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Faculty of Medicine College Hospital Neurosurgery |
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OHTA HAJIME
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Degree 【 display / non-display 】
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Doctor of Philosophy in Medicine ( 2004.7 University of Miyazaki )
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学士（医学） ( 1992.3 宮崎医科大学 )
Papers 【 display / non-display 】
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Endovascular stent therapy for extracranial and intracranial carotid artery dissection: single-center experience. Reviewed International coauthorship
Ohta H, Natarajan SK, Hauck EF, Khalessi AA, Siddiqui AH, Hopkins LN, Levy EI
Journal of neurosurgery 115 ( 1 ) 91 - 100 2011.7
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Ohta H., Nakano S., Yokogami K., Iseda T., Yoneyama T., Wakisaka S.
Stroke 35 ( 4 ) 893 - 898 2004.4
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Stroke
Background and Purpose-The purpose of this study was to evaluate the correlation between appearance of angiographic early venous filling during intra-arterial reperfusion therapy and posttherapeutic hemorrhagic complications. Methods-For the past 7 years, 104 patients prospectively underwent superselective local angiography via a microcatheter before and during intra-arterial reperfusion therapy for acute middle cerebral artery occlusion to evaluate the presence or absence of early venous filling. In principle, reperfusion therapy was discontinued just after appearance of early venous filling for fear of hemorrhage. There were 2 types of early venous filling: early filling of the thalamostriate vein from the lenticulostriate arteries and that of the cortical vein from the cortical arteries. Results-Among these 104 patients, 31 (29.8%) had early venous filling: 19 had early filling of the thalamostriate vein, and the other 12 had early filling of the cortical vein. Eight of the 19 patients (42.1%) and 2 of the 12 patients (16.7%) had massive hematoma with neurological worsening, whereas only 1 of the 73 patients (1.4%) without early venous filling had massive hematoma. There was a significant correlation between early venous filling and massive hematoma in both the deep (P<0.0001) and superficial (P=0.0019) middle cerebral artery territories. The sensitivity and specificity of the presence of early venous filling as an indicator of parenchymal hematoma were 71% and 83%, respectively. None of the 31 ischemic areas with early venous filling could escape cerebral infarction. Conclusions-Appearance of early venous filling may indicate irreversible brain damage and may be a predictive sign for parenchymal hematoma.
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Koyanagi M, Hatano T, Uchida K, Ogura T, Yamagami H, Shibata M, Enomoto Y, Fukawa N, Matsumoto Y, Sakai N, Takeuchi M, Nonaka T, Shimizu F, Ezura M, Ota T, Ohta H, Morimoto M, Morimoto T, Yoshimura S, ALVO investigators.
Cerebrovascular diseases (Basel, Switzerland) 52 ( 3 ) 1 - 11 2022.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Cerebrovascular Diseases
Introduction: We investigated whether apixaban is safe for the prevention of further adverse events in non-valvular atrial fibrillation (NVAF) patients with intra-/extracranial artery stenosis (Stenosis group) compared with acute large vessel occlusion without intra-/extracranial artery stenosis (No stenosis group). We also examined whether combination therapy using apixaban and antiplatelet is safe. Methods: ALVO (Apixaban on clinical outcome of patients with Large Vessel Occlusion [LVO] or stenosis) was a historical and prospective multicenter registry at 38 centers in Japan. Patients with NVAF and acute LVO or stenosis who received apixaban within 14 days after onset were included. We conducted the post hoc analysis using the ALVO dataset. We compared patients with stenosis versus those without stenosis in terms of the primary outcome, which was defined as a composite of all-cause death, major bleeding events, and ischemic events 365 days after onset. Results: Of the 662 patients, 54 (8.2%) patients were classified into the Stenosis group, and 104 patients of the total (16%) reached the primary outcome. The cumulative incidence of primary outcome was not significantly different between the No stenosis and the Stenosis groups (hazard ratio [HR] 1.2, 95% confidence interval [CI]: 0.64-2.4; p = 0.52). Even after adjustment for predictive clinical variates, no significant difference in the primary endpoint between the No stenosis and the Stenosis groups was shown (adjusted HR 1.2, 95% CI: 0.59-2.5; p = 0.60). Fifty patients (7.6%) used an antiplatelet with apixaban. Among the Stenosis group patients, the cumulative incidence of the primary outcome was significantly higher among patients treated with an antiplatelet and apixaban (HR 3.5, 95% CI: 1.0-12; p = 0.048). Conclusion: Apixaban monotherapy appears safe for the prevention of further adverse events in the Stenosis group patients similar to the No stenosis group patients. Concomitant use of an antiplatelet might not be favorable in patients with stenosis.
DOI： 10.1159/000526896
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Shimamura N., Naraoka M., Uchida K., Tokuda K., Sakai N., Imamura H., Yamagami H., Tanaka K., Ezura M., Nonaka T., Matsumoto Y., Shibata M., Ohta H., Morimoto M., Fukawa N., Hatano T., Enomoto Y., Takeuchi M., Ota T., Shimizu F., Kimura N., Kamiya Y., Morimoto T., Yoshimura S.
World Neurosurgery 162 e503 - e510 2022.6
Language：English Publishing type：Research paper (scientific journal) Publisher：World Neurosurgery
Objective: The initiation of anticoagulant administration after large vessel occlusion (LVO) or stenosis with nonvalvular arterial fibrillation (NAVF) is controversial. We evaluate the timing of anticoagulation and its relationship with clinical factors. Methods: We enrolled 595 anterior circulation LVO or stenosis with NAVF cases from 38 stroke centers. Laboratory data; activities of daily living; the Alberta Stroke Program Early CT Score (ASPECTS); the National Institutes of Health Stroke Scale (NIHSS) score; occluded artery; treatment methods; date of the initiation of apixaban administration and outcome were recorded. Multivariate analyses were performed after univariate analysis. Results: The median start of apixaban administration after the stroke was 2 days (interquartile range, 1–5; range, 0–14). Multivariate analysis of variance showed that non–internal carotid artery occlusion (F value 4.60), reperfusion therapy (31.1), high ASPECTS (6.27) before anticoagulant intake, and absence of intracranial hemorrhage (12.9) were significantly correlated with early apixaban administration. Multiple logistic regression analysis for independent living at 90 days after the stroke showed significant factors: aging (odds, 0.94; 95% confidence interval [CI], 0.91–0.97); male (odds, 0.46; 95% CI, 0.26–0.79); prestroke independence (odds, 20.7; 95% CI, 6.48–93.9); number of white blood cells (odds, 0.99; 95% CI, 0.97–1.00); non–internal carotid artery occlusion; NIHSS score at 72 hours after the stroke (odds 0.92; 95% CI, 0.89–0.96); ASPECTS before apixaban intake (odds, 1.15; 95% CI, 1.00–1.31) and initiation of apixaban (odds, 0.91; 95% CI, 0.83–0.99). Conclusions: Early administration of apixaban is induced by nonsevere infarction, reperfusion therapy or none of intracranial hemorrhage and it correlates with an independent long-term outcome.
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Yamashita S., Takeshima H., Kadota Y., Azuma M., Fukushima T., Ogasawara N., Kawano T., Tamura M., Muta J., Saito K., Takeishi G., Mizuguchi A., Watanabe T., Ohta H., Yokogami K.
Brain Tumor Pathology 39 ( 2 ) 88 - 98 2022.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Brain Tumor Pathology
After the new molecular-based classification was reported to be useful for predicting prognosis, the T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign has gained interest as one of the promising methods for detecting lower grade gliomas (LGGs) with isocitrate dehydrogenase (IDH) mutations and chromosome 1p/19q non-codeletion (IDH mut-Noncodel) with high specificity. Although all institutions could use T2-FLAIR mismatch sign without any obstacles, this sign was not completely helpful because of its low sensitivity. In this study, we attempted to uncover the mechanism of T2-FLAIR mismatch sign for clarifying the cause of this sign’s low sensitivity. Among 99 patients with LGGs, 22 were T2-FLAIR mismatch sign-positive (22%), and this sign as a marker of IDH mut-Noncodel showed a sensitivity of 55.6% and specificity of 96.8%. Via pathological analyses, we could provide evidence that not only microcystic changes but the enlarged intercellular space was associated with T2-FLAIR mismatch sign (p = 0.017). As per the molecular analyses, overexpression of mTOR-related genes (m-TOR, RICTOR) were detected as the molecular events correlated with T2-FLAIR mismatch sign (p = 0.020, 0.030. respectively). Taken together, we suggested that T2-FLAIR mismatch sign could pick up the IDH mut-Noncodel LGGs with enlarged intercellular space or that with overexpression of mTOR-related genes.
Books 【 display / non-display 】
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Databank of Stroke 2015
SHIRO MIYATA, HAJIME OHTA（ Role： Contributor）
Nakayamashoten 2015.2
Total pages：209 Responsible for pages：78-79 Language：Japanese Book type：Scholarly book
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Perfect Master: Neuroendovascular Therapy. Update of indispensable knowledge, 2nd edition
HAJIME OHTA（ Role： Contributor）
Medical View 2014.10
Total pages：514 Responsible for pages：190-193, 258-261, 338-343, 480-481 Language：Japanese Book type：Scholarly book
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Perfect Master: Neuroendovascular Therapy. Update of indispensable knowledge
HAJIME OHTA（ Role： Contributor）
Medical View 2010.12
Total pages：434 Responsible for pages：372-375, 424-427, 410-411 Language：Japanese Book type：Scholarly book
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Carotid Artery Stenting
HAJIME OHTA（ Role： Contributor , Management of the perioperative periods for CAS）
Medical View 2008.6
Total pages：307 Responsible for pages：82-93, 162-165 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Correction to: Safety of Early Administration of Apixaban on Clinical Outcomes in Patients with Acute Large Vessel Occlusion. Reviewed International journal
Shinichi Yoshimura, Kazutaka Uchida, Nobuyuki Sakai, Hirotoshi Imamura, Hiroshi Yamagami, Kanta Tanaka, Masayuki Ezura, Tadashi Nonaka, Yasushi Matsumoto, Masunari Shibata, Hajime Ohta, Masafumi Morimoto, Norihito Fukawa, Taketo Hatano, Yukiko Enomoto, Masataka Takeuchi, Takahiro Ota, Fuminori Shimizu, Naoto Kimura, Yuki Kamiya, Norito Shimamura, Takeshi Morimoto
Translational stroke research 12 ( 4 ) 692 - 694 2021.8
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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術前にarterial spin labelingを施行した下垂体腺腫の検討 Reviewed
武石剛, 渡邉孝, 東美菜子, 大田元, 横上聖貴, 平井俊範, 竹島秀雄
日本間脳下垂体腫瘍学会プログラム・抄録集 30th 2020
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
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スタッフの疲弊回復を念頭においた脳血栓回収療法施行体制の構築
大田元
第35回日本脳神経血管内治療学会
Event date： 2019.11.21 - 2019.11.23
Language：Japanese Presentation type：Oral presentation (general)
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Superselective transvenous coil embolization for dural AVF at hypoglossal canal International conference
Ohta H
15th Congress of world federation of interventional and therapeutic neuroradiology
Event date： 2019.10.20 - 2019.10.23
Language：Japanese Presentation type：Oral presentation (general)
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3D画像と3D血管モデルを駆使した術前シミュレーション教育システムの運用について
大田元
日本脳神経外科学会第78回学術総会
Event date： 2019.10.9 - 2019.10.12
Language：Japanese Presentation type：Oral presentation (general)
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Hight flow bypass併用母血管遮断術が有用的であった難治性鼻出血発症の内頸動脈仮性動脈瘤の一例．
大田元
第48回日本脳卒中の外科学会
Event date： 2019.3.21 - 2019.3.23
Language：Japanese Presentation type：Oral presentation (general)
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宮崎県における脳卒中診療体制の整備への取り組み
大田元
第48回日本脳卒中の外科学会
Event date： 2019.3.21 - 2019.3.23
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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第28回日本脳神経血管内治療学会 優秀応募論文賞・銅賞
2012.11 第28回日本脳神経血管内治療学会 Appearance of early venous filling during intra-arterial reperfusion therapy for acute middle cerebral artery occlusion. A predictive sign for hemorrhagic complications
大田 元
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan