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医学部 医学科 病態解析医学講座放射線医学分野 |
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助教 |
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論文 【 表示 ／ 非表示 】
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A Single-Kindred Cluster of Val122Ile Transthyretin Amyloid Cardiomyopathy: Subclinical Case Series of Three Japanese Patients. 査読あり
Tsuruda T, Kodama N, Tanahashi T, Suiko Y, Yamamoto K, Komaki S, Moribayashi K, Terakawa C, Iwai M, Sakai K, Shiomi K, Terada T, Nakada H, Ogata M, Tanaka M, Yamashita A, Iida H, Matsuura Y, Kaikita K
Internal medicine (Tokyo, Japan) advpub ( 0 ) 2026年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本内科学会
Transthyretin Val122Ile variant carriers are at risk of developing heart failure, with this variant being observed in individuals of Western African ancestry. We encountered three patients carrying this variant in a single kindred from southern Japan. The detection of amyloid in the carpal tunnel tissue prompted comprehensive clinical evaluation, confirming cardiac involvement. Speckle-tracking echocardiography and cardiac magnetic resonance imaging revealed age-related progression of myocardial involvement predominantly affecting the basal inferoseptum. The transthyretin Val122Ile variant is associated with poor clinical outcomes. Clinicians should be aware that this variant can also be sporadically present in elderly Japanese patients with cardiomyopathy or heart failure.
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Tsuruda T., Ota T., Terada T., Nakada H., Ogata M., Tanaka M., Suiko Y., Matsuura Y., Komaki S., Moribayashi K., Yamada R., Yamashita A., Yamamoto K., Nishihira K., Shibata Y., Kaikita K.
Esc Heart Failure 13 ( 2 ) 2026年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Esc Heart Failure
BACKGROUND AND AIMS: Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is now increasingly identified as a cause of heart failure in older adults. This study aimed to clarify the morphological and functional alterations of the left ventricle (LV) that define the early stage of this condition. METHODS: We prospectively evaluated 81 patients diagnosed with wild-type ATTR (ATTRwt) amyloidosis (mean age 77 ± 6 years; 88% male), categorized into three groups based on myocardial uptake on radioactive pyrophosphate scintigraphy and histological confirmation: (i) carpal ATTR without cardiac involvement (Group 1, n = 13), (ii) asymptomatic cardiac involvement (Group 2, n = 10) and (iii) overt heart failure (Group 3, n = 58). RESULTS: Compared with Group 3, Group 1 showed higher absolute global longitudinal strain (GLS) (median 19.0 [13.2-23.8]%, P < .001), a lower apical-sparing ratio (median 0.66 [0.55-1.04], P < .001) and lower brain natriuretic peptide (BNP) (median 13.5 [6-49] pg/mL, P < .001) and troponin-T concentrations (0.012 [0.006-0.022] ng/mL, P < .001), while the estimated glomerular filtration rate remained preserved (64 ± 9 mL/mL/1.73 m², P = .022). Segmental longitudinal strain (LS) differentiated Group 1 from Group 2, with basal inferoseptal LS significantly lower in patients with elevated troponin-T (> 0.014 ng/mL) than in those with lower values (13.9 ± 5.6% vs. 7.4 ± 1.8%, P = .046) in Group 1. A basal inferoseptal LS cutoff of 9.1% identified high troponin-T with an area under the curve (AUC) of 0.833 (P = .005), outperforming GLS (AUC 0.306, P = .217), BNP (AUC 0.667, P = .292), and LV ejection fraction (AUC 0.556, P = .743). CONCLUSIONS: Basal inferoseptal LS impairment may indicate early cardiac involvement in individuals with carpal tunnel syndrome carrying ATTRwt deposits.
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Characterization of left ventricular 2-dimentional strain imaging in carpal tunnel syndrome associated with wild-type transthyretin amyloidosis 査読あり
T Tsuruda , T Ota , T Terada , H Nakada , Y Suiko , Y Matsuura , M Ogata , M Tanaka , S Komaki , K Moribayashi , M Yamaguchi , H Tanaka , K Yamamoto , T Ideguchi , K Kaikita
European Heart Journal 46 2025年11月
掲載種別：研究論文（学術雑誌）
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Nogami K., Nishikawa Y., Mochida K., Terada T., Azuma M., Nakai M., Amano M.
Journal of Dermatology 52 ( 10 ) 1519 - 1526 2025年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Dermatology
The prognostic utility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in adult T-cell leukemia/lymphoma (ATLL) remains unclear, particularly in patients with indolent subtypes and cutaneous involvement. This study aimed to evaluate the usefulness of FDG-PET in predicting clinical outcomes in patients with indolent ATLL presenting with skin lesions. We retrospectively reviewed indolent ATLL with cutaneous involvement who underwent <sup>18</sup>F-fluorodeoxyglucose positron emission tomography at our institute for initial disease staging between April 2007 and March 2022. The data obtained were compared with the findings of cutaneous involvement in ATLL. The effect of maximum standardized uptake value on progression-free survival was analyzed using the Kaplan–Meier method. Patients were divided into groups based on whether their maximum standardized uptake value was above or below the overall mean maximum standardized uptake value (2.18), and progression-free survival was compared between the groups. Forty-three patients with indolent ATLL were included. We divided the cutaneous involvement of ATLL into six subtypes according to a previously reported classification of eruption types: patch, plaque, multipapular, nodulotumoral, erythrodermic, and purpuric. A total of 18 of 43 patients (41.9%) had <sup>18</sup>F-fluorodeoxyglucose-positive cutaneous lesions. However, 25 patients showed no <sup>18</sup>F-fluorodeoxyglucose uptake in cutaneous lesions. There was a significant difference in the mean maximum standardized uptake value between the nodulotumoral and multipapular (p = 0.036), nodulotumoral and patch (p = 0.036). There was a statistically significant difference in progression-free survival between the maximum standardized uptake value ≥ 2.18 and < 2.18 groups (p = 0.020). These findings indicate that the maximum standardized uptake value in cutaneous lesions could determine the prognostic association of ATLL with cutaneous lesions. Careful follow-up is required for patients with a higher maximum standardized uptake value for cutaneous lesions.
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Yamazaki K., Higashi T., Nishii R., Terada T., Mizutani Y., Ogura Y., Akamatsu M., Kuroiwa T., Makishima H., Wakatsuki M., Ishikawa H.
Annals of Nuclear Medicine 39 ( 8 ) 781 - 791 2025年8月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Annals of Nuclear Medicine
Objective: Carbon-ion radiotherapy (CIRT) is known as a promising treatment for liver tumors. However, no method has been established for estimating post-therapeutic residual liver reserve capacity (pRLRC). We previously introduced the estimation method of pRLRC using <sup>99 m</sup>Tc-galactosyl human serum albumin (<sup>99 m</sup>Tc-GSA) scintigraphy (Yamazaki method). In this study, we developed “Yamazaki-variant” method for pRLRC using dose distribution data of CIRT planning. The purpose of this study was to compare pRLRC calculated by Yamazaki method and Yamazaki-variant in CIRT patients for liver tumors, and to provide the clinical advantages in both methods in terms of estimating ability of pRLRC. Methods: Patients who received CIRT for liver tumors in our hospital and underwent <sup>99 m</sup>Tc-GSA scintigraphy before and 3 months after CIRT, and contrast-enhanced liver MRI within 1 month before CIRT were included. A total of 71 patients, 21 additional to the 50 previously reported, were evaluated. The maximal removal rate of <sup>99 m</sup>Tc-GSA (GSA-Rmax) was analyzed and the GSA-Rmax of the estimated residual liver (GSA-RL) was calculated using fusion images of MRI and SPECT by Yamazaki method. In Yamazaki-variant, multiple simulations were performed using the dose distribution of the CIRT planning and SPECT fusion images to obtain higher diagnostic accuracy of GSA-RL. Two of these estimates, Validation 1 and Validation 2 by Yamazaki-variant, were used as validation data. GSA-RL and Validation 1 and 2 were compared with GSA-Rmax 3 months after CIRT (post-GSA-Rmax) using linear regression analysis. Results: GSA-RL, Validation 1 and 2 were calculated as 0.448 ± 0.214, 0.413 ± 0.199 and 0.435 ± 0.208 mg/min, respectively. Post-GSA-Rmax was 0.428 ± 0.220 mg/min. The relationship between post-GSA-Rmax and each parameter was y = 0.02 + 0.90x (R<sup>2</sup> = 0.78) for GSA-RL, y = 0.02 + 0.94x (R<sup>2</sup> = 0.79) for Estimation 1, y = 0.02 + 0.99x (R<sup>2</sup> = 0.80) for Estimation 2, respectively (P <.0001). Both Yamazaki method and Yamazaki-variant showed comparable accurate estimation ability for post-GSA-Rmax. Conclusions: The estimation of pRLRC by Yamazaki method and Yamazaki-variant was in good agreement with post-therapeutic liver reserve capacity after CIRT, and there was no difference in the accuracy of the estimation. The usefulness of Yamazaki method, which is simpler and more clinically applicable, was confirmed. Trial registration : This study is registered in UMIN Clinical Trials Registry (UMIN-CTR) as UMIN study ID: UMIN000038328 and UMIN000049770, UMIN000038174.
書籍等出版物 【 表示 ／ 非表示 】
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画像診断
寺田珠沙、長町茂樹、平井俊範（ 担当： 共著）
学研メディカル秀潤社 2017年4月
担当ページ：595 記述言語：日本語 著書種別：学術書
MISC 【 表示 ／ 非表示 】
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Azuma M., Nakada H., Takei M., Nakamura K., Katsuragawa S., Shinkawa N., Terada T., Masuda R., Hattori Y., Ide T., Kimura A., Shimomura M., Kawano M., Matsumura K., Meiri T., Ochiai H., Hirai T.
Emergency Radiology 29 ( 2 ) 425 2022年4月
記述言語：英語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：Emergency Radiology
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虚血性心疾患診断における冠動脈領域別の位相解析指標の有用性の検討
寺田珠沙、長町茂樹、鬼塚久充、水谷陽一、平井俊範、北村和雄
臨床放射線 63 ( 2 ) 185 - 190 2018年2月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌） 出版者・発行元：金原出版
講演・口頭発表等 【 表示 ／ 非表示 】
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心機能解析ソフトウェアを用いた位相解析指標の虚血診断能の検討
寺田 珠沙
第62回日本核医学会学術総会
開催年月日： 2022年9月9日 - 2022年9月11日
会議種別：口頭発表（一般）
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虚血性心疾患診断における心筋血流SPECTを用いた位相解析の有用性
寺田 珠沙
第35回海の中道RIカンファランス
開催年月日： 2022年7月9日
会議種別：口頭発表（招待・特別）
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去勢抵抗性前立腺癌骨転移患者におけるRa-223投与後の生存期間に関連するパラメータの検討
木村 綾、寺田珠沙、水谷陽一、榮 建文、岡部 洸、寺田直樹
第192回日本医学放射線学会九州地方会 (WEB)
開催年月日： 2021年2月7日
記述言語：日本語 会議種別：口頭発表（一般）
開催地：WEB
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ANN値を用いて心筋虚血診断を行う際の真陽性群と偽陰性群の比較検討
寺田珠沙、長町茂樹、鬼塚久充、水谷陽一、平井俊範
第60回日本核医学会学術総会 (兵庫県神戸市)
開催年月日： 2020年11月12日 - 2020年11月14日
記述言語：日本語 会議種別：口頭発表（一般）
開催地：兵庫県神戸市
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Comparison of quantitative parameters between bone SPECT and spectral CT in prostate cancer patients with bone metastases
Mizutani Y, Terada T, Hirai T
第79回日本医学放射線学会総会（JRC2020） (WEB)
開催年月日： 2020年5月15日 - 2020年6月14日
記述言語：日本語 会議種別：ポスター発表
開催地：WEB