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Affiliation |
Faculty of Medicine School of Medicine Department of Internal Medicine, Cardiovascular Medicine and Nephrology |
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Assistant Professor |
KOMAKI Soichi
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Papers 【 display / non-display 】
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Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome. Reviewed
Komaki S, Matsuura Y, Tanaka H, Moribayashi K, Yamamura Y, Kurogi K, Ideguchi T, Yamamoto N, Nakai M, Tsuruda T, Kaikita K
Open heart 11 ( 1 ) 2024.1
Language：English Publishing type：Research paper (scientific journal)
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Soichi Komaki, Masanobu Ishii, Ryota Kaichi, Masafumi Takae, Takayuki Mori, Reiko Toida, Kazumasa Kurogi, Yunosuke Matsuura, Nobuyasu Yamamoto, Kenichi Tsujita, Toshihiro Tsuruda, Koichi Kaikita
Heart and vessels 38 ( 7 ) 919 - 928 2023
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Successful Stent-less Percutaneous Coronary Intervention of Chronic Total Occlusion by Ablation Devices in a Young Adult. Reviewed
Komaki S, Kurogi K, Yamamoto N, Kaikita K.
PCR online / EuroIntervention. 2021.11
Language：English Publishing type：Research paper (scientific journal)
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Association between coronary artery calcium score and stent expansion in percutaneous coronary intervention. Reviewed International journal
Soichi Komaki, Masanobu Ishii, Sou Ikebe, Ryota Kaichi, Takayuki Mori, Kyohei Marume, Kazumasa Kurogi, Nobuyasu Yamamoto
International Journal of Cardiology 334 31 - 36 2021.7
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Measurement of the coronary artery calcification score using multidetector computed tomography (MDCT) is a useful noninvasive test for the diagnosis of coronary artery disease. However, whether pre-intervention assessment of the target vessel coronary artery calcification (TV-CAC) score is associated with stent expansion failure and future target lesion revascularization (TLR), remains unknown. This study aimed to determine the association between the TV-CAC score measured by MDCT and stent expansion rate in patients who underwent IVUS-guided PCI for stable angina. METHODS: We conducted a retrospective observational study including 135 consecutive patients (186 target lesions) who underwent MDCT and were scheduled for the first PCI. The patients were divided into 2 groups based on the median value of the TV-CAC score. The primary outcome was the stent expansion rate measured by IVUS after stent implantation. The secondary outcome was TLR within 1 year. RESULTS: Stent expansion rate was associated with the TV-CAC score (p < 0.001). According to the ROC curve analysis, the TV-CAC score had the largest area under the curve (AUC) for the stent expansion area of 0.90 (AUC = 0.893, p < 0.001). The TV-CAC score was a positive predictor for stent expansion rate of <90% (odds ratio: 7.54, p < 0.001). Mediation analysis showed that stent under-expansion was a mediator of the association between high TV-CAC and TLR. CONCLUSIONS: Our study demonstrates that pre-intervention assessment of TV-CAC using MDCT is a predictor of stent expansion. The TV-CAC score might predict the complexity and help in the PCI operative strategy.
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Optical Coherence Tomography Illuminates Intravascular Ultrasound-Invisible Sac-Like Structure After Stent Implantation. Reviewed
Soichi Komaki, Masanobu Ishii, Kazumasa Kurogi, Nobuyasu Yamamoto
Circulation Journal 85 ( 7 ) 1099 - 1099 2021.6
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
MISC 【 display / non-display 】
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宮崎大学学生の医療機器開発への関心についての調査
平山 麻美, 鶴田 敏博, 小牧 聡一, 中村 小夜子, 宮田 敬公, 金子 彰彦, 福永 千紗, 岩本 脩成, 森田 徹, 荒武 尚, 医農工連携プロジェクトものづくりフェスタ2022実行委員会
宮崎県医師会医学会誌 47 ( 1 ) 117 - 121 2023.3
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)宮崎県医師会
東九州メディカルバレー構想の中で,宮崎大学医学部血液・血管先端医療学講座は,「研究開発の拠点」として血液・血管に関する研究,医療機器開発支援とともに人材育成に取り組んでいる。「第1回医農工連携プロジェクトものづくりフェスタ2022」の開催に先立ち,宮崎大学学生の医療機器開発への関心についてアンケート調査を実施した。その結果,健康・医療に関する「ものづくり(研究開発)」やデジタル通信技術の開発への関心度は高いものの,県内企業への就職希望率が極めて低く,県内企業および宮崎大学の今後の課題を示唆するものとなった。本講座は医療機器の研究開発および普及の促進に向け,開発支援および次世代の人材育成の取り組み,宮崎県の活性化に貢献したい。(著者抄録)
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一般医家のためのDOAC時代の心房細動診療 心房細動の薬物治療と管理 抗凝固療法が必要な冠動脈疾患患者に対する抗血栓療法はどうする?
小牧聡一, 松浦祐之介, 海北幸一
Medicina 60 ( 13 ) 2023
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Impact of Prehospital Nitroglycerin Use on Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome
小牧聡一, 東海達也, 開地亮太, 高江将史, 森隆之, 戸井田玲子, 黒木一公, 山本展誉, 辻田賢一, 鶴田敏博, 海北幸一
日本循環器学会学術集会(Web) 87th 2023
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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人々を繋ぎ,宮崎県から世界へ~これからの東九州メディカルバレー構想と宮崎大学の医工連携事業~
鶴田敏博, 平山麻美, 小牧聡一, 中村小夜子, 宮田敬公, 金子彰彦, 福永千紗, 岩本脩成, 森田徹, 荒武尚
宮崎県医師会医学会誌 47 ( 1 ) 2023
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
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右冠動脈入口部病変に対しOAS施行後に冠動脈穿孔を来した一例
小牧 聡一, 黒木 一公, 山本 展誉, 海北 幸一
日本心血管インターベンション治療学会抄録集 2023.8 (一社)日本心血管インターベンション治療学会
Event date： 2023.8
Language：English Presentation type：Oral presentation (general)
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Impact of Prehospital Nitroglycerin Use on Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome(タイトル和訳中)
小牧 聡一, 東海 達也, 開地 亮太, 高江 将史, 森 隆之, 戸井田 玲子, 黒木 一公, 山本 展誉, 辻田 賢一, 鶴田 敏博, 海北 幸一
日本循環器学会学術集会抄録集 2023.3
Event date： 2023.3
Language：English Presentation type：Oral presentation (general)
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Clinical Prediction of Left Ventricular Thrombus after ST-elevation Myocardial Infarction with Biochemical and Echocardiographic Findings(タイトル和訳中)
宮下 紘樹, 開地 亮太, 東海 達也, 高江 将史, 森 隆之, 小牧 聡一, 戸井田 玲子, 黒木 一公, 山本 展誉
日本循環器学会学術集会抄録集 2023.3
Event date： 2023.3
Language：English Presentation type：Oral presentation (general)
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Abstract 10765: Association Between Prehospital Nitroglycerin and Clinical Outcome in Acute Coronary Syndrome
Soichi Komaki, TATSUYA TOKAI, Ryota Kaichi, Masafumi Takae, Takayuki Mori, Reiko Toida, Kazumasa Kurogi, Nobuyasu Yamamoto, Kenichi Tsujita, Toshihiro TSURUDA, Koichi Kaikita
Circulation 2022.11.8 Ovid Technologies (Wolters Kluwer Health)
Event date： 2022.11.8
Presentation type：Oral presentation (general)
Introduction: Whether prehospital Nitroglycerin use is associated with major adverse cardiac events (MACE) remains unknown in the era of primary percutaneous coronary intervention (PCI) using stents.
Hypothesis: We hypothesized that prehospital Nitroglycerin use would be associated with MACE in acute coronary syndrome (ACS) patients who underwent primary PCI.
Methods: This retrospective observational study enrolled 947 consecutive patients who received the emergent PCI. Patients were classified into the two groups, with and without prehospital Nitroglycerin use. 250 patients were given prehospital Nitroglycerin sublingually or via oral spray or intravenously. The clinical outcome was MACE defined as a composite of all-cause death, myocardial infarction, and stroke at a one-year follow-up.
Results: The Systolic blood pressure at the emergency department was 132 (105, 141) mmHg in the prehospital Nitroglycerin, and 135 (113, 158) mmHg in the non-Nitroglycerin group (P < 0.001). Kaplan-Meier survival curves revealed that the MACE frequency was higher in the prehospital Nitroglycerin group (p = 0.021). Multivariate Cox regression analysis revealed that the prehospital Nitroglycerin use (hazard ratio, 1.65; 95% confidence interval [CI], 1.02-2.65; p = 0.002) was an independent predictor for MACE. Prehospital Nitrogricerin use, Killip classification, and Ejection fraction models resulted in a c-statistic with a statistically significant 95% PI and moderate discriminative performance (c-statistic=0.763; 95% CI, 0.7111-0.816, p<0.001).
Conclusions: The present results suggested that the prehospital Nitroglycerin use might worsen the one-year prognosis in ACS patients undergoing primary PCI. -
Abstract 10021: Prediction of Intracerebral Hemorrhage in Out-of-Hospital Cardiac Arrest Patients with Post-Resuscitation Electrocardiogram
Ryota Kaichi, Masanobu Ishii, Takafumi Mikami, Sou Ikebe, Masafumi Takae, Takayuki Mori, Soichi Komaki, Reiko Toida, Kazumasa Kurogi, Yasuhiro Nagamine, Masakazu Matsuyama, Tetsuro Yamaguchi, Takao Yano, Kenichi Tsujita, Nobuyasu Yamamoto
Circulation 2021.11.16 Ovid Technologies (Wolters Kluwer Health)
Event date： 2021.11.16
Presentation type：Oral presentation (general)
Introduction: The appropriate patient selection for urgent coronary angiography after return of spontaneous circulation (ROSC) are still unclear. Hence intracerebral hemorrhage (ICH) show non-specific ST-changes on post-resuscitation electrocardiogram (ECG) and lead to misdiagnosis and incorrect therapeutic decisions. Therefore, we evaluated the characteristics of patients with ICH in nontraumatic out-of-hospital cardiac arrests (OHCA) after ROSC to identify patients who need brain computed tomography (CT) as the next diagnostic work-up.
Methods and Results: We studied 1303 consecutive patients who transported to our hospital due to OHCA between 2008 and 2020, and 1,235 (95%) were assessed their cause of death by CT. After excluding 126 patients with obvious extracardiac causes, 329 patients with ROSC were finally included, and categorized into 2 groups: those with ICH (n=32, 10%) and those with suspected cardiac origin group (n=297). Logistic regression analyses showed that younger age (<75 years), female, no shockable rhythm change, tachycardia (≥100bpm), lateral segment elevation, inferior segment depression on ECG were independently associated with ICH. We developed a new predictive model for ICH by adding 1 point for each of the 6 factors. The ICH positive rate increased by a factor of 2.36 for each 1-point increase (P<0.001). Three points or less corresponded to a negative predictive value of 94% and 4 points or more corresponded to a positive predictive value of 31% for ICH (Figure).
Conclusion: Our new predictive model might be useful for risk stratification of ICH in OHCA patients with ROSC.