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Affiliation |
Faculty of Medicine College Hospital The first surgery |
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Title |
Assistant Professor |
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Related SDGs |
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HIGUCHI Kazuhiro
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Research Areas 【 display / non-display 】
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Life Science / Anatomy / 免疫組織化学
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Life Science / Digestive surgery
Papers 【 display / non-display 】
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SETDB1-Mediated Chromatin Regulation in Intestinal Epithelial Cells During Intestinal Ischemia-Reperfusion Injury. Reviewed
Kazuhiro Higuchi, Makoto Ikenoue, Takumi Ishizuka, Kengo Kai, Nobuyasu Takahashi, Toshiki Kubota, Shinichiro Shirouzu, Baljinnyam Lkham-Erdene, Kham Mo Aung, Michikazu Nakai, Akira Sawaguchi, Atsushi Nanashima, Yoshitaka Hishikawa
Acta histochemica et cytochemica 58 ( 1 ) 9 - 18 2025.2
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1267/ahc.24-00061
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河野 文彰, 千代反田 顕, 中目 和彦, 明利 聡瑠, 福島 剛, 佐藤 勇一郎, 山口 秀樹, 池ノ上 実, 宗像 駿, 樋口 和宏, 武野 慎祐, 七島 篤志
Endocrinology Diabetes and Metabolism Case Reports 2025 ( 2 ) e250014 2025.5
Language：English Publishing type：Case report Publisher：Bioscientifica
Summary
Spindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle aspiration cytology can be challenging. SETTLE predominantly occurs in younger individuals and has a less favorable prognosis compared to differentiated thyroid carcinoma. Therefore, ensuring accurate diagnosis and appropriate treatment is crucial. We encountered a case of spindle epithelial tumor with thymus-like differentiation in a 10-year-old patient for whom the preoperative diagnosis was successfully established through fine-needle aspiration cytology, which facilitated appropriate surgical resection. Comprehensive histopathological examination and immunohistochemical analysis are essential to ensure appropriate management and surveillance of SETTLE.
Learning points
A rare thyroid tumor, spindle epithelial tumor with thymic-like elements (SETTLE), was diagnosed preoperatively and treated surgically.
SETTLE presents with characteristic histological features that must be recognized for accurate diagnosis. In addition, diagnosis through cytology is often challenging.
The primary treatment for SETTLE is surgical intervention as radiotherapy and pharmacological treatments are generally not expected to be highly effective.
Radical resection is the only effective treatment, making the selection of the surgical procedure according to the stage of the disease essential. -
Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27. Reviewed
Kai K, Ishizuka T, Matsumoto J, Shimamawari K, Mori R, Fidya, Lkham-Erdene B, Kubota T, Ikenoue M, Higuchi K, Nanashima A, Hishikawa Y
Acta histochemica et cytochemica 58 ( 2 ) 69 - 79 2025.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1267/ahc.25-00002
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Relationship between survival outcomes in patients with colorectal liver metastasis undergoing hepatectomy and significance of fibrotic markers for liver injury assessment. Reviewed International journal
Atsushi Nanashima, Masahide Hiyoshi, Naoya Imamura, Takeomi Hamada, Yuki Tsuchimochi, Ikko Shimizu, Takahiro Ochiai, Akiko Ichihara, Kiyoaki Hamada, Nobuhiko Ichiki, Kengo Kai, Kazuhiro Higuchi
Translational cancer research 14 ( 1 ) 461 - 472 2025.1
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.21037/tcr-24-1138
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Effect of Hepatic Lipid Overload on Accelerated Hepatocyte Proliferation Promoted by HGF Expression via the SphK1/S1PR2 Pathway in MCD-diet Mouse Partial Hepatectomy. Reviewed
Baljinnyam Lkham-Erdene, Narantsog Choijookhuu, Toshiki Kubota, Tomofumi Uto, Shuya Mitoma, Shinichiro Shirouzu, Takumi Ishizuka, Kengo Kai, Kazuhiro Higuchi, Kham Mo Aung, Jargal-Erdene Batmunkh, Katsuaki Sato, Yoshitaka Hishikawa
Acta histochemica et cytochemica 57 ( 5 ) 175 - 188 2024.10
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1267/ahc.24-00046
MISC 【 display / non-display 】
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現状と理想からブレイクスルーする地方外科医の働き方改革 大学病院の立場から Reviewed
樋口 和宏, 濱田 聖暁, 市来 伸彦, 原 大介, 市原 明子, 内勢 由佳子, 落合 貴裕, 野村 信介, 池ノ上 実, 田代 耕盛, 河野 文彰, 武野 慎祐, 七島 篤志
日本臨床外科学会雑誌 84 ( 増刊 ) S60 - S60 2023.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本臨床外科学会
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繰り返す吻合部狭窄により発症した胃切除術後の盲係蹄症候群の1例 Reviewed
樋口 和宏, 池ノ上 実, 落合 貴裕, 野村 信介, 田代 耕盛, 河野 文彰, 武野 慎祐, 七島 篤志, 安倍 弘生, 河上 洋
日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 120回・114回 211 - 211 2022.12
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本消化器病学会-九州支部
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内視鏡・腹腔鏡下合同手術の現状 十二指腸腫瘍に対するDLECSの導入と実際 Reviewed
樋口 和宏, 河野 文彰, 田代 耕盛, 池ノ上 実, 野村 信介, 落合 貴裕, 猪俣 麻佑, 山田 隆盛, 武野 慎祐, 七島 篤志
日本臨床外科学会雑誌 83 ( 増刊 ) S159 - S159 2022.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本臨床外科学会
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経肛門的直腸異物の3例 Reviewed
樋口 和宏, 河野 文彰, 田代 耕盛, 野村 信介, 池ノ上 実, 落合 貴裕, 猪俣 麻佑, 山田 隆盛, 佐野 浩一郎, 末田 秀人, 武野 慎祐, 七島 篤志
Japanese Journal of Acute Care Surgery 12 ( Suppl. ) 154 - 154 2022.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本Acute Care Surgery学会
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S状結腸癌による通過障害により発症した魚骨S状結腸穿孔の1例 Reviewed
樋口 和宏, 末田 秀人, 佐野 浩一郎, 真方 寿人, 千代反田 顕, 坂元 里彩, 七島 篤志
日本大腸肛門病学会雑誌 75 ( 6 ) 312 - 313 2022.6
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本大腸肛門病学会
Awards 【 display / non-display 】
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最優秀演題賞
2019.2 第113回日本血管外科学会九州地方会若手優秀演題セッション 極めてまれな先天性腹部大動脈瘤の１例
樋口和宏
Award type：International academic award (Japan or overseas)