杉山 崇史 (スギヤマ タカシ)

SUGIYAMA Takashi

写真a

所属

医学部 附属病院 神経内科

職名

助教

外部リンク

研究分野 【 表示 / 非表示

  • ライフサイエンス / 神経内科学

 

論文 【 表示 / 非表示

  • Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis. 査読あり 国際誌

    Sugiyama T, Murao N, Kadowaki H, Nishitoh H

    Scientific reports   12 ( 1 )   21840 - 21840   2022年12月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    There are no available therapies targeting the underlying molecular mechanisms of neurodegenerative diseases. Although chaperone therapies that alleviate endoplasmic reticulum (ER) stress recently showed promise in the treatment of neurodegenerative diseases, the detailed mechanisms remain unclear. We previously reported that mice with central nervous system-specific deletion of Derlin-1, which encodes an essential component for ER quality control, are useful as models of neurodegenerative diseases such as spinocerebellar degeneration. Cholesterol biosynthesis is essential for brain development, and its disruption inhibits neurite outgrowth, causing brain atrophy. In this study, we report a novel mechanism by which chemical chaperones ameliorate brain atrophy and motor dysfunction. ER stress was induced in the cerebella of Derlin-1 deficiency mice, whereas the administration of a chemical chaperone did not alleviate ER stress. However, chemical chaperone treatment ameliorated cholesterol biosynthesis impairment through SREBP-2 activation and simultaneously relieved brain atrophy and motor dysfunction. Altogether, these findings demonstrate that ER stress may not be the target of action of chaperone therapies and that chemical chaperone-mediated improvement of brain cholesterol biosynthesis is a promising novel therapeutic strategy for neurodegenerative diseases.

    DOI: 10.1038/s41598-022-26370-0

    Scopus

    PubMed

    researchmap

  • ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. 査読あり 国際共著

    Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H.

    iScience   24 ( 7 )   102758   2021年1月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:学位論文(博士)  

    DOI: 10.1016/j.isci.2021.102758

  • Validation and Discussion of Severity Evaluation and Disease Classification Using Tremor Video 査読あり

    Hayashida T., Sugiyama T., Sakai K., Ishii N., Mochizuki H., Zin T.T.

    Electronics (Switzerland)   12 ( 7 )   2023年4月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Electronics (Switzerland)  

    A tremor is a significant symptom of Parkinson’s disease, but it can also be a characteristic of essential tremor, thereby hampering even specialists’ ability to differentiate between the two. This study proposes a system that leverages a single RGB camera to evaluate tremor severity and support the differential diagnosis of Parkinson’s disease and essential tremor. The system captures motor symptoms, performs time–frequency analysis using wavelet transforms, and classifies severity and disease using linear classification models. The results showed an accuracy rate of 0.56 for disease classification and 0.50 for severity classification (with an acceptable accuracy rate of 0.96). The analysis indicated that there was a low level of correlation between disease and each feature and a moderate correlation (about 0.6) between severity and each feature. Based on these results, this study recommends classifying severity with a linear model and disease with a nonlinear model to obtain improved accuracy.

    DOI: 10.3390/electronics12071674

    Scopus

  • RGB カメラによって観測された運動症状を用いたパーキンソン病、本態性振戦の鑑別可能性に関する研究

    林田 高典, 杉山 崇史, 酒井 克也, 石井 信之, 望月 仁志

    バイオメディカル・ファジィ・システム学会大会講演論文集   35 ( 0 )   C-1   2022年

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:バイオメディカル・ファジィ・システム学会  

    Movements that appear unconsciously are called involuntary movements. Especially, rhythmic involuntary movements are called tremors. Tremor interferes with daily life and is one of the characteristic symptoms of neurological disorders such as Parkinson's disease (PD) and essential tremor (ET). Symptoms and progression of PD patients are assessed by a neurologist through neurological examination and interview according to the revised Unified Parkinson's Disease Rating Scale (UPDRS) sponsored by the Movement Disorders Society (MDS). PD is associated with other symptoms such as bradykinesia, whereas ET is characterized by tremor alone. However, in the early onset of PD, other symptoms may not be noticeable, and even neurologists may find it difficult to differentiate it from ET. In this paper, to solve this issue of getting lost in this judgment, consider whether it is possible to distinguish between PD and ET two types of neurological disorders from two approaches, time domain and frequency domain which from observed tremor movement by using an RGB camera.

    DOI: 10.24466/pacbfsa.35.0_c-1

    CiNii Research

  • Detailed analysis of neurological symptoms and sensory disturbances due to chronic arsenic exposure in toroku, japan 査読あり 国際誌

    Sugiyama T., Ishii N., Ebihara Y., Shiomi K., Mochizuki H.

    International Journal of Environmental Research and Public Health   18 ( 20 )   10749 - 10749   2021年10月

     詳細を見る

    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Environmental Research and Public Health  

    As a result of population growth and the development of tube wells, humans’ exposure to arsenic has increased over the past few decades. The natural course of organ damage secondary to arsenic exposure is not yet well understood. In Toroku, Japan, an arsenic mine was intermittently operated from 1920 to 1962, and residents were exposed to high concentrations of arsenic. In this paper, we analyzed 190 consecutive residents for whom detailed records of neurological symptoms and findings were obtained from 1974 to 2005. All participants were interviewed regarding the presence of general, skin, hearing, respiratory, and neurological symptoms. Neurological symptoms were classified into extremity numbness or pain, constipation, dyshidrosis, sensory loss, and muscle atrophy. Superficial and vibratory sensation was also evaluated. More than 80% of participants experienced extremity numbness, and numbness was the most common neurological symptom. Numbness was associated with superficial sensory disturbance, and was correlated with the subsequent development of other neurological symptoms, including autonomic and motor symptoms. No previous studies have investigated the natural course of chronic arsenic intoxication; thus, these data serve as a guide for detecting early symptoms due to arsenic exposure.

    DOI: 10.3390/ijerph182010749

    Scopus

    PubMed

    researchmap

全件表示 >>

MISC 【 表示 / 非表示

  • コロナワクチン後に生じたと考えられる脳脊髄液減少症により体位性頻脈発作を認めた一例

    長友優菜, 金丸和樹, 杉山崇史, 宮本美由貴, 酒井克也, 中里祐毅, 望月仁志, 塩見一剛

    臨床神経学(Web)   61 ( 12 )   2021年

     詳細を見る

    掲載種別:速報,短報,研究ノート等(学術雑誌)  

    J-GLOBAL

    researchmap

講演・口頭発表等 【 表示 / 非表示

  • Derlin familyの欠損による脳の発達障害は脳内コレステロール合成低下に起因する

    杉山崇史、村尾直哉、西頭英起

    第94回日本生化学会大会  

     詳細を見る

    開催年月日: 2021年11月3日 - 2021年11月5日

    会議種別:ポスター発表  

  • 慢性砒素中毒に起因する神経障害の自然経過

    杉山崇史、望月仁志、金丸和樹、中里祐毅、酒井克也、中里雅光、塩見一剛

    第62回日本神経学会学術⼤会 

     詳細を見る

    開催年月日: 2021年5月19日 - 2021年5月22日

    会議種別:ポスター発表  

  • 発作以外の症状を欠くリウマチ性髄膜炎に対して髄液中CCP 抗体価を追跡しえた一例

    川上隆太郎、杉山崇史、金丸和樹、宮本美由貴、中里祐毅、望月仁志、塩見一剛

    第236回日本神経学会 九州地方会 

     詳細を見る

    開催年月日: 2022年6月18日

    会議種別:口頭発表(一般)  

  • 二次性に体位性頻脈症候群(POTS)を呈した脳脊髄液漏出症の1例

    林 尭樹、宮本美由貴、金丸和樹、酒井克也、中里祐毅、杉山崇史、望月仁志、塩見一剛

    第337回日本内科学会九州地方会 

     詳細を見る

    開催年月日: 2022年5月28日

    会議種別:口頭発表(一般)  

  • 70歳以上で症状が顕在化した顔面肩甲上腕型筋ジストロフィー(FSHD)の1例

    金丸和樹、宮本美由貴、酒井克也、中里祐毅、杉山崇史、望月仁志、(西野一三)、塩見一剛

    第235回日本神経学会九州地方会 

     詳細を見る

    開催年月日: 2022年3月19日

    会議種別:口頭発表(一般)  

全件表示 >>