Hirai Takuya

写真a

Affiliation

Faculty of Agriculture Department of Veterinary Science Veterinarian pathology course

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(獣医学) ( 1999.3   北海道大学 )

Research Areas 【 display / non-display

  • Life Science / Veterinary medical science

Qualification acquired 【 display / non-display

  • 日本獣医病理学専門家協会(JCVP)会員

  • Veterinarian

 

Papers 【 display / non-display

  • Rhabdomyolysis, myoglobinuric nephrosis, and crystalline nephropathy in a captive bottlenose dolphin Reviewed

    Nueangphuet P., Hamano T., Hirai T., Sakaguchi Y., Sonoda H., Otsuka M., Yamato O., Hobo S., Ikeda M., Yamaguchi R.

    Journal of Veterinary Diagnostic Investigation   34 ( 4 )   668 - 673   2022.7

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Veterinary Diagnostic Investigation  

    A 5-y-old female bottlenose dolphin (Tursiops truncatus) from an aquarium in Japan had clinical signs of anorexia, vomiting, and bradykinesia. Enrofloxacin and lactated Ringer solution were administered for treatment of bacterial infection and for rehydration. Elevations of creatine kinase and aspartate aminotransferase activities were detected on day 4 of treatment, indicating that rhabdomyolysis had developed on day 3. On day 5, serum creatinine and urea concentrations increased and remained high throughout the remaining treatment; the dolphin died on day 16. Postmortem examination revealed massive necrosis of the longissimus dorsi muscles. Histologic examination revealed extensive necrosis of skeletal myofibers, multifocal renal tubular necrosis with intratubular casts and crystals, and suppurative bronchopneumonia. The renal casts labeled positively with anti-myoglobin antibody; expression of aquaporin-1 was decreased in renal tubules compared to normal kidney tissue. To our knowledge, this description of clinicopathologic findings of rhabdomyolysis leading to acute kidney injury with concomitant crystalline nephropathy has not been reported previously in a bottlenose dolphin.

    DOI: 10.1177/10406387221090516

    Scopus

  • Detection of Swine Influenza A and Porcine Reproductive and Respiratory Syndrome Viruses in Nasopharynx-Associated Lymphoid Tissue Reviewed

    Niazi A.M., ZiHeng Z., Fuke N., Toyama K., Habibi W.A., Kawaguchi N., Yamaguchi R., Hirai T.

    Journal of Comparative Pathology   197   23 - 34   2022.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Comparative Pathology  

    Porcine respiratory disease complex, which is caused by a combination of pathogens, including swine influenza A virus (SIV) and porcine reproductive respiratory syndrome virus (PRRSV), results in significant economic losses in pig production systems. Nasopharynx-associated lymphoid tissue (NALT) plays an important role in the uptake of pathogens and defence of the nasal mucosa in rodents and humans. We characterized NALT M cells in pigs and detected SIV antigen and PRRSV nucleic acid in NALT using histopathological, immunohistochemical and in-situ hybridization analyses. All SIV- and PRRSV-positive cases examined had suppurative nasopharyngitis and pneumonia. M cells were detected by immunohistochemistry and the distribution of M cells showed an increase in the middle section of NALT. SIV antigen was detected in M cells and PRRSV nucleic acid was demonstrated in the cytoplasm of macrophages in NALT. We believe that SIV and PRRSV infection in the upper respiratory tract induces local immunosuppression and these results confirm that swine NALT is a location for virus replication and may be strongly associated with the development of pneumonia in pigs.

    DOI: 10.1016/j.jcpa.2022.06.006

    Scopus

  • Natural Mycoplasma bovis infection associated with epithelioid granulomatous caseonecrotic bronchiolitis at a progressed disease stage in calves Reviewed

    Suwanruengsri M., Uemura R., Izzati U.Z., Kanda T., Fuke N., Yasuda M., Hirai T., Yamaguchi R.

    Thai Journal of Veterinary Medicine   52 ( 1 )   33 - 44   2022.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Thai Journal of Veterinary Medicine  

    Mycoplasma bovis (M. bovis) is a pathogen that especially effects the respiratory system of cattle. We focused on the histopathological changes in the lungs caused by M. bovis because the lesions in the bronchi or bronchioles and alveoli are quite different in natural infections. Thirty-five lung samples from 2-to 12-month-old Japanese Black calves with respiratory symptoms were collected and examined for bacteria presence and pathological changes using immunohistochemistry (IHC). Using the loop-mediated isothermal amplification method, 18 of the 35 samples were found to be positive for M. bovis, which was isolated and identified. In 7 of the samples, only M. bovis was detected, whereas in the other 11, other bacteria coexisted with M. bovis. Anti-M. bovis, anti-MAC387, anti-Iba1, anti-CD3, anti-CD20, anti-AE1/AE3 cytokeratin and anti-IL8 were used for antigen detection. Histopathological studies and diagnoses of the lungs were examined in two parts; bronchiolar lesions and alveolar lesions. The bronchiolar findings were divided into three groups: granulomatous, caseonecrotic and suppurative bronchiolitis. The alveolar lesions found were quite mild, except in three cases. IHC staining revealed strong evidence of M. bovis in degenerated neutrophils, which was confirmed by electron microscopy. The main inflammatory cell response to M. bovis infections was degenerate neutrophils, which caused the destruction of the bronchial epithelium and possibly induced epithelioid granulomatous inflammation, resulting in severe chronic respiratory diseases in cattle.

    DOI: 10.14456/tjvm.2022.4

    Scopus

  • Production of granulomas in Mycoplasma bovis infection associated with meningitis-meningoencephalitis, endocarditis, and pneumonia in cattle Reviewed

    Suwanruengsri M., Uemura R., Kanda T., Fuke N., Nueangphuet P., Pornthummawat A., Yasuda M., Hirai T., Yamaguchi R.

    Journal of Veterinary Diagnostic Investigation   34 ( 1 )   68 - 76   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Veterinary Diagnostic Investigation  

    Mycoplasma bovis, the most important primary pathogen in the family Mycoplasmataceae, causes pneumonia, arthritis, otitis media, and mastitis in cattle. Histopathologic pulmonary changes associated with M. bovis infection have been characterized as suppurative-to-caseonecrotic bronchopneumonia; infection in other organs has been reported in only a few studies that examined caseonecrotic endocarditis and suppurative meningitis. Granulomatous lesions associated with M. bovis infection have been reported only rarely. We studied the granulomatous inflammation associated with M. bovis infection in several organs of 21 Japanese Black cattle. M. bovis was detected by isolation and loop-mediated isothermal amplification methods; other bacteria were detected using culture on 5% blood sheep agar and a MALDI-TOF MS Biotyper. Tissues were examined by histopathology and by immunohistochemistry (IHC) using anti–M. bovis, anti-Iba1, anti-iNOS, and anti-CD204 antibodies. All 21 cases, which included 2 cases of meningitis-meningoencephalitis, 8 cases of endocarditis, and 11 cases of bronchopneumonia, had caseonecrotic granulomatous inflammation associated with M. bovis infection. The IHC for macrophages revealed a predominance of iNOS-labeled (M1) macrophages in the inner layer of the caseonecrotic granulomas associated with meningitis-meningoencephalitis, endocarditis, and bronchopneumonia in Japanese Black cattle naturally infected with M. bovis.

    DOI: 10.1177/10406387211053254

    Scopus

  • Adenomyomatous uterine polyp in a Miniature Pinscher: histologic, immunohistochemical, and clinical aspects Reviewed

    Nueangphuet P., Tanabe M., Izzati U.Z., Fuke N., Hirai T., Yamaguchi R.

    Journal of Veterinary Diagnostic Investigation   34 ( 1 )   102 - 106   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Veterinary Diagnostic Investigation  

    A 14-y-old Miniature Pinscher bitch was admitted to a veterinary clinic because of inappetence and a distended abdomen; ultrasound examination revealed a fluid-filled uterus with a single 1-cm hyperechoic nodule in its lumen. Ovariohysterectomy was performed. Grossly, the uterine horns were distended irregularly and asymmetrically, and the uterine lumen contained 200–300 mL of brown watery fluid. A single white polypoid 0.9-cm diameter nodule was present at the site of the distended uterine horn and arose from the endometrium with a narrow stalk. Histologically, the polyp consisted of dense, smooth muscle fascicles admixed with glandular components; its surface was covered by simple cuboidal epithelium with areas of squamous metaplasia. The myomatous cells expressed the myogenic markers smooth muscle actin and desmin. We interpreted the mass as an adenomyomatous uterine polyp, which is a rare variant of an endometrial polyp.

    DOI: 10.1177/10406387211043221

    Scopus

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Books 【 display / non-display

  • 動物病理学各論 第3版

    日本獣医病理学専門家協会 編( Role: Contributor)

    文永堂出版  2021.3 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 動物病理カラーアトラス 第2版

    平井 卓哉、中山 裕之、他( Role: Contributor)

    文栄堂出版株式会社  2018.1 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 動物病理学各論 第2版

    平井 卓哉、林 俊春 他( Role: Contributor)

    文栄堂出版  2015.3 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 動物病理学総論 第3版

    平井 卓哉、中山 裕之、他( Role: Contributor)

    日本獣医病理学会  2013.4 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 獣医病理学実習マニュアル 第2版

    平井 卓哉 他( Role: Contributor)

    学窓社  2012.3 

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    Language:Japanese Book type:Textbook, survey, introduction

Presentations 【 display / non-display

  • 豚サーコウイルス2型感染豚における鼻咽腔関連リンパ組織の病理学的解析

    川口虹穂、周子恒、Niazi Ahmad Massoud、平井卓哉

    第70回九州地区獣医師大会  2021.10 

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    Event date: 2021.10.22 - 2021.10.31

    Presentation type:Oral presentation (general)  

  • 御崎馬に共通してみられた消化器病変および寄生虫性病変についての病理学的検討

    稲永美乃里、Mathurot Suwanruengsri、平井卓哉

    第164回日本獣医学会学術集会  2021.9 

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    Event date: 2021.9.7 - 2021.9.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 重症熱性血小板減少症候群を発症した猫1例の病理学的検討

    元山就斗、平井卓哉、岡林環樹、目堅博久、兼子千穂、山口良二

    第68回九州地区獣医師大会  (グランデはがくれ)  公益社団法人佐賀県獣医師会

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    Event date: 2019.11.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ  

  • 椎孔内浸潤を示した犬のダンベル型悪性末梢神経鞘腫瘍の1例

    今富美波、平井卓哉、井上賀之、山口良二

    第68回九州地区獣医師大会  (グランデはがくれ)  公益財団法人佐賀県獣医師会

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    Event date: 2019.11.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ  

  • 呼吸器病罹患豚における鼻咽腔関連リンパ組織および鼻咽腔病変の解析

    伊藤宗磨、廣池琴美、森啓太、小東智哉、平井卓哉、山口良二

    第65回九州地区獣医師大会 

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    Event date: 2016.10.15 - 2016.10.16

    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 優秀ポスター賞

    2022.3   第9回日本獣医病理学専門家協会学術集会   豚サーコウイルスⅡ型および豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭関連リンパ組織の病理学的解析

    周子恒、川口虹穂、山岸明日香、元山就斗、渡山恵子、Ahmad Massoud Niazi、平井卓哉

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 日本産業動物獣医学会奨励賞

    2014.10   九州地区獣医師会連合会  

    渡山恵子、平井卓哉、上久保正一、山口良二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • PCV2およびPRRSウイルスの鼻咽腔関連リンパ組織における増殖と病態の解明

    Grant number:22K06003  2022.04 - 2025.03

    科学研究費補助金 基盤研究(C)

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    Authorship:Principal investigator 

  • 経済的被害をもたらす子豚の呼吸器病ウイルスによる鼻咽腔および肺の病態解析

    2018.04 - 2021.03

    科学研究費補助金  基盤研究(C)

  • アジアから島伝いに北上するアルボウイルス感染症の動向予察

    2015.04 - 2018.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 南九州の豚繁殖・呼吸障害症候群ウイルス株の遺伝子解析と持続感染様式の解明

    2011.04 - 2015.03

    科学研究費補助金  基盤研究(C)