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Affiliation |
Faculty of Regional Innovation |
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Title |
Lecturer |
Degree 【 display / non-display 】
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博士（保健学） ( 2020.3 大阪府立大学 )
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修士（栄養学） ( 2014.3 徳島大学 )
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学士（栄養学） ( 2012.3 徳島大学 )
Research Areas 【 display / non-display 】
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Life Science / Nutrition science and health science
Papers 【 display / non-display 】
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Lactic acid induces HSPA1A expression through ERK1/2 activation. Reviewed
Nonaka M, Kanouchi H, Torii S, Nagano H, Kondo S, Fujii A, Nagano M, Takenaka S
Bioscience, biotechnology, and biochemistry 87 ( 2 ) 191 - 196 2023.1
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1093/bbb/zbac192
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Effect of enzymatic and dynamic high-pressure processed chicken meat on skeletal muscle of sarcopenia model mice Reviewed
Kogure Sarasa, Nagano Hikaru, Matsumoto Takehiro, Tanioka Yuri, Yamauchi Jun, Furusho Tadasu
Food Preservation Science 48 ( 3 ) 121 - 130 2022.1
Language：English Publishing type：Research paper (scientific journal)
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Elucidation of molecular mechanism of foretinib-induced adaptive resistance in colon cancer cells Reviewed
Hikaru NAGANO, Chinami MATSUYAMA, Yukari MANABE, Minori SUNAGAWA, Nanako HIGAKI, Moe YOSHIDA, Shigetada KONDO
18 1 - 6 2021.12
Authorship：Lead author Publishing type：Research paper (scientific journal)
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Effect of epigallocatechin gallate on resistance to molecular targeted anti-cancer drugs Reviewed
Yukari MANABE, Hikaru NAGANO, Moe YOSHIDA, Nanako HIGAKI, Shigetada KONDO
18 7 - 13 2021.12
Publishing type：Research paper (scientific journal)
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Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza Reviewed
Ayako Ohno, Nobuo Maita, Takanori Tabata, Hikaru Nagano, Kyohei Arita, Mariko Ariyoshi, Takayuki Uchida, Reiko Nakao, Anayt Ulla, Kosuke Sugiura, Koji Kishimoto, Shigetada Teshima-Kondo, Yuushi Okumura, Takeshi Nikawa
Life Science Alliance 4 ( 6 ) e202000849 - e202000849 2021.6
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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第30回研究助成業績集 骨格筋細胞の分化・脱分化を制御する筋特異的長鎖ノンコーディングRNAの解明
永野ひかる（ Role： Contributor）
公益財団法人中富健康科学振興財団 2019.9
Language：Japanese Book type：Report
MISC 【 display / non-display 】
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VEGFR-1はEGF-Rを介して大腸がん細胞の増殖を制御する
永野 ひかる, 冨田 知里, 山岸 直子, 近藤 茂忠
日本癌学会総会記事 79回 PJ5 - 1 2020.10
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本癌学会
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VEGF受容体阻害剤による大腸がん細胞の遊走能亢進メカニズムの解明
冨田 知里, 永野 ひかる, 山岸 直子, 近藤 茂忠
日本癌学会総会記事 79回 PJ16 - 2 2020.10
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本癌学会
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永野ひかる, 近藤茂忠, 山岸直子, 冨田知里, 真板綾子, 平坂勝也, 二川健
食品加工技術 33 ( 3 ) 139 - 145 2013
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本食品機械研究会
Presentations 【 display / non-display 】
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高校生を対象とした学際性の理解を促すサイエンス体験講座の取り組み
戸敷浩介, 西和盛, 橋口正嗣, 永野ひかる, 福島三穂子
第12回日本サイエンスコミュニケーション協会（JASC）年会開催
Event date： 2023.12.9 - 2023.12.11
Presentation type：Oral presentation (general)
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小学生を対象とした地域教育向上へ向けた取り組みーお茶を1つの事例としてー
福島三穂子, 西和盛, 橋口正嗣, 永野ひかる, 戸敷浩介
第12回日本サイエンスコミュニケーション協会（JASC）年会開催
Event date： 2023.12.9 - 2023.12.11
Presentation type：Oral presentation (general)
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小学校との連携におけるお茶を使ったPTCA活動に関する報告
福島三穂子・西和盛・戸敷浩介・橋口正嗣・永野ひかる
宮崎大学 研究・産学地域連携推進機構 第30回技術・研究発表交流会 2023.9.22
Event date： 2023.9.22
Presentation type：Poster presentation
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プロテアーゼと超高圧ホモジナイザーの併用処理した鶏肉は SAMR1 マウスの骨格筋を増量する
小暮更紗，永野ひかる，谷岡由梨，山内 淳，古庄 律
第70回日本食品科学工学会 2023.8.25
Event date： 2023.8.24 - 2023.8.26
Presentation type：Oral presentation (general)
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Effect of dynamic high-pressure treated chicken meat on skeletal muscle of sarcopenia model mice International conference
2022.12.11
Event date： 2022.12.6 - 2022.12.11
Language：English Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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大腸がんの最新治療薬の「限界」を克服する栄養学的新戦略
Grant number：22K17783 2022.04 - 2025.03
日本学術振興会 科学研究費助成事業 若手研究 若手研究
永野 ひかる
Authorship：Principal investigator
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Grant number：17K13071 2017.04 - 2019.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
nagano hikaru
Authorship：Principal investigator Grant type：Competitive
Hydrogen sulfide was detected in mammalian brain in 1989. Thus, it has become recognized as a gasotransmitter such as nitric oxide (NO) and carbon monoxide (CO). Although skeletal muscle atrophy cause a decrease in QOL (Quality of life), effective treatment for skeletal muscle atrophy has not still been established. In this study, I elucidated that hydrogen sulfide contribute to the muscle hypertrophy in a mouse skeletal muscle cell line. I further found that cysteine contribute to the muscle hypertrophy.
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Grant number：15K09585 2015.04 - 2017.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Okumura Yuushi
Authorship：Coinvestigator(s) Grant type：Competitive
Cleavage of viral envelope glycoprotein, hemagglutinin (HA), by host cellular proteases is essential step for influenza virus to enter into the target cells. We identified that ubiquitous type II transmembrane serine proteases, MSPL and its splice variant TMPRSS13, were candidates of HA-processing proteases of diverse highly pathogenic avian influenza (HPAI) viruses. In addition, we succeeded to reveal the crystal structure of MSPL/TMPRSS13. In this study, based on their structure, we first generated specific inhibitors for MSPL/TMPRSS13. To confirm the involvement of these proteases in HPAI virus infection, highly virulent virus (A/Crow/Kyoto/53/2004 (H5N1)) was infected into MSPL/TMPRSS13 stably expressed cells with or without their specific inhibitors. As a result, we concluded that these proteases specific inhibitors might be suppress HPAI virus multicycle replication and spreading. In vivo infectious experiments using their specific inhibitors are currently being investigated.