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Faculty of Medicine College Hospital Clinical training center after [sotsu] |
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Assistant Professor |
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Related SDGs |
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ODA Yasuharu
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Papers 【 display / non-display 】
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Oda Y., Tsubouchi H., Ishii N., Kitamura A., Moriyama E., Mitsutome E., Sakai K., Shiomi K., Yanagi S., Miyazaki T.
Respiratory Medicine Case Reports 46 101930 2023.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Respiratory Medicine Case Reports
Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy and are often associated with difficulty in induction of chemotherapy. Here we report the case of a patient with SCLC concomitant with two paraneoplastic syndromes, syndrome of inappropriate antidiuretic hormone secretion (SIADH) and Lambert–Eaton myasthenic syndrome (LEMS), who was treated with a platinum-doublet chemotherapy regimen. A 66-year-old male patient presented with a 1-month history of progressive proximal muscle weakness, ataxia gait and 5 kg of body weight loss. The laboratory tests revealed hyponatremia due to SIADH and the existence of antibodies against P/Q-type voltage-gated calcium channels. The nerve conduction study showed a low amplitude of compound muscle action potential (0.38 mv), a 34% decrement on 3-Hz stimulation, and a 1939% increment after maximum voluntary contraction in 10 seconds (7.75 mv). The endobronchial ultrasound transbronchial needle aspiration biopsy revealed the pathological findings of SCLC. A 2-cycle chemotherapy regimen of irinotecan plus cisplatin resulted in temporary tumor shrinkage that lasted 2 months, but the improvement of proximal muscle weakness and hyponatremia were maintained over the tumor re-progression period after chemotherapy. Although paraneoplastic syndromes accelerate the decrease in performance status, chemotherapy for SCLC may improve symptoms related to paraneoplastic syndromes and could be considered in similar cases.
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悪性胸水に対するTalcとOK-432による胸膜癒着術の検討． Reviewed
小田康晴、松元信弘、瀬戸口健介、宇都加寿子、重草貴文、松尾彩子、坪内拡伸、坂元昭裕、今津善史、有村保次、柳 重久、飯干宏俊、中里雅光
宮崎県医師会医学会誌 42 17 - 21 2018
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Mitsutome E., Yanagi S., Uchida T., Horiguchi T., Tsubouchi H., Sumiyoshi M., Kitamura A., Oda Y., Ueno H., Yamaguchi H., Miyazaki T.
Journal of Infection and Chemotherapy 31 ( 1 ) 102482 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Most cases of nontuberculous mycobacterial pulmonary disease (NTM-PD) have a progressive clinical course, and initiation of treatment is recommended rather than watchful waiting. The NTM-PD medications are frequently associated with adverse reactions, occasionally serious. Optimization of the methods for monitoring and managing adverse events in NTM-PD treatment is thus an important medical issue. Here we report a first case of postprandial hypoglycemia caused by the combination of clarithromycin (CAM) and rifampicin (RFP) in a patient with NTM-PD. A 73-year-old Japanese woman with NTM-PD was hospitalized for treatment with a combination of oral CAM, RFP, and ethambutol. She took the first doses of antibiotics before breakfast, and 3 h later went into a hypoglycemic state. Postprandial hypoglycemia occurred with high reproducibility and was accompanied by relative insulin excess. Continuous glucose monitoring with or without food and in combination with various patterns of medication revealed that the combination of CAM and RFP specifically induced postprandial hypoglycemia. Shifting the timing of administration of the CAM and RFP combination from morning to before sleep corrected the hypoglycemia and enabled continuation of the antimicrobial treatment. In conclusion, our report suggests the importance of introducing NTM-PD medication under inpatient management in order to closely monitor and early detect postprandial hypoglycemia and other serious adverse events.
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Kitamura A., Yanagi S., Shide K., Sato Y., Kamiunten A., Yamanari Y., Kitamura A., Sumiyoshi M., Oda Y., Tsubouchi H., Shimoda K., Miyazaki T.
American Journal of Case Reports 25 e945804 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Case Reports
Patient: Male, 32-year-old Final Diagnosis: B-acute lymphoblastic leukemia Symptoms: Dyspnea • face swelling Clinical Procedure: — Specialty: Oncology Objective: Unknown etiology Background: Fibrosing mediastinitis (FM) is a rare, fibroproliferative disorder within the mediastinum. It is extremely rare for hematologic malignancies to develop as FM. Case Report: A 32-year-old Japanese man with a 1-month history of headache and 2-week history of facial swelling underwent chest computed tomography (CT); a diffuse mass-like lesion was revealed in the anterior mediastinum with severe stenosis of vital mediastinal organs. After a surgical biopsy, an initial diagnosis of idiopathic FM was made. The FM lesions responded mildly to corticosteroids but recurred repeatedly. Sixteen months after the treatment initiation, blasts appeared in the peripheral blood (PB), and the patient was diagnosed with B-acute lymphoblastic leukemia/lymphoblastic lymphoma (B-ALL/LBL). Chemotherapy led to complete remission of the B-ALL/LBL and almost complete disappearance of FM-like lesions. Immunohistochemistry of the mediastinal biopsy specimen taken before the blasts’ appearance in PB demonstrated a CD34/CD7/terminal deoxynucleotidyl transferase-positive population, an identical pattern of expression common to the blasts in the patient’s PB and bone marrow. Conclusions: This is the first case report of B-ALL/LBL presenting as FM. This case underscores the importance of considering the possibility of latent hematologic malignancy even in the absence of new symptoms other than those caused by FM lesions for a long period of time. This is the first demonstration that leukemia cells may be present in the FM lesions from the initial stage of disease onset. Even if a diagnosis of idiopathic FM is confirmed, continued suspicion of the presence of hematologic malignancy is vital for improving patient outcomes.
DOI： 10.12659/AJCR.945804
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Comparison of evaluation by residents between simulation-based training and video-assisted lectures in induction training Reviewed
11 77 - 83 2023.7
Language：Japanese Publishing type：Research paper (scientific journal)
Presentations 【 display / non-display 】
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IV期EGFR陽性肺腺癌の転移性縦隔リンパ節が小細胞癌に転化した一例
大槻佑生子、堀口崇典、小田康晴、北村 彩、重草貴文、土田真平、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第62回日本呼吸器学会学術講演会
Event date： 2022.4.22 - 2022.4.24
Presentation type：Oral presentation (general)
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当院で検出したEGFR遺伝子変異陽性肺腺癌におけるuncommon mutation症 例の報告
土田真平、北村 彩、堀口崇典、重草貴文、小田康晴、坪内拡伸、柳 重久、松元信弘、宮﨑泰可
第88回日本呼吸器学会・日本結核非結核性抗酸菌症病学会九州支部春季各術講演会
Event date： 2022.3.19
Presentation type：Oral presentation (general)
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蘇生的開胸術後に左上葉肺捻転を起こした一例
北村 彩、小田康晴、宗像 駿、前田 亮、富田雅樹、堀口崇典、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第88回日本呼吸器学会・日本結核非結核性抗酸菌症病学会九州支部春季各術講演会
Event date： 2022.3.19
Presentation type：Oral presentation (general)
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デキサメタゾン投与下で両側副腎転移によるAddiso病が疑われた肺腺癌の1例
瀬戸暁子、堀口崇典、内田泰介、重草貴文、土田真平、小田康晴、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第335回日本内科学会九州地方会
Event date： 2021.11.14
Presentation type：Oral presentation (general)
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胸部外科手術後に放線菌による皮下膿瘍を発症した1例
山田愛加理、北村 彩 、堀口崇典、土田真平、重草貴文、小田康晴、坪内拡伸、柳 重久、松元信弘、宮崎泰可
第335回日本内科学会九州地方会
Event date： 2021.11.14
Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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自然肺腺癌モデルマウスの1細胞解析で発見した間葉亜集団の発癌への必須性の解明
Grant number：24K11319 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Coinvestigator(s)
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オクタン酸トリグリセリドを用いた呼吸不全カヘキシア包括的治療法の開発研究
Grant number：21K11264 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
松元 信弘
Authorship：Coinvestigator(s)
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1細胞解析結果に基づく肺癌の発癌責任間葉サブクラスターとCAF起源細胞の決定
Grant number：21K08159 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
柳 重久、坪内 拡伸、小田 康晴
Authorship：Coinvestigator(s)