Affiliation |
Faculty of Medicine School of Medicine Department of Medical Sciences, Cardiovascular Physiology |
Title |
Professor |
External Link |
WATANABE Nozomi
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Papers 【 display / non-display 】
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Madhyastha H., Madhyastha R., Chakraborty E., Banerjee K., Shah K., Nakajima Y., Chauhan N.S., Sudhakaran S.L., Ohe K., Muthukaliannan G.K., Gopalakrishnan A.V., Maruyama M., Watanabe N.
International Journal of Molecular Sciences 24 ( 4 ) 2023.2
Language:English Publishing type:Research paper (scientific journal) Publisher:International Journal of Molecular Sciences
Currently, there is a great demand for the development of nanomedicine aided wound tissue regeneration via silver doped nanoceuticals. Unfortunately, very little research is being carried out on antioxidants-doped silver nanometals and their interaction on the signaling axis during the bio-interface mechanism. In this study, c-phycocyanin primed silver nano hybrids (AgcPCNP) were prepared and analyzed for properties such as cytotoxicity, metal decay, nanoconjugate stability, size expansion, and antioxidant features. Fluctuations in the expression of marker genes during cell migration phenomena in in vitro wound healing scenarios were also validated. Studies revealed that physiologically relevant ionic solutions did not exhibit any adverse effects on the nanoconjugate stability. However, acidic, alkali, and ethanol solutions completely denatured the AgcPCNP conjugates. Signal transduction RT2PCR array demonstrated that genes associated with NFĸB- and PI3K-pathways were significantly (p < 0.5%) altered between AgcPCNP and AgNP groups. Specific inhibitors of NFĸB (Nfi) and PI3K (LY294002) pathways confirmed the involvement of NFĸB signaling axes. In vitro wound healing assay demonstrated that NFĸB pathway plays a prime role in the fibroblast cell migration. In conclusion, the present investigation revealed that surface functionalized AgcPCNP accelerated the fibroblast cell migration and can be further explored for wound healing biomedical applications.
DOI: 10.3390/ijms24043184
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The emerging role of exosomes in innate immunity, diagnosis and therapy Reviewed
Gangadaran P., Madhyastha H., Madhyastha R., Rajendran R.L., Nakajima Y., Watanabe N., Velikkakath A.K.G., Hong C.M., Gopi R.V., Muthukalianan G.K., Valsala Gopalakrishnan A., Jeyaraman M., Ahn B.C.
Frontiers in Immunology 13 1085057 2023.1
Language:English Publishing type:Research paper (scientific journal) Publisher:Frontiers in Immunology
Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining homeostasis by exchanging genetic or metabolic information between different cells. Exosomes can also play a vital role in transferring virulent factors between the host and parasite, thereby regulating host gene expression and the immune interphase. The association of inflammation with disease development and the potential of exosomes to enhance or mitigate inflammatory pathways support the notion that exosomes have the potential to alter the course of a disease. Clinical trials exploring the role of exosomes in cancer, osteoporosis, and renal, neurological, and pulmonary disorders are currently underway. Notably, the information available on the signatory efficacy of exosomes in immune-related disorders remains elusive and sporadic. In this review, we discuss immune cell-derived exosomes and their application in immunotherapy, including those against autoimmune connective tissue diseases. Further, we have elucidated our views on the major issues in immune-related pathophysiological processes. Therefore, the information presented in this review highlights the role of exosomes as promising strategies and clinical tools for immune regulation.
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JCS 2021 Guideline on the Clinical Application of Echocardiography
Ohte Nobuyuki, Ishizu Tomoko, Izumi Chisato, Itoh Hiroshi, Iwanaga Shiro, Okura Hiroyuki, Otsuji Yutaka, Sakata Yasushi, Shibata Toshihiko, Shinke Toshiro, Seo Yoshihiro, Daimon Masao, Takeuchi Masaaki, Tanabe Kazuaki, Nakatani Satoshi, Nii Masaki, Nishigami Kazuhiro, Hozumi Takeshi, Yasukochi Satoshi, Yamada Hirotsugu, Yamamoto Kazuhiro, Izumo Masaki, Inoue Katsuji, Iwano Hiroyuki, Okada Atsushi, Kataoka Akihisa, Kaji Shuichiro, Kusunose Kenya, Goda Akiko, Takeda Yasuharu, Tanaka Hidekazu, Dohi Kaoru, Hamaguchi Hirotoshi, Fukuta Hidekatsu, Yamada Satoshi, Watanabe Nozomi, Akaishi Makoto, Akasaka Takashi, Kimura Takeshi, Kosuge Masami, Masuyama Tohru, on behalf of the Japanese Circulation Society Joint Working Group
Circulation Journal 86 ( 12 ) 2045 - 2119 2022.12
Language:English Publishing type:Research paper (scientific journal) Publisher:The Japanese Circulation Society
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Miyoshi M., Watanabe N., Fukuda T., Nishino S., Kimura T., Furugen M., Ashikaga K., Takahashi N., Shibata Y.
Journal of Echocardiography 20 ( 4 ) 201 - 207 2022.12
Language:English Publishing type:Research paper (scientific journal) Publisher:Journal of Echocardiography
Background: Successful implantation of the WATCHMAN device requires an accurate understanding of left atrial appendage (LAA) anatomy and orifice dimensions. Racial differences are observed in LAA size when comparing Asians with non-Asians. Methods: A total of 170 patients (123 male, 67.4 ± 9.2 years) with paroxysmal or persistent atrial fibrillation (AF) underwent transesophageal echocardiography before catheter ablation or cardioversion (September 2018 to September 2019). As per the recommendations of the WATCHMAN device, the maximal LAA ostial diameters were measured at multiplane angles of 0°, 45°, 90°, and 135°. Results: The majority of patients (121/170, 71%) had an LAA orifice size within 17–25 mm. Fifteen (8.8%) patients had undersized (< 17 mm) and eight (0.5%) had oversized (> 31 mm) LAA. One patient in this population had no LAA. LAA size was significantly larger in patients with persistent AF than in those with paroxysmal AF (23.3 ± 4.2 mm vs. 20.0 ± 3.0 mm, p < 0.001) and in male patients than in female patients (22.4 ± 4.2 vs. 20.9 ± 3.7 mm, p = 0.03). LAA orifice dimension was significantly correlated with CHADS2 score, the left atrial volume (LAV), E/e′, and the left ventricular ejection fraction. Persistent AF, body mass index, and LAV were independently associated with LAA orifice dimension in multivariate analysis. Conclusion: This study demonstrated the distribution of LAA orifice dimension in the Japanese AF patients. This finding should be used as a reference to understand the racial characteristics of LAA size for the WATCHMAN procedure.
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Prognostic impact of incident left ventricular systolic dysfunction after myocardial infarction Reviewed
Yoshioka G., Tanaka A., Watanabe N., Nishihira K., Natsuaki M., Kawaguchi A., Shibata Y., Node K.
Frontiers in Cardiovascular Medicine 9 1009691 2022.9
Language:English Publishing type:Research paper (scientific journal) Publisher:Frontiers in Cardiovascular Medicine
Introduction: We sought to investigate the prognostic impact of incident left ventricular (LV) systolic dysfunction at the chronic phase of acute myocardial infarction (AMI). Materials and methods: Among 2,266 consecutive patients admitted for AMI, 1,330 patients with LV ejection fraction (LVEF) ≥ 40% during hospitalization who had LVEF data at 6 months after AMI were analyzed. Patients were divided into three subgroups based on LVEF at 6 months: reduced-LVEF (<40%), mid-range-LVEF (≥ 40% and < 50%) and preserved-LVEF (≥ 50%). Occurrence of a composite of hospitalization for heart failure or cardiovascular death after 6 months of AMI was the primary endpoint. The prognostic impact of LVEF at 6 months was assessed with a multivariate-adjusted Cox model. Results: Overall, the mean patient age was 67.5 ± 11.9 years, and LVEF during initial hospitalization was 59.4 ± 9.1%. The median (interquartile range) duration of follow-up was 3.0 (1.5–4.8) years, and the primary endpoint occurred in 35/1330 (2.6%) patients (13/69 [18.8%] in the reduced-LVEF, 9/265 [3.4%] in the mid-range-LVEF, and 13/996 [1.3%] in the preserved-LVEF category). The adjusted hazard ratio for the primary endpoint in the reduced-LVEF vs. mid-range-LVEF category and in the reduced-LVEF vs. preserved-LVEF category was 4.71 (95% confidence interval [CI], 1.83 to 12.13; p < 0.001) and 14.37 (95% CI, 5.38 to 38.36; p < 0.001), respectively. Conclusion: Incident LV systolic dysfunction at the chronic phase after AMI was significantly associated with long-term adverse outcomes. Even in AMI survivors without LV systolic dysfunction at the time of AMI, post-AMI reassessment and careful monitoring of LVEF are required to identify patients at risk.
Books 【 display / non-display 】
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心筋症 Multimodalityを用いた診断・評価のすべて
渡邉 望( Role: Contributor , 肥大型心筋症様のエコーを見たときの鑑別診断・重症度評価・予後予測)
日本医事新報社 2024.1
Language:Japanese Book type:Textbook, survey, introduction
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進歩した低侵襲心臓カテーテル治療
渡邉 望( Role: Joint author , 心エコー図による評価)
大道學舘出版部 2023.9
Language:Japanese Book type:Textbook, survey, introduction
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循環器診療コンプリート 弁膜症
渡邉 望( Role: Contributor , 機能性僧帽弁逆流症の成因と診断、治療ストラテジー)
秀潤社 2022.8
Language:Japanese Book type:Textbook, survey, introduction
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ASE’s Comprehensive Echocardiography Third edition
Nozomi Watanabe( Role: Joint author , Chapter 75 Takotsubo Cardiomyopathy)
SAUNDERS 2021
Language:English Book type:Textbook, survey, introduction
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ハートバルブ・カンファレンス : 弁膜症診療の“キモ"がわかる : 徹底討論!
川副 浩平, 泉 知里, 渡邉 望, 渡辺 弘之( Role: Joint author)
メジカルビュー社 2021 ( ISBN:9784758319676 )
Language:Japanese Book type:Scholarly book
MISC 【 display / non-display 】
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Dynamic Nature of the Mitral Valve Morphology: Consideration of the Normal Ranges Reviewed
Kagiyama N., Maekawara S., Izumi Y., Watanabe N., Otsuji Y., Yoshida K.
Journal of the American Society of Echocardiography 36 ( 1 ) 125 - 126 2023.1
Language:English Publishing type:Rapid communication, short report, research note, etc. (scientific journal) Publisher:Journal of the American Society of Echocardiography
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Multiple asymptomatic coronary plaque ruptures and fissures in acute myocardial infarction Reviewed
Gi T., Nishino S., Yamashita A., Watanabe N., Shibata Y., Asada Y.
Pathology International 72 ( 6 ) 355 - 357 2022.6
Language:English Publishing type:Rapid communication, short report, research note, etc. (scientific journal) Publisher:Pathology International
DOI: 10.1111/pin.13229
Presentations 【 display / non-display 】
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心臓外科医と診る僧帽弁形成術の周術期心エコー図
渡邉 望
第19回KCH-CVS心臓疾患研究会 2021.10.9
Event date: 2021.10.9
Language:Japanese Presentation type:Oral presentation (general)
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インターベンション医と診る心エコー:最新モダリティを活かしたチーム医療のために Invited
渡邉 望
第27回日本心血管インターベンション治療学会(CVIT)中国・四国地方会 2021.9.14
Event date: 2021.9.14
Language:Japanese Presentation type:Oral presentation (invited, special)
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Case, Case, Case!! 症例から学ぶ心エコー Vol.2 Invited
渡邉 望
第13回実地医家のための心エコー図勉強会 2021.9.14
Event date: 2021.9.14
Language:Japanese Presentation type:Symposium, workshop panel (nominated)
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心筋病理と診る心エコー図 Invited
渡邉 望
知っておくべきファブリー病 in 東海 2021.8.19
Event date: 2021.8.19
Language:Japanese Presentation type:Oral presentation (general)
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循環器診断における心エコーの役割:薬物治療から最先端治療まで Invited
渡邉 望
第29回宮崎心エコー研究会 2021.8.2
Event date: 2021.8.2
Language:Japanese Presentation type:Oral presentation (invited, special)
Awards 【 display / non-display 】
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8. 9th Cardiovascular Clinical Research Investigator's Award "Clinical Research Investigator
2020.3 Japanese Circulation Society
Award type:Award from international society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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FMR治療における病理、遺伝子発現機構からの検証に基づいた左房機能評価の意義の確立
Grant number:23K08239 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship:Coinvestigator(s)
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Indo-Japan seminar: Future medical health by transdisciplinary approach
Grant number:JPJSBP 220227703 2023.02
Authorship:Principal investigator
Other external funds procured 【 display / non-display 】
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Educational Network for Early Diagnosis of Cardiac Amyloidosis: Kyushu-Okinawa Cardiovascular Imaging Academy for Noninvasive Cardiologists and Sonographers
Grant number:88780665 2021.11 - 2024.03
Pfizer Pfizer Independent Medical Education Grant
Authorship:Principal investigator
Available Technology 【 display / non-display 】
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Related fields where technical consultation is available:心臓超音波検査(三次元心エコー図解析・ストレイン解析など)
分子生物学的手法(PCR,ウエスタン・ブロットなど)、細胞生物学的手法(細胞培養、細胞・免疫染色、蛍光イメージングなど)Message:当教室では、循環生理学を基盤とした臨床と基礎の融合、他の基礎教室や宮崎大学の他学部との連携を深め、大学医学部ならではの領域を超えた活動を通し、新しい形での生理学教室として発展し、世界に向けて発信することを目指します。
大学病院や他の基幹病院、実地医家を含めた臨床病院との連携を強め、宮崎県の地域医療と大学医学部の発展に貢献できるよう、活動を進めています。