HIRAI Takuya

写真a

Affiliation

Faculty of Agriculture Department of Veterinary Science Veterinarian pathology course

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(獣医学) ( 1999.3   北海道大学 )

Research Areas 【 display / non-display

  • Life Science / Veterinary medical science

Qualification acquired 【 display / non-display

  • 日本獣医病理学専門家協会(JCVP)会員

  • Veterinarian

 

Papers 【 display / non-display

  • Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus. Reviewed

    Toyama K, Hirai T, Sueyoshi M, Zhou Z, Niazi AM, Kawaguchi N, Fuke N, Yamaguchi R.

    J Vet Med Sci.   2022.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Detection of Swine Influenza A and Porcine Reproductive and Respiratory Syndrome Viruses in Nasopharynx-Associated Lymphoid Tissue Reviewed

    Niazi A.M., ZiHeng Z., Fuke N., Toyama K., Habibi W.A., Kawaguchi N., Yamaguchi R., Hirai T.

    Journal of Comparative Pathology   197   23 - 34   2022.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Comparative Pathology  

    Porcine respiratory disease complex, which is caused by a combination of pathogens, including swine influenza A virus (SIV) and porcine reproductive respiratory syndrome virus (PRRSV), results in significant economic losses in pig production systems. Nasopharynx-associated lymphoid tissue (NALT) plays an important role in the uptake of pathogens and defence of the nasal mucosa in rodents and humans. We characterized NALT M cells in pigs and detected SIV antigen and PRRSV nucleic acid in NALT using histopathological, immunohistochemical and in-situ hybridization analyses. All SIV- and PRRSV-positive cases examined had suppurative nasopharyngitis and pneumonia. M cells were detected by immunohistochemistry and the distribution of M cells showed an increase in the middle section of NALT. SIV antigen was detected in M cells and PRRSV nucleic acid was demonstrated in the cytoplasm of macrophages in NALT. We believe that SIV and PRRSV infection in the upper respiratory tract induces local immunosuppression and these results confirm that swine NALT is a location for virus replication and may be strongly associated with the development of pneumonia in pigs.

    DOI: 10.1016/j.jcpa.2022.06.006

    Scopus

  • Rhabdomyolysis, myoglobinuric nephrosis, and crystalline nephropathy in a captive bottlenose dolphin Reviewed

    Nueangphuet P., Hamano T., Hirai T., Sakaguchi Y., Sonoda H., Otsuka M., Yamato O., Hobo S., Ikeda M., Yamaguchi R.

    Journal of Veterinary Diagnostic Investigation   34 ( 4 )   668 - 673   2022.7

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Veterinary Diagnostic Investigation  

    A 5-y-old female bottlenose dolphin (Tursiops truncatus) from an aquarium in Japan had clinical signs of anorexia, vomiting, and bradykinesia. Enrofloxacin and lactated Ringer solution were administered for treatment of bacterial infection and for rehydration. Elevations of creatine kinase and aspartate aminotransferase activities were detected on day 4 of treatment, indicating that rhabdomyolysis had developed on day 3. On day 5, serum creatinine and urea concentrations increased and remained high throughout the remaining treatment; the dolphin died on day 16. Postmortem examination revealed massive necrosis of the longissimus dorsi muscles. Histologic examination revealed extensive necrosis of skeletal myofibers, multifocal renal tubular necrosis with intratubular casts and crystals, and suppurative bronchopneumonia. The renal casts labeled positively with anti-myoglobin antibody; expression of aquaporin-1 was decreased in renal tubules compared to normal kidney tissue. To our knowledge, this description of clinicopathologic findings of rhabdomyolysis leading to acute kidney injury with concomitant crystalline nephropathy has not been reported previously in a bottlenose dolphin.

    DOI: 10.1177/10406387221090516

    Scopus

  • Causes of death and detection of antibodies against japanese encephalitis virus in misaki feral horses (Equus caballus) in Southern Japan, 2015–17 Reviewed

    Niazmand M., Hirai T., Ito S., Habibi W., Noori J., Hasheme R., Yamaguchi R.

    Journal of Wildlife Diseases   55 ( 4 )   804 - 811   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Wildlife Diseases  

    We performed postmortem examinations on seven Misaki feral horses (Equus caballus) and evaluated Misaki feral horses, Japanese wild boars (Sus scrofa leucomystax), domestic pigs (Sus scrofa), and wild Japanese macaques (Macaca fuscata fuscata) from 2015 to 2017 in Cape Toi, Kushima, Miyazaki Prefecture, southern Japan, for antibodies against Japanese encephalitis virus (JEV). Strongylus vulgaris infection with severe arterial lesions and hemomelasma ilei was present in all necropsied horses. We frequently found intestinal ulcers, perihepatitis filamentosa, and poor body condition. We recorded degenerative arthropathy in metacarpophalangeal joints in two cases and a fracture of the rib with diaphragmatic rupture in one case. A total of 73% (177/242) of horses were seropositive for JEV as tested by hemagglutination inhibition (HI). The HI data also revealed that 74% (59/80) of the wild boars, 67% (60/90) of the pigs, and 29% (22/75) of the wild monkeys were seropositive for JEV. Our findings showed that Strongylus spp. are still a risk to horses in this region, and that environmental factors such as topographic location of the pasture and steep slope may have caused of degenerative arthropathy and bone fracture. Our results showed that JEV is endemic in Japan. The wild boars and pigs were presumed to act as strong amplifiers and sources of infection, with subsequent risk to humans.

    DOI: 10.7589/2018-10-265

    Scopus

  • CAUSES OF DEATH AND DETECTION OF ANTIBODIES AGAINST JAPANESE ENCEPHALITIS VIRUS Reviewed

    Niazmand MH, Hirai T, Ito S, Habibi WA, Noori J, Hasheme R, Yamaguchi R.

    J Wildl Dis.   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 【 display / non-display

  • 動物病理学各論 第3版

    日本獣医病理学専門家協会 編( Role: Contributor)

    文永堂出版  2021.3 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 動物病理カラーアトラス 第2版

    平井 卓哉、中山 裕之、他( Role: Contributor)

    文栄堂出版株式会社  2018.1 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 動物病理学各論 第2版

    平井 卓哉、林 俊春 他( Role: Contributor)

    文栄堂出版  2015.3 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 動物病理学総論 第3版

    平井 卓哉、中山 裕之、他( Role: Contributor)

    日本獣医病理学会  2013.4 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 獣医病理学実習マニュアル 第2版

    平井 卓哉 他( Role: Contributor)

    学窓社  2012.3 

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    Language:Japanese Book type:Textbook, survey, introduction

Presentations 【 display / non-display

  • 豚サーコウイルス2型および豚繁殖・呼吸障害症候群ウイルス感染豚における口蓋扁桃病変と鼻咽頭病変の比較

    山岸明日香、Niazi Ahmad Massoud、平井卓哉

    第165回日本獣医学術集会病理学分科会  2022.9.7 

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    Event date: 2022.9.6 - 2022.9.8

    Presentation type:Oral presentation (general)  

  • 豚サーコウイルス2型および豚繁殖・呼吸障害症候群ウイルス感染豚の鼻咽頭関連リンパ組織における病理学的解析と病原性細菌の検出

    山岸明日香、上久保正一、平井卓哉

    令和4年度獣医学術九州地区産業動物獣医学会  2022.9.4 

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    Event date: 2022.9.4

    Presentation type:Oral presentation (general)  

  • 豚サーコウイルス2型感染豚における鼻咽腔関連リンパ組織の病理学的解析

    川口虹穂、周子恒、Niazi Ahmad Massoud、平井卓哉

    第70回九州地区獣医師大会  2021.10 

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    Event date: 2021.10.22 - 2021.10.31

    Presentation type:Oral presentation (general)  

  • 御崎馬に共通してみられた消化器病変および寄生虫性病変についての病理学的検討

    稲永美乃里、Mathurot Suwanruengsri、平井卓哉

    第164回日本獣医学会学術集会  2021.9 

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    Event date: 2021.9.7 - 2021.9.13

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 椎孔内浸潤を示した犬のダンベル型悪性末梢神経鞘腫瘍の1例

    今富美波、平井卓哉、井上賀之、山口良二

    第68回九州地区獣医師大会  (グランデはがくれ)  公益財団法人佐賀県獣医師会

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    Event date: 2019.11.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ  

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Awards 【 display / non-display

  • 奨励賞

    2022.9   令和4年度獣医学術九州地区学会産業動物獣医学会   豚サーコウイルス2型および豚繁殖・呼吸障害症候群ウイルス感染豚の鼻咽頭関連リンパ組織における病理学的解析と病原性細菌の検出

    山岸明日香、上久保正一、平井卓哉

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 優秀ポスター賞

    2022.3   第9回日本獣医病理学専門家協会学術集会   豚サーコウイルスⅡ型および豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭関連リンパ組織の病理学的解析

    周子恒、川口虹穂、山岸明日香、元山就斗、渡山恵子、Ahmad Massoud Niazi、平井卓哉

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 日本産業動物獣医学会奨励賞

    2014.10   九州地区獣医師会連合会  

    渡山恵子、平井卓哉、上久保正一、山口良二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • PCV2およびPRRSウイルスの鼻咽腔関連リンパ組織における増殖と病態の解明

    Grant number:22K06003  2022.04 - 2025.03

    科学研究費補助金 基盤研究(C)

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    Authorship:Principal investigator 

  • 経済的被害をもたらす子豚の呼吸器病ウイルスによる鼻咽腔および肺の病態解析

    2018.04 - 2021.03

    科学研究費補助金  基盤研究(C)

  • アジアから島伝いに北上するアルボウイルス感染症の動向予察

    2015.04 - 2018.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 南九州の豚繁殖・呼吸障害症候群ウイルス株の遺伝子解析と持続感染様式の解明

    2011.04 - 2015.03

    科学研究費補助金  基盤研究(C)