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Faculty of Medicine College Hospital Anesthesiology |
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Assistant Professor |
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Related SDGs |
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HIDAKA Kotaro
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Papers 【 display / non-display 】
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文献抄訳:Clinical research on the effectiveness and safety of Uchasingihwan for low back pain with radiculopathy caused by ferniated intervertebral disc of the lumbar spine: a multicenter, randomized, controlled equivalence trial. Reviewed
児玉芳史，日髙康太郎，恒吉勇男
ペインクリニック 46 ( 9 ) 1009 - 1010 2025.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Satoshi Kouroki, Toyoaki Maruta, Kotaro Hidaka, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Syako Miura, Hikarru Nakagawa, Toshihiko Yanagita, Ryu Takeya, Isao Tsuneyoshi
PLoS One 20 ( 5 ) e0323628 2025.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS)
Neuropathic pain has a significant social impact, with high morbidity and reduced productivity, the underlying mechanisms of neuropathic pain remain poorly understood, and effective therapeutic strategies remain elusive. The development of animal models of neuropathic pain that stimulate only the nociceptors and not the other sensory receptors or motor nerves is desirable for elucidating the complex pathogenesis of neuropathic pain. We have previously reported the generation of NaV1.7−channelrhodopsin-2 (ChR2), NaV1.8−ChR2, and NaV1.9−ChR2 mice. Optogenetics was employed in these light-responsive pain mice for generating nociceptive pain by specifically exciting the spinal dorsal root ganglion neurons, in which the respective Na+ channels are expressed through exposure to blue light. This study aimed to compare the neuropathic pain produced by the prolonged exposure of light-responsive pain mice to blue light. A reversible neuropathic pain state was established persisting for a minimum of 24 hours when each light-responsive pain mouse was irradiated with light of an intensity that consistently elicited pain. Furthermore, the mice also showed pain sensitivity to light irradiation and mechanical stimulation. The expression of c-Fos, a marker for neuronal activity following noxious stimulation, was increased in the dorsal horn of the spinal cord on the light irradiated side. DS-1971a, a selective NaV1.7 inhibitor, was effective in attenuating neuropathic pain in all light-responsive pain mice. In conclusion, optogenetics helps elucidate the specific functions of sodium channel subtypes in pain signaling, thereby advancing our understanding and paving the way for the development of further effective treatments for pain disorders in the future.
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Maruta Toyoaki, Kouroki Satoshi, Kurogi Mio, Hidaka Kotaro, Koshida Tomohiro, Miura Ayako, Nakagawa Hikaru, Yanagita Toshihiko, Takeya Ryu, Tsuneyoshi Isao
Journal of Neuroscience Research 102 ( 10 ) e25386 2024.10
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/jnr.25386
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【各種難治性疼痛に対する最新治療】下肢の虚血性疼痛に対する脊髄刺激療法． Reviewed
立山慎吾，日髙康太郎
ペインクリニック 45 ( 7 ) 717 - 718 2024.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Koshida T., Maruta T., Tanaka N., Hidaka K., Kurogi M., Nemoto T., Yanagita T., Takeya R., Tsuneyoshi I.
Acta Medica Okayama 77 ( 4 ) 359 - 364 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：Acta Medica Okayama
Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia.
DOI： 10.18926/AMO/65741
Presentations 【 display / non-display 】
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低左心機能を合併した重症大動脈弁狭窄症に対し，準緊急でVA-ECMO補助下にTAVIを施行した１例．
児玉芳史，永田悠紀子，日髙康太郎，恒吉勇男
第38回日本老年麻酔学会学術集会 2026.2.28
Event date： 2026.2.28
Language：Japanese Presentation type：Oral presentation (general)
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帯状疱疹に伴う神経痛に対し桂枝加朮附湯の効果を認めた症例と認めなかった症例．
日髙康太郎
第９回九州・沖縄・山口「痛みと漢方を学ぶ会」学術集会 2026.1.24
Event date： 2026.1.24
Language：Japanese Presentation type：Oral presentation (general)
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「自分自身の予後」に対する誤解の解消によりオピオイド必要量が激減した１症例．
末田光恵，小池香苗，日髙麻希，西村亜希，湯淺由佳，谷之木佑歌，畑中真理，前田充範，赤松有希子，押川 隆，藤元貴子，日髙弘登，日髙康太郎，丸田豊明，船橋英樹，山賀昌治，藤永映人，村嶋隆哉，細川 歩
日本緩和医療学会第７回九州支部学術大会 2025.10.15
Event date： 2025.10.15
Language：Japanese Presentation type：Poster presentation
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Currarino症候群による肛門部痛・臀部痛に脊髄刺激療法が著効した１例．
立山真吾，山賀昌治，日髙康太郎
日本ペインクリニック学会第59回学術集会 2025.7
Event date： 2025.7.10 - 2025.7.12
Language：Japanese Presentation type：Oral presentation (general)
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脊髄刺激療法の問題点を打破した４例の解析．
立山真吾，日髙康太郎
日本ペインクリニック学会第59回学術集会 2025.7
Event date： 2025.7.10 - 2025.7.12
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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NaV1.7を標的とする疼痛治療薬の光遺伝学的探索：トラマドールとミロガバリン
Grant number：23K15603 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
Authorship：Principal investigator