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Affiliation |
Faculty of Medicine College Hospital Clinical training center after [sotsu] |
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Assistant Professor |
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External Link |
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ODA Yasuharu
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Papers 【 display / non-display 】
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Oda Y., Tsubouchi H., Ishii N., Kitamura A., Moriyama E., Mitsutome E., Sakai K., Shiomi K., Yanagi S., Miyazaki T.
Respiratory Medicine Case Reports 46 101930 2023.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Respiratory Medicine Case Reports
Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy and are often associated with difficulty in induction of chemotherapy. Here we report the case of a patient with SCLC concomitant with two paraneoplastic syndromes, syndrome of inappropriate antidiuretic hormone secretion (SIADH) and Lambert–Eaton myasthenic syndrome (LEMS), who was treated with a platinum-doublet chemotherapy regimen. A 66-year-old male patient presented with a 1-month history of progressive proximal muscle weakness, ataxia gait and 5 kg of body weight loss. The laboratory tests revealed hyponatremia due to SIADH and the existence of antibodies against P/Q-type voltage-gated calcium channels. The nerve conduction study showed a low amplitude of compound muscle action potential (0.38 mv), a 34% decrement on 3-Hz stimulation, and a 1939% increment after maximum voluntary contraction in 10 seconds (7.75 mv). The endobronchial ultrasound transbronchial needle aspiration biopsy revealed the pathological findings of SCLC. A 2-cycle chemotherapy regimen of irinotecan plus cisplatin resulted in temporary tumor shrinkage that lasted 2 months, but the improvement of proximal muscle weakness and hyponatremia were maintained over the tumor re-progression period after chemotherapy. Although paraneoplastic syndromes accelerate the decrease in performance status, chemotherapy for SCLC may improve symptoms related to paraneoplastic syndromes and could be considered in similar cases.
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Mitsutome E., Yanagi S., Uchida T., Horiguchi T., Tsubouchi H., Sumiyoshi M., Kitamura A., Oda Y., Ueno H., Yamaguchi H., Miyazaki T.
Journal of Infection and Chemotherapy 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Most cases of nontuberculous mycobacterial pulmonary disease (NTM-PD) have a progressive clinical course, and initiation of treatment is recommended rather than watchful waiting. The NTM-PD medications are frequently associated with adverse reactions, occasionally serious. Optimization of the methods for monitoring and managing adverse events in NTM-PD treatment is thus an important medical issue. Here we report a first case of postprandial hypoglycemia caused by the combination of clarithromycin (CAM) and rifampicin (RFP) in a patient with NTM-PD. A 73-year-old Japanese woman with NTM-PD was hospitalized for treatment with a combination of oral CAM, RFP, and ethambutol. She took the first doses of antibiotics before breakfast, and 3 h later went into a hypoglycemic state. Postprandial hypoglycemia occurred with high reproducibility and was accompanied by relative insulin excess. Continuous glucose monitoring with or without food and in combination with various patterns of medication revealed that the combination of CAM and RFP specifically induced postprandial hypoglycemia. Shifting the timing of administration of the CAM and RFP combination from morning to before sleep corrected the hypoglycemia and enabled continuation of the antimicrobial treatment. In conclusion, our report suggests the importance of introducing NTM-PD medication under inpatient management in order to closely monitor and early detect postprandial hypoglycemia and other serious adverse events.
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新研修医オリエンテーションにおける実技主体の実習と動画視聴主体の実習への研修医評価の比較 Reviewed
宮内俊一、森林耕平、小田康晴、鈴木翔、谷口智明、樋口和宏、木許恭宏、大平洋明、日高康太郎、後藤智子、小松弘幸
日本シミュレーション医療教育学会雑誌 11 77 - 83 2023.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by Ascaris suum. Reviewed
Nobuhiro Matsumoto, Hironobu Tsubouchi, Kensuke Setoguchi, Takanori Horiguchi, Takafumi Shigekusa, Shinpei Tsuchida, Ayako Matsuo, Yasuharu Oda, Shigehisa Yanagi, Haruhiko Maruyama, Masamitsu Nakazato
Internal medicine (Tokyo, Japan) 60 ( 18 ) 2899 - 2903 2021
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine
Objective Visceral larva migrans (VLM) caused by Ascaris suum is a major health problem in pig farming regions. The clinical characteristics of pulmonary VLM caused by A. suum, however, are unclear. We assessed the clinico-radiologic features of this disease. Methods Medical records, including the results of chest radiography and high-resolution computed tomography (HRCT), were retrospectively reviewed from January 2000 through June 2019, at the University of Miyazaki Hospital and Kyoritsuiin Hospital in Miyazaki Prefecture, Japan. Results Seven patients with VLM caused by A. suum were identified. All seven patients had a unique habit of consuming raw foods, such as organic vegetables, chicken, turkey, wild boar, and venison. All but one patient, who had eosinophilic pneumonia with a fever and severe fatigue, had only mild or no respiratory symptoms. All 7 patients had remarkable eosinophilia (median, 1960/μL) and high serum IgE levels (median, 1346 IU/mL). Chest HRCT revealed multiple nodules and multiple nodular ground-glass opacities in 57% and 29% of the patients, respectively. The pulmonary lesions were located predominantly in subpleural areas. All seven patients were treated with albendazole, which led to improvement within two to three months. Neither eggs nor parasites were detected in the feces or sputum of any patient. Conclusion Consumption of raw organic vegetables or raw meat is a possible route of A. suum infection. Infected patients exhibit mild respiratory symptoms, and multiple nodules with a halo in the subpleural area are a common finding on chest HRCT. Treatment with albendazole was effective in these cases.
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Yoshikawa N, Tazaki T, Hatanaka M, Oda Y, Matsumoto N, Sonoda J, Ikeda R
Journal of Clinical Pharmacy and Therapeutics 44 ( 1 ) 119 - 121 2019.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Pharmacy and Therapeutics
© 2018 John Wiley & Sons Ltd What is known and objective: Multi-drug combinations often make chemotherapy difficult owing to drug-drug interactions (DDIs). We report a rare and difficult-to-treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs. Case description: A 70-year-old Japanese woman was diagnosed as having pulmonary MAC disease. She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital. Serum phenytoin concentrations increased upon the initiation of MAC infection treatment. What is new and Conclusion: We evaluated DDIs and adjusted the dosage of drugs by monitoring the serum drug level.
DOI： 10.1111/jcpt.12764
Presentations 【 display / non-display 】
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IV期EGFR陽性肺腺癌の転移性縦隔リンパ節が小細胞癌に転化した一例
大槻佑生子、堀口崇典、小田康晴、北村 彩、重草貴文、土田真平、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第62回日本呼吸器学会学術講演会
Event date： 2022.4.22 - 2022.4.24
Presentation type：Oral presentation (general)
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蘇生的開胸術後に左上葉肺捻転を起こした一例
北村 彩、小田康晴、宗像 駿、前田 亮、富田雅樹、堀口崇典、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第88回日本呼吸器学会・日本結核非結核性抗酸菌症病学会九州支部春季各術講演会
Event date： 2022.3.19
Presentation type：Oral presentation (general)
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当院で検出したEGFR遺伝子変異陽性肺腺癌におけるuncommon mutation症 例の報告
土田真平、北村 彩、堀口崇典、重草貴文、小田康晴、坪内拡伸、柳 重久、松元信弘、宮﨑泰可
第88回日本呼吸器学会・日本結核非結核性抗酸菌症病学会九州支部春季各術講演会
Event date： 2022.3.19
Presentation type：Oral presentation (general)
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デキサメタゾン投与下で両側副腎転移によるAddiso病が疑われた肺腺癌の1例
瀬戸暁子、堀口崇典、内田泰介、重草貴文、土田真平、小田康晴、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第335回日本内科学会九州地方会
Event date： 2021.11.14
Presentation type：Oral presentation (general)
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胸部外科手術後に放線菌による皮下膿瘍を発症した1例
山田愛加理、北村 彩 、堀口崇典、土田真平、重草貴文、小田康晴、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第335回日本内科学会九州地方会
Event date： 2021.11.14
Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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オクタン酸トリグリセリドを用いた呼吸不全カヘキシア包括的治療法の開発研究
Grant number：21K11264 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
松元 信弘
Authorship：Coinvestigator(s)
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1細胞解析結果に基づく肺癌の発癌責任間葉サブクラスターとCAF起源細胞の決定
Grant number：21K08159 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
柳 重久、坪内 拡伸、小田 康晴
Authorship：Coinvestigator(s)