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Sonoda A, Shinkawa N, Kakizaki E, Yukawa N.
Forensic Science International: Reports 8 2023年12月
掲載種別：症例報告 出版者・発行元：Forensic Science International: Reports
This autopsy case involved a woman in her 60 s with a history of temporal tracheostomy. During an event in which her son allegedly experienced an epileptic seizure, he grasped the woman around the upper chest for several moments. The woman then experienced breathing difficulties, lost consciousness and died. Postmortem computed tomography revealed a pinhole-like tracheal narrowing at the level of the tracheostomy encircled by the thyroid. Autopsy revealed a modestly enlarged thyroid gland due to previously undiagnosed Hashimoto's disease and an old fracture in a tracheal ring indicating that the trachea had been compressed by the thyroid. Hashimoto's disease rarely causes sudden death through systemic endocrine disturbance, but this case may illustrate that against a background of previous tracheostomy that mechanically weakens the trachea, enlargement of the thyroid (goiter) as a local effect of the disease can also cause sudden death.
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A Suggested Mechanism for Green Discoloration of the Postmortem Brain. 査読あり
Shinkawa N, Takahashi N, Yano K, Sawaguchi A, Sonoda A, Kakizaki E, Yukawa N
The American journal of forensic medicine and pathology 2023年3月
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Shinkawa N., Kakizaki E., Sonoda A., Yukawa N.
Radiology Case Reports 18 ( 3 ) 1190 - 1196 2023年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Radiology Case Reports
We describe herein an autopsy case involving fatal hemorrhagic shock due to idiopathic sigmoid colonic intramural hematoma rupturing into the abdominal cavity. Antemortem computed tomography revealed a mass lesion in the sigmoid colon and a large amount of hemoperitoneum. On forensic autopsy, intramural hematoma of the sigmoid colon with ruptured serosa was identified, while the mucosa remained intact. Microscopically, hematomas were apparent, mainly in the muscularis propria. We diagnosed the cause of death as hemorrhagic shock due to idiopathic intramural hematoma of the sigmoid colon rupturing into the abdominal cavity. Although the patient had been receiving peritoneal dialysis, no relationship was identified between dialysis catheters and sigmoid colon intramural hematoma rupture. On computed tomography, the mass lesion was initially considered a submucosal neoplastic lesion or endometriotic lesion. Intramural hematoma should be considered as a differential diagnosis.
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Sonoda A, Kakizaki E, Shinkawa N, Matsuda H, Yukawa N.
Forensic Science International 341 111510 2022年12月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Forensic Science International
The number of diatoms detected in the kidneys and liver varies considerably when comparing various reports, but the reason remains unclear. We previously showed that the reuse of Kjeldahl flasks is susceptible to generating false positives; false-positive results were observed in 17 of 60 tested flasks, and a maximum of 290 diatoms were detected. Furthermore, these data suggested that the number of diatoms in kidney and liver tissue may be much lower than previously thought. Therefore, only new Kjeldahl flasks were used to perform diatom tests on 80 autopsy cases (drowning and non-drowning victims) in this study. When combined with the 20 cases in a previous study, a total of 100 cases were analyzed. Four grams of lung, 10–30 g each of kidney and liver, 10 mL of blood, and 50–100 mL of water (discovery site) were examined. A large number of diatoms (n = 400) were found in organs other than the lungs in only 1 of 56 cases of suspected drowning (excluding cases of suspected drowning in baths). Together with the previous 20 cases, this single case represented only 1 of 76 cases (1.3 %). In closed organs and blood samples, 3 diatoms were found in 2 of 56 victims (3.6 %), and 1 or 2 diatoms were found in 8 victims (14 %). However, 5 diatoms were found in 1 of 10 bathtub drowning victims and 12 non-drowning victims (4.5 %), and 1 or 2 diatoms were found in 6 victims (27 %). Moreover, 1 or 2 diatoms were found in negative control flasks in 3 of 80 victims (3.8 %). The results showed that distinguishing false-positive results is difficult when a small number of diatoms are found in the kidneys and liver. Thus, the presence of diatoms in closed organs and blood seems to be unreliable as evidence of death by drowning, at least in the water environments in our region (freshwater areas: 23–26,000 diatoms/mL, median 200 diatoms; brackish water areas: 26–1200 diatoms/mL, median 210 diatoms; seawater area: 2–1000 diatoms/mL, median 24 diatoms). These results also reconfirmed that the reuse of flasks is the most important cause of false positives. Conversely, the presence of a large number of diatoms in lung samples (1–850,000 diatoms/g lung tissue; median (right lung): 440 diatoms, (left lung): 320 diatoms) is very informative and is an effective diagnostic aid in many cases.
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Shinkawa N, Kakizaki E, Sonoda A, Yukawa N.
Journal of Forensic and Legal Medicine 92 102452 2022年11月
記述言語：英語 掲載種別：症例報告 出版者・発行元：Journal of Forensic and Legal Medicine
An autopsy case involving a child showing various shapes of tramline bruises caused by a single weapon is described. On autopsy, multiple tramline bruises in different orientations were found, mainly on the back. Shapes of the tramline bruises were variable, including linear, arcuate, nodular, hook-like, and hook-like with a knot at the end. Due to the presence of severe subcutaneous hemorrhages and the absence of other potentially fatal injuries or diseases, we determined the cause of death to be traumatic shock. Microscopically, of the many tramline bruises, characteristic hemorrhages were observed on the right abdominal and left lumbar regions. Those hemorrhages were observed in the dermis, corresponding to macroscopic tramline bruises. Hemorrhage was also observed in the subcutis, corresponding to the pallor of the outer surface. The mechanisms by which tramline bruises occurred in the dermis and subcutis in this case are discussed with reference to the literature. We also propose subcutaneous and intradermal hemorrhagic types of tramline bruising.
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Yukawa N, Shinkawa N, Yano K, Tachibana M, Kakizaki E, Sonoda A.
Legal Medicine 60 102176 2023年2月
記述言語：英語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：Legal Medicine
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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溺死診断におけるプランクトン検査の意義：既成概念の大幅な変革に挑戦する
研究課題/領域番号：22K19675 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費補助金 挑戦的研究(萌芽)
園田 愛
担当区分：研究代表者
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最も少ない労力で行える溺死の補助診断検査：法医実務に合わせた最も効果的な活用法
研究課題/領域番号：21H03215 2021年04月 - 2024年03月
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
湯川 修弘
担当区分：研究分担者
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水死体の鑑別診断に簡便・迅速に対応するための新規スクリーニング検査法の開発
研究課題/領域番号：18K19687 2018年04月 - 2021年03月
独立行政法人日本学術振興会 科学研究費補助金 挑戦的研究(萌芽)
園田 愛
担当区分：研究代表者
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簡便かつ安価で安全に行えるPapainを用いた新しいプランクトン検査法
研究課題/領域番号：18K10132 2018年04月 - 2020年03月
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
柿崎 英二
担当区分：研究分担者
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溺死診断のためのTaqMan PCRを用いた水棲微生物の迅速な多検体同時検出法
研究課題/領域番号：17K09269 2017年04月 - 2019年03月
科学研究費補助金 基盤研究(C)
湯川 修弘
担当区分：研究分担者