SAKAKIBARA Hiroyuki

写真a

Affiliation

Faculty of Agriculture Department of Biochemistry and Applied Biosciences

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(学術) ( 2002.3   神戸大学 )

Research Areas 【 display / non-display

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living  / 時間機能性食品学

 

Papers 【 display / non-display

  • Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice

    Matsuzaka H., Matsuyama H., Tanaka W., Tajiri H., Sakakibara H.

    Molecules   27 ( 4 )   2022.2

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Molecules  

    Diets with high daily fat consumption are associated with excess weight. However, the effects of fat type and consumption timing on excess weight remain unclear. We investigated the selection of a 30% (w/w) fat diet of soybean oil (SOY), lard (LARD), and fish oil (FISH) on the metabolic parameters of mice. Male C57BL/6 mice were divided into the double SOY-box (w-SOY), SOY-box/LARD-box (SOY-vs-LARD), or SOY-box/FISH-box (SOY-vs-FISH) groups and allowed to selectively consume for 8 weeks. The total energy intake was similar for all groups, but the mice selectively chose to consume LARD over SOY and SOY over FISH. Body weight in the SOY-vs-LARD group was significantly higher than that in the w-SOY and SOY-vs-FISH groups. Additionally, minimal but selective consumption of an omega-3 fatty-acid-rich FISH diet at the end of the active period increased the physiological fatty acid compositions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the SOY-vs-FISH group; their metabolic parameters were also lower than the SOY-vs-LARD group. In conclusion, selectively consuming small amounts of fish oil at the end of the day may prevent excess weight compared with LARD consumption.

    DOI: 10.3390/molecules27041271

    Scopus

  • Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice Reviewed

    Tajiri H., Tanaka W., Matsuyama H., Sugita T., Hidaka K., Yokoyama D., Sakakibara H.

    Metabolites   12 ( 2 )   2022.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Metabolites  

    The thinned immature fruit of the mango tree (Mangifera indica “Irwin”) are regarded as waste products. In this study, we evaluated the effects of daily consumption of a hot-water extract of thinned immature mango fruits (TIMEx) on the dyslipidemia of apolipoprotein E-deficient (ApoE−/−) mice. ApoE−/− mice and wild-type BALB/c mice were fed a 20% fat diet containing 0%, 0.1%, or 1.0% TIMEx for 8 weeks. Their body mass, food intake, and water consumption were unaffected by the TIMEx. The 1.0% TIMEx supplementation significantly reduced serum triglyceride, but not total cholesterol concentration. This effect was significant in ApoE−/− mice, but less marked under normal conditions in wild-type mice. In addition, the circulating concentrations of three hormones that regulate metabolism, resistin, leptin, and glucose-dependent insulinotropic polypeptide, were reduced by TIMEx consumption, which may be involved in its effect to prevent hypertriglyceridemia. However, none of the concentrations of TIMEx reduced the size of atherosclerotic plaque lesions. In conclusion, daily consumption of TIMEx ameliorates hypertriglyceridemia but not hypercholesterolemia in genetically predisposed mice.

    DOI: 10.3390/metabo12020116

    Scopus

  • Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats Reviewed

    Tajiri H., Tanaka W., Takashima M., Matsuyama H., Sugita T., Hidaka K., Sakakibara H.

    Toxicology Reports   8   1046 - 1053   2021.5

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Toxicology Reports  

    Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango fruits (TIMEx) administered by oral gavage at doses of 500, 1000 and 2500 mg/kg body weight/day. Treatment did not result in death or changes in the behavior or external appearance of the animals. No alterations were observed in hematological or serum chemical parameters, urinalysis, food consumption, body weight gain or organ weights at the end of the treatment period, with the exception of higher mean corpuscular volume in male rats that received high doses and lower serum creatine phosphokinase levels in female rats that received medium doses. Under the conditions of this study and based on the toxicological endpoints evaluated, the no-observed-adverse-effect level (NOAEL) for TIMEx was 2500 mg/kg/day. The findings indicate that TIMEx is safe for consumption and should be investigated as a candidate food.

    DOI: 10.1016/j.toxrep.2021.05.005

    Scopus

  • The New Sugar to Suppress Postprandial Hyperglycemia: Improvement of Refined White Sugar by Mixing Specially Grown Brown Cane Extract Reviewed

    Tsutomu Arimura, Shaw Watanabe, Hiroyuki Sakakibara and Shigekatsu Kimura

    Acta Scientific NUTRITIONAL HEALTH   5 ( 6 )   43 - 50   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Maternal quercetin consumption during pregnancy may help regulate total cholesterol/hdl-cholesterol ratio without effect on cholesterol levels in male progeny consuming high-fat diet Reviewed

    Takashima M., Tanaka W., Matsuyama H., Tajiri H., Sakakibara H.

    Nutrients   13 ( 4 )   2021.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nutrients  

    Quercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. In this study, we investigated whether maternal quercetin consumption during pregnancy has a protective effect on high-fat diet–induced hyper lipid levels and overweight in progeny. Female mice consumed a control diet or a diet containing 1.0% quercetin during breeding. The male progeny were then divided into four groups that were (1) sacrificed at postnatal day 3; (2) born to dams fed the control diet and also fed the control diet (C-C), (3) born to dams fed the control diet and then fed a 30% high-fat diet (C-HF), or (4) born to dams fed the Q-diet and then fed the HF diet (Q-HF). Maternal consumption of quercetin did not affect body weight or blood lipid parameters in either dams or neonates at postnatal day 3. After 13 weeks, the Q-HF group exhibited greater body and liver weights, and higher blood cholesterol levels than the C-HF group. However, the total cholesterol/ high density lipoprotein (HDL)-cholesterol ratios in the Q-HF and C-C groups remained similar. In conclusion, maternal quercetin consumption does not appear to protect the next generation from high-fat diet–induced hyper cholesterol level in the blood and liver, and consequently overweight, but may help regulate the total cholesterol/HDL-cholesterol ratio.

    DOI: 10.3390/nu13041242

    Scopus

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Books 【 display / non-display

  • 抗疲労・抗ストレス・睡眠改善食品の開発

    榊原啓之,下位香代子( Role: Contributor)

    シーエムシー出版  2020.4 

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    Responsible for pages:69-77   Language:Japanese Book type:Scholarly book

  • エッセンシャル食品化学 = Essential food chemistry

    中村 宜督, 榊原 啓之, 室田 佳恵子( Role: Joint author)

    講談社  2018.12 

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    Language:Japanese Book type:Textbook, survey, introduction

    CiNii Books

  • Visual栄養学テキスト 食べ物と健康I 食品学総論 食品の成分と機能

    榊原啓之( Role: Contributor ,  香気・におい成分)

    株式会社 中山書店  2018.1 

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    Total pages:148   Responsible for pages:90-95   Language:Japanese Book type:Textbook, survey, introduction

  • 機能性食品開発のための初期評価試験プロトコール集

    榊原啓之,下位香代子( Role: Contributor)

    株式会社シーエムシー出版  2017.6 

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    Total pages:366   Responsible for pages:216-231   Language:Japanese Book type:Scholarly book

  • 生物・農学系のための統計学−大学での基礎学修から研究論文まで−

    平田昌彦,宇田津徹朗,河原聡,榊原啓之( Role: Joint author)

    ㈱朝倉書店  2017.4 

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    Total pages:214   Responsible for pages:91-107   Language:Japanese Book type:Textbook, survey, introduction

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MISC 【 display / non-display

  • マウスも夜はストレスと闘っています Invited

    榊原啓之

    調査月報   331   2 - 6   2020.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • Insights into the potential benefits of black soybean (Glycine max L) polyphenols on lifestyle diseases Reviewed

    Yamashita Y., Sakaibara H., Toda T., Ashida H.

    Food & Function   11   7321 - 7339   2020.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Anti-stress effects of polyphenols: animal models and human trials Reviewed

    Sakakibara H., Shimoi K.

    Food & Function   11   5702 - 5717   2020.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 体内時計が刻むリズムと講義中の居眠りの関係を考えてみる Invited

    榊原啓之,田中航

    宮崎大学 教育・学生支援センター紀要   3   35 - 38   2019.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

  • 研究室紹介「宮崎大学 農学部 応用生物科学科 栄養化学研究室」 Invited Reviewed

    榊原啓之

    オレオサイエンス   17 ( 9 )   448 - 449   2017.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations 【 display / non-display

  • 異なる脂質由来高脂肪食に対するマウスの選択性と過体重に与える影響

    松坂 祐希,松山 弘希,田中 航,榊原 啓之

    日本農芸化学会2021年度大会 

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    Event date: 2021.3.20

    Language:Japanese   Presentation type:Poster presentation  

  • 未消化コーヒー焙煎豆の機能性

    武井 実花,TATIYANUKUL Chalinee,田中 航,榊原 啓之

    日本農芸化学会2021年度大会 

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    Event date: 2021.3.19

    Language:Japanese   Presentation type:Poster presentation  

  • 加齢が社会的ストレス負荷時の生体応答機構に与える影響

    田中 航,下位 香代子,榊原 啓之

    日本農芸化学会2021年度大会 

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    Event date: 2021.3.19

    Language:Japanese   Presentation type:Poster presentation  

  • 天日干しおよび生ダイコン摂取の血中トリグリセリド 低下効果

    松山弘希,田中航,三好規之,宮崎達雄,道本英之,榊原啓之

    第25回日本フードファクター学会学術集会 

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    Event date: 2020.11.29

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ケルセチンが有する生体調節機能の母子間伝承性

    高島正勝,田中航,松山弘希,田尻隼斗,榊原啓之

    第25回日本フードファクター学会学術集会 

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    Event date: 2020.11.29

    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 第2回宮崎テックプラングランプリ 三井化学賞

    2018.11   第2回宮崎テックプラングランプリ  

    榊原啓之(Mama to Childe)

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    Country:Japan

  • 2010年B.B.B.論文賞

    2011.3   公益財団法人日本農芸化学会  

    Kato A, Naitou H, Namioka M, Akimoto M, Ishii T, Sakakibara H, Shimoi K, Nakayama T, Ohashi N.

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  • 平成19年度科学交流フォーラム(第9回静岡ライフサイエンスシンポジウム)ポスター賞

    2008.3   平成19年度科学交流フォーラム(第9回静岡ライフサイエンスシンポジウム)  

    榊原啓之

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • Poster Award

    2007.12   ICoFF2007  

    Hiroyuki Sakakibara

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  • Young Researcher Award

    2004.6   20th General Meeting EGF2004  

    Hiroyuki Sakakibara

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    Award type:Award from international society, conference, symposium, etc.  Country:Switzerland

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Grant-in-Aid for Scientific Research 【 display / non-display

  • ストレス応答が過敏になる夜間の生体応答制御を企図した食事の効果検証

    Grant number:21H03361  2021.04 - 2025.03

    科学研究費補助金  基盤研究(B)

    榊原啓之

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    Authorship:Principal investigator 

  • 脂質摂取がアルツハイマー型認知症状に与える影響と食品によるその制圧

    Grant number:19K05881  2019.04 - 2019.11

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • ポリフェノール・パラドックスの解明

    2017.04 - 2021.03

    科学研究費補助金  基盤研究(A)

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    Authorship:Coinvestigator(s) 

  • 就眠野菜の機能性は日内リズムを刻むのか?

    2016.04 - 2018.03

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator 

    就眠野菜の機能性は日内リズムを刻むのかについて探究する

  • 品成分の生体内有効性を制御する概日リズム因子のデータベース構築とその応用

    2011.04 - 2015.03

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

    ヒトや実験動物をはじめとする生物体内では、多くの生体機能、例えば、睡眠/覚醒、神経活動、ホルモン分泌、体温、酵素活性に約24時間周期のリズム(概日リズム)が認められている。しかしながら、実験動物を用いた多くの食品機能成分の有効性評価は、生体の概日リズムを考慮に入れて実施されてこなかった。本研究では、食品機能成分が体内で有効性を発揮する過程への概日リズム因子の影響を明らかにすることで、食品成分の機能性を再評価するとともに、食品成分の新たな機能性として“概日リズム調節作用”の可能性を探究する。