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• 医薬品の開発

  その他の試験研究機関  

  研究期間： 2006年05月  -  2017年03月

• Rho-kinaseの機能解析

  ライフサイエンス基礎科学研究  

  研究期間： 2000年06月  -  2006年04月

• 睡眠覚醒の調節に関わる遺伝子発現解析

  ライフサイエンス基礎科学研究  

  研究期間： 1997年01月  -  2000年05月

• ARIA(HER2)遺伝子発現部位の解析

  ライフサイエンス基礎科学研究  

  研究期間： 1993年01月  -  1995年03月

• βアミロイドタンパク質前駆体のプロテアーゼインヒビタードメインの生理機能解析

  ライフサイエンス基礎科学研究  

  研究期間： 1990年04月  -  1992年12月

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• Genetic analysis of chymotrypsin inhibitors in the hemolymph of Bombyx mori.

  Fujii H., Doira H., Aratake H., Koga K.

  Journal of Sericultural Science of Japan   65 ( 5 ) 334 - 341   1996年

  共著

  　概要を見る

  On polyacrylamide gel electrophoresis followed by activity staining, 16 a -chymotrypsin inhibitors (CIs-1, 2, 2', 3 to 6, 6', 7 to 11, 12, 13 and 13') were revealed in the larval hemolymph of the silkworm, Bombyx mori. Here we confirmed that the expression of 11 of these are co-dominantly controlled by alleles belonging to 4 CI genes. CIs-13 and 13' were found to be controlled by the alleles Ict-AF and Asrespectively. The alleles for CIs-10 and 9 were named Ict-BF and 5srespectively, and for CIs-2', 2 and 1 Ict-HFHM and Hsrespectively. The let-A, B and H gene complex was located on the 2nd linkage group at the map position of 23.7. There were 2 “null”alleles, Bn and IP, on this linkage group. CIs-8, 7, 6' and 6 were controlled by the alleles Ict-DFDMDs and DRrespectively, located on the 19th linkage group at the map position of 29.1. The CIs belonging to the Ict-A or D group exhibited no null counterparts in all the strains so far tested and these CI components may be indispensable for the growth of the silkworm. © 1996, The Japanese Society of Sericultural Science. All rights reserved.

  DOI

• Genetic analysis of hemolymph chymotrypsin inhibitors-3 and 4 in the silkworm, Bombyx mori

  Fujii H., Aratake H., Doira H.

  Journal of Sericultural Science of Japan   65 ( 5 ) 385 - 389   1996年

  共著

  　概要を見る

  Out of 16 chymotrypsin inhibitors (CIs) present in the larval hemolymph of Bombyx mori, the 2 components CIs-3 and 4 were subjected to genetic analysis in the present study. These CIs were found to be controlled by a co-dominant autosomal gene named Ict-E, with the alleles for CIs-4 and 3 assigned to be Ict-EF and Esrespectively, since CI-4 migrated faster toward the anode than CI-3 on polyacrylamide gel electrophoresis. Linkage tests showed that the Ict-E alleles were linked to the mw (minute wing) gene located on the 22nd linkage group. Three point experiment indicated the locus of the Ict-E gene to be 8.6 units left of mw, which had previously been mapped at the starting position of the 22nd linkage group. Consequently, Ict-E should be at the starting position instead of mw, and the arrangement of the 3 genes should be Ict-E (O.O)-or (8.9)-mw (25.2). © 1996, The Japanese Society of Sericultural Science. All rights reserved.

  DOI

• Differential expression of ARIA isoforms in the rat brain

  G Corfas, K Rosen, H Aratake, R Krauss and G Fischbach

  Neuron   14 ( 1 ) 103 - 115   1995年01月  [査読有り]

  共著

• A New Compound (Az36041) Promotes the Survival of the Neurons and Reduces Neurotoxicity of Alzheimer's Beta-Amyloid Protein

  Hasegawa Y., Sugimoto E., Endo T., Ogawa K., Morikawa A., Aratake H., Kitaguchi N.

  Biological and Pharmaceutical Bulletin   18 ( 12 ) 1750 - 1754   1995年

  共著

  　概要を見る

  Alzheimer's β-amyloid protein (Aβ) is the main component of senile plaques, which are characteristic hallmarks of the Alzheimer's disease brain. Recently, there have been several reports that Aβ has toxic effects on both cultured neurons and in the brain. We confirmed the neurotoxicity of Aβ in vitro and found a new compound, called AZ36041 (4-chloro-N-(5-nitro-2-tiazoyl) benzenesulfone amide), which dramatically reduced Aβ neurotoxicity. This compound was also found to have a neuroprotective effect against toxicity of glutamate and enhanced neuronal survival in the absence of neurotoxic compounds. AZ36041 may be a useful tool for investigating the mechanism of Aβ neurotoxicity in vitro and in vivo. © 1995, The Pharmaceutical Society of Japan. All rights reserved.

  DOI

• Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

  Araki W., Kitaguchi N., Tokushima Y., Ishii K., Aratake H., Shimohama S., Nakamura S., Kimura J.

  Biochemical and Biophysical Research Communications   181 ( 1 ) 265 - 271   1991年11月

  共著

  　概要を見る

  We investigated the effect of human β-amyloid precursor protein (APP) on rat primary cerebral cortical neurons cultured in a serum-free medium. Two secretory APP species (APP667 and APP592) with and without the protease inhibitor domain were produced by COS-1 cells transfected with APP cDNAs, which encode the N-terminal portions of APP770 and APP695. Both highly purified APP species, when added to the medium, enhanced neuronal survival and neurite extension in a dose-dependent manner with a maximum effect at approximately 100 nM. These results suggest that secreted forms of APP have trophic activity for cerebral cortical neurons. © 1991 Academic Press, Inc.

  DOI

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