Presentations -
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長野県におけるSFTS発生の可能性と ワンヘルス視点からの対策 Invited
岡林 環樹
長野県「人と動物の共通感染症講習会」 2025.2.15
Event date： 2025.2.15
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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人獣共通感染症としてのSFTS Invited
岡林 環樹
第5回愛媛ワンヘルス研究会 2024.10.19
Event date： 2024.10.19
Presentation type：Public lecture, seminar, tutorial, course, or other speech
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Emerging Zoonosis: Severe Fever with Thrombocytopenia Syndrome Invited International conference
2024.9.19
Event date： 2024.9.19
Language：English Presentation type：Oral presentation (invited, special)
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Sever Fever with Thrombocytopenia Syndrome, ~Emerging hemorrhagic fever in Asia~ Invited International conference
International Conference for Health Research2022 2022.11.23
Event date： 2022.11.23 - 2022.11.24
Language：English Presentation type：Oral presentation (invited, special)
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マダニ媒介感染症の最新の状況 SFTS への取組について Invited
岡林 環樹
令和４年度厚生労働省 動物由来感染症対策技術研修会 2022.10.19
Event date： 2022.10.19
Language：Japanese Presentation type：Oral presentation (invited, special)
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動物病院内で起こった犬から猫2頭へのSFTSV感染事例
目堅博久、梅木一美 、山田健太郎、梅北邦彦、岡林環樹
SFTS研究会 2022.9.10
Event date： 2022.9.10
Presentation type：Oral presentation (general)
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「身近な人獣共通感染症の現状と課題」 重症熱性血小板減少症候群の伝播から考える Invited
岡林 環樹
野生獣オンラインセミナー 2022.2.10
Event date： 2022.2.10
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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SFTS流行地 ”宮崎” からの報告 Invited
岡林 環樹
令和3年度獣医学術九州地区学会教育講演 2021.10.22
Event date： 2021.10.22 - 2021.10.31
Language：Japanese Presentation type：Oral presentation (invited, special)
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Zoonotic Lessons from SARS-CoV-2: Emergence, Transmission, and Potential Therapeutic for the COVID-19 Pandemic Associated with the Human-Animal-Environment Interaction Invited International conference
2nd International Conference on Veterinary and Animal Science 2021.10.21
Event date： 2021.10.21
Language：English Presentation type：Oral presentation (invited, special)
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国内外の大学連携による家畜防疫に関する知の集積 Invited
岡林 環樹
第164回日本獣医学会学術集会 2021.9.9
Event date： 2021.9.7 - 2021.9.13
Presentation type：Oral presentation (invited, special)
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SFTSってなに？ネコと仲良く暮らすための人獣共通感染症の理解 Invited
岡林 環樹
宮崎大学公開講演会 2024.12.3
Event date： 2024.12.3
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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Current status of SFTS in Japan 〜Issue seen from SFTS endemic areas〜 Invited International conference
Tamaki Okabayashi
Forum for Establishment of Asian Network to Develop Vaccines against Zoonotic Diseases 2024.11.28
Event date： 2024.11.28 - 2024.11.29
Language：English Presentation type：Symposium, workshop panel (nominated)
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重症熱性血小板減少症候群から回復した妊娠猫とその胎子の事例
福家直幸、金子泰之、高田蓮栞、平井卓哉、岡林環樹
獣医学術九州地区学会 2024.11.1
Event date： 2024.11.1
Presentation type：Oral presentation (general)
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2021-23年度に実施した犬と猫のSFTS検査のまとめ
岡林環樹、目堅博久、金子泰之、平井卓哉、梅木一美、梅北邦彦、山田健太郎
獣医学術九州地区学会 2024.11.1
Event date： 2024.11.1
Presentation type：Oral presentation (general)
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Urine from cats with severe fever with thrombocytopenia syndrome could be an infectious source International conference
Hirohisa Mekata, Yasuyuki Kaneko, Kentaro Yamada, Tamaki Okabayashi, Akatsuki Saito
The4th JOint meeting of Veterinary Science in East Asia 2024.9.8
Event date： 2024.9.8 - 2024.9.9
Language：English Presentation type：Oral presentation (general)
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2021-23年度に宮崎大学で実施した伴侶動物のSFTS検査
目堅博久、金子泰之、平井卓哉、梅木一美、山田健太郎、岡林環樹
第6回SFTS研究会 2024.9
Event date： 2024.9
Presentation type：Oral presentation (general)
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SFTS回復母猫に対する堕胎手術経験例
金子 泰之、福家直幸、高田蓮栞、岡寺涼太、日髙裕貴、岡林環樹
第6回SFTS研究会 2024.9
Event date： 2024.9
Presentation type：Oral presentation (general)
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宮﨑県におけるSFTS（重症熱性血小板減少症候群） ウイルスの地域性について
成田 翼、新田 真依子、水流 奈巳、鬼塚 咲良、矢野 浩司、岡林 環樹
第6回SFTS研究会 2024.9
Event date： 2024.9
Presentation type：Oral presentation (general)
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新規SFTSV-YEZV-OZV multiplex qPCR検査系の開発
福山 圭、佐賀由美子、水間奎太、松野啓太、岡林環樹、三津橋和也、田宮和真、渡 慧、山口宏樹、谷 英樹
第6回SFTS研究会 2024.9
Event date： 2024.9
Presentation type：Oral presentation (general)
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人獣共通感染症 Invited
岡林 環樹
九州行政衛生研究会 2024.8.2
Event date： 2024.8.2
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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モバイルリアルタイムPCR ” PicoGene® PCR1100” を用いた アフリカ豚熱ウイルス検出試薬の検証
Rissar Siringo Ringo, 岡林 環樹
宮崎県養豚研究会 2024.7.23
Event date： 2024.7.23
Presentation type：Oral presentation (general)
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宮崎県におけるSFTS対策の取組 ~小さな繋がりから大きな輪へ~ Invited
岡林 環樹
岐阜大学市民公開講座「ワンヘルスを考える」 2024.3.18
Event date： 2024.3.18
Presentation type：Oral presentation (invited, special)
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身近な致死性人獣共通感染症SFTSについて Invited
岡林 環樹
鹿児島大学感染症制御のためのシンポジウム 2023.12.12
Event date： 2023.12.12
Presentation type：Oral presentation (invited, special)
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SFTS “重症熱性血小板減少症候群”対策に向けた 宮崎ワンヘルスアプローチ Invited
岡林 環樹
新潟県獣医師会「ワンヘルス県民公開講座」 2023.10.28
Event date： 2023.10.28
Presentation type：Oral presentation (invited, special)
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獣医療者に関連する人獣共通感染症 〜SFTS流行地から見えてきた新しい感染リスクとその対策〜
岡林 環樹
富山県獣医師会セミナー 2023.9.14
Event date： 2023.9.14
Presentation type：Oral presentation (invited, special)
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重症熱性血小板減少症候群(SFTS)流行地における宮崎ワンヘルス研究会の取り組み
岡林 環樹
日本獣医学会
Event date： 2023.9.5 - 2023.9.7
Presentation type：Oral presentation (invited, special)
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SFTSってなに？
岡林 環樹
ネコ市ネコ座 2023.8.6
Event date： 2023.8.5 - 2023.8.6
Presentation type：Oral presentation (invited, special)
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SFTS対策における宮崎ワンヘルス研究会の取り組み Invited
岡林 環樹
One World One Health Research Forum 2023.7.1
Event date： 2023.6.30 - 2023.7.1
Presentation type：Oral presentation (invited, special)
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Development of diagnostic system in CADIC Invited International coauthorship International conference
Tamaki Okabayashi
2nd international symposium on Fish Diseases and Seafood Safety 2023.2.10
Event date： 2023.2.10
Language：English Presentation type：Oral presentation (invited, special)
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犬から2頭の猫への重症熱性血小板減少症候群の院内感染事例 Invited International coauthorship International conference
岡林 環樹
令和4年度日本獣医師会獣医学術学会全国大会 2022.11.11
Event date： 2022.11.11 - 2022.11.13
Language：Japanese Presentation type：Oral presentation (invited, special)
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流行地宮崎から見えてきた 新たなSFTSのリスクとその対策
岡林 環樹
SFTSアップデートセミナー2022 迫る危機への準備と対応を学ぶ 〜感染リスクの高い環境下にある自分たちを守るために〜
Event date： 2022.9.28
Language：Japanese Presentation type：Oral presentation (invited, special)
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2010 FMD outbreak in Miyazaki, Japan. Lessons Learned from Miyazaki Invited
Tamaki Okabayashi
FMD: Research, Detection and Control BADAN RISET DAN INOVASI NADIONAL (National Research and Innovation Agency) 2022.5.19
Event date： 2022.5.19
Language：English Presentation type：Oral presentation (invited, special)
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PCV2: PCR検査の再検証
岡林 環樹
ベーリンガーインゲルハイム養豚セミナー2022「PCV2制御のポイント」
Event date： 2022.4.20
Presentation type：Oral presentation (invited, special)
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MOLECULAR MECHANISMS FOR ENHANCEMENT OF BACTERIAL ATTACHMENT TO BOVINE RESPIRATORY EPITHELIAL CELLS BY VIRUS INFECTION International conference
Association of Japan-Indonesia Veterinary Education (Bogor, Indonesia) IPB University
Event date： 2021.2.13
Language：English Presentation type：Oral presentation (general)
Venue：Bogor, Indonesia
Bovine respiratory disease complex (BRDC) is one of the most common and costly diseases in the cattle industry worldwide due to decreased production and increased costs associated with treatment. BRDC known as multiple infections by viruses and bacteria is considered to increase disease severity. Bovine RS virus (BRSV) and bovine coronavirus (BCoV) are the viral-pathogens causing BRDC. Pasteurella multocida (PM) was the most common bacterial agent paired with virus in BRDC.
To investigate the interaction between bovine respiratory viruses and bacteria in bovine respiratory epithelial cells, we generated respiratory epithelial cell lines derived from bovine trachea (bTEC), bronchus (bBEC), and lung (bLEC). These established cells were infected with BRSV or BCoV. After then, we inoculated PM to these viral infected cells. BRSV infection significantly increased PM adherence to bovine lower respiratory tract epithelial cells, but not upper respiratory tract epithelial cells. All the cells infected with BCoV increased adherence of PM. These results indicate that BCoV infection in the upper and lower respiratory tracts enhance adherence of bacteria, and this phenomenon was markedly different from the BRSV infection.
To investigate whether virus infection regulates any cellular adherence receptors on bovine epithelial cells, we performed proteomic and functional analyses. The proteomic analysis showed that BRSV infection decreased expression of intercellular adhesion molecule-1 (ICAM1) on bTECs. However, BRSV infection increased the accumulation of platelet-activating factor receptor (PAFR) in all cell types. Molecular experiments, including specific blockade, knockdown, and overexpression of these receptors, indicated that PM adherence to these cell types depended on PAFR expression. These data suggested that while bTECs possibly captures PM under normal condition, BRSV infection reverses this phenomena.
To examine the interaction between BCoV infection and PM adherence in bovine upper and lower respiratory tract, epithelial cells were infected with BCoV and/or PM. The cells derived from both the upper and lower respiratory tract were susceptible to BCoV infection. These PM adherences are affected by increased expression of ICAM1 and PAFR.
We have obtained evidence suggesting that the upper respiratory tract is responsible for inhibiting PM invasion of the lower respiratory tract. This inhibition is accomplished by trapping PM via ICAM1, an adherence molecule that is displayed on the cellular surface under normal conditions. By capturing microbes, ICAM1 displayed by cells of the upper respiratory tract acts as a “GATEWAY" that impedes bacterial invasion of the lower respiratory tract. BRSV infection causes malfunction of ICAM1 in the bovine upper respiratory tract, allowing bacterial invasion of the lower respiratory tract. BRSV infection increased PAFR expression in epithelial cells derived from the lower respiratory tract. We further demonstrated that PM adherence to cells of the lower respiratory tract was enhanced by upregulation of PAFR. Overall, these findings highlight the importance of the synergistic effect of BRSV infection on severe pneumonia in cattle. BCoV infection enhanced PM adherence and triggered immune responses in cells derived from upper and lower respiratory tracts. BCoV infection up-regulated both ICAM1 and PAFR expressions, enhancing the bacteria adherence to the BCoV-infected cells. The interaction between surface receptors and bacteria adherence in upper respiratory tract may prevent severe pneumonia. In contrast, infection of lower respiratory epithelial cells with BCoV increased PM adherence and stimulated an excess immune response, leading to severe pneumonia. Taken together, the present study presents the evidence for distinct mechanism of BRDC-related infections in response to viral infections in respiratory epithelial cells. Understanding this complex interplay will help us to develop new therapeutic strategies for BRDC.
Thus, we identify a possible molecular mechanism of fundamental difference of pathogenicity in bovine respiratory virus infections in BRDC.