|
所属 |
医学部 医学科 感覚運動医学講座眼科学分野 |
|
外部リンク |
|
所属学協会 【 表示 ／ 非表示 】
-
日本網膜硝子体学会
2008年4月 - 現在
-
日本緑内障学会
2006年4月 - 現在
-
The Association for Research in Vision and Ophthalmology (ARVO)
2000年10月 - 現在
-
日本遺伝子細胞治療学会
1999年4月 - 現在
-
日本眼科学会
1995年5月 - 現在
論文 【 表示 ／ 非表示 】
-
Obata S., Sawada O., Kakinoki M., Matsumoto R., Saishin Y., Ohji M., Yamamoto S., Baba T., Sato E., Kitahashi M., Tatsumi T., Miura G., Nizawa T., Sakamoto T., Yamakiri K., Yamashita T., Otsuka H., Sameshima S., Yoshinaga N., Sonoda S., Hirakata A., Koto T., Inoue M., Hirota K., Itoh Y., Orihara T., Emoto Y., Sano M., Takahashi H., Tokizawa R., Yamashita H., Nishitsuka K., Kaneko Y., Nishi K., Yoshida A., Ono S., Hirokawa H., Sogawa K., Omae T., Ishibazawa A., Kishi S., Akiyama H., Matsumoto H., Mukai R., Morimoto M., Nakazawa M., Suzuki Y., Kudo T., Adachi K., Ishida S., Noda K., Kase S., Mori S., Ando R., Saito M., Suzuki T., Takahashi K., Nagai Y., Nakauchi T., Yamada H., Kusaka S., Tsujioka D., Tsujikawa A., Suzuma K., Ishibashi T., Sonoda K.H., Ikeda Y., Kohno R., Ishikawa K., Kondo M., Kozawa M., Kitaoka T., Tsuiki E., Ogura Y., Yoshida M., Morita H., Kato A., Hirano Y., Sugitani K., Terasaki H., Iwase T., Ito Y., Ueno S., Kaneko H., Nonobe N., Kominami T., Azuma N., Yokoi T., Shimada H., Nakashizuka H., Hattori T., Shinojima A., Kitagawa Y., Shiraga F., Morizane Y., Kimura S., Ikeda T., Kida T., Sato T., Fukumoto M.
Japanese Journal of Ophthalmology 67 ( 4 ) 417 - 423 2023年7月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Ophthalmology
Purpose: To investigate the effects of internal limiting membrane (ILM) peeling on retinal attachment after a single surgery, and on postoperative visual acuity (VA) at 6 months, in eyes with macula-off rhegmatogenous retinal detachment (RRD) complicated by proliferative vitreoretinopathy (PVR). Study design: Nationwide, multicenter retrospective cohort study. Methods: The Japan-RD Registry database was used for analysis of patients who had undergone vitrectomy for macula-off RRD complicated by PVR. Multivariate analysis was performed to detect prognostic factors for retinal attachment after a single surgery and for VA at 6 months postoperatively. Retinal attachment after a single surgery or VA at 6 months postoperatively was the objective variable; ILM peeling, preoperative VA, PVR grade, age, and intraocular pressure were explanatory variables. Results: Eighty-nine eyes met the inclusion criteria; ILM peeling was performed in 25 eyes (28%). Preoperative VA was significantly associated with retinal attachment, but ILM peeling did not (odds ratios = 2.1 and 1.3, respectively; p = 0.009 and 0.67, respectively). Poor preoperative VA and younger patient age were significantly associated with poor postoperative VA, but ILM peeling was not (β-values = 0.37, −0.008, and 0.15, respectively; p < 0.001, p = 0.02, and p = 0.15, respectively. Conclusions: Preoperative VA was a risk factor associated with retinal attachment. Preoperative VA and patient age were risk factors associated with postoperative poor VA. In eyes with macula-off RRD complicated by PVR, ILM peeling did not have a clear beneficial effect on anatomical and functional outcomes, suggesting that it may be unnecessary for eyes with this condition.
-
Shimura M., Kitano S., Ogata N., Mitamura Y., Oh H., Ochi H., Ohsawa S., Hirakata A., Bolz M., Findl O., Pollreisz A., Weger M., Daskalov V., Misheva A., Petkova I., Guneva D.T., Vassileva P., Cornut P.L., Korobelnik J.F., Lebreton O., Tadayoni R., Eter N., Feltgen N., Framme C., Lorenz K., Spital G., Bator G., Seres A., Szalczer L., Toth-Molnar E., Vajas A., Varsanyi B., Goldstein M., Levy J., Morori-Katz H., Rosenblatt I., Yoreh B., Bandello F., Cagini C., Mastropasqua L., Nicolo M., Parravano M.C., Viola F., Fukutomi A., Hayashi K., Hirakata A., Honda S., Ikeda Y., Ito Y., Kawasaki T., Kimura K., Kishino G., Kitano S., Maeno T., Murakami T., Noda K., Obana A., Oh H., Sawada O., Shimouchi A., Sugimoto M., Sugita I., Takagi H., Takayama K., Tanabe T., Yasukawa T., Yoshida S., Garcia R., Rechy D.L., Canton V.M., Estudillo J.R., Barraza K., Fernandez C., Guzman M., Lujan S., Gawecki M., Herba E., Michalska-Malecka K., Muzyka-Wozniak M., Nester-Ostrowska K., Oleksy P., Wowra B., Wylęgała E., Budzinskaya M., Kulikov A., Morugova T., Hurcikova M., Kacerík M., Lipkova B., Abengoechea S., Civera A.A., Amat P., Cabrera F., Cava C., Garcia-Layana A., Ulla F.G., Moreno J.M.R.
Japanese Journal of Ophthalmology 67 ( 3 ) 264 - 279 2023年5月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Ophthalmology
Purpose: To evaluate efficacy, durability, and safety of faricimab in Japanese patients with diabetic macular edema (DME). Study design: Subgroup analysis of 2 global, multicenter, randomized, double-masked, active-comparator–controlled, phase 3 trials (YOSEMITE, NCT03622580; RHINE, NCT03622593). Methods: Patients with DME were randomized 1:1:1 to intravitreal faricimab 6.0 mg every 8 weeks (Q8W), faricimab 6.0 mg per personalized treatment interval (PTI), or aflibercept 2.0 mg Q8W through week 100. Primary endpoint was best-corrected visual acuity (BCVA) change from baseline at 1 year, averaged over weeks 48, 52, and 56. This is the first time 1-year outcomes between Japanese patients (only enrolled into YOSEMITE) and the pooled YOSEMITE/RHINE cohort (N = 1891) have been compared. Results: The YOSEMITE Japan subgroup included 60 patients randomized to faricimab Q8W (n = 21), faricimab PTI (n = 19), or aflibercept Q8W (n = 20). Consistent with global results, the adjusted mean (95.04% confidence interval) BCVA change at 1 year in the Japan subgroup was comparable with faricimab Q8W (+11.1 [7.6–14.6] letters), faricimab PTI (+8.1 [4.4–11.7] letters), and aflibercept Q8W (+6.9 [3.3–10.5] letters). At week 52, 13 (72%) patients in the faricimab PTI arm achieved ≥ Q12W dosing, including 7 (39%) patients receiving Q16W dosing. Anatomic improvements with faricimab were generally consistent between the Japan subgroup and pooled YOSEMITE/RHINE cohort. Faricimab was well tolerated; no new or unexpected safety signals were identified. Conclusion: Consistent with global results, faricimab up to Q16W offered durable vision gains and improved anatomic and disease-specific outcomes among Japanese patients with DME.
-
Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice 査読あり
Igarashi T., Ohsawa I., Kobayashi M., Miyazaki K., Igarashi T., Kameya S., Shiozawa A.L., Ikeda Y., Miyagawa Y., Sakai M., Okada T., Sakane I., Takahashi H.
Scientific Reports 12 ( 1 ) 13610 2022年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Scientific Reports
Retinitis pigmentosa (RP) is a genetically heterogeneous group of inherited retinal disorders involving the progressive dysfunction of photoreceptors and the retinal pigment epithelium, for which there is currently no treatment. The rd6 mouse is a natural model of autosomal recessive retinal degeneration. Given the known contributions of oxidative stress caused by reactive oxygen species (ROS) and selective inhibition of potent ROS peroxynitrite and OH·by H2 gas we have previously demonstrated, we hypothesized that ingestion of H2 water may delay the progression of photoreceptor death in rd6 mice. H2 mice showed significantly higher retinal thickness as compared to controls on optical coherence tomography. Histopathological and morphometric analyses revealed higher thickness of the outer nuclear layer for H2 mice than controls, as well as higher counts of opsin red/green-positive cells. RNA sequencing (RNA-seq) analysis of differentially expressed genes in the H2 group versus control group revealed 1996 genes with significantly different expressions. Gene and pathway ontology analysis showed substantial upregulation of genes responsible for phototransduction in H2 mice. Our results show that drinking water high in H2 (1.2–1.6 ppm) had neuroprotective effects and inhibited photoreceptor death in mice, and suggest the potential of H2 for the treatment of RP.
-
Takano F, Ueda K, Godefrooij DA, Yamagami A, Ishikawa H, Chuman H, Ishikawa H, Ikeda Y, Sakamoto T, Nakamura M
Orphanet journal of rare diseases 17 ( 1 ) 319 2022年8月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Orphanet Journal of Rare Diseases
Background: Leber hereditary optic neuropathy (LHON) is an acute or subacute optic neuropathy that mainly affects young males. The first nationwide epidemiological survey of LHON was conducted in 2014 in Japan, and LHON was officially designated as a rare intractable disease by the Japanese government in 2015. We conducted a second survey of the annual incidence of LHON in 2019, and estimated the total number of patients with LHON in Japan. Results: A questionnaire was sent to 997 facilities accredited by the Japanese Ophthalmological Society and/or affiliated with the councilors of the Japanese Neuro-Ophthalmology Society. Responses were received from 791 facilities, with a response rate of 79%. Fifty-five newly diagnosed cases (49 males and 6 females) of LHON were reported from 35 institutions in 2019, with a median age of 28.5 for males and 49.5 years for females. The total number of newly diagnosed cases was calculated as 69 (62 were males and 7 were females, 95% confidence interval 55–83), and the total number of patients was estimated to be 2491 (95% confidence interval: 1996–2986), suggesting a prevalence of LHON in Japan of 1:50,000. Conclusion: The incidence of LHON in 2019 was lower than the estimate in 2014, whereas its prevalence may be similar to that reported in other countries. The accurate estimation of the incidence and prevalence of patients with LHON requires prospective registration.
書籍等出版物 【 表示 ／ 非表示 】
-
眼科診療ビジュアルラーニング５ 「網膜, 硝子体」
池田 康博（ 担当： 分担執筆）
中山書店 2020年9月
記述言語：日本語
-
眼疾患アトラスシリーズ２ 「後眼部アトラス」
池田 康博（ 担当： 分担執筆）
総合医学社 2019年10月
記述言語：日本語
-
眼疾患アトラスシリーズ２ 「後眼部アトラス」
池田 康博（ 担当： 分担執筆）
総合医学社 2019年10月
記述言語：日本語
MISC 【 表示 ／ 非表示 】
-
【眼科領域の最新医療・プレシジョンメディシン】網膜色素変性の遺伝子治療
池田康博
Precision Medicine 2020年2月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
【眼科の先進的医療Up to Date】遺伝性網膜変性疾患の遺伝子治療
池田康博
あたらしい眼科 2019年11月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
機器・薬剤紹介 HOYA暗所視支援眼鏡MW-10 HiKARI
池田康博
眼科 2019年9月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
【知っておきたい稀な網膜・硝子体ジストロフィ】錐体杆体ジストロフィ
吉田倫子、池田康博
OCULISTA 2019年6月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
【眼科医の手引】 暗所視支援眼鏡
池田康博
日本の眼科 2019年3月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
-
網膜色素変性を自然発症するカニクイザルの繁殖と治療法開発への応用
研究課題/領域番号：22K09769 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
担当区分：研究代表者
-
短後毛様動脈虚血による正常眼圧緑内障モデルの作成とアドレノメジュリン効果の検討
研究課題/領域番号：22K09770 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
中馬 秀樹、
担当区分：研究分担者