., Saito A., Ida T., Mukuda T., Katayama Y., Wong M.K.S., Tsukada T.
Cell and Tissue Research 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Cell and Tissue Research
The natriuretic peptide (NP) family consists of cardiac NPs (ANP, BNP, and VNP) and brain NPs (CNPs) in teleosts. In addition to CNP1-4, a paralogue of CNP4 (named CNP4b) was recently discovered in basal teleosts including Japanese eel. Mammals have lost most Cnps during the evolution, but teleost cnps were conserved and diversified, suggesting that CNPs are important hormones for maintaining brain functions in teleost. The present study evaluated the potency of each Japanese eel CNP to their NP receptors (NPR-A, NPR-B, NPR-C, and NPR-D) overexpressed in CHO cells. A comprehensive brain map of cnps- and nprs-expressing neurons in Japanese eel was constructed by integrating the localization results obtained by in situ hybridization. The result showed that CHO cells expressing NPR-A and NPR-B induced strong cGMP productions after stimulation by cardiac and brain NPs, respectively. Regarding brain distribution of cnps, cnp1 is engaged in the ventral telencephalic area and periventricular area including the parvocellular preoptic nucleus (Pp), anterior/posterior tuberal nuclei, and periventricular gray zone of the optic tectum. cnp3 is found in the habenular nucleus and prolactin cells in the pituitary. cnp4 is expressed in the ventral telencephalic area, while cnp4b is expressed in the motoneurons in the medullary area. Such CNP isoform-specific localizations suggest that function of each CNP has diverged in the eel brain. Furthermore, the Pp lacking the blood-brain barrier expressed both npra and nprb, suggesting that endocrine and paracrine NPs interplay for regulating the Pp functions in Japanese eels.
-
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats Reviewed
Jiang D., Matsuzaki M., Ida T., Kitamura K., Tsuruda T., Kaikita K., Kato J.
Peptides 166 171035 2023.8
Language：English Publishing type：Research paper (scientific journal) Publisher：Peptides
Excessive activation of the sympathetic nervous system is involved in cardiovascular damage including cardiac hypertrophy. Natriuretic peptides are assumed to exert protective actions for the heart, alleviating hypertrophy and/or fibrosis of the myocardium. In contrast to this assumption, we show in the present study that both atrial and C-type natriuretic peptides (ANP and CNP) potentiate cardiac hypertrophic response to noradrenaline (NA) in rats. Nine-week-old male Wistar rats were continuously infused with subcutaneous 30 micro-g/h NA without or with persistent intravenous administration of either 1.0 micro-g/h ANP or CNP for 14 days. Blood pressure (BP) was recorded under an unrestrained condition by a radiotelemetry system. Cardiac hypertrophic response to NA was evaluated by heart weight/body weight (HW/BW) ratio and microscopic measurement of myocyte size of the left ventricle. Mean BP levels at the light and dark cycles rose by about 20 mmHg following NA infusion for 14 days, with slight increases in HW/BW ratio and ventricular myocyte size. Infusions of ANP and CNP had no significant effects on mean BP in NA-infused rats, while two natriuretic peptides potentiated cardiac hypertrophic response to NA. Cardiac hypertrophy induced by co-administration of NA and ANP was attenuated by treatment with prazosin or atenolol. In summary, both ANP and CNP potentiated cardiac hypertrophic effect of continuously infused NA in rats, suggesting a possible pro-hypertrophic action of natriuretic peptides on the heart.
-
Nakagami S., Notaguchi M., Kondo T., Okamoto S., Ida T., Sato Y., Higashiyama T., Tsai A.Y.L., Ishida T., Sawa S.
Science advances 9 ( 22 ) eadf4803 2023.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Science advances
Plants use many long-distance and systemic signals to modulate growth and development, as well as respond to biotic and abiotic stresses. Parasitic nematodes infect host plant roots and cause severe damage to crop plants. However, the molecular mechanisms that regulate parasitic nematode infections are still unknown. Here, we show that plant parasitic root-knot nematodes (RKNs), Meloidogyne incognita, modulate the host CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (CLE)-CLV1 signaling module to promote the infection progression. Plants deficient in the CLE signaling pathway show enhanced RKN resistance, whereas CLE overexpression leads to increased susceptibility toward RKN. Grafting analysis shows that CLV1 expression in the shoot alone is sufficient to positively regulate RKN infection. Together with results from the split-root culture system, infection assays, and CLE3-CLV1 binding assays, we conclude that mobile root-derived CLE signals are perceived by CLV1 in the shoot, which subsequently produce systemic signals to promote gall formation and RKN reproduction.
-
Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species. Reviewed
Yazawa T, Islam MS, Imamichi Y, Watanabe H, Yaegashi K, Ida T, Sato T, Kitano T, Matsuzaki S, Umezawa A, Muranishi Y
Animals : an open access journal from MDPI 13 ( 4 ) 2023.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Animals
During mammalian gestation, large amounts of progesterone are produced by the placenta and circulate for the maintenance of pregnancy. In contrast, primary plasma estrogens are different between species. To account for this difference, we compared the expression of ovarian and placental steroidogenic genes in various mammalian species (mouse, guinea pig, porcine, ovine, bovine, and human). Consistent with the ability to synthesize progesterone, CYP11A1/Cyp11a1, and bi-functional HSD3B/Hsd3b genes were expressed in all species. CYP17A1/Cyp17a1 was expressed in the placenta of all species, excluding humans. CYP19A/Cyp19a1 was expressed in all placental estrogen-producing species, whereas estradiol-producing HSD17B1 was only strongly expressed in the human placenta. The promoter region of HSD17B1 in various species possesses a well-conserved SP1 site that was activated in human placental cell line JEG-3 cells. However, DNA methylation analyses in the ovine placenta showed that the SP1-site in the promoter region of HSD17B1 was completely methylated. These results indicate that epigenetic regulation of HSD17B1 expression is important for species-specific placental sex steroid production. Because human HSD17B1 showed strong activity for the conversion of androstenedione into testosterone, similar to HSD17B1/Hsd17b1 in other species, we also discuss the biological significance of human placental HSD17B1 based on the symptoms of aromatase-deficient patients.
DOI： 10.3390/ani13040622
MISC 【 display / non-display 】
-
消化管関連ペプチドが拓く恒常性フロンティア Invited
佐藤貴弘、井田隆徳、関口俊男、中町智哉、児島将康
実験医学 37 ( 3 ) 1 - 8 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
-
Role of biological rhythms in the performance of physical activity Invited Reviewed
Sato T, Ida T, Kojima M
The Journal of Physical Fitness and Sports Medicine 6 ( 3 ) 125 - 134 2017.3
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
-
モデル生物を利用した新規摂食調節ペプチドの探索
井田隆徳
生物科学 2016.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：農山漁村文化協会
-
Sano H., Nakamura A., Texada M., Truman J., Ishimoto H., Kamikouchi A., Nibu Y., Kume K., Ida T., Kojima M.
PLoS Genetics 11 ( 9 ) 2015.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：PLoS Genetics
-
摂食調節ペプチドと飢餓応答
佐藤貴弘、井田隆徳、児島将康
The lipid 26 ( 1 ) 35 - 39 2015.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：メディカルレビュー社
Presentations 【 display / non-display 】
-
動物介在活動から考えるOne Health Invited
井田隆徳
第１６６回日本獣医学会学術集会
Event date： 2023.9.5
Presentation type：Oral presentation (general)
-
新規生理活性ペプチドの探索と応用 Invited
井田隆徳
第70回日本心臓病学会学術集会 2022.9.23
Event date： 2022.9.23
Language：Japanese Presentation type：Oral presentation (general)
-
ホルモンとライフステージ：生物の生理学的変化と適応のダイナミズム
井田隆徳、長谷川和哉
第101回日本生理学会大会
Event date： 2024.3.28
Presentation type：Symposium, workshop panel (public)
-
ウナギ脳に作用するナトリウム利尿ペプチドの内分泌・傍分泌経路の特定
和泉知輝、齋藤あみ、井田隆徳、椋田崇生、片山侑駿、Marty Kwok-Shing Wong、塚田岳大
第47回日本比較内分泌学会大会
Event date： 2023.11.17
Presentation type：Oral presentation (general)
-
新規生理活性ペプチドの探索
井田隆徳
第１3回ペプチド・ホルモン研究会
Event date： 2023.9.30
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
-
日本獣医学会生理学・生化学分科会奨励賞
2010.9 日本獣医学会
井田隆徳
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
-
11th International Conference on Human-Animal Interactions.Best Poster Award
2007.10 IAHAIO
Yoshidomi Y, Ikeda Y, Satoh H, Sekino R, Ida T, Hisatomi I, Nakatsuka K, Misawa N
Award type：Award from international society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
摂食・エネルギー代謝を制御する新規生理活性ペプチドの発見と応用
Grant number：21K05958 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究C
Authorship：Principal investigator
-
生体必須の金属補因子「鉄硫黄クラスター」の生合成機序と無細胞構築系の確立
Grant number：20H03196 2020.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究（B）
Authorship：Coinvestigator(s)
-
難治性の神経因性疼痛を抑制する脳由来新規生理活性物質の構造決定と生理作用の解析
Grant number：20K07768 2020.04 - 2023.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
-
新規NPY様RYamideペプチドの発見と食欲調節機構の解析
2017.04 - 2020.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
-
昆虫における食欲促進/減退を引き起こす生理活性ペプチドの発見
2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
昆虫における食欲促進/減退を引き起こす生理活性ペプチドの発見し解析する
Other research activities 【 display / non-display 】
-
食鳥処理施設での骨髄のサンプリング
2023.11
-
食鳥処理施設での脳のサンプリング
2019.07
-
食鳥処理施設での肝臓のサンプリング
2018.06
-
食肉処理施設における膵臓のサンプリング
2017.07
-
食鳥処理施設での脳のサンプリング
2017.05
Available Technology 【 display / non-display 】
-
新規生理活性ペプチドの探索
新規生理活性ペプチドの機能解析
病態モデル生物の作製Related fields where technical consultation is available：ペプチド抽出
受容体発現細胞を用いたセカンドメッセンジャーアッセイMessage：宮崎大学の伝統あるペプチド研究を引き継ぎ、ペプチド研究におけるプラットフォームを目指しています。