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Faculty of Medicine College Hospital Mother and child health center of integrated perinatal period |
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Assistant Professor |
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Related SDGs |
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TAKAHASHI Masako
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Papers 【 display / non-display 】
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Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts.
Hirono K, Hata Y, Ichimata S, Nishida N, Imamura T, Asano Y, Kuramoto Y, Tsuboi K, Takarada S, Okabe M, Nakaoka H, Ibuki K, Ozawa S, Muneuchi J, Yasuda K, Urayama K, Oka H, Miyamoto T, Baba K, Kato A, Saiki H, Kuwabara N, Harada M, Baba S, Morikawa M, Iwasaki H, Hirata Y, Ito Y, Sakaguchi H, Urata S, Toda K, Kittaka E, Okada S, Hasebe Y, Hoshino S, Fujii T, Mitsushita N, Nii M, Ogino K, Fujino M, Yoshida Y, Fukuda Y, Iwashima S, Takigiku K, Sakata Y, Inuzuka R, Maeda J, Hayabuchi Y, Fujioka T, Namiki H, Fujita S, Nishida K, Kuraoka A, Kan N, Kido S, Watanabe K, Ichida F
Scientific reports 14 ( 1 ) 30469 2024.12
Language：English Publishing type：Research paper (scientific journal)
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Isolated Blind-Ended Major Aortic Pulmonary Collateral Artery With an Aneurysm in an Infant With Trisomy 21.
Yonaga R, Kodama Y, Takamura K, Harada M, Moritake H
Cureus 16 ( 10 ) e72078 2024.10
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.7759/cureus.72078
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Determination of Genotype and Phenotypes in Pediatric Patients With Biventricular Noncompaction
Hirono K., Hata Y., Imamura T., Tsuboi K., Takarada S., Okabe M., Nakaoka H., Ibuki K., Ozawa S., Ichimata S., Nishida N., Iwasaki H., Urata S., Okada S., Hiratsuji T., Sakaguchi H., Takigiku K., Nakazawa M., Nishihara E., Harada M., Matsuo O., Yasuda K., Yoshida Y., Namiki H., Yasuda K., Ifuku T., Urayama K., Oka H., Ogino K., Kato A., Kan N., Seki S., Seki M., Odanaka Y., Iwashima S., Yoshida S., Miyata T., Miyamoto T., Watanabe K., Kuwabara N., Inuzuka R., Takahashi Y., Sakazaki H., Muneuchi J., Kogaki S., Numano F., Kido S., Nii M., Hoshino S., Ishida H., Maeda J., Hayabuchi Y., Otsubo Y., Ikeda K., Tsukano S., Watanabe M., Momoi N., Fujii T., Fujioka T., Fujino M., Uchiyama H., Baba S., Horigome H., Honda T., Suzuki K., Ichida F.
Journal of the American Heart Association 13 ( 21 ) 2024
Publishing type：Research paper (scientific journal) Publisher：Journal of the American Heart Association
BACKGROUND: Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy characterized by prominent tra-beculations. Detailed characteristics of biventricular noncompaction (BiVNC) remain unknown. This study aimed to elucidate the clinical characteristics and genetic landscape of BiVNC.METHODS AND RESULTS: We recruited children with left ventricular noncompaction from Japanese multi-institutional centers from 2013 to 2021. Left ventricular noncompaction was classified as BiVNC, congenital heart disease, arrhythmia, dilated car-diomyopathy, or normal function. In these patients, cardiomyopathy-associated genes were screened. A total of 234 patients (127 male; mean age, 4 months [range, 0–6.6 years]) were enrolled in this study, of whom 25 had BiVNC; 55, normal function; 84, dilated cardiomyopathy; 38, congenital heart disease; and 32, arrhythmia. BiVNC was diagnosed during the perinatal period in 10 patients, in whom the prevalence was higher than that in other patients. A total of 14 patients in the group with BiVNC had congenital heart disease, but not necessarily right heart lesions. Left ventricular dyskinesis was frequently observed in the lateral wall (24%) and apex (28%). Eleven pathogenic variants were found in 11 patients with BiVNC (44.0%). The group with BiVNC had a higher ratio of mitochondrial and developmental gene variants than the other groups. Among all groups, the group with BiVNC had the worst survival rate (P=0.0009). CONCLUSIONS: Pediatric patients with BiVNC had a high rate of ventricular dyskinesis and poor outcome. A comprehensive and careful screening for disease-causing genes and phenotype may help identify specific patients with left ventricular noncom-paction and mortality-related cardiac phenotypes.
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Cytokine Storm Originating from the Intrapericardial Cavity in a Child With Pericardial Effusion Following COVID-19
Ebihara Shusei, Kodama Yoshihiko, Takamura Kazunari, Harada Masako, Moritake Hiroshi
Journal of Pediatric Cardiology and Cardiac Surgery advpub ( 0 ) 82 - 86 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児循環器学会
Symptoms of coronavirus infectious disease 2019 (COVID-19) are usually mild in young patients. Some children, however, present with a significant degree of complications which may be associated with an excessive reaction by the immune system. Herein, we report an analysis of cytokine and chemokine in an 11-year-old girl diagnosed with left ventricular dysfunction and cardiac tamponade complicated with COVID-19. She recovered without complications after intravenous immunoglobulin, dexamethasone, remdesivir, and surgical pericardial drainage. Cytokine concentrations had markedly increased in the pericardial fluid specimen; especially for interleukin-6 being disproportionate to its serum concentration. Cytokine storm originating from the pericardial cavity was considered an underlying mechanism of her condition.
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宮崎県における免疫グロブリン療法不応川崎病に対する 血漿交換療法の現状 Reviewed
山本 絵里子
宮崎医会誌 47 ( 1 ) 36 - 40 2023.3
Language：Japanese Publishing type：Research paper (scientific journal)
MISC 【 display / non-display 】
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Chida-Nagai A., Masaki N., Maeda K., Sasaki K., Sato H., Muneuchi J., Ochiai Y., Murayama H., Tahara M., Shiono A., Shinozuka A., Kono F., Machida D., Toyooka S., Sugimoto S., Nakamura K., Akagi S., Kondo M., Kasahara S., Kotani Y., Koizumi J., Oda K., Harada M., Nakajima D., Murata A., Nagata H., Yatsunami K., Kobayashi T., Matsunaga Y., Inoue T., Yamagishi H., Nakagawa N., Ohtani K., Yamamoto M., Ito Y., Hokosaki T., Kuwahara Y., Masutani S., Nomura K., Wada T., Sawada H., Abiko M., Takahashi T., Ishikawa Y., Okada S., Naitoh A., Toda T., Ando T., Masuzawa A., Hoshino S., Kawada M., Nomura Y., Ueno K., Ohashi N., Tachibana T., Cao Y., Ueda H., Yanagi S., Koide M., Mitsushita N., Higashi K., Minosaki Y., Hayashi T., Okamoto T., Kuraishi K., Ehara E., Ishida H., Horigome H., Murakami T., Takei K., Ishii T., Harada G., Hirata Y., Maeda J., Tatebe S., Ota C., Hayabuchi Y., Sakazaki H., Sasaki T., Hirono K., Suzuki S., Yasuda M., Takeda A., Sawada M., Miyaji K., Kitagawa A., Nakai Y., Kakimoto N., Agematsu K., Manabe A., Saiki Y.
Frontiers in Cardiovascular Medicine 11 1369831 2024
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Frontiers in Cardiovascular Medicine
In the published article, an author name was incorrectly written as Madoka Sawai. The correct spelling is Madoka Sawada. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.