研究者詳細 - 井上　健太郎

論文 - 井上　健太郎

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Anti-transferrin receptor antibody (JST-TFR09/PPMX-T003) induces ferroptosis in adult T-cell leukemia/lymphoma (ATLL) cells 査読あり

Yanuar Rahmat Fauzi, Shingo Nakahata, Kazuya Shimoda, Tadashi Matsuura, Shinji Hagiwara, Takuya Yokokawa, Kentaro Inoue, Hiroshi Moritake, Kazuhiro Morishita

Biochemical and Biophysical Research Communications 756 151564 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： https://doi.org/10.1016/j.bbrc.2025.151564

Regulation mechanisms of CARMA1–Bcl10–MALT1 complex assembly inferred from the analysis of TRAF6-deficient cells 査読あり

Kentaro Inoue, Tomoharu Yasuda, Yoshihiro Baba, Tadashi Yamamoto, Tomohiro Kurosaki, Hisaaki Shinohara

Genes to Cells 28 ( 6 ) 411 - 421 2023年3月

担当区分：筆頭著者掲載種別：研究論文（学術雑誌）

DOI： https://doi.org/10.1111/gtc.13022

Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations 査読あり

Kosuke Mochida, Shingo Nakahata, Yutaka Suzuki, Kentaro Inoue, Sayaka Moriguchi, Atsushi Yamashita, Masahiro Amano, Kazuhiro Morishita

Journal of Dermatological Science 109 ( 2 ) 80 - 88 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： https://doi.org/10.1016/j.jdermsci.2023.02.001

Integrin α6A (ITGA6A)-type Splice Variant in Extracellular Vesicles Has a Potential as a Novel Marker of the Early Recurrence of Pancreatic Cancer 査読あり

Asada T., Nakahata S., Fauzi Y.R., Ichikawa T., Inoue K., Shibata N., Fujii Y., Imamura N., Hiyoshi M., Nanashima A., Morishita K.

Anticancer Research 42 ( 4 ) 1763 - 1775 2022年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Anticancer Research

Background/Aim: Pancreatic ductal adenocarcinoma (PDAC) is one of the most common cancers worldwide, with a poor prognosis. Owing to the difficulty of early diagnosis, the aim of this study was to isolate biomarkers from extracellular vesicles (EVs) that can lead to early diagnosis. Materials and Methods: EVs in the culture supernatant were isolated from a pancreatic cancer cell line (PK-1) and expanded by using two-dimensional gel electrophoresis, and protein identification from each spot was performed by using matrix-assisted laser desorption ionization mass spectrometry. The identified proteins were classified and compared with previously reported results for EVs from murine pancreatic cancer PAN02 cells, and their expression specificity was examined using PDAC cell lines and patient-derived PDAC tissues. In addition, the significance of selected biomarker(s) was examined based on the changes in biomarkers in the blood EVs of PDAC patients after surgery. Results: We found that the ITGA6A splice variant was predominantly expressed in several pancreatic cancer cell lines and blood EVs from patients with PDAC, whereas the ITGA6B splice variant was predominantly expressed in EVs from the blood of normal volunteers. In the expression pattern of ITGA6 in EVs from blood samples of two PDAC patients before and after resection surgery, the expression of ITGA6A in EVs significantly decreased after surgery and increased several months before clinical recurrence. Furthermore, the increased expression of ITGA6A in EVs occurred much earlier than that of CA19-9. Conclusion: Determination of ITGA6A expression in blood EVs in PDAC patients could be a useful blood marker for the early diagnosis of PDAC recurrence.

DOI： 10.21873/anticanres.15653

Scopus

Essential Role of STAT3 Signaling in Hair Follicle Homeostasis 査読あり

Kosuke Miyauchi, Sewon Ki, Masao Ukai, Yoshie Suzuki, Kentaro Inoue, Wataru Suda, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko J. Tanaka, Mariko Okada-Hatakeyama, Masato Kubo

Frontiers in Immunology 12 1 - 13 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.3389/fimmu.2021.663177

Network design for session type NIDS 査読あり

Ryo Saito, Kunihito Yamamori, Masaru Aikawa, Kentaro Inoue

Proceedings of the 26th International Symposium on Artificial Life and Robotics 518 - 523 2021年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Delivery Route Suboptimization Combined by Map Application and Genetic Algorithm 査読あり

Yoshitaka Matsushita, Masaru Aikawa, Kentaro Inoue, Kunihito Yamamori

Proceedings of the 26th International Symposium on Artificial Life and Robotics 524 - 528 2021年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Computer aided arrangements using cadences and melodic regularity 査読あり

Kosuke Yoshida, Kunihito Yamamori, Masaru Aikawa, Kentaro Inoue

Proceedings of the 26th International Symposium on Artificial Life and Robotics 529 - 532 2021年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Reinforcement Learning Approach for Incomplete Information Games 査読あり

Akinobu Iwai, Kunihito Yamamori, Masaru Aikawa, Kentaro Inoue

Proceedings of the 26th International Symposium on Artificial Life and Robotics 533 - 538 2021年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Tuning Support Tool for WAF Mod Security by Log Analysis with Machine Learning 査読あり

Chihiro Kudo, Kunihito Yamamori, Masaru Aikawa, Kentaro Inoue, Ryo Saito

Proceedings of the 26th International Symposium on Artificial Life and Robotics 539 - 543 2021年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Feedback enrichment analysis for transcription factor-target genes in signaling pathways 査読あり

Kentaro Inoue

BioSystems 198 104262 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.biosystems.2020.104262

PubMed

生物モデルにおける同じ動態を再現可能なパラメタセットのグローバルなパラメタ変動解析

井上健太郎

情報処理学会バイオ情報学研究報告 63 ( 3 ) 1 - 6 2020年8月

記述言語：日本語掲載種別：研究論文（研究会，シンポジウム資料等）

Affect of data unbalance in "Kyoto 2016 Dataset" for NIDS with machine learning 査読あり

Ryo Saito, Masaru Aikawa, Kentaro Inoue, Kunihito Yamamori

Proceedings of The Twenty-fifth International Symposium on Artificial Life and Robotics 612 - 616 2020年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs 査読あり

Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M. Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita and Osamu Takeuchi

Nucleic Acids Research 47 ( 16 ) 8838 - 8859 2019年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1093/nar/gkz628

PubMed

Sensitivity analysis for reproducible candidate values of model parameters in signaling hub model 査読あり

Kentaro Inoue

PLoS ONE 14 ( 2 ) e0211654 2019年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1371/journal.pone.0211654

PubMed

その他リンク： https://www.scopus.com/record/display.uri?eid=2-s2.0-85061474976&origin=resultslist&sort=plf-f&src=s&st1=Sensitivity+analysis+for+reproducible+candidate+values+of+model+parameters+in+signaling+hub+model&st2=&sid=d9db02e30ab3f8132f692c9bd67a3ab9&sot=b&sdt=b&sl=112&s=TITLE-ABS-KEY%28Sensitivity+analys

Hierarchical policy gradient method with the combination of reinforcement and auxiliary learning 査読あり

Masaya Yoshida, Kentaro Inoue, Masaru Aikawa, Kunihito Yamamori

Proceedings of the 24th International Symposium on Artificial Life and Robotics 706 - 710 2019年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression 査読あり

Hasi Rani Saha, Kazuko Kaneda-Nakashima, Shunsuke Shimosaki, Akira Suekane, Bidhan Sarkar, Yusuke Saito, Honami Ogoh, Shingo Nakahata, Kentaro Inoue, Takayoshi Watanabe, Hiroki Nagase, Kazuhiro Morishita

Scientific Reports 8 13741 2018年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/s41598-018-32205-8

PubMed

その他リンク： https://www.scopus.com/record/display.uri?eid=2-s2.0-85053339237&origin=resultslist&sort=plf-f&src=s&st1=Suppression+of+GPR56+expression+by+pyrrole-imidazole+polyamide+represents+a+novel+therapeutic+drug+for+AML+with+high+EVI1+expression&st2=&sid=d9db02e30ab3f8132f692c9bd67a3ab9&sot=b&sdt=b&sl=147&s

Reinforcement learning approach for smart air traffic control support system 査読あり

M.Watanabe, K.Yamamori, M.Aikawa, K.Inoue

Proc. 23rd International Symposium on Artificial Life and Robotics 457 - 461 2018年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Lightweight virtual node protocol for large scale IoT device networks 査読あり

Y.Shinooka, K.Yamamori, M.Aikawa, K.Inoue

Proc. 23rd International Symposium on Artificial Life and Robotics 478 - 483 2018年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

A novel audio fingerprinting method based on music elements for similar music retrieval 査読あり

T.Aoshima, K.Yamamori, M.Aikawa, K.Inoue

Proc. 23rd International Symposium on Artificial Life and Robotics 452 - 456 2018年1月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

シグナル伝達系の大規模数理モデルにおけるパラメタ推定法

井上健太郎

研究報告バイオ情報学, 2017-BIO-51(8), 1-2, 2017 2017年9月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）

Protective neutralizing influenza antibody response in the absence of T follicular helper cells 査読あり

Kosuke Miyauchi, Akiko Sugimoto-Ishige, Yasuyo Harada, Yu Adachi, Yoshiko Usami, Tomohiro Kaji, Kentaro Inoue, Hideki Hasegawa, Takashi Watanabe, Atsushi Hijikata, Satoshi Fukuyama, Tadashi Maemura, Mariko Okada-Hatakeyama, Osamu Ohara, Yoshihiro Kawaoka, Yoshimasa Takahashi, Toshitada Takemori, Masato Kubo

Nature Immunology 17 1447 - 1458 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/ni.3563

Oscillation dynamics underlie functional switching of NF-κB for B-cell activation 査読あり

Kentaro Inoue, Hisaaki Shinohara, Marcelo Behar, Noriko Yumoto, Gouhei Tanaka, Alexander Hoffmann, Kazuyuki Aihara, Mariko Okada-Hatakeyama

npj Systems Biology and Applications 2 ( 16024 ) 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/npjsba.2016.24

Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling 査読あり

Hisaaki Shinohara, Kentaro Inoue, Noriko Yumoto, Takeshi Nagashima, Mariko Okada-Hatakeyama

Scientific Reports 6 ( 27706 ) 2016年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/srep27706

Web Application for Genetic Modification Flux with Database to Estimate Metabolic Fluxes of Genetic Mutants 査読あり

Noorlin Mohd Ali, Ryo Tsuboi, Yuta Matsumoto, Daisuke Koishi, Kentaro Inoue, Kazuhiro Maeda, Hiroyuki Kurata

Journal of Bioscience and Bioengineering 122 ( 1 ) 111 - 116 2015年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.jbiosc.2015.12.001

Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages 査読あり

Keisuke Yoshida, Claire Renard-Guillet, Kentaro Inoue, Katsuhiko Shirahige, Mariko Okada-Hatakeyama, Shunsuke Ishii

Genomics Data 7 90 - 91 2015年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.gdata.2015.11.028

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory 査読あり

Keisuke Yoshida, Claire Renard-Guillet, Kentaro Inoue, Katsuhiko Shirahige, Mariko Okada-Hatakeyama, Shunsuke Ishii

Nature Immunology 16 1034 - 1043 2015年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/ni.3257

CADLIVE Toolbox for MATLAB: Automatic dynamic modeling of biochemical networks with comprehensive system analysis 査読あり

Kentaro Inoue, Kazuhiro Maeda, Takaaki Miyabe, Yu Matsuoka, Hiroyuki Kurata

Bioprocess and Biosystems Engineering 37 ( 9 ) 1925 - 1927 2014年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00449-014-1167-8

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation 査読あり

Hisaaki Shinohara, Marcelo Behar, Kentaro Inoue, Michio Hiroshima, Tomoharu Yasuda, Takeshi Nagashima, Shuhei Kimura, Hideki Sanjo, Shiori Maeda, Noriko Yumoto, Sewon Ki, Shizuo Akira, Yasushi Sako, Alexander Hoffmann, Tomohiro Kurosaki, Mariko Okada-Hatakeyama

Science 344 ( 6185 ) 760 - 764 2014年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1126/science.1250020

Application of Approximate Pattern Matching in Two Dimensional Space to Grid Layout for Biochemical Network Maps 査読あり

Kentaro Inoue, Shinichi Shimozono, Hideaki Yoshida, Hiroyuki Kurata

PLoS ONE 7 ( 6 ) e37739 2012年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1371/journal.pone.0037739

CADLIVE Optimizer: Web-based Parameter Estimation for Dynamic Models 査読あり

Kentaro Inoue, Kazuhiro Maeda, Yuki Kato, Shinpei Tonami, Shogo Takagi, Hiroyuki Kurata

Source Code for Biology and Medicine 7 ( 9 ) 2012年4月

記述言語：英語掲載種別：研究論文（学術雑誌）