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Faculty of Medicine College Hospital Department of Gastroenterology |
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Assistant Professor |
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Related SDGs |
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IWAKIRI Hisayoshi
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Papers 【 display / non-display 】
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Reactivation of hepatitis C virus caused by steroid monotherapy for sudden deafness Reviewed
Kaneko H., Ozono Y., Iwakiri H., Hatada H., Uchiyama N., Komaki Y., Nakamura K., Hasuike S., Nagata K., Kawakami H.
Clinical Journal of Gastroenterology 17 ( 3 ) 505 - 510 2024.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical Journal of Gastroenterology
Hepatitis C virus (HCV) reactivation has been reported to be caused due to several anticancer drugs and immunosuppressive agents; however, HCV reactivation after steroid monotherapy has rarely been reported. Here, we report the case of a 65-year-old Japanese man with HCV infection who developed HCV reactivation after the administration of prednisolone (PSL) for 6 days for sudden deafness. In the patient history, the positivity for anti-HCV antibody was observed, but serum level of HCV RNA was not measured. Two months after PSL administration, the patient experienced an alanine aminotransferase (ALT) flare and the serum level of HCV RNA was observed to be 6.2 log IU/mL; then, the patient was admitted to our hospital for hepatitis treatment. Based on the clinical course and laboratory findings, the patient was diagnosed with HCV reactivation. Although the ALT levels decreased spontaneously during follow-up, they did not drop to normal range; subsequently, sofosbuvir and ledipasvir treatments were started. A sustained virological response 24 weeks after the end of treatment was achieved. This case study suggests that HCV reactivation with hepatitis flare can occur even after a steroid monotherapy, and doctors should pay attention to HCV reactivation when administering PSL for patients with HCV infection.
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Hasuike S., Ozono Y., Uchida K., Ogawa S., Tamura H., Uchiyama N., Hatada H., Komaki Y., Nakamura K., Iwakiri H., Sueta M., Nagata K., Toyoki Nishimura , Matsuyama M., Sawada H., Oguri T., Sato Y., Kawakami H.
Medicine United States 103 ( 22 ) e38383 2024.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Medicine United States
Background: Nonalcoholic steatohepatitis (NASH) is an important etiology of hepatocellular carcinoma (HCC), and there is no established therapy for this syndrome. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor (ROHHAD(NET)) is an extremely rare syndrome considered to be life-threatening, with death occurring around 10 years of age. We present the oldest known autopsy case of this syndrome that developed HCC. This case provided important information on not only improving the course of this syndrome, but also understanding the natural history and therapeutic modalities of NASH and HCC. Methods: The patient was diagnosed with ROHHAD(NET) syndrome in childhood, and liver cirrhosis due to NASH was diagnosed at age 17. HCC was detected at age 20, and embolization and irradiation were performed. At age 21, she died from accidental acute pancreatitis and subsequent liver failure and pulmonary hemorrhage. Results: Rapid onset of obesity, hypoventilation, and hypothalamic disturbance appeared in childhood and was diagnosed as this syndrome. At age 17, liver cirrhosis due to NASH was diagnosed by liver biopsy, and at age 20, HCC was diagnosed by imaging. Transarterial chemoembolization and irradiation were performed, and the HCC was well controlled for a year. Conclusion: At age 21, she died from accidental acute pancreatitis, subsequent liver failure and pulmonary hemorrhage. Autopsy revealed that the HCC was mostly necrotized. This case was valuable not only for other ROHHAD(NET) syndrome cases, but also in improving our understanding of the natural history of NASH and HCC.
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Tamura H., Ozono Y., Uchida K., Uchiyama N., Hatada H., Ogawa S., Iwakiri H., Kawakami H.
World Journal of Hepatology 16 ( 12 ) 1505 - 1514 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：World Journal of Hepatology
BACKGROUND The purpose of this case report is to describe a case of multiple intrahepatic artery aneurysms during treatment for IgG4-related sclerosing cholangitis (IgG4-SC) and to provide information for daily practice. CASE SUMMARY A 64-year-old Japanese woman was diagnosed with IgG4-SC five years prior and was receiving maintenance treatment with prednisolone 7.5–10 mg/day. She developed abdominal pain and a sudden onset of black stool and was admitted to our hospital. Abdominal contrast-enhanced computed tomography (CT) and ultra -sonography (US) revealed multiple intrahepatic artery aneurysms that developed during the treatment for IgG4-SC. Emergency transarterial embolization for multiple hepatic artery aneurysms was performed. Hepatic artery aneurysms disappeared on contrast-enhanced CT and US, the progression of anemia ceased, and the melena resolved. Thus, hemostasis was achieved. CONCLUSION Hepatic artery aneurysms should be considered poor prognostic complications of IgG4-SC.
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Nanashima A., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Nagata K., Hasuike S., Nakamura K., Iwakiri H., Kawakami H.
Translational Cancer Research 13 ( 5 ) 2332 - 2345 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Translational Cancer Research
Background: Progression of chronic liver fibrosis and related increased fibrotic markers are associated with functional liver reserves or patient prognosis as well as tumor factors in hepatocellular carcinoma (HCC) patients. The aim of this study was to newly clarify the relationship between fibrotic markers and HCC malignant behaviors or its long-term postoperative prognosis by the retrospective cohort study. Methods: We examined the relationship between tumor-related factors or six liver fibrosis-associated parameters, including platelet count, hyaluronic acid (HA), Mac-2 binding protein glycosylation isomer (M2BPGi), type IV collagen 7S (T4C7), aspartate aminotransferase-to-platelet ratio index (APRI), fibrosis-4 (Fib-4) index, and clinicopathological parameters, surgical records, and postoperative prognosis in 130 HCC who underwent curative hepatectomy. Results: Histological fibrosis stage 4 as cirrhosis was in 31%. The platelet count significantly decreased in stage 4 fibrosis and correlated with grade B liver damage (P<0.01). HA levels were significantly increased in multiple HCC, stage 4 fibrosis, and grade B liver damage (P<0.01). T4C7 was significantly increased in patients with post-hepatectomy tumor recurrence compared to those without (P<0.01). Additionally, M2BPGi was significantly higher in stage 4 fibrosis and liver damage grade B, and was significantly associated with poor prognosis (P<0.05). Fib-4 index was significantly higher in patients with liver damage B (P<0.05), and T4C7 alone did not correlate with other five fibrosis markers. Stage 4 fibrosis, higher T4C7, higher M2BPGi, and increased tumor size were significantly associated with shorter cancer-free, overall, and cancer-specific survivals. Higher T4C7, non-met Milan criteria, liver damage B, blood transfusion, and curability C were independently associated with cancer-specific survivals (P<0.05). Conclusions: Type IV collagen 7S (T4C7) may reflect not only impaired liver function but also HCC malignant behaviors and patient survivals.
DOI： 10.21037/tcr-24-94
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Hasuike Satoru, Nagata Kenji, Sasaki Haruka, Hirata Tomoya, Suzuki Sho, Komaki Yuri, Ozono Yoshinori, Nakamura Kenichi, Miike Tadashi, Iwakiri Hisayoshi, Sueta Mitsue, Yamamoto Shojiro, Maekawa Kazuya, Kawakami Hiroshi
Internal Medicine 62 ( 21 ) 3143 - 3149 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine
We reported a notable case of inflammatory hepatocellular adenoma that grew during pregnancy, consequently changing its appearance on magnetic resonance imaging remarkably. A 5-months-pregnant 35-year-old woman presented with a 37-mm liver nodule that had been diagnosed as focal nodular hyperplasia 3 years earlier. She had never used oral contraceptives. After 2 months, the nodule grew to 57 mm. The patient delivered a full-term infant without complications. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging performed after delivery revealed markedly different findings compared with the first images. A liver biopsy was performed, and the tumor was diagnosed as inflammatory hepatocellular adenoma.
MISC 【 display / non-display 】
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インターフェロンによる精神症状発現の予測 気質・性格特性の関与
直野慶子、安部 博史、武田 龍一郎、岩切 久芳、蓮池 悟、永田 賢治、下田 和哉、石田 康
精神医学 2015.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：医学書院
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B型肝硬変症への長期アデホビル投与でFanconi症候群を来した低リン血症性骨軟化症の1例 (共著)
中里 浩子, 山口 秀樹, 坂本 武郎, 岩切 久芳, 野田 智穂, 海老原 枝美, 清水 浩一郎, 迫田 秀之, 上野 浩晶, 米川 忠人, 下田 和哉, 帖佐 悦男, 中里 雅光
宮崎県医師会医学会誌 2014.9
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：宮崎県医師会
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Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with membranous nephropathy treated with immunosuppression ["jointly worked"]
54 ( 1 ) 74 - 80 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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CD3 and EBER double positive cells in bone marrow are a diagnostic aid for EBV-positive T-cell lymphoproliferative disorders of childhood:
Yamada Y ,他
Internal Cancer Conf 1 33 - 36 2012.3
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Springer Japan KK
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A Case of Henoch-Schonlein Purpura Associated with Acute Pancreatitis
Gastroenterological Endoscopy 53 ( 5 ) 1465 - 1471 2011.5
Language：Japanese Publishing type：Research paper, summary (national, other academic conference)
Presentations 【 display / non-display 】
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大腸癌化学療法により発症した類洞閉塞症候群の一例 Invited
岩切久芳
宮崎県肝疾患治療カンファレンス(MLC)特別講演会 (宮崎市) 宮崎県肝疾患治療カンファレンス(MLC)、MSD株式会社
Event date： 2017.3.15
Language：Japanese Presentation type：Oral presentation (general)
Venue：宮崎市
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潜在性肝性脳症を呈した肝内門脈静脈瘻の2例
田中友梨、中村憲一、高石優佳、中津留佳菜子、坂元一樹、山田優里、夏田朱一郎、土持舞衣、橋本神奈、山路卓巳、三池忠、安倍弘生、岩切久芳、末田光恵、山本章二朗、蓮池悟、永田賢治、下田和哉
第108回日本消化器病学会九州支部例会、第102回日本消化器内視鏡学会九州支部例会 (熊本市) 日本消化器病学会、日本消化器内視鏡学会
Event date： 2016.11.25 - 2016.11.26
Language：Japanese Presentation type：Oral presentation (general)
Venue：熊本市
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当科における孤立性胃・十二指腸静脈瘤急性出血例に対する内視鏡的ヒストアクリル注入法の治療成績
中村憲一、岩切久芳、蓮池悟、永田賢治、下田和哉
第108回日本消化器病学会九州支部例会、第102回日本消化器内視鏡学会九州支部例会 (熊本市) 日本消化器病学会、日本消化器内視鏡学会
Event date： 2016.11.25 - 2016.11.26
Language：Japanese Presentation type：Symposium, workshop panel (public)
Venue：熊本市
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C型肝炎の最新治療について Invited
岩切久芳
市民公開講座 知っておきたい肝臓病の新知識 (宮崎市) 日本肝臓学会宮崎支部
Event date： 2016.11.19
Language：Japanese Presentation type：Oral presentation (general)
Venue：宮崎市
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C型慢性肝疾患に対するソホスブビル+リバビリン併用療法の臨床的有用性の検討
駒田直人、永田賢治、高石優佳、山田優里、土持舞、中村憲一、岩切久芳、末田光恵、蓮池悟、大園芳範、黒木和男、楠元寿典、落合俊也、赤須郁太郎、加藤順也、弘野修一、重平正文、下田和哉
第20回日本肝臓学会大会 (神戸市) 日本肝臓学会
Event date： 2016.11.3 - 2016.11.4
Language：Japanese Presentation type：Poster presentation
Venue：神戸市