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• 上大静脈症候群およびTrousseau症候群を伴った転移性尿路上皮癌に対してエンホルツマブ・ベドチン療法が著効した1例 査読あり

  飛田 卓哉, 藤田 直子, 村嶋 隆哉, 藤井 将人, 永井 崇敬, 鬼塚 千衣, 西本 紘嗣郎, 澤田 篤郎, 向井 尚一郎, 賀本 敏行

  泌尿器科紀要   71 ( 6 )   191 - 195   2025年6月

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  記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：泌尿器科学術研究会  

  We report a case of superior vena cava syndrome and trousseau syndrome in a patient with metastatic urothelial carcinoma treated with enfortumab vedotin. The patient was a 59-year-old woman diagnosed with left renal pelvic cancer with multiple lymph node metastases and liver metastasis. Treatment with gemcitabine and cisplatin reduced the size of the local tumor but resulted in liver metastasis progression after three cycles. The patient was switched to pembrolizumab which resulted in rapid tumor growth causing superior vena cava syndrome and trousseau syndrome. Hyper-progression was suspected and the patient was immediately switched to enfortumab vedotin. After enfortumab vedotin therapy, the tumor and multiple metastases shrank significantly and tumor reduction was maintained.

  DOI： 10.14989/actauroljap_71_6_191

  CiNii Research

• Mixed sex cord stromal tumor of the testis composed of granulosa, Leydig, and Sertoli cell tumor components: a case report 査読あり

  村嶋 隆哉, 藤井 将人, 永井 崇敬, 向井 尚一郎, 賀本 敏行

  Journal of Medical Case Reports   19   118   2025年3月

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  記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

  Introduction
  Mixed sex cord stromal tumor is defined as a tumor consisting of various combinations of sex cord stromal elements, and the tumor is extremely rare.
  
  Case presentation
  A 76-year-old Japanese male visited our hospital complaining of left scrotal swelling. Magnetic resonance imaging of the mass showed a multilocular cystic pattern with different degrees of intensities in each cyst. The solid component was observed in part showing hypointensity on the T2-weighted image. Although there was no apparent evidence of malignancy in cytology of punctured fluid of the cystic tumor, malignant potential was not ruled out completely. Therefore, transinguinal radical orchiectomy was performed, and the tumor was diagnosed as mixed sex cord stromal tumor consisting of adult-type granulosa cell tumor, Leydig cell tumor and Sertoli cell tumor components. The patient recovered without any postoperative event. In addition, neither apparent recurrence nor metastasis was observed at 7 years after surgery.
  
  Conclusion
  The tumor showed a multilocular cystic appearance with solid component, which was similar in appearance to previous reports of the same pathological features. Pathological findings of each component were compatible with those of mixed sex cord stromal tumor, and immunohistochemical analysis was useful for accurate diagnosis. The tumor was successfully resected, and no apparent recurrence was observed at 7 years after surgery.

  CiNii Research

• Paratesticular cellular angiofibroma: a case report 査読あり

  Takaya Murashima

  Journal of Medical Case Reports   18 ( 1 )   170   2024年4月

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  担当区分：筆頭著者   記述言語：英語   掲載種別：症例報告  

  DOI： 10.1186/s13256-024-04499-y

  PubMed