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Affiliation |
Frontier Science Research Center Life science field of inquiry physiology activator function analysis field |
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DATE Yukari
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Degree 【 display / non-display 】
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博士（医学） ( 1995.3 宮崎医科大学 )
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医学士 ( 1987.3 大分医科大学 )
Research Areas 【 display / non-display 】
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Life Science / Metabolism and endocrinology / Metabolism
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Life Science / Metabolism and endocrinology / Endocrinology
Papers 【 display / non-display 】
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Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus.
Jang Y, Heo JY, Lee MJ, Zhu J, Seo C, Go DH, Yoon SK, Yukari D, Oike Y, Sohn JW, Shong M, Kweon GR
International journal of molecular sciences 22 ( 7 ) 2021.3
Language：Japanese Publishing type：Research paper (scientific journal)
DOI： 10.3390/ijms22073443
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Akieda-Asai S., Ma H., Date Y.
American Journal of Physiology - Cell Physiology 317 ( 6 ) C1239 - C1246 2019
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：American Journal of Physiology - Cell Physiology
Recently, we showed that double-transgenic rats overexpressing guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), specifically in macrophages demonstrate an antiobesity phenotype and low-expression levels of proinflammatory cytokines in the mesenteric fat even when fed a high-fat diet. Here, we examined the levels and mechanism of Gn and GC-C transcription following saturated fatty acid and lipopolysaccharide (LPS), an activator of Toll-like receptor 4 (TLR4), exposure by using the NR8383 macrophage cell line. In addition, the levels of guanylin and cGMP were increased by addition of either palmitic acid or LPS. Next, we investigated the interaction of the gene transcription and nuclear factor-κB (NF-κB) by using an NF-κB inhibitor and chromatin immunoprecipitation assay. We showed that palmitic acid induced Gn gene expression via TLR4 and NF-κB. Moreover, we demonstrated that NF-κB binding to the Gn promoter was responsible for the induction of gene transcription by palmitic acid or LPS. Our results indicate that saturated fatty acids such as palmitic acid activate Gn gene expression via the NF-κB pathway, raising the possibility that the activated Gn-GC-C system may contribute to the inhibition of high-fat diet-induced proinflammatory cytokines in macrophages.
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Influence of food texture on energy metabolism and adiposity in male rats.
Han W, Utoyoma M, Akieda-Asai S, Hidaka A, Yamada C, Hasegawa K, Nunoi H, Date Y
Exp Physiol 103 ( 10 ) 1347 - 1356 2018.10
Language：English Publishing type：Research paper (scientific journal)
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Interleukin-15 derived from Guanylin–GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y
Peptides 99 14 - 19 2018.1
Language：English Publishing type：Research paper (scientific journal)
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Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue.
Yasuda M, Kawabata J, Akieda-Asai S, Nasu T, Date Y
J Vet Sci 18 ( 3 ) 341 - 348 2017.9
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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Brain and Orexin
Date Y（ Role： Joint author）
Kyouritsu Syuppann 2005.9
Language：Japanese Book type：Scholarly book
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Gastro-Entero-Pancreatic Action of Ghrelin
Date Y 他（ Role： Joint author）
Springer 2003.4
Language：English Book type：Scholarly book
MISC 【 display / non-display 】
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Koike H., Nakamura T., Nishi R., Ikeda S., Kawagashira Y., Iijima M., Yasuda T., Mukai E., Date Y., Shiomi K., Nakazato M., Katsuno M., Sobue G.
Amyloid 26 ( sup1 ) 24 - 25 2019.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Amyloid
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グレリン関連物質
伊達紫
ホルモンと臨床 54 ( 12 ) 116 - 120 2006.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：医学の世界社
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PYY3-36
伊達 紫
内分泌・糖尿病科 23 ( 3 ) 309 - 312 2006.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：科学評論社
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摂食行動の分子メカニズム
伊達 紫
実験医学 24 ( 15 ) 2434 - 2439 2006.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：羊土社
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消化管由来摂食調節因子（グレリンとCCKを中心に）
伊達 紫
内分泌・糖尿病科 22 ( 5 ) 499 - 504 2006.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：科学評論社
Presentations 【 display / non-display 】
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グアニリン・グアニル酸シクラーゼC発現マクロファージ由来のIL-15による脂肪蓄積抑制機構 International conference
秋枝さやか, 伊達紫
第40回日本肥満学会
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Influence of food texture on energy metabolism and adiposity in male rats. International conference
Han W, Utoyama M, Akieda-Asai S, Date Y
Influence of food texture on energy metabolism and adiposity in male rats.
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グアニリンおよびグアニル酸シクラーゼC高発現マクロファージ由来のIL-15は脂肪細胞の脂肪酸合成を抑制する International conference
秋枝さやか, 井田隆徳, 宮里幹也, 伊達紫
第91回日本内分泌学会
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農と食の未来を切り拓け！ホルモン研究-「食物の性状が糖代謝や脂質代謝に及ぼす影響」 International conference
秋枝さやか, 伊達紫
ConBio2017
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Sex differences in high-fat diet-induced obesity in rats International conference
Sex differences in high-fat diet-induced obesity in rats
Awards 【 display / non-display 】
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日本肥満学会学術奨励賞
2007.10 日本肥満学会
伊達 紫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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日本内分泌学会研究奨励賞
2006.5 日本内分泌学会
伊達 紫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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川上賞
2004.10 日本神経内分泌学会
伊達 紫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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トランスサイレチン変異による心アミロイドーシスの遺伝子解析と臨床像の特徴
2001.4 日本内科学会
伊達 紫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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軟らかい食べ物が招く生活習慣病の発症機序に関する研究
Grant number：22H00952 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
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軟らかい食物摂取により引き起こされる日本人型糖尿病の病態解析
2016.04 - 2019.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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軟らかい食物が小太り糖尿病をまねく機序とその分子機構の解明
2013.04 - 2016.03
科学研究費補助金 挑戦的萌芽研究
Authorship：Principal investigator
軟らかい食物が小太り糖尿病をまねく機序とその分子機構の解明
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脂肪滴蓄積制御におけるグアニリン/GC-C発現マクロファージの役割
2013.04 - 2015.03
科学研究費補助金 新学術領域研究（研究領域提案型）（公募研究）
Authorship：Principal investigator
脂肪滴蓄積制御におけるグアニリン/GC-C発現マクロファージの役割
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肥満制御に機能する腸間膜生理活性ペプチドの役割
2011.04 - 2013.03
科学研究費補助金 新学術領域研究
Authorship：Principal investigator
肥満制御に機能する腸間膜生理活性ペプチドの役割