MARUYAMA Keisuke

写真a

Affiliation

Faculty of Agriculture Department of Veterinary Science

Title

Associate Professor

External Link

Research Areas 【 display / non-display

  • Life Science / Metabolism and endocrinology  / 比較内分泌

 

Papers 【 display / non-display

  • Distribution of neuromedin U (NMU)-like immunoreactivity in the goldfish brain, and effect of intracerebroventricular administration of NMU on emotional behavior in goldfish. Reviewed International journal

    Kouhei Matsuda, Keisuke Watanabe, Yoshiki Miyagawa, Keisuke Maruyama, Norifumi Konno, Tomoya Nakamachi

    Peptides   156   170846 - 170846   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Neuromedin U (NMU) is a multifunctional neuropeptide implicated in regulation of smooth muscle contraction in the circulatory and digestive systems, energy homeostasis and the stress response, but especially food intake in vertebrates. Recent studies have indicated the possible involvement of NMU in the regulation of psychomotor activity in rodents. We have identified four cDNAs encoding three putative NMU variants (NMU-21, -25 and -38) from the goldfish brain and intestine. Recently, we have also purified these NMUs and the truncated C-terminal form NMU-9 from these tissues, and demonstrated their anorexigenic action in goldfish. However, there is no information on the brain localization of NMU-like immunoreactivity and the psychophysiological roles of NMU in fish. Here, we investigated the brain distribution of NMU-like immunoreactivity and found that it was localized throughout the fore- and mid-brains. We subsequently examined the effect of intracerebroventricular (ICV) administration of NMU-21, which is abundant only in the brain on psychomotor activity in goldfish. As goldfish prefer the lower to the upper area of a tank, we developed an upper/lower area preference test in a tank for evaluating the psychomotor activity of goldfish using a personal tablet device without an automatic behavior-tracking device. ICV administration of NMU-21 at 10 pmol g-1 body weight (BW) prolonged the time spent in the upper area of the tank, and this action mimicked that of ICV administration of the central-type benzodiazepine receptor (CBR) agonist tofisopam at 100 pmol g-1 BW. These results suggest that NMU-21 potently induces anxiolytic-like action in the goldfish brain.

    DOI: 10.1016/j.peptides.2022.170846

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  • Comparison of physiological functions between neuromedin U-related peptide and neuromedin S-related peptide in the rat central nervous system Reviewed

    Tanaka Y., Taguchi S., Maruyama K., Mori K., Miyazato M., Kangawa K., Murakami N., Nakahara K.

    Biochemical and Biophysical Research Communications   534   653 - 658   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Biochemical and Biophysical Research Communications  

    © 2020 Elsevier Inc. Two novel peptides, neuromedin U precursor-related peptide (NURP) and neuromedin S precursor-related peptide (NSRP), are produced from neuromedin U (NMU) and neuromedin S (NMS) precursors, respectively, as these precursors have multiple consensus sequences for proteolytic processing. Our group has shown previously that one of these two novel peptides, NURP, stimulates body temperature and locomotor activity, but not food intake. However, the physiological function of the other peptide, NSRP, has remained unclear. Therefore, the aim of this study was to characterize differences in the regions of the rat brain targeted by the NMU/NMS peptide family, including NURP and NSRP, and their physiological functions. First, we explored the regions of c-Fos expression after intracerebroventricular (i.c.v.) injection of NURP and NSRP and found that these were fewer than after i.c.v. injection of NMU and NMS in the hypothalamus, possibly because NURP and NSRP cannot activate NMU/NMS receptors. In the ventral subiculum, which is one region of the hippocampus, c-Fos expression was evident only after i.c.v. injection of NURP. We also examined the effects of NSRP on food intake, body temperature and locomotor activity. Like NURP, NSRP increased both body temperature and locomotor activity, but not food intake, indicating that NSRP is also a functional peptide. However, these effects of NSRP were distinctly weaker than those of NURP. These findings suggest differences in the affinity of NURP and/or NSRP for specific receptors, or in their respective biological activities.

    DOI: 10.1016/j.bbrc.2020.11.025

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  • Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus. Reviewed

    Nakahara K, Maruyama K, Ensho T, Mori K, Miyazato M, Kangawa K, Uemura R, Sakoda H, Nakazato M, Murakami N

    Biochemical and biophysical research communications   521 ( 2 )   521 - 526   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.10.156

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  • Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents. Reviewed

    Islam MN, Mita Y, Maruyama K, Tanida R, Zhang W, Sakoda H, Nakazato M

    The Journal of endocrinology   244 ( 1 )   13 - 23   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1530/JOE-19-0102

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  • Purification and identification of native forms of goldfish neuromedin U from brain and gut. Reviewed

    Maruyama K, Kaiya H, Miyazato M, Murakami N, Nakahara K, Matsuda K

    Biochemical and biophysical research communications   517 ( 3 )   433 - 438   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.07.108

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Books 【 display / non-display

  • 肥満外科モデル動物の作製と意義 最新肥満症学

    宮澤崇、丸山圭介、山下貴裕( Role: Joint author)

    日本臨牀社  2014.5 

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    Language:Japanese

Presentations 【 display / non-display

  • ニューロメジンS前駆体中の新規ペプチド(NSRP)の生理機能の探索

    田口 史門、延生 卓也、森 健二、宮里 幹也、寒川 賢治、丸山 圭介、村上 昇、中原 桂子

    第162回日本獣医学会学術集会  (茨城県つくば市 つくば国際会議場)  日本獣医学会

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    Event date: 2019.9.10 - 2019.9.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:茨城県つくば市 つくば国際会議場  

Grant-in-Aid for Scientific Research 【 display / non-display

  • 摂食・エネルギー代謝を制御する新規生理活性ペプチドの発見と応用

    Grant number:21K05958  2021.04 - 2024.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 新規ペプチド"NURP"と"NSRP"のトランスレーショナルリサーチ

    Grant number: 20H03153  2020.04 - 2024.03

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  • NMUとの機能的連関に着目した、新規ペプチドホルモンNURPの生理機能の解明

    Grant number:19K09009  2019 - 2022.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 肥満減量手術モデルラットの消化管から分泌される機能性タンパク質の生理機能の解明

    Grant number: 16K19553  2016.04 - 2019.03

    科学研究費補助金  若手研究(B)

  • 新たに見出されたNMU/NMS関連ホルモンの視床下部における生理機能の探索

    Grant number:25850221  2013.04 - 2016.03

    科学研究費補助金  若手研究(B)

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