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Faculty of Medicine Center for the Support and Development of Medical Professionals Department of Clinical Education |
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ABE Hiroo
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Papers 【 display / non-display 】
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TET2 mutation in diffuse large B-cell lymphoma.
Kubuki Y, Yamaji T, Hidaka T, Kameda T, Shide K, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Kitanaka A, Shimoda K
Journal of clinical and experimental hematopathology : JCEH 56 ( 3 ) 145 - 149 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本リンパ網内系学会
<i>Ten-eleven translocation-2 (TET2)</i> mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. <i>TET2</i> mutation presents across disease entities and was reported in lymphoid malignancies. We investigated <i>TET2</i> mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). <i>TET2</i> mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.
DOI： 10.3960/jslrt.56.145
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Miike T., Yamamoto S., Miyata Y., Hirata T., Noda Y., Noda T., Suzuki S., Takeda S., Natsuda S., Sakaguchi M., Maemura K., Hashimoto K., Yamaji T., Abe H., Iwakiri H., Tahara Y., Hasuike S., Nagata K., Kitanaka A., Shimoda K.
Gastroenterology Research and Practice 2016 6527653 2016
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Gastroenterology Research and Practice
© 2016 Tadashi Miike et al. Background and Aim. It is difficult to master the skill of discriminating gastric adenoma from early gastric cancer by conventional endoscopy or magnifying endoscopy combined with narrow-band imaging, because the colors and morphologies of these neoplasms are occasionally similar. We focused on the surrounding gastric mucosa findings in order to determine how to discriminate between early gastric cancer and gastric adenoma by analyzing the characteristics of the gastric background mucosa. Methods. We retrospectively examined 146 patients who underwent endoscopic submucosal dissection for gastric neoplasm between October 2009 and January 2015. The boundary of atrophic gastritis was classified endoscopically according to the Kimura-Takemoto classification system. Of 146 lesions, 63 early gastric cancers and 21 gastric adenomas were ultimately evaluated and assessed. Results. Almost all gastric adenomas were accompanied by open-type gastritis, whereas 47 and 16 early gastric cancers were accompanied by open-type and closed-type gastritis, respectively (p = 0.037). Conclusions. The evaluation of the boundary of atrophic gastritis associated with gastric neoplasms appears to be useful for discrimination between early gastric cancer and gastric adenoma. When gastric neoplasm is present in the context of surrounding localized gastric atrophy, gastric cancer is probable but not certain.
DOI： 10.1155/2016/6527653
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Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator （共著） Reviewed
Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada ,Abe H, MiikeT,Hisayoshi Iwakiri H,Tahara Y, Sueta M, Yamamoto S,Hasuike S,Nagata K, Iwama A,Kitana
blood 2015.1
Language：English Publishing type：Research paper (scientific journal)
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TET2 Mutation in Adult T-Cell Leukemia/Lymphoma
Shimoda K., Shide K., Kameda T., Hidaka T., Kubuki Y., Kamiunten A., Sekine M., Akizuki K., Shimoda H., Yamaji T., Nakamura K., Abe H., Miike T., Iwakiri H., Tahara Y., Sueta M., Yamamoto S., Hasuike S., Nagata K., Kitanaka A.
Journal of clinical and experimental hematopathology : JCEH 55 ( 3 ) 145 - 149 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of clinical and experimental hematopathology : JCEH
Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7～12% of diffuse large B-cell lymphomas and 18～83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated TET2 mutations in 22 adult T-cell leukemia/lymphoma (ATLL) patients and identified a missense mutation in 3 cases (14%). TET2 mutation occurred in a number of ATLL patients and was likely involved in their leukemogenesis.
DOI： 10.3960/jslrt.55.145
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Gastrointestinal bleeding in acutemyeloid leukemia patients receiving intensive induction chemotherapy (共著) Reviewed
Yamamoto S, Miike T, Kubuki Y, Yamaji T, Nakamura K, Abe H, Hashimoto K, Natsuda S, H-Sakaguchi M, Tahara Y, Harada T, Iwakiri H, Hasuike S, Nagata K, Kitanaka A, Matsumoto T, Shimoda K
JSM Gastroenterology and Hepatology 2014.3
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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実践! IBD 診療
山本章二朗， 三池忠，安倍弘生，下田和哉（ Role： Joint author）
医学出版 2014.5
Language：Japanese Book type：Scholarly book
Presentations 【 display / non-display 】
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潰瘍性大腸炎の経過中に原発性胆汁性肝硬変を合併した1例
後田優香、山本章二朗，山田優里，鈴木翔，橋本神奈，三池忠，安倍弘生，岩切久芳，田原良博，下田和哉：
第308回日本内科学会九州地方会 (福岡市) 日本内科学会九州支部
Event date： 2015.1.10
Language：Japanese Presentation type：Oral presentation (general)
Venue：福岡市
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Landscape of Genetic Alterations in Adult T-Cell Leukemia/Lymphoma International conference
keisuke Kataoka，Yasunobu Nagata,Akira Kitanaka,Yasushi Totoki,Jun-ichirou Yasunaga, Shinichi Kotani, Aiko Sato-Otsubo, Masaaki Sanada, Yuichi Shiraishi, Teppei Shimamura, Kenichi Chiba, Hiriko Tanaka, Hiromichi Suzuki, Yusuke Sato, Yusuke Shiozawa, Tetsui
56th ASH Annual Meeting and Exposition (San Fransisco) San Fransisco
Event date： 2014.12.7 - 2014.12.10
Language：English Presentation type：Oral presentation (general)
Venue：San Fransisco
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食道入口部に発生した巨大脂肪腫の1例
宮後冴、鈴木翔、加来英典、野田貴穂、野田裕子、上原なつみ、竹田幸子、坂口舞、夏田朱一郎、橋本神奈、山路卓巳、安倍弘生、三池忠、田原良博、山本章二朗、井出慎介、東野哲也、盛口清香、丸塚浩助、下田和哉
第98回日本消化器内視鏡学会九州支部例会 (大分市) 日本消化器内視鏡学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大分市
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抗血栓薬服用者における胃ESD
鈴木翔、三池忠、野田貴穂、野田裕子、上原なつみ、竹田幸子、夏田朱一郎、坂口舞、前村幸輔、橋本神奈、山路卓巳、安倍弘生、田原良博、山本章二朗、下田和哉
第98回日本消化器内視鏡学会九州支部例会 (大阪市) 日本消化器内視鏡学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大阪市
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潰瘍性大腸炎術後13年目に発症し、インフリキシマブが奏功した重度の回腸嚢炎の1例
佐々木良子、山本章二朗、安倍弘生、野田裕子、野田貴穂、鈴木翔、上原なつみ、竹田幸子、坂口舞、夏田朱一郎、橋本神奈、前村幸輔、山路卓巳、三池忠、岩切久芳、田原良博、蓮池悟、永田賢治、下田和哉
第104回日本消化器病学会九州支部例会 (大分市) 日本消化器病学会九州支部
Event date： 2014.12.5 - 2014.12.6
Language：Japanese Presentation type：Oral presentation (general)
Venue：大分市