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Affiliation |
Faculty of Medicine School of Medicine Department of Medical Sciences, Cardiovascular Physiology |
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External Link |
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WATANABE Nozomi
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Papers 【 display / non-display 】
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Potential Effects of Mild Atrial Secondary Mitral Regurgitation in Patients With Isolated Atrial Fibrillation. Reviewed
Akashi J, Iwataki M, Nabeshima Y, Onoue T, Hayashi A, Tanaga T, Nishino S, Kimura T, Yano M, Watanabe N, Tsuda Y, Araki M, Shibata Y, Nishimura Y, Otsuji Y, Kataoka M.
Circ Cardiovasc Imaging. 2024.3
Language：English Publishing type：Research paper (scientific journal)
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Mitral Valve Early Systolic Billowing Induces Following Annular Expansion and Leaflet Augmentation in Barlow's Disease: Sequential Analysis using Three-dimensional Echocardiography. Reviewed
Amano M, Izumi C, Toki M, Yanagi Y, Hayashida A, Kawamoto T, Hiraoka A, Fukushima S, Sakaguchi T, Watanabe N, Yoshida K.
Eur Heart J Cardiovasc Imaging 1 - 11 2024.1
Language：English Publishing type：Research paper (scientific journal)
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Direct Oral Anticoagulants Would Be Best Choice for Atrial Fibrillation Patients After Coronary Stenting: Retrospective Study in a Japanese Population. Reviewed
Koiwaya H, Watanabe N, Kuriyama N, Shibata Y.
Kurume Medical Journal 68 ( 2 ) 97 - 106 2023.7
Language：English Publishing type：Research paper (scientific journal)
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Leaflet tear or what? A challenging echocardiographic diagnosis after percutaneous mitral valve edge-to-edge repair. Reviewed
Furugen M, Watanabe N, Kimura T, Yano M, Shibata Y.
Journal of Echocardiography 21 ( 1 ) 61 - 62 2023.3
Language：English Publishing type：Case report
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Madhyastha H., Madhyastha R., Chakraborty E., Banerjee K., Shah K., Nakajima Y., Chauhan N.S., Sudhakaran S.L., Ohe K., Muthukaliannan G.K., Gopalakrishnan A.V., Maruyama M., Watanabe N.
International Journal of Molecular Sciences 24 ( 4 ) 2023.2
Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Molecular Sciences
Currently, there is a great demand for the development of nanomedicine aided wound tissue regeneration via silver doped nanoceuticals. Unfortunately, very little research is being carried out on antioxidants-doped silver nanometals and their interaction on the signaling axis during the bio-interface mechanism. In this study, c-phycocyanin primed silver nano hybrids (AgcPCNP) were prepared and analyzed for properties such as cytotoxicity, metal decay, nanoconjugate stability, size expansion, and antioxidant features. Fluctuations in the expression of marker genes during cell migration phenomena in in vitro wound healing scenarios were also validated. Studies revealed that physiologically relevant ionic solutions did not exhibit any adverse effects on the nanoconjugate stability. However, acidic, alkali, and ethanol solutions completely denatured the AgcPCNP conjugates. Signal transduction RT2PCR array demonstrated that genes associated with NFĸB- and PI3K-pathways were significantly (p < 0.5%) altered between AgcPCNP and AgNP groups. Specific inhibitors of NFĸB (Nfi) and PI3K (LY294002) pathways confirmed the involvement of NFĸB signaling axes. In vitro wound healing assay demonstrated that NFĸB pathway plays a prime role in the fibroblast cell migration. In conclusion, the present investigation revealed that surface functionalized AgcPCNP accelerated the fibroblast cell migration and can be further explored for wound healing biomedical applications.
DOI： 10.3390/ijms24043184
Books 【 display / non-display 】
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心筋症 Multimodalityを用いた診断・評価のすべて
渡邉 望（ Role： Contributor , 肥大型心筋症様のエコーを見たときの鑑別診断・重症度評価・予後予測）
日本医事新報社 2024.1
Language：Japanese Book type：Textbook, survey, introduction
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進歩した低侵襲心臓カテーテル治療
渡邉 望（ Role： Joint author , 心エコー図による評価）
大道學舘出版部 2023.9
Language：Japanese Book type：Textbook, survey, introduction
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循環器診療コンプリート 弁膜症
渡邉 望（ Role： Contributor , 機能性僧帽弁逆流症の成因と診断、治療ストラテジー）
秀潤社 2022.8
Language：Japanese Book type：Textbook, survey, introduction
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ASE’s Comprehensive Echocardiography Third edition
Nozomi Watanabe（ Role： Joint author , Chapter 75 Takotsubo Cardiomyopathy）
SAUNDERS 2021
Language：English Book type：Textbook, survey, introduction
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ハートバルブ・カンファレンス : 弁膜症診療の“キモ"がわかる : 徹底討論!
川副 浩平, 泉 知里, 渡邉 望, 渡辺 弘之（ Role： Joint author）
メジカルビュー社 2021 （ ISBN:9784758319676 ）
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Mitral regurgitation improvement after successful atrial fibrillation ablation by using a 3D mapping system. Reviewed
Watanabe N, Ashikaga K.
Ann Cardiothoracsrg 13 ( 1 ) 99 - 101 2024.1
Authorship：Lead author Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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心エコー図による評価 Reviewed
渡邉 望
臨牀と研究 100 ( 9 ) 8 - 14 2023.9
Authorship：Lead author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Dynamic Nature of the Mitral Valve Morphology: Consideration of the Normal Ranges Reviewed
Kagiyama N., Maekawara S., Izumi Y., Watanabe N., Otsuji Y., Yoshida K.
Journal of the American Society of Echocardiography 36 ( 1 ) 125 - 126 2023.1
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Journal of the American Society of Echocardiography
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Multiple asymptomatic coronary plaque ruptures and fissures in acute myocardial infarction Reviewed
Gi T., Nishino S., Yamashita A., Watanabe N., Shibata Y., Asada Y.
Pathology International 72 ( 6 ) 355 - 357 2022.6
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Pathology International
DOI： 10.1111/pin.13229
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機能性僧帽弁逆流と治療：弁膜症治療ガイドライン2020改定を踏まえて Reviewed
渡邉 望
宮崎県医師会医学会誌 46 ( 1 ) 1 - 7 2022.3
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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経カテーテル的大動脈弁留置後の感染性心内膜炎に対し外科的大動脈弁置換術・僧帽弁置換術を要した一 例
尾方 美幸、松浦 祐之介、山村 善政 、海野 光佑、伊藤 芽生 、田中 美与 、海北 幸一、古川 貢之、渡邉 望
一般社団法人日本心エコー図学会第35回学術集会
Event date： 2024.4.19 - 2024.4.21
Presentation type：Poster presentation
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未修復複雑先天性心疾患の60歳代男性：不整脈と構造的心疾患に対するハートチームとしてのアプローチ
田中美与、山村 善政、冨田 俊介、尾方 美幸、兒玉 祥彦、海北 幸一 、古川 貢之、渡邉 望
一般社団法人日本心エコー図学会第35回学術集会
Event date： 2024.4.19 - 2024.4.21
Presentation type：Oral presentation (general)
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「三尖弁」未修復先天性心疾患の成人期に合併する高度TR:何をすべきか、何ができるのか
渡邉望
第8回江東豊洲心血管カンファレンス
Event date： 2024.3.23
Presentation type：Oral presentation (invited, special)
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成人領域における弁膜症、心筋症の心エコー図診断 up to date
渡邉望
第7回日本小児心臓MR研究会学術集会 2024.3.16
Event date： 2024.3.16
Presentation type：Oral presentation (invited, special)
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僧帽弁治療 Invited
渡邉望
第88回日本循環器学会学術集会
Event date： 2024.3.8 - 2024.3.10
Presentation type：Oral presentation (invited, special)
Awards 【 display / non-display 】
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8. 9th Cardiovascular Clinical Research Investigator's Award "Clinical Research Investigator
2020.3 Japanese Circulation Society
Award type：Award from international society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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FMR治療における病理、遺伝子発現機構からの検証に基づいた左房機能評価の意義の確立
Grant number：23K08239 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究（C）
Authorship：Coinvestigator(s)
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Indo-Japan seminar: Future medical health by transdisciplinary approach
Grant number：JPJSBP 220227703 2023.02
Authorship：Principal investigator
Other external funds procured 【 display / non-display 】
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Educational Network for Early Diagnosis of Cardiac Amyloidosis: Kyushu-Okinawa Cardiovascular Imaging Academy for Noninvasive Cardiologists and Sonographers
Grant number：88780665 2021.11 - 2024.03
Pfizer Pfizer Independent Medical Education Grant
Authorship：Principal investigator
Available Technology 【 display / non-display 】
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Related fields where technical consultation is available：心臓超音波検査（三次元心エコー図解析・ストレイン解析など）
分子生物学的手法（PCR,ウエスタン・ブロットなど）、細胞生物学的手法（細胞培養、細胞・免疫染色、蛍光イメージングなど）Message：当教室では、循環生理学を基盤とした臨床と基礎の融合、他の基礎教室や宮崎大学の他学部との連携を深め、大学医学部ならではの領域を超えた活動を通し、新しい形での生理学教室として発展し、世界に向けて発信することを目指します。
大学病院や他の基幹病院、実地医家を含めた臨床病院との連携を強め、宮崎県の地域医療と大学医学部の発展に貢献できるよう、活動を進めています。
