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転移性腎癌に伴うStauffer症候群様の所見が分子標的治療により改善した1例
伊藤 歌織, 髙森 大樹, 秋岡 貴弘, 飛田 卓哉, 岡部 洸, 木田 和貴, 寺田 直樹, 上村 敏雄, 向井 尚一郎, 賀本 敏行
泌尿器科紀要 67 ( 7 ) 309 - 312 2021年7月
記述言語:日本語 掲載種別:研究論文(学術雑誌) 出版者・発行元:泌尿器科紀要刊行会
We report a case of Stauffer syndrome-like findings in a patient with metastatic renal carcinoma treated by surgery and molecular targeted therapy. The patient was a 58-year-old woman diagnosed with renal carcinoma with multiple metastases. She had hepatosplenomegaly and hepatic dysfunction with elevated serum liver enzyme and IL-6 levels. Treatment with temsirolimus and axitinib reduced the size of the local and metastatic tumors and simultaneously improved the hepatosplenomegaly. The local tumor was excised by laparoscopic nephrectomy, treated with axitinib and then with nivolumab. With the reduction in the metastatic tumor size, serum liver enzyme and IL-6 levels decreased. It was suggested that molecular targeted therapy is an effective treatment when the findings of metastatic renal cell carcinoma, are similar to those of Stauffer syndrome.