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Affiliation |
Faculty of Medicine College Hospital Anesthesiology |
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Title |
Assistant Professor |
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External Link |
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HIDAKA Kotaro
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Papers 【 display / non-display 】
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Extracellular signal-regulated kinase phosphorylation enhancement and Na<sub>V</sub>1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy.
Hidaka K, Maruta T, Koshida T, Kurogi M, Kage Y, Kouroki S, Shirasaka T, Takeya R, Tsuneyoshi I
Molecular pain 18 17448069221089784 2022.1
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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左上肢運動麻痺，著明な浮腫を合併した帯状疱疹関連痛に対し，ステロイドパルス療法が有効であった１症例． Reviewed
内村修二，山賀昌治，川﨑祐子，日髙康太郎，渡部由美，恒吉勇男
日本ペインクリニック学会誌 29 ( 1 ) 9 - 11 2022.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.
Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R, Tsuneyoshi I
PloS one 17 ( 10 ) e0275751 2022
Language：English Publishing type：Research paper (scientific journal)
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難治性がん性疼痛に対する治療法の選択が難航した症例． Reviewed
門田瑤子，内村修二，日髙康太郎，川﨑祐子，渡部由美，山賀昌治，恒吉勇男
日本ペインクリニック学会誌 27 ( 3 ) 1 - 17 2020.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Toyoaki Maruta, Takayuki Nemoto, Koutaro Hidaka, Tomohiro Koshida, Tetsuro Shirasaka, Toshihiko Yanagita, Ryu Takeya Isao Tsuneyoshi
PLoS ONE 14 ( 11 ) e0225586 2019.11
Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE
© 2019 Maruta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Oxaliplatin is the first-line chemotherapy for metastatic colorectal cancer. Unlike other platinum anticancer agents, oxaliplatin does not result in significant renal impairment and ototoxicity. Oxaliplatin, however, has been associated with acute and chronic peripheral neuropathies. Despite the awareness of these side-effects, the underlying mechanisms are yet to be clearly established. Therefore, in this study, we aimed to understand the factors involved in the generation of chronic neuropathy elicited by oxaliplatin treatment. We established a rat model of oxaliplatin-induced neuropathic pain (4 mg kg-1 intraperitoneally). The paw withdrawal thresholds were assessed at different time-points after the treatment, and a significant decrease was observed 3 and 4 weeks after oxaliplatin treatment as compared to the vehicle treatment (4.4 ± 1.0 vs. 16.0 ± 4.1 g; P < 0.05 and 4.4 ± 0.7 vs. 14.8 ± 3.1 g; P < 0.05, respectively). We further evaluated the role of different mitogen-activated protein kinases (MAPKs) pathways in the pathophysiology of neuropathic pain. Although the levels of total extracellular signal-regulated kinase (ERK) 1/2 in the dorsal root ganglia (DRG) were not different between oxaliplatin and vehicle treatment groups, phosphorylated ERK (pERK) 1/2 was up-regulated up to 4.5-fold in the oxaliplatin group. Administration of ERK inhibitor PD98059 (6 μg day-1 intrathecally) inhibited oxaliplatin-induced ERK phosphorylation and neuropathic pain. Therefore, upregulation of p-ERK by oxaliplatin in rat DRG and inhibition of mechanical allodynia by an ERK inhibitor in the present study may provide a better understanding of intracellular molecular alterations associated with oxaliplatin-induced neuropathic pain and help in the development of potential therapeutics.
Presentations 【 display / non-display 】
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難治性後頭部痛に対して，大後頭神経へのパルス高周波法が有効であった一症例．
吉海瑞穂，日髙康太郎，渡部由美，山賀昌治，恒吉勇男
日本ペインクリニック学会第２回九州支部学術集会
Event date： 2022.2.28 - 2022.3.13
Language：Japanese Presentation type：Oral presentation (general)
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帯状疱疹後神経痛モデルラットにおける高周波パルス療法の作用機序の検討．
日髙康太郎，丸田豊明，越田智広，興梠聡志，白阪哲朗，恒吉勇男
第43回日本疼痛学会
Event date： 2021.12.10 - 2021.12.11
Language：Japanese Presentation type：Oral presentation (general)
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声門上デバイス（i-gel）下に摘出した小児気管支内異物の１例．
押川 隆，永田悠紀子，日髙康太郎，白阪哲朗，恒吉勇男
九州麻酔科学会第59回大会
Event date： 2021.9.4 - 2021.10.4
Language：Japanese Presentation type：Oral presentation (general)
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術後の疼痛コントロールに難渋したブプレノルフィン貼付剤使用患者の一例．
門田瑶子，日髙康太郎，内村修二，渡部由美，山賀昌治，恒吉勇男
日本ペインクリニック学会第55回大会
Event date： 2021.7.22 - 2021.7.24
Language：Japanese Presentation type：Oral presentation (general)
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レシニフェラトキシン誘発性疼痛ラットでのトラマドール治療後の高周波パルス療法の有効性と作用機序の検討（優秀演題）．
日髙康太郎，丸田豊明，門田瑶子，興梠聡志，越田智広，渡部由美，山賀昌治，恒吉勇男
日本ペインクリニック学会第55回大会
Event date： 2021.7.22 - 2021.7.24
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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NaV1.7を標的とする疼痛治療薬の光遺伝学的探索：トラマドールとミロガバリン
Grant number：23K15603 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
Authorship：Principal investigator