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Faculty of Medicine College Hospital Mother and child health center of integrated perinatal period |
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Assistant Professor |
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MURAOKA Junsuke
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Papers 【 display / non-display 】
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A Case of Systemic Chemotherapy With Paclitaxel/Cisplatin Followed by Wide Local Vulvectomy in Pelvic Lymph Nodes-Related Stage IVB Vulvar Cancer Reviewed
Junsuke Muraoka, Naotake Tanaka, Takahiro Sugiyama, Makiko Itami, Kiyomi Suzuka
Cureus 16 ( 5 ) 2024.4
Authorship：Lead author Language：English Publishing type：Case report
DOI： 10.7759/cureus.60432
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Impact of COVID-19 on Cytomegalovirus Immunoglobulin M Antibody Index Reviewed
Kaneko M., Muraoka J., Yang L., Tokunaga S., Minematsu T.
Clinical and Experimental Obstetrics and Gynecology 50 ( 12 ) 2023.12
Publishing type：Research paper (scientific journal) Publisher：Clinical and Experimental Obstetrics and Gynecology
Background: Coronavirus disease 2019 (COVID-19) influenced the prevalence of other infectious diseases, including congenital cytomegalovirus (CMV) infection. However, the effect of COVID-19 on antibody titers has not been reported. This study aimed to explore the influence of COVID-19 on levels of CMV immunoglobulin M (IgM) in pregnant women. Methods: This cross-sectional study included pregnant women who visited the University Hospital due to CMV IgM positivity during the 7th and 8th waves of COVID-19. Data, including maternal characteristics, history of COVID-19, CMV immunoglobulin G (IgG) and IgM index, and IgG avidity index (AI) were collected. Chemiluminescent immunoassay was performed to measure levels of IgG and IgM. Polymerase chain reaction using neonatal urine was performed to confirm congenital infection. Results: Of the 89 pregnant women, 36 (40%) (low IgG AI: n = 10; high IgG AI: n = 26) contracted COVID-19. Among 21 women with low IgG AI, 9 (false IgM positive: n = 8; primary infection: n = 1) had an IgG AI of 0. Among the eight women with false IgM positivity, six (75%) contracted COVID-19. The IgM index of pregnant women with false IgM positivity was 12.6 ± 10.9. Meanwhile, the CMV IgM index of pregnant women with false IgM positivity in the non-COVID-19-infected group was 1.7 ± 0.5. When the IgM indices of women who contracted (n = 36) and did not contract (n = 53) COVID-19 were compared, the IgM index of infected women (4.4 ± 5.7) was higher than those of non-infected women (2.7 ± 3.0) (p = 0.01). Regarding IgM and IgG AI, multiple logistic regression analysis revealed that there were no significantly different variables between the two groups. Conclusions: High prevalence of false IgM positivity was observed among women who contracted COVID-19. The IgM index of pregnant women with false IgM positivity was high. Caution should be exercised in interpreting CMV IgM indices in pregnant women with a history of COVID-19.
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Sakakibara Kouhei, Yamada Naoshi, Kodama Yuki, Obata Shizuka, Tsuzuki Yasue, Muraoka Junsuke, Aoki Yoshinori, Yamashita Rie, Nakame Kazuhiko, Kaneko Masatoki, Katsuragi Shinji, Tsuzuki Ryo, Sato Yuichiro
Journal of Japan Society of Perinatal and Neonatal Medicine 59 ( 1 ) 116 - 121 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Perinatal and Neonatal Medicine
Here we report a case of pulmonary lymphangiectasia that caused exacerbation of respiratory status after an infection. A preterm infant born at 23 weeks of gestation without obvious clinical intrauterine infection showed worsening respiratory status and increased c-reactive protein on day 15 of life. Chest X-ray showed consolidation in right upper lobe and whole left lung. Several broad-spectrum antibiotics were administered unsuccessfully. Finally, <i>Ureaplasma urealyticum</i> was detected in sputum culture, and azithromycin was administered. Although the inflammation improved, tension pneumothorax and pulmonary hypertension developed and he died on day 44 of life. At autopsy, there were few findings of lung inflammation, and congenital lymphangiectasia was diagnosed. It seems that exacerbation was triggered by the infection, although there was no remarkable evidence to support causality. There have been few case reports of pulmonary lymphangiectasia in extremely low birth weight infants. This case was considered to be classified as primary, although the respiratory condition at birth was relatively good. There are no clear diagnostic criteria for this disease and no effective treatments. Clinically, neonatologists should keep in mind pulmonary lymphangiectasia if respiratory failure in newborns does not respond to common treatment approach.
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Fetal Distress and Neonatal Death After Thoracoamniotic Shunting Therapy Due to Hydrops Associated With Transient Abnormal Myelopoiesis. Reviewed
Muraoka J, Yoshimoto N, Ohsawa A, Matsuzawa S, Katsuragi S
Cureus 14 ( 9 ) e28991 2022.9
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.7759/cureus.28991
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Muraoka J., Kaneko M., Doi K., Kodama Y., Sameshima H.
Microbiology Research 13 ( 3 ) 598 - 608 2022.9
Publishing type：Research paper (scientific journal) Publisher：Microbiology Research
The use of prenatal antibiotics should be carefully considered, owing to their potential adverse effects on neonatal outcomes. This study aimed to identify the contributing factors to early-onset neonatal infection and to determine the influence of antepartum antibiotics on women and neonates. This study included 127 pregnant women without obvious intra-amniotic infection on admission, who delivered under 34 weeks of gestation. Information on maternal and neonatal characteristics was obtained from their medical charts. Vaginal swabs were taken from all women on admission. In total, 29 (22.8%) neonates developed early-onset infection. Multivariate analysis revealed that antepartum antibiotics were the most strongly associated factor for early-onset neonatal infection (odds ratio, 11.2; 95% confidence interval, 4.08–31.02). The frequency of early-onset neonatal infection was significantly higher in women who received antibiotic therapy than in those who did not; no significant difference in prolonging their gestation or neonatal morbidities was observed. The prevalence of women who hosted vaginal microorganisms on admission was similar to that in women whose infants subsequently developed early-onset neonatal infection compared with that of women whose infants did not. Among infants of the 40 women who received antepartum antibiotic therapy, 21 developed early-onset infection. Of the women who delivered these 21 infants, 62% (13/21) showed reduced lactobacilli and 43% (9/21) had resistant bacterial strains in their vaginal microbiota at the time of delivery. The use of antepartum antibiotics is the most strongly associated factor in early-onset neonatal infection; it does not prolong gestation and would change the vaginal environment.
Books 【 display / non-display 】
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改定第2版 早産のすべて
村岡純輔，児玉由紀（ Role： Contributor , 子宮内感染／炎症の原因検索を目的とした羊水穿刺の意義と実際について教えてください）
メジカルビュー社 2025.7
Book type：Scholarly book
Presentations 【 display / non-display 】
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子宮体部中腎様腺癌の細胞像
村岡純輔，佐藤勇一郎，野口裕史，平田徹，桂木真司
第64回日本臨床細胞学会秋期大会 2025.11.29
Event date： 2025.11.29 - 2025.11.30
Presentation type：Oral presentation (general)
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子宮瘤膿腫の穿孔による汎発性腹膜炎の1例
村岡純輔、山内綾、大塚晃生、寺尾公成
第76回九州連合産科婦人科学会・第70回九州ブロック産婦人科医会
Event date： 2019.5.18 - 2019.5.19
Language：Japanese Presentation type：Oral presentation (general)
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周産期ネットワークシステムの報告
村岡純輔
宮崎市郡産婦人科医会4月例会
Event date： 2019.4.28
Language：Japanese Presentation type：Oral presentation (general)
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腟閉鎖術後に診断し手術加療した子宮体癌の1例
村岡純輔、山内綾、大塚晃生、寺尾公成
2019年度宮崎県産婦人科医会・宮崎県産科婦人科学会春期定時総会・学術講演会
Event date： 2019.4.27
Language：Japanese Presentation type：Oral presentation (general)
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シートベルト外傷により子宮胎盤損傷並びに胎児死亡を来した一例
村岡純輔、山内綾、大塚晃生、寺尾公成
第71回日本産科婦人科学会学術講演会
Event date： 2019.4.11 - 2019.4.14
Language：Japanese Presentation type：Oral presentation (general)