YAMASAKI Masao

写真a

Affiliation

Faculty of Agriculture Department of Biochemistry and Applied Biosciences Food function chemical course

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(農学) ( 2001.3   九州大学 )

Research Areas 【 display / non-display

  • Life Science / Food sciences

 

Papers 【 display / non-display

  • Vaccinium virgatum aiton leaves extract suppressed lipid accumulation and uric acid production in 3T3-L1 adipocytes

    Yamasaki M., Kiue Y., Fujii K., Sushida M., Yamasaki Y., Sugamoto K., Suzuki Y., Koga Y., Kunitake H., Kai H., Ogawa K., Nishiyama K., Goto Y., Nakayama T.

    Plants   10 ( 12 )   2021.12

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Plants  

    Blueberry (Vaccinium virgatum Aiton; Kinisato 35 Gou) leaves have recently attracted in-creasing attention as a useful material for the prevention of lifestyle diseases. Here, we examined the effects of the hot water extract of blueberry leaves (BLEx) on lipogenesis and uric acid production in 3T3-L1 adipocytes. The results showed that BLEx suppressed lipid accumulation and the mRNA expression of differentiation markers in 3T3-L1 adipocytes. A fractionation study showed that the highly polymerized proanthocyanidin-rich fraction was responsible for this effect. Upon maturation to adipocytes, 3T3-L1 cells produced uric acid and tumor necrosis factor-α, and hypoxia stimulated the production of uric acid and xanthine oxidoreductase activity. BLEx suppressed the production of uric acid under these conditions. Although BLEx inhibited the enzymatic activity of xanthine oxidase, this activity was observed in several fractions containing catechin, epicatechin, chlorogenic acid, rutin, and low molecular weight proanthocyanidins. Taken together, these results indicate that BLEx contains various compounds with the ability to suppress lipid accumulation and uric acid production in adipocytes.

    DOI: 10.3390/plants10122638

    Scopus

  • Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted from kumquats by complexation with casein Reviewed

    Ohima T, Takanashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N

    Food Chemistry   360   129822   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.foodchem.2021.129822

  • Onion (Allium cepa L.)-Derived Nanoparticles Inhibited LPS-Induced Nitrate Production, however, Their Intracellular Incorporation by Endocytosis Was Not Involved in this Effect on RAW264 Cells. Reviewed

    Yamasaki M, Yamasaki Y, Furusho R, Kimura H, Kamei I, Sonoda H, Ikeda M, Oshima T, Ogawa K, Nishiyama K

    Molecules   26 ( 9 )   2763   2021.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules26092763

  • Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds. Reviewed

    Zahid MK, Sufian HB, Choudhury M, Yamasaki M, Al-Harrasi A, Moustaid-Moussa N, Rahman SM

    Biochemical Journal   478   1359 - 1375   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1042/BCJ20200894

  • Polyphenol contents, antioxidant activities, and anti-cancer cell proliferation properties at each stage of fruit development in intersectional hybrids between highbush blueberry and shashanbo (Vaccinium bracteatum Thunb.)

    Toyama Y., Toshima S., Hirano T., Yamasaki M., Kunitake H.

    Journal of Berry Research   11 ( 4 )   689 - 704   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Berry Research  

    BACKGROUND: In blueberries, the total polyphenol contents, total anthocyanin contents, and antioxidant activities of fruits in blueberries and their relatives are becoming important targets for breeders. Recently, intersectional hybrids between Japanese wild species Shashanbo and highbush blueberry were produced using polyploid breeding for the first time. However, the polyphenol contents, antioxidant activities, and anti-cancer cell proliferation properties of the fruits of these intersectional hybrids have not been studied sufficiently. OBJECTIVE: The objectives of this study were to determine the anthocyanin contents, polyphenol contents, and antioxidant activities at each stage of fruit development in intersectional hybrids, and to examine the effects of the fruit extracts on anti-cancer cell proliferation properties using human promyelocytic leukemia (HL-60) cells. METHODS: Freeze-dried fruit samples of three intersectional hybrids and their parents at five developmental stages were used to evaluate their polyphenol contents, anthocyanin contents, and levels of two types of antioxidant activities (DPPH and ORAC). The anti-cancer cell proliferation properties of each extract were also evaluated according to the survival rate of HL-60 cells. RESULTS: The total polyphenol contents in fruits of the intersectional hybrids gradually decreased as the fruits grew, but the contents increased slightly at the mature stage. Meanwhile, the total anthocyanin contents increased strongly to the mature stage. In addition, the fruit extract of intersectional hybrid JM1 was found to be more effective for inhibiting the growth of HL-60 human leukemia cells in vitro. Total polyphenol content correlated highly with antioxidant activities and anti-cancer cell proliferation properties. CONCLUSIONS: We clarified that the intersectional hybrids had produced have abundant bioactive compounds, high levels of antioxidant activities, and anti-cancer cell proliferation properties. The results proved the effectiveness of the use of Japanese wild Vaccinium species for the strategic breeding of blueberries with high levels of bioactive compounds.

    DOI: 10.3233/JBR-210713

    Scopus

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Books 【 display / non-display

  • 『食品機能性脂質の基礎と応用』

    山崎正夫( Role: Sole author)

    シーエムシー出版  2018.6 

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    Language:Japanese Book type:Scholarly book

  • Advances in Conjugated Linoleic Acid Research 3

    M. Yamasaki, H. Chujo, and K. Yamada. ( Role: Joint author)

    AOCS press  2006.11 

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    Language:English Book type:Scholarly book

  • 「食品成分のはたらき」

    山崎正夫、山田耕路( Role: Joint author)

    朝倉書店  2004.3 

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    Language:Japanese Book type:Scholarly book

  • Advances in Conjugated Linoleic Acid Research 1

    M. Sugano, M. Yamasaki, K. Yamada, and Y.-S. Huang( Role: Joint author)

    AOCS press  1999.11 

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    Language:English Book type:Scholarly book

MISC 【 display / non-display

  • 食品が私たちの体に語りかけること Invited

    山﨑正夫

    日本醸造学会誌   2021.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:日本醸造学会  

  • 脂質分析の観点から見たin vivoにおける抗アレルギー活性評価法

    山崎正夫、西山和夫

    生物機能研究法   2013.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:生物機能研究所  

  • がん悪性形質のレドックス制御機能評価法

    西山先生、岩瀬将弘、山崎正夫

    生物機能研究法   2013.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:生物機能研究所  

  • Conjugated linoleic acids inhibit hypoxia inducible factor-1α stabilization under hypoxic condition in human hepatocellular carcinoma cells

    Yamasaki M., Nagatomo T., Matsuyama T., Ikeho Y., Kato E., Nishiyama K., Sakakibara Y., Suiko M., Nishiyama K.

    Journal of Oleo Science   61 ( 9 )   491 - 496   2012.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Journal of Oleo Science  

    The anti-cancer effects of various fatty acids are drawing a lot of attention. To determine whether different fatty acids affect the hypoxic response of liver cancer cells, we examined the effects of various fatty acids on the stabilization of the hypoxia-inducible factor (HIF)-1α protein in the HepG2 human hepatocellular carcinoma (HCC) cell line under condition containing 1% O 2 . Of the fatty acids examined, only 9cis, 11trans (c9, t11)-conjugated linoleic acid (CLA) and 10trans, 12cis (t10, c12)-CLA inhibited hypoxia-induced HIF-1α stabilization. In addition, HIF-1α prolyl hydroxylase or proteasome inhibition abrogated the effects of c9, t11- and t10, c12-CLA. Moreover, c9, t11- and t10, c12-CLA significantly inhibited cell proliferation and induced apoptotic cell death under hypoxia. This is the first study showing that c9, t11- and t10, c12-CLA inhibit the hypoxic response in HCC cells. ©2012 by Japan Oil Chemists' Society.

    DOI: 10.5650/jos.61.491

    Scopus

  • 大豆イソフラボンの抗ATL(成人T細胞性白血病)作用

    山崎正夫、西山和夫

    バイオサイエンスとインダストリー   68 ( 5 )   2010.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:バイオインダストリー協会  

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Presentations 【 display / non-display

  • 葛根湯およびその構成生薬の成人T細胞白血病細胞増殖抑制効果

    甲斐久博、内本凛果、下西智彩、山崎正夫、森下和広、馬場正樹、矢久保修嗣

    第39回 和漢医薬学会  2022.8.27 

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    Event date: 2022.8.27 - 2022.8.28

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 自己免疫疾患シェーグレン症候群の涙液分 泌機能に及ぼすブルーベリー葉エキスの作 用

    田頭明音、浦田果林、小河原康貴、 大野雄太、佐藤慶太郎、鈴木耀介、 菅本和寛、山崎正夫、古賀靖子、 国武久登、西山和夫、後藤陽、中山貴之、 小川健二郎

    第76回日本栄養・食糧学会  2022.6.11 

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    Event date: 2022.6.10 - 2022.6.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • アブラナ科野菜由来ナノベシクルの単離と 機能性評価

    森田優花、押川妃乃、小野江梨花、 園田紘子、池田正浩、山崎有美、 大島達也、立花宏文、小川健二郎、 西山和夫、山崎正夫

    第76回日本栄養・食糧学会  2022.6.12 

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    Event date: 2022.6.10 - 2022.6.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 宮崎県産無農薬バナナ果皮の脂肪細胞にお ける脂質蓄積抑制作用

    小河原康貴、山田喜之、古賀靖子、 山崎正夫、西山和夫、國武久登、 菅本和寛、内田匡彦、小川健二郎

    第76回日本栄養・食糧学会  2022.6.11 

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    Event date: 2022.6.10 - 2022.6.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 青色光誘発網膜視細胞障害に対するブルー ベリー素材の網膜保護作用

    小川健二郎、浦田果林、山崎正夫、 國武久登、西山和夫、後藤陽、中山貴之

    第76回日本栄養・食糧学会  2022.6.11 

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    Event date: 2022.6.10 - 2022.6.12

    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 日本栄養・食糧学会 奨励賞

    2013.5   日本栄養・食糧学会  

    山崎正夫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本農芸化学会西日本支部奨励賞

    2004.1   日本農芸化学会  

    山崎正夫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 脂肪細胞の低酸素ストレス抑制による生活習慣 病予防

    Grant number:21H02142  2021.04 - 2024.03

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  • プラント・オパール中の遺伝情報を利用した稲 作史研究手法の構築に向けた学際的研究

    Grant number:19H00542  2021.04 - 2024.03

    日本学術振興会  科学研究費補助金  基盤A

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    Authorship:Coinvestigator(s) 

  • 食機能実行分子とその機能的相互作用の統合的理解

    Grant number:20H05683  2020.08 - 2025.03

    科学研究費補助金  基盤研究(S)

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    Authorship:Coinvestigator(s) 

  • 機能性脂質による高尿酸血症の改善

    Grant number:18K05520  2018.04 - 2021.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 種を超えたエクソソームシグナル伝達による画期的食品機能性発現の可能性

    2015.04 - 2018.03

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator 

    植物性食品中の微粒子の存在同定と、機能性評価

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Other research activities 【 display / non-display

  • CLA懇話会事務局

    2004.04 - 2010.10

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    CLA懇話会開催、会計、諸雑務