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Affiliation |
Faculty of Medicine College Hospital Department of Gastroenterology |
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Title |
Assistant Professor |
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External Link |
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IWAKIRI Hisayoshi
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Papers 【 display / non-display 】
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NAKAMURA K., KUSUMOTO K., OZONO Y., KUROKI K., MATSUURA Y., MUKUDA T., OCHIAI T., TSUCHIMOCHI M., IWAKIRI H., HASUIKE S., SHIMODA K., NAGATA K.
Anticancer Research 41 ( 8 ) 4127 - 4131 2021.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Background/Aim: Direct-acting antiviral (DAA) therapies for patients with hepatitis C virus (HCV) infection deliver higher cure rates and lower frequencies of adverse events than existing therapies, though DAA treatment costs $45,000-64,000 in Japan. The prognosis of patients who require new long-term care insurance (LTCI) certification is inferior to that of patients who do not. Here, we clarify the factors associated with new LTCI certification in elderly patients with HCV infection who undergo DAA therapy. Patients and Methods: We retrospectively surveyed 53 patients aged ≥70 years who were treated with DAAs, and evaluated the factors associated with new LTCI certification. Results: Of 53 patients, 10 required new LTCI certification. Age ≥85 years and a modified Japanese Cardiovascular Health Study index ≥2 were independently associated with new LTCI certification. Conclusion: In elderly HCV patients, poor frailty status strongly predicted new LTCI certification after DAA therapy.
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Ozono Y., Shide K., Kameda T., Kamiunten A., Tahira Y., Sekine M., Akizuki K., Nakamura K., Iwakiri H., Sueta M., Hidaka T., Kubuki Y., Yamamoto S., Hasuike S., Sawaguchi A., Nagata K., Shimoda K.
Leukemia 35 ( 2 ) 454 - 467 2021.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Leukemia
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by clonal myeloproliferation, progressive bone marrow (BM) fibrosis, splenomegaly, and anemia. BM fibrosis was previously thought to be a reactive phenomenon induced by mesenchymal stromal cells that are stimulated by the overproduction of cytokines such as transforming growth factor (TGF)-β1. However, the involvement of neoplastic fibrocytes in BM fibrosis was recently reported. In this study, we showed that the vast majority of collagen- and fibronectin-producing cells in the BM and spleens of Jak2V617F-induced myelofibrosis (MF) mice were fibrocytes derived from neoplastic hematopoietic cells. Neoplastic monocyte depletion eliminated collagen- and fibronectin-producing fibrocytes in BM and spleen, and ameliorated most characteristic MF features in Jak2V617F transgenic mice, including BM fibrosis, anemia, and splenomegaly, while had little effect on the elevated numbers of megakaryocytes and stem cells in BM, and leukothrombocytosis in peripheral blood. TGF-β1, which was produced by hematopoietic cells including fibrocytes, promoted the differentiation of neoplastic monocytes to fibrocytes, and elevated plasma TGF-β1 levels were normalized by monocyte depletion. Collectively, our data suggest that neoplastic fibrocytes are the major contributor to BM fibrosis in PMF, and TGF-β1 is required for their differentiation.
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Shide K., Kameda T., Kamiunten A., Ozono Y., Tahira Y., Yokomizo-Nakano T., Kubota S., Ono M., Ikeda K., Sekine M., Akizuki K., Nakamura K., Hidaka T., Kubuki Y., Iwakiri H., Hasuike S., Nagata K., Sashida G., Shimoda K.
Blood 136 ( 1 ) 106 - 118 2020.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Blood
Mutations in JAK2, myeloproliferative leukemia virus (MPL), or calreticulin (CALR) occur in hematopoietic stem cells (HSCs) and are detected in more than 80% of patients with myeloproliferative neoplasms (MPNs). They are thought to play a driver role in MPN pathogenesis via autosomal activation of the JAK-STAT signaling cascade. Mutant CALR binds to MPL, activates downstream MPL signaling cascades, and induces essential thrombocythemia in mice. However, embryonic lethality of Calr-deficient mice precludes determination of a role for CALR in hematopoiesis. To clarify the role of CALR in normal hematopoiesis and MPN pathogenesis, we generated hematopoietic cell-specific Calr-deficient mice. CALR deficiency had little effect on the leukocyte count, hemoglobin levels, or platelet count in peripheral blood. However, Calr-deficient mice showed some hematopoietic properties of MPN, including decreased erythropoiesis and increased myeloid progenitor cells in the bone marrow and extramedullary hematopoiesis in the spleen. Transplantation experiments revealed that Calr haploinsufficiency promoted the self-renewal capacity of HSCs. We generated CALRdel52 mutant transgenic mice with Calr haploinsufficiency as a model that mimics human MPN patients and found that Calr haploinsufficiency restored the self-renewal capacity of HSCs damaged by CALR mutations. Only recipient mice transplanted with Lineage−Sca1+c-kit+ cells harboring both CALR mutation and Calr haploinsufficiency developed MPN in competitive conditions, showing that CALR haploinsufficiency was necessary for the onset of CALR-mutated MPNs. Key Points: • Calr deficiency induces reduction of erythropoiesis in the bone marrow and extramedullary hematopoiesis in the spleen. • CALR haploinsufficiency restores the self-renewal capacity of HSCs damaged by CALR del52 and is required for the development of MPN.
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Differences in Hematological and Clinical Features Between Essential Thrombocythemia Cases With JAK2- or CALR-Mutations. Reviewed
Kubuki Y, Shide K, Kameda T, Yamaji T, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hashimoto K, Yamamoto S, Hasuike S, Hidaka T, Nagata K, Kitanaka A, Shimoda K
Annals of laboratory medicine. 37 ( 2 ) 159 - 161 2017.3
Language：English Publishing type：Research paper (scientific journal)
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TET2 mutation in diffuse large B-cell lymphoma. Reviewed
Yoko Kubuki, Takumi Yamaji, Tomonori Hidaka, Takuro Kameda, Kotaro Shide, Masaaki Sekine, Ayako Kamiunten, Keiichi Akizuki, Haruko Shimoda, Yuuki Tahira, Kenichi Nakamura, Hiroo Abe, Tadashi Miike, Hisayoshi Iwakiri, Yoshihiro Tahara, Mitsue Sueta, Shojiro Yamamoto, Satoru Hasuike, Kenji Nagata, Akira Kitanaka, Kazuya Shimoda
Journal of clinical and experimental hematopathology 56 ( 3 ) 145 - 149 2017
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3960/jslrt.56.145
MISC 【 display / non-display 】
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インターフェロンによる精神症状発現の予測 気質・性格特性の関与
直野慶子、安部 博史、武田 龍一郎、岩切 久芳、蓮池 悟、永田 賢治、下田 和哉、石田 康
精神医学 2015.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：医学書院
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B型肝硬変症への長期アデホビル投与でFanconi症候群を来した低リン血症性骨軟化症の1例 (共著)
中里 浩子, 山口 秀樹, 坂本 武郎, 岩切 久芳, 野田 智穂, 海老原 枝美, 清水 浩一郎, 迫田 秀之, 上野 浩晶, 米川 忠人, 下田 和哉, 帖佐 悦男, 中里 雅光
宮崎県医師会医学会誌 2014.9
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：宮崎県医師会
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Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with membranous nephropathy treated with immunosuppression ["jointly worked"]
54 ( 1 ) 74 - 80 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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CD3 and EBER double positive cells in bone marrow are a diagnostic aid for EBV-positive T-cell lymphoproliferative disorders of childhood:
Yamada Y ,他
Internal Cancer Conf 1 33 - 36 2012.3
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Springer Japan KK
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A Case of Henoch-Schonlein Purpura Associated with Acute Pancreatitis
Gastroenterological Endoscopy 53 ( 5 ) 1465 - 1471 2011.5
Language：Japanese Publishing type：Research paper, summary (national, other academic conference)
Presentations 【 display / non-display 】
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大腸癌化学療法により発症した類洞閉塞症候群の一例 Invited
岩切久芳
宮崎県肝疾患治療カンファレンス(MLC)特別講演会 (宮崎市) 宮崎県肝疾患治療カンファレンス(MLC)、MSD株式会社
Event date： 2017.3.15
Language：Japanese Presentation type：Oral presentation (general)
Venue：宮崎市
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潜在性肝性脳症を呈した肝内門脈静脈瘻の2例
田中友梨、中村憲一、高石優佳、中津留佳菜子、坂元一樹、山田優里、夏田朱一郎、土持舞衣、橋本神奈、山路卓巳、三池忠、安倍弘生、岩切久芳、末田光恵、山本章二朗、蓮池悟、永田賢治、下田和哉
第108回日本消化器病学会九州支部例会、第102回日本消化器内視鏡学会九州支部例会 (熊本市) 日本消化器病学会、日本消化器内視鏡学会
Event date： 2016.11.25 - 2016.11.26
Language：Japanese Presentation type：Oral presentation (general)
Venue：熊本市
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当科における孤立性胃・十二指腸静脈瘤急性出血例に対する内視鏡的ヒストアクリル注入法の治療成績
中村憲一、岩切久芳、蓮池悟、永田賢治、下田和哉
第108回日本消化器病学会九州支部例会、第102回日本消化器内視鏡学会九州支部例会 (熊本市) 日本消化器病学会、日本消化器内視鏡学会
Event date： 2016.11.25 - 2016.11.26
Language：Japanese Presentation type：Symposium, workshop panel (public)
Venue：熊本市
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C型肝炎の最新治療について Invited
岩切久芳
市民公開講座 知っておきたい肝臓病の新知識 (宮崎市) 日本肝臓学会宮崎支部
Event date： 2016.11.19
Language：Japanese Presentation type：Oral presentation (general)
Venue：宮崎市
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C型慢性肝疾患に対するソホスブビル+リバビリン併用療法の臨床的有用性の検討
駒田直人、永田賢治、高石優佳、山田優里、土持舞、中村憲一、岩切久芳、末田光恵、蓮池悟、大園芳範、黒木和男、楠元寿典、落合俊也、赤須郁太郎、加藤順也、弘野修一、重平正文、下田和哉
第20回日本肝臓学会大会 (神戸市) 日本肝臓学会
Event date： 2016.11.3 - 2016.11.4
Language：Japanese Presentation type：Poster presentation
Venue：神戸市