Affiliation |
Faculty of Agriculture Department of Veterinary Science |
Title |
Professor |
External Link |
SUEYOSHI Masuo
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Degree 【 display / non-display 】
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学位(獣医学) ( 1992.9 北海道大学 )
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農学修士 ( 1983.3 宮崎大学 )
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農学学士 ( 1981.3 宮崎大学 )
Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
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Life Science / Gastroenterology
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Life Science / Veterinary medical science
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Life Science / Animal production science
Papers 【 display / non-display 】
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The current porcine epidemic diarrhea (PED) situation in Japan Invited Reviewed
Masuo Sueyoshi
Thai J Vet Med. 53 ( 2 ) S5 - S6 2023.6
Authorship:Lead author Language:English Publishing type:Research paper (scientific journal)
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Farm Biosecurity ~Disinfection~ (Cattle) Invited Reviewed
Masuo Sueyoshi
The Journal of Farm Animal in Infectious Disease 12 ( 1 ) 1 - 9 2023.1
Authorship:Lead author Language:Japanese Publishing type:Research paper (scientific journal)
The basics of farm biosecurity are: (1) No bring pathogens into the farm, (2) No spread pathogens on the farm, and (3) No take pathogens out of the farm. For this purpose, it is important to restrict the entry and delivery of livestock, vehicles, people, livestock materials, etc. entering and leaving the farm, or we need to be thoroughly disinfected. "Disinfection" in it is ambiguous, and effective "disinfection" is necessary. Now that we have become "with coronavirus", the term and equipment of "disinfection" are everywhere in daily life. However, in some situations, "shedding" by "flushing and washing" is more effective than "disinfecting". The phenomenon is the same in the livestock industry. Here I outline the basic stages of an effective "disinfection" method.
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Prevalence of equine proliferative enteropathy in Hidaka district, Hokkaido, over five seasons Reviewed
Hidekazu NIWA, Toru HIGUCHI, Seiichi FUJII, Yuta KINOSHITA, Eri UCHIDA-FUJII, Masuo SUEYOSHI, Toshio NUKADA, Takanori UENO
Journal of Equine Science 33 ( 4 ) 71 - 74 2023.1
Language:English Publishing type:Research paper (scientific journal)
Equine proliferative enteropathy (EPE) is an equine infectious disease that can lead to severe weight loss and hyperplasia of the intestinal mucosa due to infection with Lawsonia intracellularis. In this study, we investigated the prevalence of EPE in a major Thoroughbred breeding area: Hidaka district, Hokkaido, Japan. Of the 252 symptomatic horses that we tested, 192 EPE cases (76.2%), including 8 fatal cases, were confirmed from April 2015 to March 2020 by etiological and/or serological investigation. Most of the EPE cases were observed in foals (88.5%), with fewer cases in yearlings (7.3%) and adults (4.2%). Asymptomatic infection was observed in 62.9% of the horses kept with affected horses. These results suggest that EPE is an enzootic disease in Hidaka district.
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The presence of adhesion factors NOX, α-enolase, TrmFO, P27, and VpmaX in Mycoplasma bovis wild isolates in Japan Reviewed
Shitamori F., Uemura R., Kanda T., Sueyoshi M.
Open Veterinary Journal 12 ( 6 ) 782 - 786 2022.12
Language:English Publishing type:Research paper (scientific journal)
Background: Mycoplasma bovis causes various diseases such as bronchopneumonia, otitis media, arthritis, and mastitis in cattle. Mycoplasma bovis is often isolated from the deep pharynges of healthy cattle and is generally considered not to cause clinical symptoms while in the upper respiratory tract. In mycoplasma infections, adhesion to the host cells is a crucial step. In recent years, five new adhesins, NOX, α-enolase, TrmFO, P27, and VpmaX, have been reported in M. bovis strains from pneumonia cases. However, the presence of these adhesins in wild isolates has not been established.
Aim: This study aimed to investigate the presence of these adhesin genes in wild isolates isolated from cattle nasal cavities and lesion sites (pneumonia, otitis media, arthritis, and mastitis) in various regions in Japan and clarify the relationship between adhesion and the symptoms caused by M. bovis infection.
Methods: A total of 141 M. bovis wild isolates isolated from nasal cavities (healthy or sick cattle), lungs with pneumonia, ears with otitis media, joint fluids of arthritic animals, and milk of mastitic animals. Mycoplasma bovis type strain PG45 was also used. Specific polymerase chain reaction reactions were performed to detect nox, α-enolase, trmFO, P27, and vpmaX, which are adhesins of M. bovis.
Results: This study reports 139 M. bovis wild isolates were positive for nox, α-enolase, trmFO, P27, and vpmaX, while two isolates each lacked α-enolase or P27 genes. Mycoplasma bovis PG45 also had all five adherens genes.
Conclusion: Almost all M. bovis wild isolates possessed all nox, α-enolase, trmFO, P27, and vpmaX genes regardless of the lesion site or region of origin. This means no relationship was found between the presence of the five adhesins and lesion sites in M. bovis and M. bovis isolated from the nasal cavities of asymptomatic cattle have the same numbers and types of adhesins as isolates from symptomatic lesion sites (pneumonia, otitis media, arthritis, and mastitis). This suggests that not only M. bovis isolates from pulmonary lesions, but also M. bovis existing in the nasal cavity has the potential to causes symptoms in the host. -
Toyama K., Hirai T., Sueyoshi M., Zhou Z., Niazii A. M., Kawaguchi N., Fuke N., Yamaguchi Y.
J. Vet. Med. Sci. 84 ( 11 ) 1536 - 1542 2022.10
Authorship:Corresponding author Language:English Publishing type:Research paper (scientific journal) Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE
Porcine circovirus 2 (PCV2) causes porcine circovirus-associated disease, and coinfection
with porcine reproductive and respiratory syndrome virus (PRRSV) severely affects the
pig breeding industry. Both viruses target the macrophages in lymphoid tissues. Various porcine
pathogens enter via the nasal cavity, and the nasopharynx-associated lymphoid tissue (NALT) acts
as the mucosal immune system. However, the pathological analysis has not progressed. This study
aimed to histologically examine the NALT of pigs with suspected PCV2 and PRRSV infections. Six pigs
were subjected to necropsy, and their NALT, tonsils, and mesenteric lymph nodes were collected.
Macrophages, lymphocytic depletion, multinucleated giant cells, intracytoplasmic inclusion bodies,
and neutrophil infiltration increased in the NALT. In situ hybridization revealed positive signals for
PCV2 in the NALT of all pigs and PRRSV in the NALT of three pigs. PCV2-positive macrophages were
mainly identified in the follicles, whereas PRRSV-positive tissues were found primarily around the
crypt and directly below the epithelium. Quantitative PCR revealed 108–1010 copies of PCV2 DNA/μL
and 102–104 copies of PRRSV DNA/μL in the NALT. Therefore, both PCV2 and PRRSV were detected in
the NALT of pigs. In conclusion, the infection and replication of both viruses in the NALT and tonsils
may suppress host immunity and promote co-infection with other pathogens.Other Link: https://jsvetsci.jp/jvms/
Books 【 display / non-display 】
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動物病理学各論第3版
末吉益雄他( Role: Joint author)
文永堂 2021.3
Language:Japanese Book type:Textbook, survey, introduction
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家禽疾病学. 第2版
末吉益雄他( Role: Joint author)
鶏病研究会 2021.3
Total pages:292 Responsible for pages:60-63 Language:Japanese Book type:Textbook, survey, introduction
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動物の衛生 第2版
末吉益雄他( Role: Edit)
文永堂 2020.3
Total pages:295 Responsible for pages:1-2, 2-6, 6-11, 35-36, 86-105,135-145, 165-171, 218-221. Language:Japanese Book type:Textbook, survey, introduction
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養豚用語事典
末吉益雄他( Role: Joint author)
日本養豚学会編 創文 2019.3
Language:Japanese Book type:Textbook, survey, introduction
養豚関連の衛生と疾病に関する専門用語について概説した。
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動物感染症学 第4版
末吉益雄他( Role: Joint author)
近代出版 2019.3
Responsible for pages:p.184-186, p.179-180, p.178-179, p.177-178, p.118-119, p.211 Language:Japanese Book type:Textbook, survey, introduction
動物の感染症の腸腺腫症候群、豚赤痢、豚のサルモネラ症、豚の大腸菌症、鶏の大腸菌症、子牛の大腸菌性下痢について概説した。
MISC 【 display / non-display 】
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高まるアフリカ豚熱(ASF)侵入リスクへの備えを! Invited
伊藤聡, 末吉益雄,伊藤貢
ピッグジャーナル 27 ( 2 ) 12 - 15 2024.2
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:アニマル・メディア社
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牛の環境衛生のポイント Invited
末吉益雄
臨床獣医 41 ( 12 ) 18 - 22 2023.12
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher:緑書房
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豚関連家畜伝染病の発生状況. In: 新・養豚版 バイオセキュリティ Invited
末吉益雄
養豚界 58 ( 8 ) 20 - 26 2023.8
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher:緑書房
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口蹄疫発生現場の実態と繰り返さないためには Invited
末吉益雄
JASV会報 32 ( 1 ) 2 - 5 2023.3
Authorship:Lead author Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:緑書房
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腸管の仕組みと大腸菌症の基礎 Invited
末吉益雄
養豚界 57 ( 1 ) 28 - 34 2022.1
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher:緑書房
Presentations 【 display / non-display 】
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子牛の呼吸器病診断における鼻腔拭い液試料の意義
米倉淳大, 壱岐佳浩, 林 淳, 末吉益雄, 上村涼子
令和5年度日本産業動物獣医学会 (鹿児島市(オンライン)) 2023.9.10 日本産業動物獣医学会
Event date: 2023.9 - 2023.10
Language:Japanese Presentation type:Oral presentation (general)
Venue:鹿児島市(オンライン)
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デキサメタゾン投与牛の末梢血由来好中球のMycoplasma bovisに対する応答
石崎絢大, 末吉益雄, 上村涼子
令和5年度日本産業動物獣医学会 (鹿児島市(オンライン)) 2023.9.10 日本産業動物獣医学会
Event date: 2023.9 - 2023.10
Language:Japanese Presentation type:Oral presentation (general)
Venue:鹿児島市(オンライン)
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The current porcine epidemic diarrhea (PED) situation in Japan International conference
Sueyoshi M.
2023.6.5
Event date: 2023.6.4 - 2023.6.7
Language:English Presentation type:Oral presentation (general)
Country:Thailand
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Study on the effect of probiotics on the proliferation and release of Shiga toxin-producing Escherichia coli from calves International conference
Sueyoshi M.
2023.5.7
Event date: 2023.5.7 - 2023.5.10
Language:English Presentation type:Oral presentation (general)
Country:Canada
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The outbreak of porcine epidemic diarrhea in Japan International conference
Sueyoshi M.
2023.4.26
Event date: 2023.4.26 - 2023.4.29
Language:English Presentation type:Oral presentation (general)
Country:Taiwan, Province of China
Awards 【 display / non-display 】
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日本産業動物獣医学会長賞
2023.9 令和5年度日本産業動物獣医学会(九州地区) デキサメタゾン投与牛の末梢血由来好中球のMycoplasma bovisに対する応答
石崎絢大, 末吉益雄, 上村涼子
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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九獣連会長賞
2022.9 令和4年度日本産業動物獣医学会(九州地区) 培養基中の植物性蛋白質は豚の浮腫病由来志賀毒素産生性大腸菌の志賀毒素産生を増加させる
永田 舜. 上村涼子, 末吉益雄.
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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JASV2020学生アワード受賞
2021.1 日本養豚開業獣医師協会年次学会 豚由来マクロファージ内侵入サルモネラに対するフルオロキノロン系抗菌薬の殺菌効果
黒田翔太、上村涼子、末吉益雄.
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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第163回日本獣医学会学術集会若手奨励賞
2020.9 日本獣医学会学術集会 牛好中球へのMycoplasma bovis感作の影響
上村悠祐、上村涼子、小林郁雄、末吉益雄.
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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第162回日本獣医学会学術集会第10回若手奨励賞
2019.9 日本獣医学会学術集会 Mycoplasma bovis感作に対する牛肺胞マクロファージのサイトカイン発現応答
甲斐慎二他
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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クリーン模範養豚場の作出
2012.04 - 2015.03
科学研究費補助金 挑戦的萌芽研究
Authorship:Principal investigator
安全な豚肉を食卓に届けるために。生産の場である養豚場環境の清浄化を模索する。消毒方法の見直し、豚舎器材の抗菌化について検討する。
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韓国に生息するキバノロの生体および生理機構の網羅的解明と潜在的感染症の疫学的調査
2011.04 - 2014.03
科学研究費補助金 基盤研究(B)
Authorship:Coinvestigator(s)
韓国に生息している原始的な反芻動物であるキバノロの生体及び生理機構を網羅的に解明し、系統発生学的に比較解析するとともに、人獣共通感染症や海外悪性伝染病の疫学調査を行い、その潜在的病態を把握する。
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分娩後早期の牛の発情同期化と、交配後非妊娠牛に対する適切な再同期化処置法の開発
2007.04 - 2009.03
科学研究費補助金 基盤研究(C)
Authorship:Coinvestigator(s)
分娩後のVWP自発的繁殖待ち期間に牛の生殖器の修復や卵巣機能回復を検査し、個々の牛に応じた卵巣賦活や発情同期化処置を行う。分娩後早期の卵巣賦活による定時人工授精後、なるべく早期に妊娠診断を行い、非妊娠牛に対して、その時点での卵巣所見に適応した再同期化処置を行う。乳牛での分娩後85日、黒毛和種での80日までに2回の人工授精により75%の牛群妊娠率を目指す繁殖管理技術の開発を目指す。
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難培養性細菌トレポネーマを中心とした混合感染症のゲノム解析とその応用
2005.04 - 2007.03
科学研究費補助金 特定領域研究
Authorship:Coinvestigator(s)
伝染性の強い牛趾乳頭腫症の原因菌は未だ不明のままである。それらの病変部から種々の微生物が形態学的あるいは遺伝子学的に検出されているが、有意な病原体の分離はいまだにない。本課題では、病理形態遺伝子学的に病変部における局在を検索する。
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病原性大腸菌健康保菌動物摘発法の開発研究
2003.04 - 2005.03
科学研究費補助金 挑戦的萌芽研究
Authorship:Principal investigator
ヒトの腸管出血性大腸菌感染症の感染源は牛などの家畜がその一つとされている。しかし、ヒトに病原性のあるO157大腸菌などは牛に感染しても無症状であるため発見されにくい。そこで、それらの健康保菌動物を摘発する方法を開発する。
Other research activities 【 display / non-display 】
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家畜疾病の病性鑑定
2000.04
南九州地域を中心とした牛および豚の農場における不明疾病等について、農場主、管理獣医師から病性鑑定の依頼があった場合、その原因究明、疾病診断、治療あるいは予防について対応している。
Available Technology 【 display / non-display 】
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産業動物の疾病予防に関する調査・研究
農場バイオセキュリティに関する調査・研究
越境性産業動物伝染病の防疫に関する調査・研究Home Page: 農学部獣医学科産業動物衛生学研究室
Related fields where technical consultation is available:産業動物衛生に関連した牛、豚、鶏など家畜の疾病対策
Message:口蹄疫を二度経験し、高病原性鳥インフルエンザ(HPAI)を複数回経験した畜産県宮崎、今、さらに、アフリカ豚熱と豚熱の侵入リスクに曝されています。地域、社会貢献に従事しつつ、大学院生、学部学生教育をも礎に、産業動物生産性の向上に努力してまいります。