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Loss of Tyrosine Kinase 2 Does Not Affect the Severity of <i>Jak2</i>V617F-induced Murine Myeloproliferative Neoplasm. 査読あり
Yamaji T, Shide K, Kameda T, Sekine M, Kamiunten A, Hidaka T, Kubuki Y, Shimoda H, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Shimoda K
Anticancer research 37 ( 7 ) 3841 - 3847 2017年7月
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Differences in Hematological and Clinical Features Between Essential Thrombocythemia Cases With JAK2- or CALR-Mutations. 査読あり
Kubuki Y, Shide K, Kameda T, Yamaji T, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hashimoto K, Yamamoto S, Hasuike S, Hidaka T, Nagata K, Kitanaka A, Shimoda K
Annals of laboratory medicine 37 ( 2 ) 159 - 161 2017年3月
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TET2 mutation in diffuse large B-cell lymphoma. 査読あり
Kubuki Y, Yamaji T, Hidaka T, Kameda T, Shide K, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Kitanaka A, Shimoda K
Journal of clinical and experimental hematopathology 56 ( 3 ) 145 - 149 2017年
記述言語:英語 掲載種別:研究論文(学術雑誌) 出版者・発行元:日本リンパ網内系学会
<i>Ten-eleven translocation-2 (TET2)</i> mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. <i>TET2</i> mutation presents across disease entities and was reported in lymphoid malignancies. We investigated <i>TET2</i> mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). <i>TET2</i> mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.
DOI: 10.3960/jslrt.56.145
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Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.
Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K
Blood 125 ( 2 ) 304 - 15 2015年1月