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医学部 附属病院 泌尿器科 |
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Determination of three C18-oxygenated steroids in adrenal lesion segments in primary aldosteronism by super-selective adrenal venous sampling and LC/ESI-MS/MS. 査読あり
Mizumoto Y, Hirakawa A, Sugiura Y, Nishikawa T, Nishimoto K, Mano Y, Higashi T
Biomedical chromatography : BMC e5841 2024年2月
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Matsushita Y., Miyake M., Nishimura N., Nishimoto K., Fukuhara H., Kobayashi K., Oyama M., Inoue K., Matsuyama H., Fujimoto K., Miyake H.
International Journal of Clinical Oncology 29 ( 2 ) 205 - 212 2024年2月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：International Journal of Clinical Oncology
Background: Among patients with non-muscle-invasive bladder cancer (NMIBC), systematic reviews showed lower recurrence rate in patients treated with photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumor (TURBT) than with white-light (WL) TURBT. However, the result is not consistent between clinical trials and the significance of preoperatively available factors in disease recurrence after PDD-TURBT remains unclear. Methods: The present study retrospectively analyzed 1174 NMIBC patients who underwent TURBT and were followed up for ≥ 6 months. Among 1174 patients, 385 and 789 underwent PDD-TURBT with oral 5-aminolevulinic acid (the PDD group) and WL-TURBT (the WL group), respectively. Recurrence-free survival (RFS) was compared between the PDD and WL groups before and after propensity score matching, and the impact of several baseline parameters on RFS between the 2 groups was investigated after matching. Results: Before propensity score matching, RFS was significantly longer in the PDD group than in the WL group (P = 0.006). After matching, 383 patients were included in both groups, and RFS was significantly longer in the PDD group than in the WL group (P < 0.001). In the cohort after matching, RFS between the two groups was compared in each subgroup classified according to baseline parameters, including age, sex, history of previous or concomitant upper urinary tract urothelial carcinoma, preoperative urinary cytology, tumor multiplicity, and tumor size, and significantly longer RFS was observed in the PDD group in all subgroups, except for the patients with tumors ≥ 30 mm (P = 0.21). Conclusion: These results suggest that PDD-TURBT prolongs RFS in NMIBC patients, except for those with tumors ≥ 30 mm.
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Pathology and gene mutations of aldosterone-producing lesions
Nishimoto K., Ogishima T., Sugiura Y., Suematsu M., Mukai K.
Endocrine Journal 70 ( 12 ) 1113 - 1122 2023年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本内分泌学会
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for CYP11B2 of both rats and humans and applied it clinically to visualize the functional histology of aldosterone-producing adenoma (APA) causing primary aldosteronism (PA). We discovered aldosterone-producing cell clusters (APCCs) and possible APCC-to-APA transitional lesions (pAATLs) and further visualized aldosterone-producing lesions for rare forms of PA including familial hyperaldosteronism type 3 and novel non-familial juvenile PA. Here we review the history of our research on aldosterone-producing lesions.
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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病変に着目した原発性アルドステロン症進展メカニズムの解明
研究課題/領域番号：22K09509 2022年04月 - 2027年03月
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
担当区分：研究代表者
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機械学習を用いた原発性アルドステロン症における個別化医療基盤の確立
研究課題/領域番号：22K08627 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
担当区分：研究分担者
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副腎皮質細胞の形質遷移に着目した細胞層構築・維持と破綻に関する分子基盤の解明
研究課題/領域番号：22K08634 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
担当区分：研究分担者