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医学部 附属病院 総合周産期母子医療センター |
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助教 |
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宮崎県における免疫グロブリン療法不応川崎病に対する 血漿交換療法の現状 査読あり
山本 絵里子
宮崎医会誌 47 ( 1 ) 36 - 40 2023年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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BMPR2 variant may be related to pulmonary hypertension after lung irradiation
Harada M., Yamada A., Nagasawa S., Yamashita N., Kinoshita M., Yoshiura K.i., Moritake H.
Pediatrics International 65 ( 1 ) e15652 2023年1月
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Chida-Nagai A., Masaki N., Maeda K., Sasaki K., Sato H., Muneuchi J., Ochiai Y., Murayama H., Tahara M., Shiono A., Shinozuka A., Kono F., Machida D., Toyooka S., Sugimoto S., Nakamura K., Akagi S., Kondo M., Kasahara S., Kotani Y., Koizumi J., Oda K., Harada M., Nakajima D., Murata A., Nagata H., Yatsunami K., Kobayashi T., Matsunaga Y., Inoue T., Yamagishi H., Nakagawa N., Ohtani K., Yamamoto M., Ito Y., Hokosaki T., Kuwahara Y., Masutani S., Nomura K., Wada T., Sawada H., Abiko M., Takahashi T., Ishikawa Y., Okada S., Naitoh A., Toda T., Ando T., Masuzawa A., Hoshino S., Kawada M., Nomura Y., Ueno K., Ohashi N., Tachibana T., Cao Y., Ueda H., Yanagi S., Koide M., Mitsushita N., Higashi K., Minosaki Y., Hayashi T., Okamoto T., Kuraishi K., Ehara E., Ishida H., Horigome H., Murakami T., Takei K., Ishii T., Harada G., Hirata Y., Maeda J., Tatebe S., Ota C., Hayabuchi Y., Sakazaki H., Sasaki T., Hirono K., Suzuki S., Yasuda M., Takeda A., Sawai M., Miyaji K., Kitagawa A., Nakai Y., Kakimoto N., Agematsu K., Manabe A., Saiki Y.
Frontiers in Cardiovascular Medicine 10 1212882 2023年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Frontiers in Cardiovascular Medicine
Aims: Limited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH. Methods: This retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death. Results: The 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P =.037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45–13.73; P =.009). Conclusions: The IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered.
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Left atrial appendage aneurysm enlarged in the neonatal period.
Yamashita N, Harada M, Moritake H
Cardiology in the young 33 ( 8 ) 1 - 3 2022年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Cardiology in the Young
We describe a newborn with a congenital left atrial appendage aneurysm. The aneurysm size did not change prenatally. However, it rapidly enlarged after birth. MRI was useful for assessing the aneurysm extent and exact size, and for diagnosis. Respiratory distress and feeding difficulties appeared, and surgery was performed. These symptoms disappeared post-operatively. The patient is alive without complications or recurrence.
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市中感染型メチシリン耐性黄色ブドウ球菌菌血症を併発した細菌性気管炎. 査読あり
入佐浩史
日本小児救急医学会雑誌. 22 ( 1 ) 20 - 24 2022年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
受託研究受入実績 【 表示 ／ 非表示 】
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ウプトラビ錠0.2mg・0.4mg特定使用成績調査（長期使用に関する調査）
2018年06月 - 2023年09月
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レバチオ特定使用成績調査（小児を対象とした長期使用に関する調査）
2018年02月 - 2022年08月
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ヴォリブリス錠2.5mg使用成績調査
2015年10月 - 2020年01月