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Kawaguchi N., Fuke N., Nueangphuet P., Pornthummawat A., Niazi A.M., Izzati U.Z., Hirai T., Yamaguchi R.
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 86 ( 1 ) 49 - 53 2024年1月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本獣医学会
After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.
DOI： 10.1292/jvms.23-0152
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Investigation of preinguinal approach for removal of urachal abscess in three Japanese black cattle older than 18 months of age. 査読あり
Sato R, Hayashi J, Fuke N, Saito E, Hidaka K, Saka H, Satoh H, Steiner A
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ advpub ( 0 ) 2024年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本獣医学会
This study investigated the diagnostic and surgical management of urachal abscessation involving the urinary bladder in three cattle aged >18 months. While the abdominal floor or paralumbar fossa are typically considered for accessing the urachus and bladder in calves and heifers, the distance is too great to perform the procedure under direct vision in adult cows. Therefore, a novel preinguinal approach was used for access in cows with urachal abscesses after 18 months. Access was successfully achieved in all the three cows through a preinguinal incision to the urachal abscess at the apex of the bladder. However, in cases wherein the abscess and adhesions are severe, removal may be challenging or may necessitate a combined median or paramedian approach.
DOI： 10.1292/jvms.24-0011
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Surgical management of a dermoid cyst with mandibular gland tissue in a Japanese Black calf 査読あり
Sato R., Sonoda M., Matsuo R., Takada R., Kanda I., Satoh H., Fuke N., Yamada K., Hirai T.
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 85 ( 10 ) 1110 - 1115 2023年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本獣医学会
A 131-day-old male Japanese Black calf presented with a swollen right cheek from birth. Imaging examination revealed a cyst under the right buccal area and debris-containing fluid inside the cyst, and puncture aspiration revealed a mildly cloudy fluid containing hair and tissue fragments. Histological examination of the excised cyst revealed stratified squamous epithelium with skin appendages in the cyst wall, which was diagnosed as a dermoid cyst. In addition, some submandibular gland tissue was found within the cyst wall. After removal of the cyst, there was swelling in the same area, which resolved with steroid administration. Surgical treatment of buccal dermoid cysts should be performed with caution to avoid damage to adjacent salivary gland tissue.
DOI： 10.1292/jvms.23-0248
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Niazi A.M., ZiHeng Z., Fuke N., Toyama K., Habibi W.A., Kawaguchi N., Yamaguchi R., Hirai T.
Journal of Comparative Pathology 197 23 - 34 2022年9月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Comparative Pathology
Porcine respiratory disease complex, which is caused by a combination of pathogens, including swine influenza A virus (SIV) and porcine reproductive respiratory syndrome virus (PRRSV), results in significant economic losses in pig production systems. Nasopharynx-associated lymphoid tissue (NALT) plays an important role in the uptake of pathogens and defence of the nasal mucosa in rodents and humans. We characterized NALT M cells in pigs and detected SIV antigen and PRRSV nucleic acid in NALT using histopathological, immunohistochemical and in-situ hybridization analyses. All SIV- and PRRSV-positive cases examined had suppurative nasopharyngitis and pneumonia. M cells were detected by immunohistochemistry and the distribution of M cells showed an increase in the middle section of NALT. SIV antigen was detected in M cells and PRRSV nucleic acid was demonstrated in the cytoplasm of macrophages in NALT. We believe that SIV and PRRSV infection in the upper respiratory tract induces local immunosuppression and these results confirm that swine NALT is a location for virus replication and may be strongly associated with the development of pneumonia in pigs.
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Suwanruengsri M., Uemura R., Izzati U.Z., Kanda T., Fuke N., Yasuda M., Hirai T., Yamaguchi R.
Thai Journal of Veterinary Medicine 52 ( 1 ) 33 - 44 2022年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thai Journal of Veterinary Medicine
Mycoplasma bovis (M. bovis) is a pathogen that especially effects the respiratory system of cattle. We focused on the histopathological changes in the lungs caused by M. bovis because the lesions in the bronchi or bronchioles and alveoli are quite different in natural infections. Thirty-five lung samples from 2-to 12-month-old Japanese Black calves with respiratory symptoms were collected and examined for bacteria presence and pathological changes using immunohistochemistry (IHC). Using the loop-mediated isothermal amplification method, 18 of the 35 samples were found to be positive for M. bovis, which was isolated and identified. In 7 of the samples, only M. bovis was detected, whereas in the other 11, other bacteria coexisted with M. bovis. Anti-M. bovis, anti-MAC387, anti-Iba1, anti-CD3, anti-CD20, anti-AE1/AE3 cytokeratin and anti-IL8 were used for antigen detection. Histopathological studies and diagnoses of the lungs were examined in two parts; bronchiolar lesions and alveolar lesions. The bronchiolar findings were divided into three groups: granulomatous, caseonecrotic and suppurative bronchiolitis. The alveolar lesions found were quite mild, except in three cases. IHC staining revealed strong evidence of M. bovis in degenerated neutrophils, which was confirmed by electron microscopy. The main inflammatory cell response to M. bovis infections was degenerate neutrophils, which caused the destruction of the bronchial epithelium and possibly induced epithelioid granulomatous inflammation, resulting in severe chronic respiratory diseases in cattle.
DOI： 10.14456/tjvm.2022.4
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牛の精巣
福家直幸
第64回獣医病理学研修会 2024年3月28日
開催年月日： 2024年3月28日 - 2024年3月29日
記述言語：英語 会議種別：口頭発表（一般）
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PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
第11回日本獣医病理学専門家協会学術集会 2024年3月29日
開催年月日： 2024年3月28日 - 2024年3月29日
記述言語：日本語 会議種別：ポスター発表
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宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
第11回日本獣医病理学専門家協会学術集会 2024年3月29日
開催年月日： 2024年3月28日 - 2024年3月29日
記述言語：日本語 会議種別：ポスター発表
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Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
令和5年度獣医学術九州地区学会 日本産業動物獣医学会 2023年9月10日
開催年月日： 2023年9月10日
記述言語：日本語 会議種別：口頭発表（一般）
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御岬馬でみられた心臓病変とその原因に関する病理学的検討
齋藤江連、山下鉄平、中井睦、高田蓮栞、安部陽、垣屋美穂、Asmaa Answer Hegazy, Amaal Ezzat Hussein Ahmed, 小林郁雄、福家直幸、平井卓哉
第166回日本獣医学術集会病理学分科会 2023年9月5日
開催年月日： 2023年9月5日 - 2023年9月8日
会議種別：口頭発表（一般）
受賞 【 表示 ／ 非表示 】
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優秀ポスター賞
2024年3月 日本獣医病理学専門家協会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞
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優秀ポスター賞
2024年3月 日本獣医病理学専門家協会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞
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九州地区獣医師会連合会長賞
2023年9月 九州地区獣医師会連合会 Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞