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研究・産学地域連携推進機構 知的財産・研究リスクマネジメント部門 |
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Genetic analysis of chymotrypsin inhibitors in the hemolymph of Bombyx mori.
Fujii H., Doira H., Aratake H., Koga K.
Journal of Sericultural Science of Japan 65 ( 5 ) 334 - 341 1996年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Sericultural Science of Japan
On polyacrylamide gel electrophoresis followed by activity staining, 16 a -chymotrypsin inhibitors (CIs-1, 2, 2', 3 to 6, 6', 7 to 11, 12, 13 and 13') were revealed in the larval hemolymph of the silkworm, Bombyx mori. Here we confirmed that the expression of 11 of these are co-dominantly controlled by alleles belonging to 4 CI genes. CIs-13 and 13' were found to be controlled by the alleles Ict-AF and Asrespectively. The alleles for CIs-10 and 9 were named Ict-BF and 5srespectively, and for CIs-2', 2 and 1 Ict-HFHM and Hsrespectively. The let-A, B and H gene complex was located on the 2nd linkage group at the map position of 23.7. There were 2 “null”alleles, Bn and IP, on this linkage group. CIs-8, 7, 6' and 6 were controlled by the alleles Ict-DFDMDs and DRrespectively, located on the 19th linkage group at the map position of 29.1. The CIs belonging to the Ict-A or D group exhibited no null counterparts in all the strains so far tested and these CI components may be indispensable for the growth of the silkworm. © 1996, The Japanese Society of Sericultural Science. All rights reserved.
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Genetic analysis of hemolymph chymotrypsin inhibitors-3 and 4 in the silkworm, Bombyx mori
Fujii H., Aratake H., Doira H.
Journal of Sericultural Science of Japan 65 ( 5 ) 385 - 389 1996年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Sericultural Science of Japan
Out of 16 chymotrypsin inhibitors (CIs) present in the larval hemolymph of Bombyx mori, the 2 components CIs-3 and 4 were subjected to genetic analysis in the present study. These CIs were found to be controlled by a co-dominant autosomal gene named Ict-E, with the alleles for CIs-4 and 3 assigned to be Ict-EF and Esrespectively, since CI-4 migrated faster toward the anode than CI-3 on polyacrylamide gel electrophoresis. Linkage tests showed that the Ict-E alleles were linked to the mw (minute wing) gene located on the 22nd linkage group. Three point experiment indicated the locus of the Ict-E gene to be 8.6 units left of mw, which had previously been mapped at the starting position of the 22nd linkage group. Consequently, Ict-E should be at the starting position instead of mw, and the arrangement of the 3 genes should be Ict-E (O.O)-or (8.9)-mw (25.2). © 1996, The Japanese Society of Sericultural Science. All rights reserved.
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Differential expression of ARIA isoforms in the rat brain 査読あり
G Corfas, K Rosen, H Aratake, R Krauss and G Fischbach
Neuron 14 ( 1 ) 103 - 115 1995年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Hasegawa Y., Sugimoto E., Endo T., Ogawa K., Morikawa A., Aratake H., Kitaguchi N.
Biological and Pharmaceutical Bulletin 18 ( 12 ) 1750 - 1754 1995年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Biological and Pharmaceutical Bulletin
Alzheimer's β-amyloid protein (Aβ) is the main component of senile plaques, which are characteristic hallmarks of the Alzheimer's disease brain. Recently, there have been several reports that Aβ has toxic effects on both cultured neurons and in the brain. We confirmed the neurotoxicity of Aβ in vitro and found a new compound, called AZ36041 (4-chloro-N-(5-nitro-2-tiazoyl) benzenesulfone amide), which dramatically reduced Aβ neurotoxicity. This compound was also found to have a neuroprotective effect against toxicity of glutamate and enhanced neuronal survival in the absence of neurotoxic compounds. AZ36041 may be a useful tool for investigating the mechanism of Aβ neurotoxicity in vitro and in vivo. © 1995, The Pharmaceutical Society of Japan. All rights reserved.
DOI： 10.1248/bpb.18.1750
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Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture
Araki W., Kitaguchi N., Tokushima Y., Ishii K., Aratake H., Shimohama S., Nakamura S., Kimura J.
Biochemical and Biophysical Research Communications 181 ( 1 ) 265 - 271 1991年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Biochemical and Biophysical Research Communications
We investigated the effect of human β-amyloid precursor protein (APP) on rat primary cerebral cortical neurons cultured in a serum-free medium. Two secretory APP species (APP667 and APP592) with and without the protease inhibitor domain were produced by COS-1 cells transfected with APP cDNAs, which encode the N-terminal portions of APP770 and APP695. Both highly purified APP species, when added to the medium, enhanced neuronal survival and neurite extension in a dose-dependent manner with a maximum effect at approximately 100 nM. These results suggest that secreted forms of APP have trophic activity for cerebral cortical neurons. © 1991 Academic Press, Inc.
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第57回宮崎日日新聞賞
2021年11月 宮崎日日新聞社 ブルーベリー茎葉抽出成分の新型コロナウイルス不活化効果
森下和広、岡林環樹、國武久登、菅本和寛
受賞区分：出版社・新聞社・財団等の賞
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実用化に向けたロコモ年齢測定システムの開発
2022年11月 - 2023年03月
吉玉精鍍株式会社 国内共同研究
鄧 鋼、帖佐 悦男、荒武 尚
担当区分：研究分担者 共同研究区分：国内共同研究