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Affiliation |
Faculty of Agriculture Region of Veterinary Science |
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Professor |
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Related SDGs |
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HIRAI Takuya
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Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Qualification acquired 【 display / non-display 】
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日本獣医病理学専門家協会（JCVP）会員
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Veterinarian
Papers 【 display / non-display 】
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Detection of bovine respiratory disease complex-related pathogens in nasopharynx-associated lymphoid tissue. Reviewed
Hegazy AA, Nakai M, Fuke N, Hussein AE, Kondo H, Hirai T.
J Vet Diagn Invest 37 ( 2 ) 284 - 297 2025.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus. Reviewed
Toyama K, Hirai T, Sueyoshi M, Zhou Z, Niazi AM, Kawaguchi N, Fuke N, Yamaguchi R.
J Vet Med Sci. 2022.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Niazi A.M., ZiHeng Z., Fuke N., Toyama K., Habibi W.A., Kawaguchi N., Yamaguchi R., Hirai T.
Journal of Comparative Pathology 197 23 - 34 2022.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Comparative Pathology
Porcine respiratory disease complex, which is caused by a combination of pathogens, including swine influenza A virus (SIV) and porcine reproductive respiratory syndrome virus (PRRSV), results in significant economic losses in pig production systems. Nasopharynx-associated lymphoid tissue (NALT) plays an important role in the uptake of pathogens and defence of the nasal mucosa in rodents and humans. We characterized NALT M cells in pigs and detected SIV antigen and PRRSV nucleic acid in NALT using histopathological, immunohistochemical and in-situ hybridization analyses. All SIV- and PRRSV-positive cases examined had suppurative nasopharyngitis and pneumonia. M cells were detected by immunohistochemistry and the distribution of M cells showed an increase in the middle section of NALT. SIV antigen was detected in M cells and PRRSV nucleic acid was demonstrated in the cytoplasm of macrophages in NALT. We believe that SIV and PRRSV infection in the upper respiratory tract induces local immunosuppression and these results confirm that swine NALT is a location for virus replication and may be strongly associated with the development of pneumonia in pigs.
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Rhabdomyolysis, myoglobinuric nephrosis, and crystalline nephropathy in a captive bottlenose dolphin Reviewed
Nueangphuet P., Hamano T., Hirai T., Sakaguchi Y., Sonoda H., Otsuka M., Yamato O., Hobo S., Ikeda M., Yamaguchi R.
Journal of Veterinary Diagnostic Investigation 34 ( 4 ) 668 - 673 2022.7
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Veterinary Diagnostic Investigation
A 5-y-old female bottlenose dolphin (Tursiops truncatus) from an aquarium in Japan had clinical signs of anorexia, vomiting, and bradykinesia. Enrofloxacin and lactated Ringer solution were administered for treatment of bacterial infection and for rehydration. Elevations of creatine kinase and aspartate aminotransferase activities were detected on day 4 of treatment, indicating that rhabdomyolysis had developed on day 3. On day 5, serum creatinine and urea concentrations increased and remained high throughout the remaining treatment; the dolphin died on day 16. Postmortem examination revealed massive necrosis of the longissimus dorsi muscles. Histologic examination revealed extensive necrosis of skeletal myofibers, multifocal renal tubular necrosis with intratubular casts and crystals, and suppurative bronchopneumonia. The renal casts labeled positively with anti-myoglobin antibody; expression of aquaporin-1 was decreased in renal tubules compared to normal kidney tissue. To our knowledge, this description of clinicopathologic findings of rhabdomyolysis leading to acute kidney injury with concomitant crystalline nephropathy has not been reported previously in a bottlenose dolphin.
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Niazmand M., Hirai T., Ito S., Habibi W., Noori J., Hasheme R., Yamaguchi R.
Journal of Wildlife Diseases 55 ( 4 ) 804 - 811 2019.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Wildlife Diseases
We performed postmortem examinations on seven Misaki feral horses (Equus caballus) and evaluated Misaki feral horses, Japanese wild boars (Sus scrofa leucomystax), domestic pigs (Sus scrofa), and wild Japanese macaques (Macaca fuscata fuscata) from 2015 to 2017 in Cape Toi, Kushima, Miyazaki Prefecture, southern Japan, for antibodies against Japanese encephalitis virus (JEV). Strongylus vulgaris infection with severe arterial lesions and hemomelasma ilei was present in all necropsied horses. We frequently found intestinal ulcers, perihepatitis filamentosa, and poor body condition. We recorded degenerative arthropathy in metacarpophalangeal joints in two cases and a fracture of the rib with diaphragmatic rupture in one case. A total of 73% (177/242) of horses were seropositive for JEV as tested by hemagglutination inhibition (HI). The HI data also revealed that 74% (59/80) of the wild boars, 67% (60/90) of the pigs, and 29% (22/75) of the wild monkeys were seropositive for JEV. Our findings showed that Strongylus spp. are still a risk to horses in this region, and that environmental factors such as topographic location of the pasture and steep slope may have caused of degenerative arthropathy and bone fracture. Our results showed that JEV is endemic in Japan. The wild boars and pigs were presumed to act as strong amplifiers and sources of infection, with subsequent risk to humans.
DOI： 10.7589/2018-10-265
Books 【 display / non-display 】
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動物病理学各論 第3版
日本獣医病理学専門家協会 編（ Role： Contributor）
文永堂出版 2021.3
Language：Japanese Book type：Textbook, survey, introduction
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動物病理カラーアトラス 第2版
平井 卓哉、中山 裕之、他（ Role： Contributor）
文栄堂出版株式会社 2018.1
Language：Japanese Book type：Textbook, survey, introduction
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動物病理学各論 第2版
平井 卓哉、林 俊春 他（ Role： Contributor）
文栄堂出版 2015.3
Language：Japanese Book type：Textbook, survey, introduction
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動物病理学総論 第3版
平井 卓哉、中山 裕之、他（ Role： Contributor）
日本獣医病理学会 2013.4
Language：Japanese Book type：Textbook, survey, introduction
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獣医病理学実習マニュアル 第２版
平井 卓哉 他（ Role： Contributor）
学窓社 2012.3
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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Kawaguchi N., Fuke N., Nueangphuet P., Pornthummawat A., Niazi A.M., Izzati U.Z., Hirai T., Yamaguchi R.
Journal of Veterinary Medical Science 86 ( 1 ) 49 - 53 2024
Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Journal of Veterinary Medical Science
After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.
DOI： 10.1292/jvms.23-0152
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Aquaporin 3 is expressed in the basaloid cells of canine sebaceous glands
Sonoda H., Taniguchi Y., Fujimoto N., Higashijima Y., Matsuzaki T., Hirai T., Itoh T., Uchida K., Ikeda M.
Journal of Veterinary Medical Science 86 ( 10 ) 1063 - 1067 2024
Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Journal of Veterinary Medical Science
The role of aquaporin proteins (AQPs) in tumor biology has attracted attention over the past 20 years. However, the expression profiles of AQPs in canine sebaceous gland tumors remain obscure. This study was performed to clarify the expression of AQP1, 3, 5, the most studied AQPs in tumor biology, in sebaceous adenoma and sebaceous epithelioma. Among these AQPs, only AQP3 was expressed in normal tissue and both tumor types and located to only undifferentiated sebocytes (basaloid cells). A cellular proliferation marker, Ki-67, was detected only in the area including basaloid cells in both tumor types. These findings suggest that AQP3 is useful for clarifying the origin of sebaceous gland tumors, and that AQP3 may be related to sebaceous gland development.
DOI： 10.1292/jvms.24-0188
Presentations 【 display / non-display 】
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宮崎県串間市の御崎馬における仔馬の死因調査
齋藤江連、福家直幸、小林郁夫、平井卓哉
日本ウマ科学会 2024.11.26
Event date： 2024.11.25 - 2024.11.26
Presentation type：Oral presentation (general)
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豚呼吸器複合病における扁桃病変と鼻咽頭関連リンパ組織病変の比較検討
齋藤江連、垣屋美穂、坂本英午、福家直幸、平井卓哉
令和6年度獣医学術九州地区学会 日本産業動物学会（九州地区） 2024.11.1
Event date： 2024.11.1
Presentation type：Oral presentation (general)
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Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
令和5年度獣医学術九州地区学会 日本産業動物獣医学会 2023.9.10
Event date： 2023.9.10
Presentation type：Oral presentation (general)
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鼻咽頭関連リンパ組織における牛呼吸器病ウイルスの増殖と病態解析
中井睦、Asmaa Anwer Mahmoud Hegazy、Amaal Ezzet Hussein Ahmed、 近藤弘章、平井卓哉
令和5年度獣医学術九州地区学会 日本産業動物獣医学会
Event date： 2023.9.10
Presentation type：Oral presentation (general)
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遺伝的に異なる2つのPRRSV変異株に重複感染した豚の病理学的解析
山下鉄平、 中井睦、 高田蓮栞、 齋藤江連、 坂本英午、福家直幸、 平井卓哉
第166回日本獣医学術集会病理学分科会 2023.9.5
Event date： 2023.9.5 - 2023.9.8
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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九獣連会長賞
2024.11 令和6年度獣医学術九州地区学会産業動物獣医学会 豚呼吸器複合病における扁桃と鼻咽頭関連リンパ組織病変の比較検討
齋藤江連、垣屋美穂、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 第11回日本獣医病理学専門家協会学術集会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 第11回日本獣医病理学専門家協会学術集会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検査
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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九獣連会長賞
2023.9 令和5年度獣医学術九州地区学会産業動物獣医学会 Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
Award type：International academic award (Japan or overseas)
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奨励賞
2022.9 令和4年度獣医学術九州地区学会産業動物獣医学会 豚サーコウイルス2型および豚繁殖・呼吸障害症候群ウイルス感染豚の鼻咽頭関連リンパ組織における病理学的解析と病原性細菌の検出
山岸明日香、上久保正一、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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豚呼吸器病ウイルス感染豚の鼻咽頭粘膜関連リンパ組織における免疫抑制機序の解明
Grant number：25K09418 2025.04 - 2028.03
科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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PCV2およびPRRSウイルスの鼻咽腔関連リンパ組織における増殖と病態の解明
Grant number：22K06003 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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経済的被害をもたらす子豚の呼吸器病ウイルスによる鼻咽腔および肺の病態解析
Grant number：18K05974 2018.04 - 2021.03
科学研究費補助金 基盤研究(C)
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アジアから島伝いに北上するアルボウイルス感染症の動向予察
Grant number：15K07724 2015.04 - 2018.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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南九州の豚繁殖・呼吸障害症候群ウイルス株の遺伝子解析と持続感染様式の解明
Grant number：23580425 2011.04 - 2015.03
科学研究費補助金 基盤研究(C)
Available Technology 【 display / non-display 】
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Related fields where technical consultation is available：・各種動物の不審死・大量死の死因究明および病理学的評価
・腫瘍マーカーの有用性に関する病理学的評価Message：産業動物の疾患だけでなく、各種動物の病理学的評価にも対応できます。
