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Affiliation |
Faculty of Agriculture Department of Biochemistry and Applied Biosciences Food function chemical course |
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Professor |
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External Link |
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KAWAHARA Satoshi
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Degree 【 display / non-display 】
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Doctor (Agriculture) ( 2003.3 Kagoshima University )
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農学修士 ( 1994.3 九州大学 )
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農学士 ( 1992.3 九州大学 )
Research Areas 【 display / non-display 】
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Life Science / Food sciences
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Life Science / Animal production science
Papers 【 display / non-display 】
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Naturally occurring phytanic acid exerts anti-inflammatory effects in a mouse model of dextran sulfate sodium-induced colitis Reviewed International coauthorship
Nakanishi T., Suga K., Wakitani S., Yamaguchi K., Sugamoto K., Erickson L., Kawahara S.
European Journal of Lipid Science and Technology 2024.3
Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：European Journal of Lipid Science and Technology
Phytanic acid is one of the branched-chain fatty acids in the human diet. Humans incorporate it into their bodies through the ingestion of ruminant meat and milk since these animal products contain the 3RS, 7R, 11R-isomer, as naturally occurring phytanic acid (nPA). Although phytanic acid has been reported to have health-promoting effects such as immunomodulatory effects, these findings were obtained mostly from in vitro cell-based experiments. In this study, the in vivo anti-inflammatory effects of nPA were investigated using a mouse model of dextran sulfate sodium (DSS)-induced colitis. Mice were fed diets containing 0%, 0.05%, or 0.1% nPA for 4 weeks. During the fourth week, acute colitis was induced by administration of a 3% DSS solution. The intake of 0.05% and 0.1% nPA inhibited DSS-induced body weight loss in mice, and showed improvement of histopathological changes in colon epithelium. nPA also inhibited the production of proinflammatory cytokines, especially macrophage-related cytokines such as interleukin-1β in the colon. These results suggest that nPA exerts anti-inflammatory effects under in vivo physiological conditions. Practical application: There is a growing demand for fatty acids possessing distinct nutritional and physical characteristics in the realms of health, nutrition, and food-related applications. The present study demonstrated that a branched-chain fatty acid, phytanic acid, exerts anti-inflammatory activity under not only in vitro but also in vivo conditions, using a commonly used mouse model of human inflammatory bowel disease. Our findings encourage further studies to determine whether phytanic acid elicits beneficial properties in humans, and suggest that phytanic acid enrichment can be a novel product strategy in the food market.
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In vitro characterization of anti-inflammatory activities of 3RS, 11R-phytanic acid Reviewed International coauthorship
Tomonori Nakanishi, Mikihisa Izumi, Ryoji Suzuki, Kohta Yamaguchi, Kazuhiro Kagamizono, Laurie Erickson, Satoshi Kawahara
Journal of Dairy Research 2023.3
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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In vitro characterization of anti-inflammatory activities of 3RS, 7R, 11R-phytanic acid
Nakanishi T., Izumi M., Suzuki R., Yamaguchi K., Sugamoto K., Erickson L., Kawahara S.
Journal of Dairy Research 90 ( 1 ) 92 - 99 2023.2
Publishing type：Research paper (scientific journal) Publisher：Journal of Dairy Research
The aim of the research described here was to investigate the in vitro immunomodulatory effects of 3RS, 7R, 11R-phytanic acid (3RS-PHY) from the perspective of efficacy against autoimmune diseases. 3RS-PHY is a milk component with strong agonist activity at the peroxisome proliferator activated receptor (PPAR). As PPAR is a therapeutic target for several human diseases, 3RS-PHY intake may have possible health benefits. Recently, we chemically synthesized a preparation of 3RS-PHY and demonstrated that 3RS-PHY inhibited T-cell production of interferon (IFN)-γ. However, the overall immunomodulatory effects were not evaluated. In this study, mouse splenocytes, purified T-cells and B-cells were stimulated by mitogens and incubated with 3RS-PHY, followed by evaluation of cytokine and antibody production. A macrophage-like cell line J774.1 was also incubated with 3RS-PHY to evaluate nitric oxide production. 3RS-PHY decreased mRNA levels not only of IFN-γ but also of interleukin (IL)-2, IL-10 and IL-17A in splenocytes and similar effects were confirmed at the protein level. In addition, 3RS-PHY had a direct action on T-cells with preferential inhibitory effects on Th1 and Th17 cytokines such as IFN-γ and IL-17A. Furthermore, 3RS-PHY suppressed antibody secretion by B-cells and nitric oxide production by J774.1 almost completely, indicating that 3RS-PHY is a bioactive fatty acid with anti-inflammatory properties. These findings encourage further investigations, including in vivo experiments, to evaluate whether 3RS-PHY actually shows the potential to prevent autoimmune diseases, and provide basic information to produce milk and dairy products with an increased 3RS-PHY concentration.
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Antemortem inhibition of phosphoinositide 3-kinase causes changes in meat quality traits in broiler chickens Reviewed International coauthorship
Nakanishi T, Watanabe K, Erickson L, Kawahara S
Domestic Animal Endocrinology 75 1 - 7 2021.4
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Dietary phytanic acid-induced changes in tissue fatty acid profiles in mice Reviewed
Tomonori Nakanishi, Kazuhiro Kagamizono, Sayaka Yokoyama, Ryoji Suzuki, Hiroyuki Sakakibara, Kazuhiro Sugamoto, Laurie Erickson, Satoshi Kawahara
Journal of Dairy Research 87 ( 4 ) 498 - 500 2020.11
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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Analysis of volatile components that from the scent of male pigs and identification of terms that describe them
（ Role： Sole author）
2023.11
Language：Japanese Book type：Report
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生物・農学系のための統計学 : 大学での基礎学修から研究論文まで
平田 昌彦 , 宇田津 徹朗 , 河原 聡 , 榊原 啓之 （ Role： Joint author , 第4章 確率分布）
朝倉書店 2023.2 （ ISBN:9784254122855 ）
Language：Japanese Book type：Textbook, survey, introduction
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Development of quality control method of meat products based on flavor analysis
（ Role： Sole author）
2021.11
Language：Japanese Book type：Report
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乳肉卵の機能と利用
玖村朗人，若松純一，八田 一，河原 聡 他（ Role： Contributor）
アイ・ケイ コーポレーション 2018.10
Total pages：327 Responsible for pages：40 Language：Japanese Book type：Textbook, survey, introduction
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生物・農学系のための統計学
平田 昌彦，宇田津 徹朗，河原 聡，榊原 啓之（ Role： Joint author , 第4章 確率分布）
株式会社 朝倉書店 2017.4
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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The influences of different factors on the flavors of meat and meat products Invited Reviewed
Satoshi Kawahara
295 ( 3 ) 21 - 29 2022.9
Authorship：Lead author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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第67回国際食肉科学技術会議（ICoMST2021）に参加して
坂田亮一、松石昌典、河原 聡ほか
食肉の科学 62 ( 2 ) 145 - 177 2021.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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食肉科学研究の歴史をひもとく Invited
河原 聡
アグリバイオ 4 ( 6 ) 6 - 7 2020.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：北隆館
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食品機能からの食肉脂質の評価
河原 聡
食肉の栄養・機能と健康2019 50 - 56 2020.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益財団法人 日本食肉消費流通センター
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ドライエイジング牛肉に特徴的な香気成分に関する研究 Invited
河原 聡
畜産技術 773 ( 10 ) 36 - 41 2019.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益社団法人 畜産技術協会
Presentations 【 display / non-display 】
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Effect if sodium chloride on myoglobin and lipid oxidation in pork International conference
Tomohiro Uchiyama, Mizuki Kimoto, Tomonori Nakanishi, Satoshi Kawahara
The 68th International Congress of Meat Science and Technology 2022.8.23
Event date： 2022.8.22 - 2022.8.25
Language：English Presentation type：Poster presentation
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Novel anti-inflammatory effects of 3RS, 7R, 11R-phytanic acid International conference
Tomonori Nakanishi, Keisuke Suga, Ryoji Suzuki, Satoshi Kawahara
The 68th International Congress of Meat Science and Technology 2022.8.25
Event date： 2022.8.22 - 2022.8.25
Language：English Presentation type：Poster presentation
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食肉脂質の食品学的再検討
河原 聡
日本食肉研究会第60回大会 (麻布大学) 日本食肉研究会
Event date： 2019.3.30
Language：Japanese Presentation type：Oral presentation (general)
Venue：麻布大学
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ジビエの食肉特性
河原 聡
宮崎大学第8回国際シンポジウム 国境なき家畜伝染病防疫対策の取り組み (宮崎大学創立330記念交流会館) 宮崎大学産業防疫リサーチセンター
Event date： 2019.2.15
Language：Japanese Presentation type：Oral presentation (general)
Venue：宮崎大学創立330記念交流会館
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酵母エキス製造残渣による食肉製品の保水性改善
河原 聡，後藤千絵，松藤 久，脇谷晶一，仲西友紀，伏見善也
日本畜産学会第124回大会 (東京大学) 日本畜産学会
Event date： 2018.3.27 - 2018.3.29
Language：Japanese Presentation type：Oral presentation (general)
Venue：東京大学
Awards 【 display / non-display 】
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伊藤記念財団賞
2018.6 公益財団法人 伊藤記念財団 食肉脂質の食品栄養学的再評価に関する研究
河原 聡
Award type：Award from publisher, newspaper, foundation, etc. Country：Japan
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イノベーションネットアワード2014 全国イノベーション推進機関ネットワーク会長賞
2014.6 全国イノベーション推進機関ネットワーク 宮崎大学エコフィード高品質肉生産プロジェクト
入江正和, 河原 聡 他
Country：Japan
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Animal Science Journal 優秀論文賞
2007.3 日本畜産学会
片山員典，河原 聡，六車三治男
Award type：Honored in official journal of a scientific society, scientific journal Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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天然塩に含まれる無機塩類による食肉製品の脂質酸化抑制機構の解明
Grant number：23K01987 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
Authorship：Principal investigator
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反芻動物ルーメンにおけるフィタン酸の生成機構と機能性評価に関する研究
2015.04 - 2018.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
近年、新規機能性脂肪酸として反芻動物由来食品の脂肪中に存在するフィタン酸が注目されている。申請者はこれまでにフィタン酸の分析定量法について検討し、簡便かつ定量性の良い分析手法を考案した。本研究はこの定量法を駆使し、反芻動物ルーメン内でのフィタン酸の生成機構を解明し、乳・肉中のフィタン酸含量を制御する飼料給与体系を考案すること、そしてフィタン酸による免疫調節機能の評価を通して乳・肉の付加価値向上に資する知見を得ることが目的である。本研究で計画している具体的な検討項目は、①ルーメン微生物によるフィタン酸生成の律速段階の解明、②国内で生産される乳・肉のフィタン酸含量調査と給与飼料との相関性の解析、③フィタン酸がマウス脾臓細胞の活性に及ぼす影響の評価、の３点である。
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亜硝酸塩による豚肉製品のトランス脂肪酸生成：そのメカニズムと制御法の研究
2012.04 - 2105.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
食肉加工時に添加される亜硝酸塩が，豚肉製品中にトランス脂肪酸を生成させるメカニズムを解明し，その制御法を考案する。
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食事成分に起因する乳腺炎発症の生化学的解析
2012.04 - 2015.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
食事成分が異なる条件下で飼育した泌乳マウスから採取した乳汁の成分分析を実施する。
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高機能発酵食肉製品の開発研究
2010.04 - 2013.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
乳酸菌を用いて調製した発酵食肉製品中における機能性ペプチドの含有量変化を検討し，高機能性発酵食肉製品の開発を目指す。
Other external funds procured 【 display / non-display 】
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Analysis of volatile components that form the scent of male pigs and identification of terms that describe them
2022.06 - 2023.03
Private Foundations
Authorship：Principal investigator Grant type：Competitive
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Establishment of a method for quantitative analysis of a novel functional fatty acid, phytanic acid
2014.07 - 2015.03
Private Foundations
Authorship：Principal investigator Grant type：Competitive
Available Technology 【 display / non-display 】
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畜産食品の生産・加工に伴う脂質成分の変動に関する研究
食肉加工品の脂質酸化制御に関する研究
畜産食品の付加価値向上を目指した加工技術と品質評価に関する研究Home Page： 畜産食品科学研究室
Related fields where technical consultation is available：・食肉製品，乳製品，卵製品の加工・製造
・上記食品の品質評価や食味性評価
・動物性素材の利活用Message：・共同研究の希望テーマ：畜産物の加工や品質維持・向上に関する研究であればどのようなことでも。
・肉と乳に関するご質問があれば、まずはご相談ください。