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Faculty of Medicine College Hospital Anesthesiology |
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Assistant Professor |
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HIDAKA Kotaro
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Papers 【 display / non-display 】
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Maruta T., Kouroki S., Kurogi M., Hidaka K., Koshida T., Miura A., Nakagawa H., Yanagita T., Takeya R., Tsuneyoshi I.
Journal of Neuroscience Research 102 ( 10 ) e25386 2024.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Neuroscience Research
Voltage-gated sodium channels, including NaV1.7, NaV1.8, and NaV1.9, play important roles in pain transmission and chronic pain development. However, the specific mechanisms of their action remain unclear, highlighting the need for in vivo stimulation studies of these channels. Optogenetics, a novel technique for targeting the activation or inhibition of specific neural circuits using light, offers a promising solution. In our previous study, we used optogenetics to selectively excite NaV1.7-expressing neurons in the dorsal root ganglion of mice to induce nocifensive behavior. Here, we further characterize the impact of nocifensive behavior by activation of NaV1.7, NaV1.8, or NaV1.9-expressing neurons. Using CRISPR/Cas9-mediated homologous recombination, NaV1.7–iCre, NaV1.8–iCre, or NaV1.9–iCre mice expressing iCre recombinase under the control of the endogenous NaV1.7, NaV1.8, or NaV1.9 gene promoter were produced. These mice were then bred with channelrhodopsin-2 (ChR2) Cre–reporter Ai32 mice to obtain NaV1.7–ChR2, NaV1.8–ChR2, or NaV1.9–ChR2 mice. Blue light exposure triggered paw withdrawal in all mice, with the strongest response in NaV1.8–ChR2 mice. These light sensitivity differences observed across NaV1.x–ChR2 mice may be dependent on ChR2 expression or reflect the inherent disparities in their pain transmission roles. In conclusion, we have generated noninvasive pain models, with optically activated peripheral nociceptors. We believe that studies using optogenetics will further elucidate the role of sodium channel subtypes in pain transmission.
DOI： 10.1002/jnr.25386
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【各種難治性疼痛に対する最新治療】下肢の虚血性疼痛に対する脊髄刺激療法． Reviewed
立山慎吾，日髙康太郎
ペインクリニック 45 ( 7 ) 717 - 718 2024.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Koshida T., Maruta T., Tanaka N., Hidaka K., Kurogi M., Nemoto T., Yanagita T., Takeya R., Tsuneyoshi I.
Acta Medica Okayama 77 ( 4 ) 359 - 364 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：Acta Medica Okayama
Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia.
DOI： 10.18926/AMO/65741
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MIYAUCHI Shunichi, MORIBAYASHI Kohei, ODA Yasuharu, SUZUKI Syo, TANIGUCHI Tomoaki, HIGUCHI Kazuhiro, KIMOTO Yasuhiro, OOHIRA Hiroaki, HIDAKA Koutaro, YAMAGUCHI Tomoko, KOMATSU Hiroyuki
Journal of Japan Association for Simulation-based Education in Healthcare Professionals 11 ( 0 ) 77 - 83 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Association for Simulation-based Education in Healthcare Professionals
We conducted a questionnaire survey on basic clinical-skills training and resuscitation training for newly employed residents. We compared the responses between the residents who had experienced simulation-based training (simulation group, n = 33) and those who had experienced video-assisted lectures (video group, n = 26). Across the eight procedures, the percentage of respondents who was "useful for subsequent clinical practice" was significantly higher in the simulation group than in the video group (91% vs. 75%, p = 0.001). We need to consider factors such as the frequency and difficulty of the procedures, the content of available teaching materials, and the curriculum in each medical school. In addition, we have to seek out practical training content with better teaching efficiency and better learning efficiency by effectively incorporating practical skills.
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左上肢運動麻痺，著明な浮腫を合併した帯状疱疹関連痛に対し，ステロイドパルス療法が有効であった1症例 Reviewed
内村 修二, 山賀 昌治, 川﨑 祐子, 日髙 康太郎, 渡部 由美, 恒吉 勇男
日本ペインクリニック学会誌 29 ( 1 ) 9 - 11 2022.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本ペインクリニック学会
Presentations 【 display / non-display 】
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陰部痛に対して効果不十分であったくも膜下フェノールブロックの一例．
押川 隆，松川美澄，日髙康太郎，山賀昌治，恒吉勇男
日本ペインクリニック学会第5回九州支部学術集会 2025.2.8
Event date： 2025.2.8
Language：Japanese Presentation type：Oral presentation (general)
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不眠・精神不安を伴う下肢神経痛に漢方薬を使用した症例．
日髙康太郎
第８回九州・沖縄・山口「痛みと漢方を学ぶ会」学術集会 2025.1.25
Event date： 2025.1.25
Language：Japanese Presentation type：Oral presentation (general)
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光応答性疼痛マウスに持続的な光照射をすることで作製した神経障害性疼痛モデルの検討．
興梠聡志，丸田豊明，日髙康太郎，越田智広，恒吉勇男
第46回日本疼痛学会 2024.11.17
Event date： 2024.11.16 - 2024.11.17
Language：Japanese Presentation type：Oral presentation (general)
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再生不良性貧血による血小板減少，貧血により終末期まで継続的に輸血を要した再発子宮頸癌の一例．
後藤裕磨，佐藤謙成，松 敬介，藤﨑 碧，平田 徹，村岡麻里奈，日髙麻希，谷之木佑歌，畑中真理，矢野祐衣，末田光恵，松山桃子，藤元貴子，船橋英樹，日髙康太郎，山賀昌治，桂木真司
日本緩和医療学会第６回九州支部学術大会 2024.11.16
Event date： 2024.11.16
Language：Japanese Presentation type：Poster presentation
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消化管障害によりオキシコドン・メサドンの効果減弱が疑われた難治性がん疼痛の一例．
畑中真理，谷之木佑歌，千阪智美，村岡麻里奈，日髙麻希，太田原 優，西村亜希，湯淺由佳，藤元貴子，松山桃子，押川 隆，日髙康太郎，川﨑祐子，丸田豊明,船橋英樹，末田光恵，山賀昌治，平原康寿，細川 歩，池田龍二
日本緩和医療学会第６回九州支部学術大会 2024.11.16
Event date： 2024.11.16
Language：Japanese Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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NaV1.7を標的とする疼痛治療薬の光遺伝学的探索：トラマドールとミロガバリン
Grant number：23K15603 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
Authorship：Principal investigator