所属 |
医学部 附属病院 消化管・内分泌・小児外科 |
職名 |
助教 |
研究室住所 |
宮崎市清武町木原5200 |
連絡先 |
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外部リンク |
所属学協会 【 表示 / 非表示 】
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日本光線力学学会
2019年 - 現在
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日本組織細胞化学会
2019年 - 現在
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日本内視鏡外科学会
2018年 - 現在
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日本腹部救急医学会
2018年 - 現在
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日本大腸肛門病学会
2018年 - 現在
論文 【 表示 / 非表示 】
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A Preliminary Pathological Evaluation of Extracellular Volume Fraction with Contrast-enhanced Computed Tomography as a Novel Quantitative Parameter of Pancreatic Fibrosis. 査読あり
Kai K, Hiyoshi M, Imamura N, Hamada T, Yano K, Sato Y, Sakae T, Komi M, Nakamura T, Choijookhuu N, Hishikawa Y, Nanashima A
Internal medicine (Tokyo, Japan) 62 ( 8 ) 1107 - 1115 2023年
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An alternative option of the retroperitoneal laparoscopic approach for limited hepatectomy for recurrent hepatocellular carcinoma at the transected edge after previous hepatectomy. 査読あり
Hamada T, Yano K, Kitamura E, Hiyoshi M, Imamura N, Kai K, Tahira K, Kawano F, Ohta Y, Nanashima A
Asian journal of endoscopic surgery 2023年3月
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Correction: Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. 査読あり
Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y
Journal of ovarian research 16 ( 1 ) 21 2023年1月
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Kai K., Hamada T., Sato Y., Hiyoshi M., Imamura N., Yano K., Ikeda T., Ichihara A., Ogata S., Choijookhuu N., Hishikawa Y., Hosokawa A., Nanashima A.
Journal of Oncology 2023 1440257 2023年
記述言語:日本語 掲載種別:研究論文(学術雑誌) 出版者・発行元:Journal of Oncology
Background. Oxaliplatin (OX)-based chemotherapy induces sinusoidal obstruction syndrome (SOS) in the nontumorous liver parenchyma, which can increase the risk of liver resection due to colorectal liver metastasis (CRLM). The extracellular volume (ECV) calculated from contrast-enhanced computed tomography (CT) has been reported to reflect the morphological change of hepatic fibrosis. The present retrospective study aimed to evaluate the ECV fraction as a predictive factor for OX-induced SOS. Methods. Our study included 26 patients who underwent liver resection for CRLM after OX-based chemotherapy with a preoperative dynamic CT of appropriate quality. We investigated the relationship between the pathological SOS grade and the ECV fraction. Results. Overall, 26 specimens from the patients were graded with the SOS classification of Rubbia-Brandt et al. as follows: grade 0, n = 17 (65.4%); grade 1, n = 4 (15.4%); and grade 2, n = 5 (19.2%). No specimens showed grade 3 SOS. In a univariate analysis, the ECV fraction in grade 0 SOS was significantly lower than that in grade 1 + 2 SOS (26.3 ± 3.4% vs. 30.6 ± 7.0%; P = 0.025). The cutoff value and AUC value of the ECV fraction to distinguish between grades 0 and 1 + 2 were 27.5% and 0.771, respectively. Conclusions. Measurement of the ECV fraction was found to be a potential noninvasive diagnostic method for determining early-stage histopathological sinusoidal injury induced by OX-based chemotherapy.
DOI: 10.1155/2023/1440257
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Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. 査読あり
Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y
Journal of ovarian research 15 ( 1 ) 133 2022年12月
MISC 【 表示 / 非表示 】
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Rare resected eight cases of duodenal adenocarcinomas
Nanashima A., Tanoue Y., Imamura N., Hiyoshi M., Yano K., Hamada T., Nishida T., Kai K., Suzuki Y., Sato Y., Nakashima K., Hosokawa A., Nagayasu T.
International Journal of Surgery Case Reports 86 106384 2021年9月
記述言語:日本語 掲載種別:速報,短報,研究ノート等(学術雑誌) 出版者・発行元:International Journal of Surgery Case Reports
Introduction: Duodenal adenocarcinoma is a rare malignancy; recently, it has been found to be accompanied by operative indications. Methods: Nine consecutive rare cases were diagnosed with duodenal carcinoma (DC), in which clinicopathological characteristics were retrospectively examined. Age was ranged over middle-aged males and females. No clinical onset with severe symptoms was observed, and the specific treatment for accompanied diseases or habits was not found. Outcomes: One case of two T1 stage DCs that underwent pancreas-sparing duodenectomy. Stage II DC was diagnosed in three cases, and stage III DC was diagnosed in four cases. Pancreaticoduodenectomy (PD) mainly occurred in seven patients, and duodenectomy was limited in two patients. All operations were safely performed, and the postoperative course showed no severe morbidity. Histological findings showed R0 resection in eight cases and R1 at the retroperitoneal dissecting part in one case. Five patients with advanced-stage DC underwent adjuvant chemotherapy; however, four patients showed tumor recurrence within 12 months. With additional strong chemotherapy, eight patients survived up to 84 months, and one died of liver metastasis at 43 months after surgery. Three representative cases of mucosal invasion with widespread pancreas-sparing duodenectomy and advanced-stage DC cases undergoing duodenectomy or PD are shown. Conclusion: In the field of upper digestive tract surgery, duodenal adenocarcinoma and various applications of surgery or adjuvant chemotherapy for long-term survival are important.
講演・口頭発表等 【 表示 / 非表示 】
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A Clinicopathological Study of Extracellular Volume Fraction Determined by Contrast Enhanced Computed Tomography as a Predictive Factor of Pancreatic Fistula after Pancreaticoduodenectomy 国際会議
Kai K, Hiyoshi M, Imamura N, Hamada T, Yano K, Sato Y, Sakae T, Choijookhuu N, Hishikawa Y, Nanashima A
15th IHPBA World Congress
開催年月日: 2022年3月30日 - 2022年4月2日
会議種別:ポスター発表
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当院における妊娠合併虫垂炎に対する 腹腔鏡下虫垂切除術の経験と工夫
甲斐健吾,池田拓人,市原明子,河野文彰,濱田朗子,松澤聡,鮫島浩,七島篤志
第13回Acute care surgery学会学術集会
開催年月日: 2021年11月4日 - 2021年11月27日
会議種別:シンポジウム・ワークショップ パネル(公募)
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膵頭十二指腸切除術における術後膵液漏の発生と造影CTによる細胞外血管外腔算出値の関連
甲斐健吾,旭吉雅秀,矢野公一,今村直哉,濱田剛臣,佐藤勇一朗,榮建文,七島篤志
JDDW 2021 KOBE
開催年月日: 2021年11月4日 - 2021年11月7日
会議種別:口頭発表(一般)
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当科における大腸癌肝転移に対する初回肝切除の治療成績と血清CRP・アルブミン比の意義
甲斐健吾,濱田剛臣,池田拓人,市原明子,今村直哉,旭吉雅秀,内勢由佳子,原大介,鈴木康人,七島篤志
第46回日本大腸肛門病学会九州地方会
開催年月日: 2021年10月16日
会議種別:シンポジウム・ワークショップ パネル(公募)
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当院での経腹壁的エラストグラフィによる膵線維化診断能の病理学的検証
甲斐健吾,濱田剛臣,旭吉雅秀,矢野公一,今村直哉,佐藤勇一朗,河上洋,田島栄美,七島篤志
日本超音波医学会第31回九州地方会学術集会
開催年月日: 2021年10月3日
会議種別:口頭発表(一般)
科研費(文科省・学振・厚労省)獲得実績 【 表示 / 非表示 】
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食道癌に対する光線力学療法による薬剤耐性軽減効果の証明と新規治療開発に向けた検証
研究課題/領域番号:20K17694 2020年04月 - 2023年03月
独立行政法人日本学術振興会 科学研究費補助金 若手研究
担当区分:研究代表者