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Affiliation |
Faculty of Medicine School of Medicine Department of Internal Medicine, Hematology, Diabetes, and Endocrinology |
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Assistant Professor |
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External Link |
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MIIKE Tadashi
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Research Areas 【 display / non-display 】
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Life Science / Gastroenterology
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Life Science / Tumor diagnostics and therapeutics
External Career 【 display / non-display 】
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長野県厚生農業協同組合連合会 佐久総合病院 職員（医療系）
2008.3 - 2009.4
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串間市民病院 職員（医療系）
2004.6 - 2005.7
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和田病院 職員（医療系）
2003.6 - 2004.5
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都城市郡医師会病院 職員（医療系）
2002.8 - 2003.5
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国民健康保険中部病院 職員（医療系）
2001.6 - 2002.7
Papers 【 display / non-display 】
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Suzuki S., Kawakami H., Miike T.
Digestive Endoscopy 33 ( 3 ) e28 - e30 2021.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Digestive Endoscopy
DOI： 10.1111/den.13899
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Complete remission of colon cancer with ipilimumab monotherapy Reviewed
Suzuki S., Kawakami H., Miike T., Yamamoto S.
Internal Medicine 60 ( 6 ) 957 - 958 2021
Language：English Publishing type：Research paper (scientific journal) Publisher：Internal Medicine
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Miike T., Kawakami H., Kameda T., Yamamoto S., Tahara Y., Hidaka T., Kubuki Y., Yorita K., Akiyama Y., Arimura Y., Kubota Y., Kataoka H., Shimoda K.
BMC Gastroenterology 20 ( 1 ) 298 2020.9
Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Gastroenterology
Background: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastrointestinal (GI) tract, can be involved. However, there are few detailed reports on ATLL infiltration in the GI tract. We investigated the clinical characteristics of ATLL infiltration in the GI tract. Methods: This retrospective observational single-center study included 40 consecutive ATLL patients who underwent GI endoscopy. The patients' demographic and clinical characteristics and endoscopic findings were analyzed retrospectively. Patients with ATLL who were diagnosed by histological examination were divided into two groups based on GI tract infiltration. Results: Multivariate analysis revealed that the absence of skin lesions was significantly associated with GI infiltration (P < 0.05). Furthermore, the infiltration group tended to have similar macroscopic lesions in the upper and lower GI tracts, such as diffuse type, tumor-forming type, and giant-fold type. Conclusions: GI endoscopy may be considered for ATLL patients without skin lesions.
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Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests: A Case Report. Reviewed
Hiroshi Kawakami, Tadashi Miike, Shojiro Yamamoto, Hiroo Abe, Kazuya Shimoda, Shinya Ashizuka, Haruhiko Inatsu, Yoshimasa Kubota, Tesshin Ban, Kenji Yorita, Hiroaki Kataoka
Internal medicine 2020.3
Language：English Publishing type：Research paper (scientific journal)
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A novel endoscopic submucosal dissection training model using skinned chicken meat with gel Reviewed
Suzuki S., Kawakami H., Miike T., Ishikawa Y., Hirata T., Ichinari N., Komura A.
Endoscopy 2020
Language：English Publishing type：Research paper (scientific journal) Publisher：Endoscopy
DOI： 10.1055/a-1287-8567
Books 【 display / non-display 】
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膠原病と食道病変
三池忠、河上洋、山本章二朗、鈴木翔、平田智也、市成直樹（ Role： Contributor）
科学評論社 2022.7
Language：Japanese Book type：Scholarly book
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大腸疾患アトラスupdate 2020：消化管T 細胞リンパ腫
三池忠、山本章二朗、河上洋（ Role： Contributor）
東京医学社 2020.6
Language：Japanese Book type：Scholarly book
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Endoscopic Diagnosis of Esophageal Carcinoma for ESD Question 6: WhatIs the Histologigal Type?
Miike Tadashi（ Role： Contributor）
Springer 2020.1
Language：English Book type：Scholarly book
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Endoscopic Diagnosis of Superficial Gastric Cancer for ESD Question 18: Which Type of Gastric Carcinoma Do You Think This Is?
Miike Tadashi（ Role： Contributor）
Springer 2016.10
Language：English Book type：Scholarly book
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ESDのための食道癌術前診断 Question6. 組織型は?
三池忠（ Role： Contributor）
南江堂 2017.6
Total pages：110 Responsible for pages：115 Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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GASTROINTESTINAL LESIONS IN PATIENTS WITH ADULT T-CELL LEUKEMIA/LYMPHOMA Invited
MIIKE Tadashi, KAWAKAMI Hiroshi, YAMAMOTO Shojiro
GASTROENTEROLOGICAL ENDOSCOPY 63 ( 6 ) 1218 - 1231 2021
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Japan Gastroenterological Endoscopy Society
<p>Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). The clinical characteristics of ATLL are very heterogeneous, and ATLL is a systemic disease with an unfavorable prognosis. It is difficult to perform gastrointestinal (GI) endoscopy in all ATLL patients due to the poor condition of some ATLL patients. However, we observed that the characteristic endoscopic findings of the GI tract of ATLL patients consist of multiple mucosal protrusions and ulcers, GI wall thickening, and the presence of similar macroscopic findings in various GI organs such as the stomach and colon. The endoscopist should organize current classification methods and endoscopic findings to assist in the diagnosis of ATLL, because patients with ATLL have heterogeneous GI lesions as part of the systemic disease of ATLL. We searched PubMed for articles published between 1965 and 2020 using the terms "adult T-cell leukemia/lymphoma" and "gastrointestinal tract". We also review endoscopic and characteristic findings of ATLL infiltration in the GI tract.</p>
DOI： 10.11280/gee.63.1218
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内視鏡的消化管腫瘍摘出法 Invited
三池忠、小山恒男
Pharma Medica 2009.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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メインデバイスとしてのHookKnifeJの効果的な手技とコツ
三池 忠, 河上 洋, 小山恒男
日本消化器内視鏡学会雑誌 2022.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【食道良性疾患の診断・治療】 膠原病と食道病変
三池 忠, 河上 洋, 山本 章二朗, 鈴木 翔, 平田 智也, 市成 直樹
消化器・肝臓内科 2022.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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成人T細胞白血病/リンパ腫に合併する消化管病変
三池 忠, 河上 洋, 山本 章二朗
日本消化器内視鏡学会雑誌 2021.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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Endoscopic evaluation of immunogloblin G4-related gastrointestinal disease
Tadashi MIIKE, Shojiro YAMAMOTO, Hiroshi KAWAKAMI
Japan Digestive Disease Week (JDDW) 2021 2021.11.4
Event date： 2021.11.4 - 2021.11.7
Language：English Presentation type：Symposium, workshop panel (public)
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Endoscopic evaluation of esophageal lesions in connective tissue disease
Tadashi MIIKE, Shojiro YAMAMOTO, Hiroshi KAWAKAMI
Japan Digestive Disease Week (JDDW) 2020
Event date： 2020.11.5 - 2020.11.7
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Endoscopic evaluation of lower gastrointestinal lesions in connective tissue disease
Tadashi MIIKE, Shojiro YAMAMOTO, Hiroshi KAWAKAMI
Japan Digestive Disease Week (JDDW) 2019 (神戸)
Event date： 2019.11.21 - 2019.11.24
Language：Japanese Presentation type：Symposium, workshop panel (public)
Venue：神戸
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CLINICAL MANIFESTATIONS OF T-CELL LEUKEMIA/LYMPHOMA INFILTRATION OF UPPER GASTROINTESTINAL TRACT LESIONS International conference
Tadashi Miike, Shojiro Yamamoto, Naoki Ichinari, Emi Yonezawa, Kazuki Sakamoto, Tomoya Hirata, Takaho Noda, Sho Suzuki, Shuichiro Natsuda, Hiroo Abe, Yoshihiro Tahara, Kazuya Shimoda, Hiroshi Kawakami
Digestive Disease Week (DDW) 2018 (Washington, DC)
Event date： 2018.6.2 - 2018.6.5
Language：English Presentation type：Poster presentation
Venue：Washington, DC
Introduction: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by the human T-cell lymphotropic virus type I. ATLL has a various clinical manifestations, because latent ATLL develops over years. ATLL is a systemic disease with an unfavorable prognosis, and ATLL with upper gastrointestinal tract lesions has been described recently years. Few detailed studies, however, have investigated ATLL infiltration into upper gastrointestinal tract lesions. Aims & Methods: This study evaluated the clinical manifestations of ATLL with upper gastrointestinal tract lesions and the infiltration of ATLL into these lesions. Clinical data were collected retrospectively from the medical records of 40 patients diagnosed with ATLL and upper gastrointestinal tract lesions between January 2009 and December 2015 at the University of Miyazaki in Japan. Patients were classified into the four clinical subtypes of ATLL defined by the Japan Clinical Oncology Group-Lymphoma Study Group: acute, lymphoma, chronic, and smoldering. The 40 patients were examined by upper gastrointestinal endoscopy. Biopsy specimens of the gastrointestinal tracts were examined histologically. Patients with and without ATLL infiltration of the upper gastrointestinal tract were compared. The study conformed to the Declaration of Helsinki and was approved by the ethics committee and institutional review board of the University of Miyazaki. Results: Of the 40 patients, 11 showed ATLL infiltration of the upper gastrointestinal tract, whereas 29 did not. There were no differences in age, sex, swelling of superficial lymph nodes, and the presence of hepatosplenomegaly, digestive symptoms, and opportunistic infections between patients with and without ATLL infiltration of the upper gastrointestinal tract. Univariate analysis showed that clinical subtypes and absence of skin lesions were significantly associated with ATLL infiltration into the upper gastrointestinal tract (P < 0.05 each). Multivariate logistic regression analysis showed that the absence of skin lesions tended to be associated with ATLL infiltration of the upper gastrointestinal tract (P = 0.058). Magnified endoscopic images with narrow band imaging (NBI) of 3 patients showed that all had obscure glandular structures and bifurcated blood vessels, presumably caused by the infiltration of ATLL cells. Interestingly, abnormal findings on NBI were specific to lymphoproliferative disease. Conclusion: Patients with ATLL should be examined by gastrointestinal endoscopy to assess ATLL infiltration into the upper gastrointestinal tract and by magnifying endoscopy with NBI to evaluate the occurrence of lymphoproliferative disease. The abnormal finding on NBI and the absence of skin lesions may be helpful in diagnosing ATLL infiltration into the upper gastrointestinal tract.
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RISK FACTORS FOR ASPIRATION PNEUMONIA AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR GASTRIC NEOPLASIA International conference
Miike Tadashi, Yamamoto Shojiro, Miyata Yoshifumi, Hirata Tomoya, Noda Yuko, Noda Takaho, Suzuki Sho, Takeda Sachiko, Sakaguchi Mai, Natsuda Shuichiro, Maemura Kosuke, Hashimoto Kanna, Yamaji Takumi, Abe Hiroo, Tahara Yoshihiro, Arimura Yasuji, Shimoda Kazuya
Digestive Disease Week (DDW) 2016 (San Diego)
Event date： 2016.5.21 - 2016.5.24
Language：English Presentation type：Poster presentation
Venue：San Diego
Introduction: The incidence rates of gastric cancer are high in Japan. Gastric cancer is mostly screened using endoscopy. Endoscopic submucosal dissection (ESD) is commonly performed for early gastric cancers that are confined to the mucosa and do not show lymph node metastasis. ESD, however, is a time-consuming procedure that requires a high level of endoscopic skill to resect in an en bloc fashion and sometimes causes serious adverse events. Therefore, endoscopists performing ESD should have sufficient knowledge of the complications associated with the procedure. One of the important complications is aspiration pneumonia (AP). AP can prolong hospital stay, be costly, and increase in-hospital mortality. Reports on AP after ESD are rare; the risk factors are unidentified, and the clinical course is unclear. Aims & Methods: We aimed to analyze the risk factors for AP after ESD and develop a treatment plan. We retrospectively examined 114 patients who underwent ESD for gastric neoplasia between April 2011 and January 2015 at the University of Miyazaki, Japan. We evaluated AP according to the JRS guideline for the management of hospital-acquired pneumonia in adults. Diagnosis of AP was confirmed based on the following indications: abnormal swallowing function or dysphagia, infiltrative shadows on chest radiography, and elevated peripheral white blood cell count (≥10,000/μL). We intermittently administered an intravenous bolus of midazolam /pentazocine if the patient started moving or showing signs of discomfort. Under these settings, we aimed at conscious sedation. Results: Sixteen patients were diagnosed with AP and 98 without AP. There was no difference between the groups in age and sex, specimen size, macroscopic type, histological type and depth, procedure time, the presence of ulcer scar in the tumor, and perforation. We evaluated the risk factors for AP by comparing the
patients with AP to those without AP. Pulmonary disease was associated with AP in the univariate analysis (P < 0.05). To identify the association of each analyzed factor with AP, we performed a multivariate analysis. Of interest, the location of tumor, pulmonary disease, and pentazocine administration were associated with AP in the multiple logistic regression analysis (P < 0.05). Conclusion: The location of tumor (middle or lower), pulmonary disease, and pentazocine administration might be independent predictors of AP after ESD for gastric neoplasia.