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• A case of rapidly progressive Salmonella aortic aneurysm with acute pericarditis manifesting as a precursor 査読あり

  Harada K., Kawagoe K., Matsuura Y., Kawano M., Suiko Y., Tanaka H., Moribayashi K., Ishii H., Ideguchi T., Furukawa K., Kaikita K.

  Journal of Cardiology Cases   31 ( 3 )   76 - 79   2025年3月

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  記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Cardiology Cases  

  We report a case of Salmonella cardiovascular infection presenting with acute pericarditis as a precursor to the rapid progression of aortic aneurysm. An 81-year-old man presented with persistent fever and chest pain worsened with inspiration and was admitted to a nearby hospital with a diagnosis of bacterial pericarditis. However, hoarseness emerged two days later, and the patient was transferred to our hospital because of concerns about extracardiac inflammatory foci. Computed tomography (CT) revealed a periaortic exudate and aortic arch aneurysm. After transfer, blood cultures confirmed Salmonella infection. Ampicillin (ABPC) was initiated for long-term treatment of Salmonella infection, and pericarditis was treated with ibuprofen and colchicine for approximately one month. The associated symptoms and inflammatory blood data significantly improved, but five weeks later, follow-up CT revealed enlargement of the arch aneurysm. Due to the patient's age and nutritional status, thoracic endovascular aortic repair (TEVAR) was performed along with continued ABPC. Postoperatively, the infection was well-controlled, and follow-up CT revealed a size reduction in the treated aneurysm. No recurrent Salmonella-related vascular events were observed for two years after TEVAR. Learning objective: Acute pericarditis can present as a precursor to life-threatening vascular lesions associated with Salmonella infection and requires timely and appropriate diagnosis of the etiology behind the manifestation. Patients with aortic aneurysms caused by Salmonella often do not tolerate invasive surgical treatment when diagnosed, and the lesions progress rapidly. Therefore, endovascular treatment combined with long-term antibiotic therapy may be a practical option.

  DOI： 10.1016/j.jccase.2024.11.006

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• Optical coherence tomography imaging of coronary thrombosis developed after rotational atherectomy despite appropriate antithrombotic therapy 査読あり

  Komaki S., Moribayashi K., Matsuura Y., Tanaka H., Kaikita K.

  Cardiovascular Intervention and Therapeutics   39 ( 4 )   493 - 494   2024年10月

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  記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Cardiovascular Intervention and Therapeutics  

  DOI： 10.1007/s12928-024-01009-1

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• Basal inferoseptal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived amyloid cardiomyopathy 査読あり

  Tsuruda T., Nakada H., Yamamura Y., Matsuura Y., Ogata M., Tanaka M., Suiko Y., Komaki S., Tanaka H., Moribayashi K., Ideguchi T., Terada T., Ota T., Yamamoto K., Nishihira K., Shibata Y., Kaikita K.

  European Heart Journal Open   4 ( 5 )   oeae076   2024年9月

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  記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：European Heart Journal Open  

  Aims. While the prevalence of transthyretin-derived amyloid cardiomyopathy (ATTR-CM) is on the rise, detailed understanding of its morphological and functional characteristics within the left ventricle (LV) across heart failure (HF) remains limited. Methods and results. Utilizing two-dimensional (2D) speckle-tracking echocardiography, we assessed longitudinal strain (LS) in 63 histology-confirmed ATTR-CM patients. Additionally, cardiac magnetic resonance (CMR) images measured native T1 and extracellular volume (ECV), compared with LS across 18 LV segments. Patients were categorized into three groups based on HF status: Group 1 (no HF symptoms), Group 2 (HF with preserved LV ejection fraction), and Group 3 (HF with reduced LV ejection fraction). LS analysis unveiled susceptibility to deformation in the basal inferoseptal segment, persisting even in asymptomatic cases. CMR demonstrated increasing native T1 deviation, particularly evident in segments distant from the inferoseptal region. Contrastingly, maximal ECV was consistently observed in the basal and mid-ventricular inferior-septum, even in asymptomatic individuals. Segmental LS decline correlated with ECV expansion but not with native T1 values. Conclusion. Our findings suggest that the inferoseptal segment is highly susceptible to amyloid infiltration, and 2D speckle-tracking echocardiography and CMR may serve as a valuable tool for its early detection.

  DOI： 10.1093/ehjopen/oeae076

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• Very Late Stent Thrombosis Complicating Immune Thrombocytopenia: Insights From Optical Coherence Tomography and Thrombopathology 査読あり

  Shimazu H., Matsuura Y., Moribayashi K., Gi T., Suiko Y., Tanaka H., Komaki S., Ishikawa T., Yamashita A., Kaikita K.

  JACC: Case Reports   24   102017   2023年10月

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  記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JACC: Case Reports  

  Immune thrombocytopenia (ITP) carries bleeding and thrombotic risks; however, thromboses associated with ITP have not been histologically examined. This report presents optical coherence tomography images of the culprit lesion and histology of coronary aspirates in very late stent thrombosis complicating severe ITP, providing evidence of platelet-rich thrombus formation. (Level of Difficulty: Advanced.)

  DOI： 10.1016/j.jaccas.2023.102017

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• Sitosterolemia Exhibiting Severe Hypercholesterolemia with Tendon Xanthomas Due to Compound Heterozygous ABCG5 Gene Mutations Treated with Ezetimibe and Alirocumab 査読あり

  Hiroki Tanaka 1, Yuki Watanabe 1, Shuji Hirano 1, Hayato Tada 2, Akihiro Nomura 2, Masa-Aki Kawashiri 2, Makoto Takenaga 1

  Intern Med   2020年7月

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  担当区分：筆頭著者   掲載種別：症例報告