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Affiliation |
Faculty of Medicine College Hospital Clinical training center after [sotsu] |
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Title |
Assistant Professor |
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External Link |
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KIMOTO Yasuhiro
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Papers 【 display / non-display 】
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Kimoto Yasuhiro, Kurogi Atsuko, Taniguchi Elina, Ikeda Toshio, Moritake Hiroshi
NO TO HATTATSU 54 ( 1 ) 51 - 55 2022
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Child Neurology
Acute encephalitis with refractory, repetitive partial seizures (AERRPS) are extremely intractable encephalitides that require intensive care, including long-term mechanical ventilation management. Continuous intravenous administration of barbiturate is commonly performed for seizure suppression ; however, it may have serious complications. Here, we present a 6-year-old boy with AERRPS. Generalized tonic seizures followed by focal seizures frequently occurred after high-grade fever. Seizures were refractory to conventional treatment, and ventilatory management and brain normothermia therapy were then performed in the intensive care unit. Following diagnosis of AERRPS, administration of continuous thiamylal infusion resulted in disappearance of seizures ; however, it induced organ damage. Thus, administration of very-high-dose phenobarbital (PB) (maximum blood concentration is 243μg/mL) instead of thiamylal was selected. As seizures recurred when the dose of PB was reduced, concomitant treatment with a ketogenic diet was performed, and the seizures disappeared and the electroencephalogram improved promptly. To withdraw PB, perampanel (PER) was selected. PER administration induced a reduction in PB and withdrawal of mechanical ventilation on day 49. Subsequently, the patient was adjusted for antiepileptic drugs and the seizures became weekly short focal seizures, and was discharged on foot. In conclusion, we experienced a case of AERRPS that could be managed with very-high-dose PB therapy, which had the same efficacy as the continuous intravenous high-dose barbiturate infusion. Moreover, PER is effective for withdrawal from acute treatment, and active use of PER for younger AERRPS is considered to be one of the options.
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Tokyo Women's Medical University Journal 4 ( 0 ) 94 - 97 2020.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Society of Tokyo Women's Medical University
Books 【 display / non-display 】
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画像で診る遺伝性白質疾患 診断の手引き
木許恭宏（ Role： Contributor , 脱髄型末梢神経障害，中枢性髄鞘形成不全症，Waardenburg症候群，Hirschsprung病を伴う髄鞘形成不全症（PCWH））
診断と治療社 2021.6
Language：Japanese Book type：Scholarly book
Presentations 【 display / non-display 】
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A case of PCWH with a novel missense mutation in the SOX10 gene.
2021.5.27
Event date： 2021.5.27 - 2021.5.29
Language：Japanese Presentation type：Poster presentation