Affiliation |
Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Dermatology |
Title |
Professor |
External Link |
AMANO Masahiro
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Degree 【 display / non-display 】
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博士(医学) ( 2008.4 宮崎大学 )
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医学士 ( 1986.3 宮崎医科大学 )
Papers 【 display / non-display 】
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MiniReport 再発を繰り返し急速に増大した毛母腫の1例
森 愛菜, 後田 優香, 長野 愛実, 大栗 伸行, 天野 正宏
皮膚科の臨床 65 ( 8 ) 1304 - 1305 2023.7
Publishing type:Research paper (scientific journal) Publisher:金原出版
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症例報告 アダリムマブと植皮術が有効であった壊疽性膿皮症の1例
森 愛菜, 西川 陽太郎, 中村 俊央, 天野 正宏
臨床皮膚科 77 ( 6 ) 457 - 462 2023.5
Publishing type:Research paper (scientific journal) Publisher:株式会社医学書院
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症例報告 ボリコナゾール長期内服による多発有棘細胞癌の治療中に生じたMerkel細胞癌の1例
森 愛菜, 持田 耕介, 西川 陽太郎, 中村 俊央, 魏 峻洸, 河野 徳明, 天野 正宏
臨床皮膚科 77 ( 6 ) 433 - 438 2023.5
Publishing type:Research paper (scientific journal) Publisher:株式会社医学書院
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Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations
Mochida K., Nakahata S., Suzuki Y., Inoue K., Moriguchi S., Yamashita A., Amano M., Morishita K.
Journal of Dermatological Science 109 ( 2 ) 80 - 88 2023.2
Language:English Publishing type:Research paper (scientific journal) Publisher:Journal of Dermatological Science
Background: Patients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin eruptions are associated with different prognoses. Objective: Genomic analysis of patients with skin eruptions of smoldering ATLL will be performed to determine the mechanism of ATLL development and its association with prognosis. Methods: DNA from skin biopsy specimens was used for targeted sequencing of 280 genes to examine the association between genomic variation and prognosis. Results: Due to the small number of smoldering ATLL patients (27 cases), we could not find a clear relationship between skin eruption and prognosis in this study. Genomic analysis identified 247 genomic variants (108 genes), with an average of 9.2 variants and 3.2 variants as driver genes. Pathway analysis of the driver genes showed activation of the pathway associated with HTLV-1 infection, as well as activation of the signaling pathway observed throughout ATLL. Furthermore, multivariate analysis identified age>70 years and STAT3 mutation as prognostic risk factors and TBL1XR1 mutation as a risk factor for progression-free survival. Conclusion: Although the small number of patient samples did not allow us to determine a prognostic association with skin eruption, STAT3 mutation was identified as a prognostic risk factor for smoldering ATLL with skin eruption. Further studies are needed to increase the number of patients with this disease.
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Imaizumi Y., Iwanaga M., Nosaka K., Ishitsuka K., Ishizawa K., Ito S., Amano M., Ishida T., Uike N., Utsunomiya A., Ohshima K., Tanaka J., Tokura Y., Tobinai K., Watanabe T., Uchimaru K., Tsukasaki K.
International Journal of Hematology 117 ( 2 ) 206 - 215 2023.2
Language:English Publishing type:Research paper (scientific journal) Publisher:International Journal of Hematology
Adult T cell leukemia-lymphoma (ATL) is clinically heterogeneous and is classified into four subtypes: acute, lymphoma, chronic, and smoldering. Recently, a new prognostic index based on the value of soluble interleukin-2 receptor, denoted the “iATL-PI,” has been proposed for patients with smoldering and chronic ATL. To evaluate the effectiveness of the iATL-PI, we re-analyzed our previously published data on 176 patients with smoldering or chronic ATL (76 smoldering, 100 chronic) diagnosed between 2010 and 2011, as well data from the subsequent follow-up study on prognosis between 2016 and 2017. The proportions for the low-, intermediate-, and high-risk iATL-PI groups at the time of ATL diagnosis were 44.7%, 48.7%, and 5% for smoldering ATL; 6.3%, 71.9%, and 21.9% for favorable chronic ATL; and 5.9%, 27.9%, and 66.2% for unfavorable chronic ATL, respectively. The survival of patients with smoldering or chronic ATL as a whole was significantly stratified according to the three iATL-PI groups. Most patients with unfavorable chronic ATL in the low iATL-PI risk group had indolent clinical courses. Our results showed that iATL may become a useful tool to predict the prognosis of smoldering and chronic ATL, which have diverse clinical courses.
Books 【 display / non-display 】
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今日の治療指針 私はこう治療している 2023 ポケット判
天野正宏 他( Role: Sole author)
医学書院 2023.1
Language:Japanese
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成人T細胞白血病/リンパ腫(ATLL)
天野正宏 他( Role: Joint author)
南江堂 2023.1
Language:Japanese
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口腔粘膜・皮膚症状から見抜く全身疾患ーオラドローム・デルマドロームー
天野正宏, 出光敏郎、神部芳則編集( Role: Joint author)
南江堂 2020.10
Language:Japanese Book type:Scholarly book
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膿皮症 pyoderma今日の治療指針 2020年版 私はこう治療している(デスク版、ポケット版)
天野正宏.、総編集:山口 徹・他監
医学書院 2020.1
Language:Japanese
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5 熱傷 IX 物理的・化学的皮膚障害 皮膚疾患最新の治療2019-2020
天野正宏、古川福実, 佐伯秀久編集
南江堂 2019.1
Language:Japanese
MISC 【 display / non-display 】
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T-cell prolymphocytic leukemia with follicular mucinosis
Nemoto R., Nishikawa Y., Mochida K., Amano M.
International Journal of Dermatology 62 ( 3 ) e151 - e153 2023.3
Language:English Publishing type:Rapid communication, short report, research note, etc. (scientific journal) Publisher:International Journal of Dermatology
DOI: 10.1111/ijd.16347
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菌状息肉症(MF)・Sézary症候群を見逃さない エキスパートへの近道!間違いやすい皮膚疾患の見極め
天野正宏 他
Derma 320 120 - 126 2022.4
Language:Japanese
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Adult T-cell leukemia/lymphoma with pagetoid reticulosis-like skin lesions
Nishikawa Y., Kanemaru S., Mori A., Nagano M., Mochida K., Amano M.
International Journal of Dermatology 60 ( 9 ) e342 - e344 2021.9
Language:English Publishing type:Rapid communication, short report, research note, etc. (scientific journal) Publisher:International Journal of Dermatology
DOI: 10.1111/ijd.15446
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疫学と症状Ⅶ.皮膚リンパ腫 皮膚悪性腫瘍(第2版)下ー基礎と臨床の最新研究動向ー
天野正宏 他
日本臨牀 79 ( 3 ) 2021.7
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal)
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HTLV-1の概説ー発がん機構を中心にーⅦ.皮膚リンパ腫 皮膚悪性腫瘍(第2版)下ー基礎と臨床の最新研究動向ー
天野正宏 他
日本臨牀 79 ( 3 ) 2021.7
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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在宅患者で留意すべき皮膚疾患-新たな爪白癬治療を含めて-
天野正宏
串間市・志布志市爪白癬治療セミナー
Event date: 2020.3.31
Language:Japanese
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「皮膚T細胞リンパ腫(CTCL)」-皮膚病変の鑑別と治療-
天野正宏
多摩地区皮膚疾患学術セミナー
Event date: 2020.2.28
Language:Japanese
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当科で行っている創傷治療~熱傷から褥瘡、下腿潰瘍まで~
天野正宏
第142回 宮崎県皮膚科懇話会
Event date: 2020.2
Language:Japanese
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成人T細胞白血病/リンパ腫(ATLL)-乾癬との類似性と鑑別について-
天野正宏
第11回 Tokyo Skin Seminar
Event date: 2019.11
Language:Japanese
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えびの市医療講演会
天野正宏
皮膚がん-早期発見、早期治療-
Event date: 2019.7
Language:Japanese Presentation type:Public lecture, seminar, tutorial, course, or other speech
Other research activities 【 display / non-display 】
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Journal of Dermatology誌の論文レビュー
2006.01
日本皮膚科学会が出版するJournal of Dermatology誌から送られてきた投稿論文を読み、雑誌に掲載可能かどうかの可否および掲載可能であれば訂正や加筆の必要性をコメントする。レビューする投稿論文は、自分の専門分野である皮膚悪性リンパ腫に関するものがほとんどを占める。
Available Technology 【 display / non-display 】
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皮膚がんに関する講演会と皮膚がん検診
皮膚病変を有するATLLの皮膚浸潤の遺伝子解析と臨床病型及び予後との関連
アトピー性皮膚炎の発症メカニズムの解明Related fields where technical consultation is available:がん関連、アレルギー疾患
Message:今後、人口の高齢化に伴い皮膚がんは増加傾向にあります。また最近、アレルギー疾患が増加しており、その増加・増悪の要因として環境要因の変化が挙げられています。当科では実臨床に即した臨床研究を行っています。