Details of a Researcher - KAIKITA Koichi

Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease Reviewed

Suzuki S., Kaikita K., Yamamoto E., Jinnouchi H., Tsujita K.

Cardiovascular Intervention and Therapeutics 36 ( 1 ) 39 - 51 2021.1

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Coronary angiography (CAG) sometimes shows nonobstructive coronary arteries in patients with suspected angina or acute coronary syndrome (ACS). The high prevalence of nonobstructive coronary artery disease (CAD) in those patients has recently been reported not only in Japan but also in Western countries, and is clinically attracting attention. Coronary spasm is considered to be one of the leading causes of both suspected stable angina and ACS with nonobstructive coronary arteries. Coronary spasm could also be associated with left ventricular dysfunction leading to heart failure, which could be improved following the administration of calcium channel blockers. Because we rarely capture spontaneous attacks of coronary spasm with electrocardiograms or Holter recordings, an invasive diagnostic modality, acetylcholine (ACh) provocation test, can be useful in detecting coronary spasm during CAG. Furthermore, we can use the ACh-provocation test to identify high-risk patients with coronary spasm complicated with organic coronary stenosis, and then treat with intensive care. Nonobstructive CAD includes not only epicardial coronary spasm but also microvascular spasm or dysfunction that can be associated with recurrent anginal attacks and poor quality of life. ACh-provocation test could also be helpful for the assessment of microvascular spasm or dysfunction. We hope that cardiologists will increasingly perform ACh-provocation test to assess the pathophysiology of nonobstructive CAD.

DOI： 10.1007/s12928-020-00720-z

Utility of Kumamoto criteria in diagnosing transthyretin cardiac amyloidosis in real-world practice ― reply ― Reviewed

Correction to: Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease.

Suzuki S, Kaikita K, Yamamoto E, Jinnouchi H, Tsujita K.

Cardiovascular Intervention and Therapeutics 36 52 - 53 2021.1

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

DOI： 10.1007/s12928-020-00735-6.

DOACの心保護作用

海北幸一、中西信博、辻󠄀田賢一

循環器内科 90 549 - 554 2021

Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Inhibitory effect of rivaroxaban on atrial arrhythmogenesis via protease-activated receptor 2 pathway. Reviewed

Kaikita K, Tsujita K.

Circulation Journal 85 1392 - 1393 2021

Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

心房細動合併PCI施行患者の抗血栓療法

海北幸一、辻田賢一

Cardiac Practice 32 38 - 43 2021

Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Takashio S., Marume K., Nishi M., Kaikita K., Tsujita K.

Circulation Journal 84 ( 4 ) 681 - 682 2020

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Circulation Journal

DOI： 10.1253/circj.CJ-20-0059

Current status and future perspective of structural heart disease intervention Reviewed

Tabata N., Sinning J.M., Kaikita K., Tsujita K., Nickenig G., Werner N.

Journal of Cardiology 74 ( 1 ) 1 - 12 2019.7

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Valvular heart diseases are one of the most frequent causes for heart failure. Degenerative diseases of the aortic and mitral valve as well as a dysfunctional tricuspid valve disease result in a worse clinical outcome if severe. Minimal-invasive, surgical and/or catheter-based structural heart disease (SHD) interventions have recently seen a dramatic increase. Transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) is a disruptive technology, and next generation devices and careful patient selection will minimize limitations of TAVI such as paravalvular leak, conductance disturbances, ischemic stroke, and vascular complications. The indication of TAVI continues to shift toward lower risk patients and patients with complex anatomy such as bicuspid AS or native pure aortic regurgitation. Successful clinical results in TAVI have generated considerable interest in further transcatheter technologies targeting mitral regurgitation (MR) and also toward tricuspid regurgitation (TR). The efficacy and safety of edge-to-edge with or without annuloplasty leaflet repair mimicking surgical repair will have to be confirmed by technical improvement, device development, and further emerging studies. Transcatheter mitral valve implantation might be an alternative strategy in patients with symptomatic severe MR and favorable anatomy. Possible interventional treatment approaches for TR have gained more attention. Improvement and development of SHD interventions have enabled more patients to receive minimally invasive heart valve interventions and these procedures have prolonged life and/or improved quality of life for many patients who were previously considered unsuitable for surgery. Continued technical and device improvements and accumulated evidence will expand its possibility and future of SHD interventions.

DOI： 10.1016/j.jjcc.2019.02.022

Overview of 2018 ESC/EACTS Guidelines on myocardial revascularization

Cardioangiology 85 ( 4 ) 463 - 467 2019.4

Authorship：Last author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

MINOCA

85 ( 4 ) 586 - 590 2019.4

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

冠動脈疾患 (特集心不全のみきわめ方と適切な管理) -- (心不全併存症の管理)

坂本憲治, 海北幸一, 辻田賢一

臨牀と研究 = The Japanese journal of clinical and experimental medicine 96 ( 3 ) 335 - 338 2019.3

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Total Thrombus-Formation Analysis System (T-TAS): Clinical Application of Quantitative Analysis of Thrombus Formation in Cardiovascular Disease Reviewed

Kaikita K., Hosokawa K., Dahlen J.R., Tsujita K.

Thrombosis and Haemostasis 19 ( 10 ) 1554 - 1562 2019

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Various antithrombotic agents are clinically used to inhibit the cascade of arterial or venous thrombosis in cardiovascular diseases. Dual antiplatelet therapy with aspirin and P2Y inhibitors is prescribed in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Direct oral anticoagulants (DOACs) are widely used for the prevention or treatment of thromboembolism in patients with atrial fibrillation (AF) and venous thromboembolism. However, there has been no definitive tool to simultaneously monitor the antithrombotic effects of these drugs. The Total Thrombus-Formation Analysis System (T-TAS), a microchip-based flow chamber system that mimics in vivo conditions for evaluating whole blood thrombogenicity, was developed for the quantitative analysis of thrombus formation in whole blood specimens. The utility of T-TAS has been evaluated in CAD patients treated with antiplatelet therapies. The T-TAS PL chip area under the flow pressure curve (AUC) accurately assesses primary hemostasis and is sensitive to the therapeutic effects of various antiplatelet therapies. In addition, low AUC results are a significant predictor of periprocedural bleeding events in CAD patients undergoing PCI. The T-TAS AR chip AUC result is useful for assessing the efficacy of DOACs and warfarin in AF patients undergoing catheter ablation, and it is also a potential independent predictor of periprocedural bleeding events and avoidance of thrombosis in patients having undergone total knee arthroplasty. In conclusion, T-TAS is a useful index for evaluating the total antithrombotic effects of combination antithrombotic agents in patients with various cardiovascular diseases. 12

DOI： 10.1055/s-0039-1693411

断端が多動性に富む三尖弁腱索自然断裂の1例

本里康太，三角郁夫，宇宿弘輝，坂本憲治，海北幸一，辻田賢一

日本超音波医学会雑誌 46 259 - 260 2019

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

抗血小板薬の種類と作用機序　特集抗血小板療法のジレンマ予防すべきは血栓か出血か？抗血小板薬の特性を理解する

海北幸一，辻田賢一

医学書院 56 238 - 243 2019

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Fetal origins of hypertension Reviewed

Arima Y., Nishiyama K., Izumiya Y., Kaikita K., Hokimoto S., Tsujita K.

Advances in Experimental Medicine and Biology 1012 41 - 48 2018

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Hypertension is a common noncommunicable disease. According to the World Health Organization, 1.13 billion people were suffering from hypertension in the year 2015. High blood pressure, hypertension, has a multifactorial etiology. Arterial atherosclerotic changes, systolic or diastolic dysfunction of the heart, and other noncardiac factors are involved. Epidemiological evidence has revealed that perinatal growth disturbance elevates the prevalence of hypertension. However, the specific effects of developmental disturbances on the pathological process of hypertension are poorly understood. Recently, it has become apparent that the perinatal period plays many essential roles in cardiovascular development. In this chapter, we focus on the perinatal development of the cardiovascular system, especially in murine models. Individual organs, blood, blood vessels, and the heart show unique growth characteristics during this period. We also introduce evidence from related clinical studies regarding the developmental origins of hypertension. Finally, evidence from several animal models is presented to reveal the effects of developmental disturbance or stress on arterial pathology. Improving our understanding of both developmental events and the results of clinical studies will give fresh insight into the fetal origins of hypertension.

DOI： 10.1007/978-981-10-5526-3_5

Atherosclerotic coronary plaque development visualized by in vivo coronary imaging Reviewed

Sakamoto K., Nagamatsu S., Yamamoto E., Kaikita K., Tsujita K.

Circulation Journal 82 ( 7 ) 1727 - 1734 2018

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

In the past decades, coronary imaging has evolved as a valuable adjunct to angiography, providing scientific insights into vascular biology and practical guidance by direct visualization of atherosclerosis and other pathologic conditions within the vessel walls. Especially with intravascular ultrasound (IVUS), the signal is able to penetrate below the luminal surface, so the entire cross-section of an artery, including the complete thickness of the plaque, can be imaged in real-time. On the other hand, optical coherence tomography (OCT) has been offering higher image resolution of both the plaque and the luminal surface. These technologies offer the opportunity to gather diagnostic information about the process of atherosclerosis and to directly observe the effects of various interventions on the plaque and arterial walls. IVUS has proven itself to be a practical and useful tool in the evaluation and optimal guidance of interventional vascular medicine. In this review, we detail the current modalities of coronary imaging and their usefulness in the diagnosis and management of patients with high-risk coronary plaques.

DOI： 10.1253/circj.CJ-18-0516