Papers - KAIKITA Koichi
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Bystander-witnessed cardiopulmonary resuscitation by nonfamily is associated with neurologically favorable survival after out-of-hospital cardiac arrest in Miyazaki City District. Reviewed
Tsuruda T, Hamahata T, Endo GJ, Tsuruda Y, Kaikita K
PloS one 17 ( 10 ) e0276574 2022.10
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Fujisue K, Yamamoto E, Sueta D, Arima Y, Hirakawa K, Tabata N, Ishii M, Ito M, Yamanaga K, Hanatani S, Hoshiyama T, Kanazawa H, Takashio S, Araki S, Usuku H, Nakamura T, Soejima H, Kaikita K, Kawano H, Matsushita K, Tsujita K
Journal of atherosclerosis and thrombosis 29 ( 9 ) 1285 - 1294 2022.9
Language：English Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本動脈硬化学会
<b>Aims: </b>Royal jelly, a creamy substance secreted by honeybees, has been reported to have beneficial effects against dyslipidemia and metabolic syndrome. However, the effects of royal jelly on atherogenesis remain unknown. Hence, we prospectively evaluated whether royal jelly augments vascular endothelial function, which can reflect early atherogenesis, in healthy volunteers.<b> </b><b>Methods: </b>This was a single-center, double-blind, 1:1 randomized placebo-controlled study conducted from October 2018 to December 2019. A total of 100 healthy volunteers were randomly assigned to receive either royal jelly 690 mg or placebo daily for 4 weeks. The primary endpoint was augmentation in vascular endothelial function as assessed using the change in the reactive hyperemia peripheral arterial tonometry index (RH-PAT) index, and the secondary endpoints were the changes in liver function and lipid profiles between baseline and 4 weeks after enrollment.<b> </b><b>Results: </b>The mean age of the participants was 35.0±9.3 years in the placebo group and 36.1±9.1 years in the royal jelly groups; 45% and 50% of the placebo and the royal jelly groups, respectively, were male. The percentage relative change in the RH-PAT index was significantly higher in the royal jelly group than in the placebo group (21.4%±53.1% vs. 0.05%±40.9%, <i>P</i>=0.037). The percentage relative changes in alanine aminotransferase and γ-glutamyl transpeptidase were significantly lower in the royal jelly group than in the placebo group (alanine aminotransferase: −6.06%±22.2% vs. 11.6%±46.5%, <i>P</i>=0.02; γ-glutamyl transpeptidase: −3.45%±17.8% vs. 4.62%±19.4%, <i>P</i>=0.045). Lipid profiles were not significantly different between the two groups.<b> </b><b>Conclusions: </b>Royal jelly might have antiatherogenic property by improving vascular endothelial function. It also augmented liver functions in healthy volunteers.
DOI： 10.5551/jat.63044
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Apical flow and wall motion dynamics in left ventricular outflow obstruction: a case report. Reviewed
Misumi I, Sato K, Nagano M, Haba K, Ohba K, Kaikita K, Tsujita K
Journal of echocardiography 20 ( 3 ) 178 - 179 2022.9
Language：English Publishing type：Research paper (scientific journal)
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Attempt of quality management seminar for clinical research by visitation in clinical departments at the University of Miyazaki Hospital: results from questionnaire survey Reviewed
Hitomi Morita, Toshihiko Yanagita, Koichiro Itai, Sosuke Iwae, Koichi Kaikita, Hideo Takeshima
50 ( suppl. 1 ) s62 - s66 2022.8
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Rivaroxaban Monotherapy vs Combination Therapy With Antiplatelets on Total Thrombotic and Bleeding Events in Atrial Fibrillation With Stable Coronary Artery Disease: A Post Hoc Secondary Analysis of the AFIRE Trial. Reviewed
Naito R, Miyauchi K, Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Hagiwara N, Kimura K, Hirayama A, Matsui K, Ogawa H, AFIRE Investigators.
JAMA cardiology 7 ( 8 ) 787 - 794 2022.6
Language：English Publishing type：Research paper (scientific journal)
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Rivaroxaban Underdose for Atrial Fibrillation with Stable Coronary Disease: The AFIRE Trial Findings. Reviewed
Arashi H, Yamaguchi J, Hagiwara N, Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Kimura K, Hirayama A, Matsui K, Ogawa H
Thrombosis and haemostasis 122 ( 9 ) 1584 - 1593 2022.6
Language：English Publishing type：Research paper (scientific journal)
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Impact of statins in patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association. Reviewed
Mori H, Takahashi J, Sato K, Miyata S, Takagi Y, Tsunoda R, Sumiyoshi T, Matsui M, Tanabe Y, Sueda S, Momomura SI, Kaikita K, Yasuda S, Ogawa H, Shimokawa H, Suzuki H, Japanese Coronary Spasm Association.
Journal of cardiology 80 ( 3 ) 226 - 231 2022.5
Language：English Publishing type：Research paper (scientific journal)
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Takotsubo cardiomyopathy after vaccination for coronavirus disease 2019 in a patient on maintenance hemodialysis. Reviewed
Toida R, Uezono S, Komatsu H, Toida T, Imamura A, Fujimoto S, Kaikita K
CEN case reports 11 ( 2 ) 220 - 224 2022.5
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Nakanishi N., Kaikita K., Ishii M., Kuyama N., Tabata N., Ito M., Yamanaga K., Fujisue K., Hoshiyama T., Kanazawa H., Hanatani S., Sueta D., Takashio S., Arima Y., Araki S., Usuku H., Nakamura T., Suzuki S., Yamamoto E., Soejima H., Matsushita K., Tsujita K.
Nutrition, Metabolism and Cardiovascular Diseases 32 ( 5 ) 1227 - 1235 2022.5
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Nutrition, Metabolism and Cardiovascular Diseases
Background and aims: Although antithrombotic treatments are established for coronary artery disease (CAD), they increase the bleeding risk, especially in malnourished patients. The total thrombus-formation analysis system (T-TAS) is useful for the assessment of thrombogenicity in CAD patients. Here, we examined the relationships among malnutrition, thrombogenicity and 1-year bleeding events in patients undergoing percutaneous coronary intervention (PCI). Methods and results: This was a retrospective analysis of 300 consecutive CAD patients undergoing PCI. Blood samples obtained on the day of PCI were used in the T-TAS to compute the thrombus formation area under the curve. We assigned patients to two groups based on the geriatric nutritional risk index (GNRI): 102 patients to the lower GNRI group (≤98), 198 patients to the higher GNRI group (98<). The primary endpoint was the incidence of 1-year bleeding events defined by Bleeding Academic Research Consortium criteria types 2, 3, or 5. The T-TAS levels were lower in the lower GNRI group than in the higher GNRI group. Kaplan-Meier analysis showed worse 1-year bleeding event-free survival in the lower GNRI group compared with the higher GNRI group. The combined model of the GNRI and the Academic Research Consortium for High Bleeding Risk (ARC-HBR) had good calibration and discrimination for bleeding risk prediction. In addition, having a lower GNRI and ARC-HBR positivity was associated with 1-year bleeding events. Conclusion: A lower GNRI could reflect low thrombogenicity evaluated by the T-TAS and determine bleeding risk in combination with ARC-HBR positivity.
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Increased thrombogenicity is associated with revascularization outcomes in patients with chronic limb-threatening ischemia. Reviewed
Kuyama N, Kaikita K, Ishii M, Mitsuse T, Nakanishi N, Fujisue K, Otsuka Y, Hanatani S, Sueta D, Takashio S, Araki S, Yamamoto E, Matsushita K, Tsujita K
Journal of vascular surgery 76 ( 2 ) 513 - 522 2022.4
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity. Reviewed
Tsuruda T, Sato Y, Tomita M, Tanaka H, Hatakeyama K, Otsu M, Kawano A, Nagatomo K, Yoshikawa N, Ikeda R, Asada Y, Kaikita K
Frontiers in cardiovascular medicine 9 833649 2022.4
Language：English Publishing type：Research paper (scientific journal)
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Kurogi K, Ishii M, Ikebe S, Kaichi R, Mori T, Komaki S, Yamamoto N, Yamanaga K, Arima Y, Yamamoto E, Kaikita K, Matsushita K, Tsujita K
Cardiovascular intervention and therapeutics 37 ( 2 ) 312 - 323 2022.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Cardiovascular Intervention and Therapeutics
Optical coherence tomography (OCT) has a higher resolution than intravascular ultrasound (IVUS) and enables a more precise evaluation of calcium severity. We investigated the impact of the imaging method (OCT versus IVUS) on stent expansion during intravascular imaging-guided percutaneous coronary intervention (PCI) in calcified lesions. In this single-center, retrospective, observational study, 145 lesions with moderate to severe calcification were divided into four groups: 40 IVUS-guided rotational atherectomy (RA), 38 IVUS-guided non-RA, 35 OCT-guided RA, and 32 OCT-guided non-RA. Lesions without pre-procedural intravascular imaging were excluded. OCT-guided RA was associated with greater stent expansion at the target calcium compared with IVUS-guided RA (median 88.0%, interquartile range [78.0–96.0] vs. 76.5% [71.0–84.3], P = 0.008). Furthermore, stent expansion in OCT-guided non-RA was similar to OCT-guided RA. OCT-guided RA used a larger burr compared to IVUS-guided RA (1.75 mm [1.50–2.0] vs. 1.50 mm [1.50–1.75], P = 0.004). In OCT-guided RA, the median minimum calcium thickness was significantly reduced from 800 (640–980) µm to 550 (350–680) µm (P < 0.001). There was no significant difference in the incidence of ischemia driven target lesion revascularization between the four groups (P = 0.37). By determining the indication and endpoint of lesion modification by RA based on the thickness of calcium, OCT-guided PCI was associated with significantly greater stent expansion compared with IVUS-guided PCI.
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Myocardial Tissue Characterization by Combining Extracellular Volume Fraction and T2 Mapping. Reviewed
Kidoh M, Oda S, Nakaura T, Nagayama Y, Funama Y, Takashio S, Kaikita K, Tsujita K, Hirai T
JACC. Cardiovascular imaging 15 ( 4 ) 700 - 704 2022.4
Language：English Publishing type：Research paper (scientific journal) Publisher：JACC: Cardiovascular Imaging
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Stratifying Bleeding Risk and Beyond - Predicting Where Bleeding Will Occur. Reviewed
Moribayashi K, Matsuura Y, Kaikita K
Circulation journal : official journal of the Japanese Circulation Society 86 784 - 786 2022.3
Language：English Publishing type：Research paper (scientific journal)
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Misumi I, Sato K, Nagano M, Korogi W, Usuku H, Kaikita K, Tsujita K
Journal of echocardiography 20 ( 1 ) 59 - 61 2022.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Echocardiography
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The impact of kidney function in patients on antithrombotic therapy: a post hoc subgroup analysis focusing on recurrent bleeding events from the AFIRE trial. Reviewed
Matsui K, Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Kimura K, Hirayama A, Ogawa H
BMC medicine 20 ( 1 ) 69 2022.2
Language：English Publishing type：Research paper (scientific journal)
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Increased soluble programed cell death-ligand 1 is associated with acute coronary syndrome. Reviewed
Fujisue K, Yamamoto E, Sueta D, Takae M, Nishihara T, Komorita T, Usuku H, Yamanaga K, Ito M, Hoshiyama T, Kanazawa H, Takashio S, Arima Y, Araki S, Soejima H, Kaikita K, Matsushita K, Tsujita K
International journal of cardiology 349 1 - 6 2022.2
Language：English Publishing type：Research paper (scientific journal)
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Dose-Dependent Inhibitory Effect of Rosuvastatin in Japanese Patients with Acute Myocardial Infarction on Serum Concentration of Matrix Metalloproteinases-INVITATION Trial. Reviewed
Shirakawa T, Fujisue K, Nakamura S, Yamamoto N, Oshima S, Matsumura T, Tsunoda R, Hirai N, Koide S, Tayama S, Kikuta K, Hirose T, Maruyama H, Fujimoto K, Kajiwara I, Sakamoto T, Nakao K, Sakaino N, Nagayoshi Y, Hokamaki J, Shimomura H, Sakamoto K, Yamamoto E, Izumiya Y, Kaikita K, Hokimoto S, Ogawa H, Tsujita K
Journal of atherosclerosis and thrombosis 29 ( 2 ) 229 - 241 2022.2
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Effect of the ALDH2 Variant on the Prevalence of Atrial Fibrillation in Habitual Drinkers. Reviewed
Yamashita T, Arima Y, Hoshiyama T, Tabata N, Sueta D, Kawahara Y, Ito M, Kanazawa H, Ishii M, Yamanaga K, Hanatani S, Takashio S, Araki S, Suzuki S, Yamamoto E, Kaikita K, Oniki K, Saruwatari J, Matsushita K, Tsujita K
JACC. Asia 2 ( 1 ) 62 - 70 2022.2
Language：English Publishing type：Research paper (scientific journal)
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Malnutrition-associated high bleeding risk with low thrombogenicity in patients undergoing percutaneous coronary intervention. Reviewed
Nakanishi N, Kaikita K, Ishii M, Kuyama N, Tabata N, Ito M, Yamanaga K, Fujisue K, Hoshiyama T, Kanazawa H, Hanatani S, Sueta D, Takashio S, Arima Y, Araki S, Usuku H, Nakamura T, Suzuki S, Yamamoto E, Soejima H, Matsushita K, Tsujita K
Nutrition, metabolism, and cardiovascular diseases : NMCD 32 ( 5 ) 1227 - 1235 2022.1
Language：English Publishing type：Research paper (scientific journal)