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医学部 附属病院 精神科 |
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講師 |
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Roles of 5-HT<inf>3</inf> and 5-HT<inf>7</inf> receptors in acute pruriceptive processing in mice 査読あり
Miyahara Y., Funahashi H., Haruta-Tsukamoto A., Kogoh Y., Kanemaru-Kawazoe A., Nishimori T., Ishida Y.
European Journal of Pharmacology 911 174513 2021年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Journal of Pharmacology
The roles of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing have been demonstrated using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the involvement of 5-HT in acute pruriceptive processing has not yet been elucidated in detail. Scratching events induced by chloroquine (CQ) were attenuated by the administration of milnacipran or mirtazapine, and these effects were reversed by a treatment with ondansetron, a 5-HT3 antagonist, or SB26970, a 5-HT7 antagonist. CQ-induced scratching events were also ameliorated by the intrathecal administration of 5-HT, SR572227A and RS56812 (5-HT3 agonists), and LP211 and LP44 (5-HT7 agonists), indicating the modulation of CQ-induced scratching events by 5-HT and noradrenaline. By contrast, histamine-induced scratching events were not markedly affected by the administration of 5-HT and 5-HT7 agonists, whereas 5-HT3 agonists exerted attenuating effects. Similarly, they were not clearly reversed by the administration of the 5-HT7 antagonist, unlike a 5-HT3 antagonist. Therefore, 5-HT is involved in the attenuating effects of milnacipran and mirtazapine on CQ- and histamine-induced scratching events, and 5-HT3 and 5-HT7 receptors play different roles in pruriceptive processing induced by histamine or CQ.
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Differential onset time of mirtazapine on pruritus and depression in a patient receiving hemodialysis. 査読あり
Miyahara Y, Haruta-Tsukamoto A, Funahashi H, Matsuo H, Kanemaru-Kawazoe A, Nishimori T, Ishida Y
SAGE open medical case reports 9 2050313X20988408 2021年
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Serotonin and noradrenaline modulate chronic itch processing in mice 査読あり
Miyahara Y., Funahashi H., Naono-Nakayama R., Haruta-Tsukamoto A., Muroi C., Kogoh Y., Nishimori T., Ishida Y.
European Journal of Pharmacology 883 173319 2020年9月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Journal of Pharmacology
© 2020 Elsevier B.V. The roles of serotonin and noradrenaline in the modulation of chronic pruriceptive processing currently remain unclear. To clarify the contribution of serotonin and noradrenaline to chronic itch, the effects of the administration of antidepressants or noradrenaline reuptake inhibitors were evaluated in the present study. A pretreatment with milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuated the induction of spontaneous scratching behavior in mice with chronic itch. The administration of a serotonin reuptake inhibitor, such as fluvoxamine and paroxetine, but not escitalopram, or a noradrenaline reuptake inhibitor, such as atomoxetine and nisoxetine, ameliorated the induction of spontaneous scratching behavior in mice with chronic itch. Furthermore, this attenuation was reversed by the administration of yohimbine, a selective α2-adrenoceptor antagonist, or methysergide, a non-selective serotonin receptor antagonist. These results suggest that elevated serotonin and noradrenaline levels are involved in the attenuation of scratching behavior induced by chronic itch, and serotonin receptors and an α2-adrenoceptor play a crucial role in chronic pruriceptive processing.
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Pharmacological characteristics of hemokinin-1-derived peptides in rat pruriceptive processing. 査読あり
Funahashi H, Miyahara Y, Haruta-Tsukamoto A, Matsuo T, Naono-Nakayama R, Ebihara K, Nishimori T, Ishida Y
Peptides 124 170232 2020年2月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Peptides
Hemokinin-1 (HK-1) is a member of mammalian tachykinin peptide family, and [Leu11]-HK-1 has an antagonistic effect on HK-1. The attenuation of pruritogen-induced scratching behavior by pretreatment with [Leu11]-HK-1 indicates the involvement of HK-1 in pruriceptive processing. However, it remains unclear whether the intrathecal or intranasal administration of HK-1-derived peptides, such as [D-Trp7,9]-[Leu11]-HK-1 or [D-Trp7]-[Leu11]-HK-1, elicits the effects different from [Leu11]-HK-1. The induction of scratching by intrathecal administration of HK-1 was attenuated 30 min, 4 h and 24 h after pretreatment with [Leu11]-HK-1, [D-Trp7,9]-[Leu11]-HK-1 and [D-Trp7]-[Leu11]-HK-1 or [D-Trp9]-[Leu11]-HK-1, respectively. Similarly, the scratching induced by subcutaneous injection of pruritogens as chloroquine and histamine was ameliorated 30 min and 24 h after pretreatment with [Leu11]-HK-1 and these three HK-1-derived peptides, respectively. Moreover, the effective minimum concentrations of intrathecal administrations of [D-Trp9]-[Leu11]-HK-1 on scratching induced by chloroquine and histamine were 10−6 M, while the effective minimum concentrations of intranasal administration of this peptide on scratching induced by chloroquine and histamine were 10-5 M and 10-4 M, respectively. Thus, the present results indicate that the intrathecal administration of HK-1-derived peptides with D-Trp extends its effective time on scratching induced by intrathecal administration of HK-1 and pruritogens such as chloroquine and histamine. Similarly, the induction of scratching by pruritogens was attenuated by intranasal administration of HK-1-derived peptide, although the effective minimum concentration of this peptide was slightly lower than that of intrathecal administration, indicating that intranasal administration is an effective tool for carrying peptides into the brain.
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Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice 査読あり
Haruta-Tsukamoto A., Miyahara Y., Funahashi H., Nishimori T., Ishida Y.
Biochemical and Biophysical Research Communications 533 ( 4 ) 1102 - 1108 2020年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Biochemical and Biophysical Research Communications
© 2020 Elsevier Inc. An itch is defined as an unpleasant sensation that evokes a desire to scratch. Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system and has a crucial role in pruriceptive processing in the spinal dorsal horn. It is well known that glutamate exerts its effects by binding to various glutamate receptors including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, and that AMPA/kainate receptors play a crucial role in pruriceptive processing; however, the precise role of AMPA receptors remains uncertain. Perampanel, an antiepileptic drug, is an antagonist of AMPA receptors. Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine. In addition, the induction of scratching in mice painted with diphenylcyclopropenone and NC/Nga mice treated with Biostir AD, animal models of contact dermatitis and atopic dermatitis, respectively, was dose-dependently alleviated by administration of perampanel. These findings indicate that AMPA receptors play a crucial role in pruriceptive processing in mice with acute or chronic pruritus.
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痒み動物モデルにおける抗うつ薬の効果 国際会議
宮原裕他
国際疼痛学会 (パシフィコ横浜) 野口光一
開催年月日： 2016年9月26日 - 2016年9月30日
記述言語：英語 会議種別：ポスター発表
開催地：パシフィコ横浜
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脊髄における痒み伝達へのタキキニン受容体の関与 国際会議
直野留美他
国際疼痛学会 (パシフィコ横浜) 野口光一
開催年月日： 2016年9月26日 - 2016年9月30日
記述言語：英語 会議種別：口頭発表（一般）
開催地：パシフィコ横浜
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ラットの三叉神経節および三叉神経感覚核におけるサブスタンス P および ヘモキニン ‒1の分布
井川加織他
日本脳科学会 (ANAホリデイインリゾート宮崎) 高宮考悟
開催年月日： 2015年11月12日 - 2015年11月13日
記述言語：日本語 会議種別：口頭発表（一般）
開催地：ANAホリデイインリゾート宮崎
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ラットにおけるHK-1の抗掻効果 国際会議
船橋英樹他
第8回世界かゆみ学会 (奈良春日野国際フォーラム) 室田浩之
開催年月日： 2015年9月27日 - 2015年9月29日
記述言語：英語 会議種別：ポスター発表
開催地：奈良春日野国際フォーラム
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宮崎大学医学部附属病院精神科外来における統合失調症圏患者の抗コリン薬処方状況に関する後方視的研究.
宮原裕他
九州精神神経学会 (福岡国際会議場) 神庭重信
開催年月日： 2014年12月4日 - 2014年12月5日
記述言語：日本語 会議種別：口頭発表（一般）
開催地：福岡国際会議場