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Faculty of Medicine School of Medicine Department of Anatomy, Histochemistry and Cell Biology |
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Assistant Professor |
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Laboratory Address |
宮崎市清武町木原5200 |
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Contact information |
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External Link |
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KAI Kengo
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Education 【 display / non-display 】
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University of Tsukuba
2002.4 - 2008.4
Campus Career 【 display / non-display 】
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University of Miyazaki Faculty of Medicine School of Medicine Department of Anatomy, Histochemistry and Cell Biology Assistant Professor
2024.04 - Now
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University of Miyazaki Faculty of Medicine College Hospital A Assistant Professor
2020.04 - 2024.03
Professional Memberships 【 display / non-display 】
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日本光線力学学会
2019
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日本組織細胞化学会
2019
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日本内視鏡外科学会
2018
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日本消化器病学会
2018
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日本消化器内視鏡学会
2018
Papers 【 display / non-display 】
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Kai Kengo, Hiyoshi Masahide, Imamura Naoya, Hamada Takeomi, Yano Koichi, Sato Yuichiro, Sakae Takehumi, Komi Masanori, Nakamura Takashi, Choijookhuu Narantsog, Hishikawa Yoshitaka, Nanashima Atsushi
Internal Medicine 62 ( 8 ) 1107 - 1115 2023
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine
<b>Objective </b>The extracellular volume (ECV) calculated based on contrast-enhanced computed tomography (CT) has been reported as a novel imaging parameter reflecting the morphological change of fibrosis in several parenchymal organs. Our retrospective study assessed the validity of the ECV fraction for diagnosing pancreatic fibrosis and the appropriate imaging condition as the "equilibrium phase". <b>Methods </b>In 27 patients undergoing multiphasic CT and subsequent pancreaticoduodenectomy, we investigated pathological fibrotic changes related to the ECV fraction and conducted analyses using the value obtained by subtracting the equilibrium CT value of the portal vein from that of the abdominal aorta (Ao-PV<sub>equilibrium</sub>) to estimate eligibility of the equilibrium phase. <b>Results </b>In all patients, the ECV fraction showed a weak positive correlation with the collagenous compartment ratio (r=0.388, p=0.045). All patients were divided into two groups - the high-Ao-PV<sub>equilibrium</sub> group and low-Ao-PV<sub>equilibrium</sub> group - based on the median value. No significant correlation was found in the high-Ao-PV<sub>equilibrium</sub> group, whereas a significant correlation was observed in the low-Ao-PV<sub>equilibrium</sub> group (r=0.566, p=0.035). <b>Conclusion </b>The ECV fraction is a possible predictive factor for histopathological pancreatic fibrosis. In its clinical application, the eligibility of the "equilibrium phase" may affect the diagnostic capability. It will be necessary to verify the imaging conditions in order to improve the accuracy of the diagnosis.
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Hamada T, Yano K, Kitamura E, Hiyoshi M, Imamura N, Kai K, Tahira K, Kawano F, Ohta Y, Nanashima A
Asian journal of endoscopic surgery 16 ( 3 ) 567 - 570 2023.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Asian Journal of Endoscopic Surgery
Laparoscopic hepatectomy is safely performed with minimal invasiveness on patients with recurrent liver tumors after previous hepatectomy. However, it is still difficult to dissect and expose the operative field at the transected edge or plane after open right hepatectomy, even for limited resection by a laparoscopic approach, due to severe adhesion to the surrounding peritoneum or organs. We herein applied the retroperitoneal laparoscopic approach to limited resection of the dorsal surface at the transected edge of Couinaud's segment 6 after previous repeated hepatectomies in a patient with recurrent hepatocellular carcinoma (HCC) by avoiding severe intra-abdominal adhesion. We safely resected recurrent HCC via the retroperitoneal space. This approach is a useful and alternative option for laparoscopy which minimizes the dissecting time and avoids organ injury on the right side of the transected area of the liver after hepatectomy in patients with liver malignancies.
DOI： 10.1111/ases.13185
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Correction: Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. Reviewed
Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y
Journal of ovarian research 16 ( 1 ) 21 2023.1
Language：English Publishing type：Research paper (scientific journal)
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Kai K., Hamada T., Sato Y., Hiyoshi M., Imamura N., Yano K., Ikeda T., Ichihara A., Ogata S., Choijookhuu N., Hishikawa Y., Hosokawa A., Nanashima A.
Journal of Oncology 2023 1440257 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Oncology
Background. Oxaliplatin (OX)-based chemotherapy induces sinusoidal obstruction syndrome (SOS) in the nontumorous liver parenchyma, which can increase the risk of liver resection due to colorectal liver metastasis (CRLM). The extracellular volume (ECV) calculated from contrast-enhanced computed tomography (CT) has been reported to reflect the morphological change of hepatic fibrosis. The present retrospective study aimed to evaluate the ECV fraction as a predictive factor for OX-induced SOS. Methods. Our study included 26 patients who underwent liver resection for CRLM after OX-based chemotherapy with a preoperative dynamic CT of appropriate quality. We investigated the relationship between the pathological SOS grade and the ECV fraction. Results. Overall, 26 specimens from the patients were graded with the SOS classification of Rubbia-Brandt et al. as follows: grade 0, n = 17 (65.4%); grade 1, n = 4 (15.4%); and grade 2, n = 5 (19.2%). No specimens showed grade 3 SOS. In a univariate analysis, the ECV fraction in grade 0 SOS was significantly lower than that in grade 1 + 2 SOS (26.3 ± 3.4% vs. 30.6 ± 7.0%; P = 0.025). The cutoff value and AUC value of the ECV fraction to distinguish between grades 0 and 1 + 2 were 27.5% and 0.771, respectively. Conclusions. Measurement of the ECV fraction was found to be a potential noninvasive diagnostic method for determining early-stage histopathological sinusoidal injury induced by OX-based chemotherapy.
DOI： 10.1155/2023/1440257
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Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. Reviewed
Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y
Journal of ovarian research 15 ( 1 ) 133 2022.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Ovarian Research
Background: High-Mobility Group Box 1 (HMGB1) and HMGB2 are chromatin-associated proteins that belong to the HMG protein family, and are involved in the regulation of DNA transcription during cell differentiation, proliferation and regeneration in various tissues. However, the role of HMGB2 in ovarian folliculogenesis is largely unknown. Methods: We investigated the functional role of HMGB1 and HMGB2 in ovarian folliculogenesis and fertilization using C57BL/6 wild type (WT) and HMGB2-knockout (KO) mice. Ovarian tissues were obtained from WT and HMGB2-KO mice at postnatal days 0, 3, 7, and 2, 6 months of age, then performed immunohistochemistry, qPCR and Western blotting analyses. Oocyte fertilization capability was examined by natural breeding and in vitro fertilization experiments. Results: In HMGB2-KO mice, ovary weight was decreased due to reduced numbers of oocytes and follicles. Natural breeding and in vitro fertilization results indicated that HMGB2-KO mice are subfertile, but not sterile. Immunohistochemistry showed that oocytes expressed HMGB2, but not HMGB1, in neonatal and adult WT ovaries. Interestingly, in HMGB2-KO ovaries, a compensatory increase in HMGB1 was found in oocyte nuclei of neonatal and 2-month-old mice; however, this was lost at 6 months of age. Conclusions: The depletion of HMGB2 led to alterations in ovarian morphology and function, suggesting that HMGB2 plays an essential role in ovarian development, folliculogenesis and fertilization.
Books 【 display / non-display 】
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Borre K. (Kai), Fernández-Hernández Ignacio, López-Salcedo José A., Bhuiyan M. Zahidul H.（ Role： Sole author）
Cambridge University Press 2023 （ ISBN:9781108837019 ）
Language：English
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Student engagement in the language classroom
Hiver Phil, Al-Hoorie Ali H., Mercer Sarah（ Role： Sole author）
Multilingual Matters 2021 （ ISBN:9781788923590 ）
Language：English
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Student engagement in the language classroom
Hiver Phil, Al-Hoorie Ali H., Mercer Sarah（ Role： Sole author）
Multilingual Matters 2021 （ ISBN:9781788923606 ）
Language：English
MISC 【 display / non-display 】
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Shirouzu S., Sugita N., Choijookhuu N., Yamaguma Y., Takeguchi K., Ishizuka T., Tanaka M., Fidya , Kai K., Chosa E., Yamashita Y., Koshimoto C., Hishikawa Y.
Journal of Ovarian Research 16 ( 1 ) 21 2023.12
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Journal of Ovarian Research
Following publication of the original article [1], the uthors identified an error in authorgroup. Author name Fidya Fidya should be Fidya. The original article has been corrected.
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Rare resected eight cases of duodenal adenocarcinomas
Nanashima A., Tanoue Y., Imamura N., Hiyoshi M., Yano K., Hamada T., Nishida T., Kai K., Suzuki Y., Sato Y., Nakashima K., Hosokawa A., Nagayasu T.
International Journal of Surgery Case Reports 86 106384 2021.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：International Journal of Surgery Case Reports
Introduction: Duodenal adenocarcinoma is a rare malignancy; recently, it has been found to be accompanied by operative indications. Methods: Nine consecutive rare cases were diagnosed with duodenal carcinoma (DC), in which clinicopathological characteristics were retrospectively examined. Age was ranged over middle-aged males and females. No clinical onset with severe symptoms was observed, and the specific treatment for accompanied diseases or habits was not found. Outcomes: One case of two T1 stage DCs that underwent pancreas-sparing duodenectomy. Stage II DC was diagnosed in three cases, and stage III DC was diagnosed in four cases. Pancreaticoduodenectomy (PD) mainly occurred in seven patients, and duodenectomy was limited in two patients. All operations were safely performed, and the postoperative course showed no severe morbidity. Histological findings showed R0 resection in eight cases and R1 at the retroperitoneal dissecting part in one case. Five patients with advanced-stage DC underwent adjuvant chemotherapy; however, four patients showed tumor recurrence within 12 months. With additional strong chemotherapy, eight patients survived up to 84 months, and one died of liver metastasis at 43 months after surgery. Three representative cases of mucosal invasion with widespread pancreas-sparing duodenectomy and advanced-stage DC cases undergoing duodenectomy or PD are shown. Conclusion: In the field of upper digestive tract surgery, duodenal adenocarcinoma and various applications of surgery or adjuvant chemotherapy for long-term survival are important.
Presentations 【 display / non-display 】
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A Clinicopathological Study of Extracellular Volume Fraction Determined by Contrast Enhanced Computed Tomography as a Predictive Factor of Pancreatic Fistula after Pancreaticoduodenectomy International conference
Kai K, Hiyoshi M, Imamura N, Hamada T, Yano K, Sato Y, Sakae T, Choijookhuu N, Hishikawa Y, Nanashima A
15th IHPBA World Congress
Event date： 2022.3.30 - 2022.4.2
Presentation type：Poster presentation
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当院における妊娠合併虫垂炎に対する 腹腔鏡下虫垂切除術の経験と工夫
甲斐健吾，池田拓人，市原明子，河野文彰，濱田朗子，松澤聡，鮫島浩，七島篤志
第13回Acute care surgery学会学術集会
Event date： 2021.11.4 - 2021.11.27
Presentation type：Symposium, workshop panel (public)
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膵頭十二指腸切除術における術後膵液漏の発生と造影CTによる細胞外血管外腔算出値の関連
甲斐健吾，旭吉雅秀，矢野公一，今村直哉，濱田剛臣，佐藤勇一朗，榮建文，七島篤志
JDDW 2021 KOBE
Event date： 2021.11.4 - 2021.11.7
Presentation type：Oral presentation (general)
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当科における大腸癌肝転移に対する初回肝切除の治療成績と血清CRP・アルブミン比の意義
甲斐健吾，濱田剛臣，池田拓人，市原明子，今村直哉，旭吉雅秀，内勢由佳子，原大介，鈴木康人，七島篤志
第46回日本大腸肛門病学会九州地方会
Event date： 2021.10.16
Presentation type：Symposium, workshop panel (public)
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当院での経腹壁的エラストグラフィによる膵線維化診断能の病理学的検証
甲斐健吾，濱田剛臣，旭吉雅秀，矢野公一，今村直哉，佐藤勇一朗，河上洋，田島栄美，七島篤志
日本超音波医学会第31回九州地方会学術集会
Event date： 2021.10.3
Presentation type：Oral presentation (general)
Industrial property rights 【 display / non-display 】
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直腸固有筋膜近接神経検査方法、及び神経検査装置
甲斐 健吾
Applicant：宮崎大学
Application no：2022-100239 Date applied：2022.6.22
Announcement no：2024-001530 Date announced：2024.1.10
Country of applicant：Domestic
Grant-in-Aid for Scientific Research 【 display / non-display 】
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食道癌に対する光線力学療法による薬剤耐性軽減効果の証明と新規治療開発に向けた検証
Grant number：20K17694 2020.04 - 2023.03
独立行政法人日本学術振興会 科学研究費補助金 若手研究
Authorship：Principal investigator
Available Technology 【 display / non-display 】
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低強度光線力学療法を用いた抗癌剤耐性の軽減効果の実証
Photodaynamic primingを用いた新規腹膜播種治療の開発Related fields where technical consultation is available：培養細胞を用いた光線力学療法の実施
Message：臨床経験から着想を得た研究で、実現すれば多くの癌患者さんの助けになると考えています。少しでも前に進めていけるように、多分野から様々なアドバイスを頂ければと思い掲載を希望しました。