水谷 真也 (ミズタニ シンヤ)

MIZUTANI Shinya

写真a

職名

特別助教

研究分野・キーワード

臨床獣医学

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  • 宮崎大学 -  博士(獣医学)

専門分野(科研費分類) 【 表示 / 非表示

  • 獣医学

 

研究経歴 【 表示 / 非表示

  • イヌの胆嚢疾患の病態解明

    (選択しない)  

    研究期間: 2013年04月  -  継続中

論文 【 表示 / 非表示

  • Effects of a single-bolus bupivacaine injection into the coccygeal spinal canal of rabbits

    Ong B.H.E., Hidaka Y., Kaneko Y., Yamamoto S., Mizutani S., Sekiguchi S., Torisu S., Naganobu K.

    Journal of Veterinary Medical Science   82 ( 2 ) 197 - 203   2020年

    共著

     概要を見る

    © 2020 The Japanese Society of Veterinary Science. It has been reported that drugs intended for epidural administration through the lumbosacral junction are accidentally administered into the subarachnoid space frequently in rabbits. Therefore, we evaluated the epidural single-bolus injection technique for the administration of bupivacaine into the coccygeal spinal canal of rabbits. After epidural distribution was confirmed by the injection of iohexol into the coccygeal spinal canal, 0.3 ml/kg 0.5% bupivacaine or 0.3 ml/kg normal saline was injected via the same needle. After the first attempt of iohexol injection, although the contrast was found in the epidural space in all rabbits, the additional contrast was also found in blood vessel in 3 rabbits and in muscular layer in 1 rabbit. Subarachnoid distribution was not observed in any of the rabbits. The time taken to regain normal anal reflex, movement of the hind limbs during walking, conscious proprioception of the hind limbs, and pain sensation of the tail and left hind limb, following coccygeal spinal canal injection, were significantly longer in the bupivacaine group than in the normal saline group. These findings indicated that coccygeal epidural injection of bupivacaine in rabbits may provide anesthesia for the hind limbs, perineum, and tail, but inadvertent vascular entry of the epidural drug may occur.

    DOI PubMed CiNii

  • Usefulness of Urinary Creatinine/Urea Nitrogen Ratio as Indicator of Body Protein Catabolism in Dogs Fed Low Protein Diets

    Yamamoto S., Ohta Y., Hasegawa E., Hashida S., Kaneko Y., Mizutani S., Ong B., Naganobu K., Torisu S.

    Frontiers in Veterinary Science   6   449   2019年12月

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     概要を見る

    © Copyright © 2019 Yamamoto, Ohta, Hasegawa, Hashida, Kaneko, Mizutani, Ong, Naganobu and Torisu. Low protein diets (LPs) constitute a reportedly effective form of nutritional therapy for canine chronic kidney disease and cirrhosis. These diets have long been feared to result in reduced muscle mass due to protein catabolism. This adverse effect, however, remains largely unrecognized in veterinary medicine as there are no easily applicable catabolism indicators. Therefore, we focused on urinary creatinine, a metabolite of protein in the urine, and examined whether its ratio to urinary urea nitrogen (UCrn/UN) can be used to assess protein catabolism. In Experiment 1, we first consecutively fed seven healthy beagles an LP, standard protein (SP), and high protein (HP) diet for 1 week each and then measured the UCrn/UN ratio at 2-h intervals from fasting to 16 h post-prandially. We consequently found that the UCrn/UN ratio was significantly elevated in the LP pre-prandially and at all post-prandial measurement points (P < 0.01). No significant differences were observed between the SP and HP. Analysis of fasting plasma amino-acid concentrations revealed that the concentration of methionine was significantly lower in the LP than in the other diets (P < 0.05). Although the effects of this change in amino-acid concentration were unclear, the UCrn/UN ratio was considered having increased due to a deficiency in protein and/or amino acids during LP feeding. In Experiment 2, we continuously fed five healthy beagles an LP for 18 weeks and then measured the UCrn/UN ratio as described above. We also measured changes in body composition with computed tomography. At weeks 10 and 18, the fasting UCrn/UN ratio was significantly higher than it was prior to the start of the LP; however, post-prandially, the UCrn/UN ratio decreased to the point that the significant difference disappeared. Muscle mass decreased at weeks 10 and 18. These results suggest that the fasting UCrn/UN ratio could be used as an indicator of protein catabolism in LP feeding. Our experiments thus indicate that examination of potential increases in the UCrn/UN ratio 1 week after introduction of LP feeding to healthy dogs could enable detection of body protein catabolism in long-term feeding of LP before muscle breakdown occurs.

    DOI PubMed

  • Retrospective analysis of canine gallbladder contents in biliary sludge and gallbladder mucoceles

    Mizutani S., Torisu S., Kaneko Y., Yamamoto S., Fujimoto S., Ong B., Naganobu K.

    Journal of Veterinary Medical Science   79 ( 2 ) 366 - 374   2017年02月

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     概要を見る

    © 2017 The Japanese Society of Veterinary Science. The pathophysiology of canine gallbladder diseases, including biliary sludge, gallbladder mucoceles and gallstones, is poorly understood. This study aimed to evaluate the component of gallbladder contents and bacterial infection of the gallbladder in order to elucidate the pathophysiology of biliary sludge and gallbladder mucoceles. A total of 43 samples of canine gallbladder contents (biliary sludge, 21 and gallbladder mucoceles, 22) were subjected to component analysis by infrared spectroscopy, and the resultant infrared spectra were compared with that of swine mucin. Of the 43 samples, 41 were also evaluated by aerobic and anaerobic bacterial culture. The contents of 20 (95.2%) biliary sludge and 22 (100%) gallbladder mucocele samples exhibited similar infrared spectra as swine mucin. Although biliary sludge and gallbladder mucocele contents exhibited similar infrared spectra, one sample of biliary sludge (4.8%) was determined to be composed of proteins. The rate of bacterial infection of the gallbladder was 10.0% for biliary sludge and 14.3% for gallbladder mucoceles. Almost all of the identified bacterial species were intestinal flora. These results indicate that the principal components of gallbladder contents in both gallbladder mucoceles and biliary sludge are mucins and that both pathophysiologies exhibit low rates of bacterial infection of the gallbladder. Therefore, it is possible that gallbladder mucoceles and biliary sludge have the same pathophysiology, and, rather than being independent diseases, they could possibly represent a continuous disease. Thus, biliary sludge could be considered as the stage preceding the appearance of gallbladder mucoceles.

    DOI CiNii

  • A case report of suspected hepatopulmonary syndrome secondary to ductal plate malformation with chronic active hepatitis in a dog

    Yasuyuki KANEKO, Shidow TORISU, Mitsuyoshi HAGIO, Ryoji YAMAGUCHI, Shinya MIZUTANI, Kiyokazu NAGANOBU

    The Japanese Society of Veterinary Science   78 ( 3 ) 493 - 497   2016年  [査読有り]

    共著

  • Arterial blood gas anomaly in canine hepatobiliary disease

    KANEKO Yasuyuki, TORISU Shidow, KOBAYASHI Takumi, MIZUTANI Shinya, TSUZUKI Nao, SONODA Hiroko, IKEDA Masahiro, NAGANOBU Kiyokazu

    Journal of Veterinary Medical Science   77 ( 12 ) 1633 - 1638   2015年

    共著

     概要を見る

    Arterial blood gas analysis is an important diagnostic and monitoring tool for respiratory abnormalities. In human medicine, lung complications often occur as a result of liver disease. Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered hypoxemia in dogs with liver disorders, especially extrahepatic biliary obstruction. In addition, respiratory disorders account for 20% of perioperative fatalities in dogs. Therefore, in this study, we evaluated the respiratory status in dogs with hepatobiliary disease by arterial blood gas analysis. PaO<sub>2</sub> and PaCO<sub>2</sub> were measured. Alveolar-arterial oxygen difference (AaDO<sub>2</sub>), the indicator of gas exchange efficiency, was calculated. Compared to healthy dogs (control group), hepatobiliary disease dogs had significantly lower PaO<sub>2</sub> and higher AaDO<sub>2</sub>. Hypoxemia (PaO<sub>2</sub> of ≤80 mmHg) was observed in 28/71 dogs with hepatobiliary disease. AaDO<sub>2</sub> was higher (≥30 mmHg) than the control group range (11.6 to 26.4 mmHg) in 32/71 hepatobiliary disease dogs. By classifying type of hepatobiliary disease, dogs with extrahepatic biliary obstruction and chronic hepatitis showed significantly lower PaO<sub>2</sub> and higher AaDO<sub>2</sub> than in a control group. Dogs with chronic hepatitis also had significantly lower PaCO<sub>2</sub>. The present study shows that dogs with hepatobiliary disease have respiratory abnormalities more than healthy dogs. Preanesthetic or routine arterial blood gas analysis is likely beneficial to detect the respiratory abnormalities in dogs with hepatobiliary disease, especially extrahepatic biliary obstruction and chronic hepatitis.

    DOI CiNii

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総説・解説記事 【 表示 / 非表示

  • こうすればよかった 見逃し・後悔症例カンファレンス Vol.2 Case8 鼻の上に穴が空いて血が出ています

    水谷真也

    SAMedicine ( インターズー )  120   20 - 27   2019年04月  [査読有り]  [依頼有り]

    総説・解説(商業誌)   単著

  • 総胆汁酸の院内迅速検査の有用性

    水谷真也, 鳥巣至道

    CAP ( 株式会社 緑書房 )  340   95 - 99   2017年10月  [依頼有り]

    総説・解説(商業誌)   共著

学術関係受賞 【 表示 / 非表示

  • 獣医学術学会賞

    2019年02月09日   日本獣医師会   腹腔鏡で視認した牛の立位時腹腔内潜在精巣の解剖学的位置と腹腔内触診によるアプローチ法の検討  

    受賞者:  鳥巣至道、保坂悠歩、金子泰之、北原豪、佐藤裕之、水谷真也、山本集士、 Benedict Huai Ern ONG、水谷祐子、桐野有美、日高勇一、浅沼武敏、永延清和

  • 第10回アワード 優秀賞

    2019年01月13日   第97回日本獣医麻酔外科学会・2018年秋季合同学会   肋骨弓内に存在する巨大腫瘤への新しい手術アプローチ法の検討  

    受賞者:  赤松大、鳥巣至道,金子泰之, 水谷真也,水谷祐子,山本集士, Benedict Huai Ern ONG,野矢みどり,和田正太,永延清和

  • 学会長賞

    2018年10月14日   九州地区獣医師大会 日本小動物獣医学会  

    受賞者:  保坂悠歩、鳥巣至道、金子泰之、北原豪、佐藤裕之、水谷真也、山本集士、 Benedict Huai Ern ONG、水谷祐子、桐野有美、日高勇一、浅沼武敏、永延清和

  • フレッシャー・アワード

    2018年10月14日   九州地区獣医師大会 日本小動物獣医学会   アミノ酸製剤の腹腔内投与を実施した肝疾患罹患犬の6例  

    受賞者:  山本集士、鳥巣至道、太田能之、長谷川悦子、金子泰之、水谷真也、 Benedict Huai Ern ONG、赤松大、野矢みどり 、藤本晋輔、永延清和

     概要を見る

    アミノ酸欠乏性の疾患の犬に対し腹腔内アミノ酸投与を試みた報告

  • 坂本賞

    2018年07月22日   九州地区小動物獣医学会卒後研修会  

    受賞者:  赤松大、野谷みどり、和田正太、 Benedict Huai Ern ONG、山本集士、水谷真也、水谷裕 子、金子泰之、中村健介、永延清和、鳥巣至道

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研究発表 【 表示 / 非表示

  • 副腎腫瘍摘出のために画像を読む

    水谷真也

    若手獣医師による若手獣医師のためのBasicセミナー  (埼玉県大宮市 大宮ソニックシティ)  2019年06月  -  2019年06月    第98回日本獣医麻酔外科学会 2019年春季合同学会

  • 人工腸弁形成により症状改善が認められた短結腸症の犬の1例

    金子泰之,鳥巣至道,日高裕貴, 水谷真也,山本集士, Benedict Huai Ern ONG,永延清和

    第98回日本獣医麻酔外科学会・2019年春季合同学会  2019年06月  -  2019年06月   

  • 腹腔鏡で視認した牛の立位時腹腔内潜在精巣の解剖学的位置と腹腔内触診によるアプローチ法の 検討

    保坂悠歩、鳥巣至道、金子泰之、北原豪、佐藤裕之、水谷真也、山本集士、 Benedict Huai Ern ONG、水谷祐子、桐野有美、日高勇一、浅沼武敏、永延清和

    平成30年度 九州地区獣医師大会 日本産業動物獣医学会  2018年10月  -  2018年10月   

  • アミノ酸製剤の腹腔内投与を実施した肝疾患罹患犬の6例

    山本集士、鳥巣至道、太田能之、長谷川悦子、金子泰之、水谷真也、 Benedict Huai Ern ONG、赤松大、野矢みどり 、藤本晋輔、永延清和

    平成30年度 九州地区獣医師大会 日本小動物獣医学会  2018年10月  -  2018年10月   

  • 正常犬のMRI拡散テンソル画像パラメータ分析

    平山瑞紀、水谷祐子、水谷真也、中村健介、佐藤裕之、浅沼武敏

    平成30年度 九州地区獣医師大会 日本小動物獣医学会  2018年10月  -  2018年10月   

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