野村 信介 (ノムラ シンスケ)

NOMURA Shinsuke

写真a

所属

医学部 附属病院 肝胆膵外科

職名

助教

研究分野 【 表示 / 非表示

  • ライフサイエンス / 生体医工学  / 光温熱癌治療

  • ライフサイエンス / 外科学一般、小児外科学  / 低侵襲手術

  • ライフサイエンス / 消化器外科学  / 食道癌、胃癌

  • ライフサイエンス / 外科学一般、小児外科学  / 外科侵襲学

  • ライフサイエンス / 消化器外科学  / 内視鏡外科

 

論文 【 表示 / 非表示

  • Clinical Relevance of Tissue and Serum Human Epidermal Growth Factor Receptor 2 Expression in Patients With Esophageal Squamous Cell Carcinoma. 国際誌

    Hiromi Nagata, Hironori Tsujimoto, Hiroyuki Horiguchi, Hidekazu Sugasawa, Keita Kouzu, Yujiro Itazaki, Yusuke Ishibashi, Satoshi Tsuchiya, Takao Sugihara, Nozomi Ito, Manabu Harada, Shinsuke Nomura, Yoji Kishi, Hideki Ueno

    The Journal of surgical research   269   189 - 200   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Serum and tissue human epidermal growth factor receptor 2 (HER2) levels were evaluated in resected esophageal squamous cell carcinoma (SCC) specimens to assess the relationship between HER2 expression and long-term prognosis. METHODS: We included 95 patients who underwent esophagectomy for esophageal SCC. The serum HER2-extracellular domain (sHER2-ECD) levels were measured using an ELISA kit. A time-dependent receiver operating characteristics curve for censored survival outcomes was constructed to estimate the optimal cut-off value of sHER2-ECD (set at 4211 pg/mL). Immunohistochemical (IHC) staining was performed for HER2, and specimens were classified based on low (0 or 1+) or high HER2-IHC expression (2+ or 3+). RESULTS: Patients with low sHER2-ECD levels showed poorly differentiated tumors, nodal involvement, and larger tumor size more frequently compared to patients with high sHER2-ECD levels. There were no differences in clinicopathological features based on HER2-IHC expression. Between patients with high and low HER2-IHC expression, the former group showed significantly higher sHER2-ECD levels. Patients with high sHER2-ECD levels had significantly favorable relapse-free survival (RFS) and overall survival (OS) compared to those with low sHER2-ECD levels. Conversely, patients with high HER2-IHC expression had significantly poorer RFS than did patients with low HER2-IHC expression, although no difference was observed in OS. Additionally, patients with high sHER2-ECD levels and low HER2-IHC expression had the highest OS and RFS among the patients studied. CONCLUSIONS: The correlation among sHER2-ECD levels, HER2-IHC expression, and prognosis was demonstrated. Prospective studies are required to validate the impact of serum and tissue HER2 expression in esophageal SCC prognosis.

    DOI: 10.1016/j.jss.2021.07.046

    PubMed

  • Impact of postoperative infectious complications on adjuvant chemotherapy administration after gastrectomy for advanced gastric cancer. 国際誌

    Hironori Tsujimoto, Keita Kouzu, Hidekazu Sugasawa, Shinsuke Nomura, Nozomi Ito, Manabu Harada, Takao Sugihara, Yusuke Ishibashi, Yoji Kishi, Hideki Ueno

    Japanese journal of clinical oncology   51 ( 3 )   379 - 386   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The aim of this study was to investigate the impact of postoperative infectious complications on adjuvant chemotherapy administration in patients with gastric cancer. METHODS: A retrospective review of 308 patients who underwent curative resection for gastric cancer was performed. Patients were divided into two groups based on the presence (90 patients, 29.2%) or absence (218 patients, 70.8%) of postoperative infectious complications to analyze clinicopathological characteristics, treatment factors and survival. RESULTS: Fewer patients with postoperative infectious complication received adjuvant chemotherapy compared to those without postoperative infectious complication. The proportion of patients who started treatment within 6 weeks after surgery was significantly lower in patients with postoperative infectious complication. The treatment completion rate was significantly lower in patients with postoperative infectious complication. The number of treatment cycles and relative dose intensity was significantly lower in patients with postoperative infectious complication. In univariate analysis, only postoperative infectious complication was significantly associated with continuation of adjuvant chemotherapy. Multivariate analysis demonstrated tumor depth, nodal involvement, postoperative infectious complication and adjuvant chemotherapy were significantly associated with overall survival. CONCLUSION: Postoperative infectious complications are significantly associated with the delay of adjuvant chemotherapy and predict adverse clinical outcome in patients with gastric cancer.

    DOI: 10.1093/jjco/hyaa223

    PubMed

  • Correlation Between Immunoinflammatory Measures and Periostin Expression in Esophageal Squamous Cell Carcinoma: A Single-Center, Retrospective Cohort Study. 国際誌

    Yusuke Ishibashi, Hironori Tsujimoto, Takahiro Einama, Satsuki Mochizuki, Keita Kouzu, Shinsuke Nomura, Nozomi Ito, Manabu Harada, Hidekazu Sugasawa, Eiji Shinto, Yoji Kishi, Hideki Ueno

    Annals of surgical oncology   28 ( 2 )   1228 - 1237   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Immunoinflammatory measures such as the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and the C-reactive protein (CRP)-albumin ratio (CAR) are useful prognostic measures in various malignancies. However, no study has investigated the correlation of these measures with microenvironmental inflammation. Periostin (POSTN), a small extracellular matrix protein, strongly associates with cancer microenvironmental inflammation. The current study investigated the correlation of NLR, PLR, and CAR with periostin expression in esophageal squamous cell carcinoma (ESCC). METHODS: The study retrospectively evaluated preoperative NLR, PLR, and CAR hematologically and POSTN immunohistochemically in 171 patients. The correlation of immunoinflammatory measures, POSTN expression, and survival outcomes was measured. RESULTS: The study showed a significant correlation of POSTN-positive expression with poor overall survival (OS) (P < 0.0001) and recurrence-free survival (RFS) (P = 0.03). The POSTN-positive group had higher PLR (189.6 ± 8 vs. 159.3 ± 12; P = 0.04) and CAR (0.36 ± 0.06 vs. 0.14 ± 0.09; P < 0.05) than the POSTN-negative group, whereas NLR did not differ between the two groups (3.27 ± 0.19 vs. 2.65 ± 0.28; P = 0.07). The uni- and multivariate analyses showed that POSTN-positive expression (hazard ratio [HR], 1.595; 95% confidence interval [CI], 0.770-3.031; P = 0.03), CAR (HR, 1.663; 95% CI, 1.016-2.764; P = 0.03), gender (HR, 2.303; 95% CI, 1.067-6.019; P = 0.03), and tumor depth (HR, 1.957; 95% CI, 1.122-3.526; P = 0.01) were independent prognostic factors. CONCLUSIONS: Because POSTN-positive expression strongly correlates with immunoinflammatory measures, especially PLR and CAR, it is an independent prognostic factor in ESCC.

    DOI: 10.1245/s10434-020-08765-3

    PubMed

  • Postoperative pneumonia causes the loss of skeletal muscle volume and poor prognosis in patients undergoing esophagectomy for esophageal cancer.

    Seiichiro Fujishima, Hironori Tsujimoto, Ken Nagata, Hidekazu Sugasawa, Shinsuke Nomura, Nozomi Ito, Manabu Harada, Takao Sugihara, Yusuke Ishibashi, Keita Kouzu, Hiroshi Shinmoto, Yoji Kishi, Hideki Ueno

    General thoracic and cardiovascular surgery   69 ( 1 )   84 - 90   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSES: This retrospective study investigated the effect of postoperative pneumonia on the loss of skeletal muscle volume after esophagectomy for esophageal cancer. METHODS: A total of 123 patients who had undergone esophagectomy for esophageal cancer and had (30 patients) or did not have (93 patients) postoperative pneumonia were included in the analysis. The association of clinicopathological characteristics with loss of skeletal muscle volume and long-term survival were evaluated in patients with or without postoperative pneumonia. RESULTS: There were no differences in the psoas muscle volume index (PI), lymphocyte count, serum albumin level, or prognostic nutritional index between the two groups both preoperatively and at 6 months after surgery. The decrease in PI at 6 months after surgery was significant in patients with postoperative pneumonia (- 9.9 ± 2.5%) but not in those without pneumonia (- 2.6 ± 1.6%). Patients with postoperative pneumonia had a significantly increased frequency of asymptomatic pneumonia at 6 months after surgery compared with those who did not have postoperative pneumonia (36.7% vs. 19.4%). Overall survival was significantly poorer in patients with postoperative pneumonia than in those without pneumonia (p < 0.05). CONCLUSIONS: Postoperative pneumonia was associated with the loss of skeletal muscle volume and asymptomatic pneumonia within 6 months of surgery as well as poorer overall survival.

    DOI: 10.1007/s11748-020-01482-4

    PubMed

  • Efficacy of artificial pneumothorax under two-lung ventilation in video-assisted thoracoscopic surgery for esophageal cancer. 国際誌

    Shinsuke Nomura, Hironori Tsujimoto, Yusuke Ishibashi, Seiichiro Fujishima, Keita Kouzu, Manabu Harada, Nozomi Ito, Yoshihisa Yaguchi, Daizoh Saitoh, Takehiko Ikeda, Kazuo Hase, Yoji Kishi, Hideki Ueno

    Surgical endoscopy   34 ( 12 )   5501 - 5507   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: One-lung ventilation (OLV) is the standard and widely applied ventilation approach used in video-assisted thoracoscopic surgery for esophageal cancer (VATS-e). To address the disadvantages of OLV with respect to difficulties in intubation and induction, as well as the risk of respiratory complications, two-lung ventilation (TLV) with artificial pneumothorax has been introduced for use in VATS-e. However, no studies have yet compared TLV and OLV with postoperative infection and inflammation in the prone position over time postoperatively. Here, we investigated the efficacy of TLV in patients undergoing VATS-e in the prone position. METHODS: Between April 2010 and December 2016, 119 patients underwent VATS-e under OLV or TLV with carbon dioxide insufflation. Clinical characteristics, surgical outcomes, and postoperative outcomes, including oxygenation and systemic inflammatory responses, were compared between patients who underwent OLV and those who underwent TLV. RESULTS: Clinical characteristics other than pT stage were comparable between groups. The TLV group had shorter thoracic operation time than the OLV group. No patients underwent conversion to open thoracotomy. The PaO2/FiO2 ratios of the TLV group on postoperative day (POD) 5 and on POD7 were significantly higher than those of the OLV group. C-reactive protein levels on POD7 were lower in the TLV group than in the OLV group. There were no significant differences with respect to postoperative complications between the OLV and TLV groups. In the TLV group, the white blood cell count on POD7 was significantly lower than that in the OLV group; body temperature showed a similar trend immediately after surgery and on POD1. CONCLUSIONS: In this study, we demonstrated that, compared with OLV, TLV in the prone position provides better oxygenation and reduced inflammation in the postoperative course. Accordingly, TLV might be more useful than OLV for ventilation during esophageal cancer surgery.

    DOI: 10.1007/s00464-019-07347-z

    PubMed

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MISC 【 表示 / 非表示

講演・口頭発表等 【 表示 / 非表示

  • ラット肝細胞癌モデルを用いた腹腔鏡下光温熱治療の有用性に関する検討

    原田 学, 守本 祐司, 辻本 広紀, 板崎 勇二郎, 石橋 勇輔, 野村 信介, 若松 高太郎, 菅澤 英一, 岸 庸二, 上野 秀樹

    日本消化器外科学会総会  2021年7月  (一社)日本消化器外科学会

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    開催年月日: 2021年7月

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 新規開発したサーモグラフィ内視鏡を用いたラット肝細胞癌に対する鏡視下レーザーアブレーション治療

    原田 学, 守本 祐司, 尾原 睦月, 大谷 淳, 正宗 賢, 辻本 広紀, 杉原 崇夫, 野村 信介, 石橋 勇輔, 伊藤 希, 岸 庸二, 上野 秀樹

    日本外科学会定期学術集会抄録集  2021年4月  (一社)日本外科学会

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    開催年月日: 2021年4月

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 食道癌におけるMesothelin発現の臨床的意義に関する検討

    石橋 勇輔, 辻本 広紀, 永生 高広, 菅澤 英一, 野村 信介, 伊藤 希, 原田 学, 杉原 崇生, 板崎 勇二郎, 神津 慶多, 土屋 智, 神藤 英二, 岸 庸二, 上野 秀樹

    日本外科学会定期学術集会抄録集  2021年4月  (一社)日本外科学会

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    開催年月日: 2021年4月

    記述言語:日本語   会議種別:口頭発表(一般)  

  • [総論]ICG蛍光ナビゲーション手術のこれから 消化管間葉系腫瘍に対する術中ナビゲーションのためのICGアナログ製剤の開発

    野村 信介, 辻本 広紀, Kang Homan, 横溝 真哉, 上野 秀樹, Kashiwagi Satoshi, Choi Hak Soo

    日本消化器外科学会総会  2020年12月  (一社)日本消化器外科学会

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    開催年月日: 2020年12月

    記述言語:日本語   会議種別:口頭発表(一般)  

  • [胃]胃切除後のQOL向上を目指したエビデンスの創生 手術成績からみた早期胃癌に対するLAPPGの有用性に関する検討 LDGとの比較

    石橋 勇輔, 辻本 広紀, 野村 信介, 伊藤 希, 原田 学, 杉原 崇生, 矢口 義久, 菅澤 英一, 岸 庸二, 上野 秀樹

    日本消化器外科学会総会  2020年12月  (一社)日本消化器外科学会

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    開催年月日: 2020年12月

    記述言語:日本語   会議種別:口頭発表(一般)  

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