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Affiliation |
Faculty of Medicine Center for the Support and Development of Medical Professionals Department of Clinical Education |
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Related SDGs |
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MIYAMOTO Miyuki
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Papers 【 display / non-display 】
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Ishii Nobuyuki, Miyamoto Miyuki
Internal Medicine advpub ( 0 ) 2025
Language：English Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本内科学会
We describe a rare case of Miller Fisher syndrome (MFS) in a 37-year-old woman characterized by paralytic ileus and isolated internal ophthalmoplegia without any external ophthalmoplegia. The patient initially presented with severe abdominal pain and photophobia. A physical examination revealed mydriasis, impaired pupillary light reflexes, ataxia, and areflexia; however, her extraocular movements were preserved. The serum test results were positive for anti-GQ1b IgG antibodies. Treatment with intravenous immunoglobulin led to a near-complete resolution of the symptoms. This case demonstrates that MFS can manifest as significant gastrointestinal autonomic dysfunction and isolated internal ophthalmoplegia, which may not fit the classic triad presentation. Clinicians should include MFS in the differential diagnosis of patients with unexplained autonomic symptoms even in the absence of external ophthalmoplegia, and a thorough pupillary examination is crucial.
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Endo Y., Fukui S., Umekita K., Suzuki T., Miyamoto J., Morimoto S., Shimizu T., Koga T., Kawashiri S.y., Iwamoto N., Ichinose K., Tamai M., Origuchi T., Okada A., Fujikawa K., Mizokami A., Matsuoka N., Aramaki T., Ueki Y., Eguchi K., Kariya Y., Hashiba Y., Hidaka T., Okayama A., Kawakami A., Nakamura H.
Modern Rheumatology 31 ( 5 ) 972 - 978 2021
Publishing type：Research paper (scientific journal) Publisher：Modern Rheumatology
Objectives: Our previous study showed that the effectiveness of tumor necrosis factor (TNF) inhibitors was attenuated in anti-human T-cell leukemia virus type 1 (HTLV-1) antibody-positive patients with rheumatoid arthritis (RA). We aimed to evaluate the effectiveness and safety of non-TNF inhibitors in anti-HTLV-1 antibody-positive patients with RA. Methods: We reviewed patients with RA who received abatacept or tocilizumab as the first biologic agent. We used the data of patients treated with TNF inhibitors from our previous study to compare the effectiveness between the anti-HTLV-1 antibody-positive patients treated with TNF inhibitors and non-TNF inhibitors using the inverse probability of treatment weights (IPTW) method. Results: A total of 359 patients were divided into anti-HTLV-1 antibody-negative and -positive patients of 332 and 27, respectively. No statistically significant difference was observed in the change in the clinical disease activity index between the anti-HTLV-1 antibody-positive and -negative patients. The results using the IPTW method showed a significant association between the non-TNF inhibitors treatment and a better response. None of the patients developed adult T-cell leukemia/lymphoma or HTLV-1-associated myelopathy/tropical spastic paraparesis during the 24 weeks. Conclusion: Our results indicate that non-TNF inhibitors treatment is safety, and the effectiveness is not attenuated also in anti-HTLV-1 antibody-positive patients.
Presentations 【 display / non-display 】
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当院で遺伝学的に診断にしたCANVASの臨床的検討
杉山崇史、宮武聡子、宮本美由貴、酒井克也、中里祐毅、湯地俊子、高橋邦行、興水江里子、松本直通、塩見一剛
第66回日本神経学会学術大会
Event date： 2025.5.21 - 2025.5.24
Presentation type：Poster presentation
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HTLV-1関連脊髄症診断における髄液line immunoassay法の意義
中里祐毅、佐藤有生、金丸和樹、宮本美由貴、酒井克也、杉山崇史、塩見一剛
第66回日本神経学会学術大会
Event date： 2025.5.21 - 2025.5.24
Presentation type：Poster presentation
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早朝高血圧を契機にPRESを発症した慢性腎不全合併パーキンソン病の1例
海老原由佳、佐藤有生、金丸和樹、宮本美由貴、酒井克也、塩見一剛、望月仁志
第345回日本内科学会九州地方会
Event date： 2025.4.25
Presentation type：Oral presentation (general)
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頭痛が併存したために診断に苦慮した Fisher 症候群の１例 宮崎大学医学部附属病院 脳神経内科
金丸和樹、木下真由、宮本美由貴、杉山崇史、塩見一剛
第247 回 日本神経学会九州地方会
Event date： 2025.3.15
Presentation type：Oral presentation (general)
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MSSA菌血症をきたし硬膜外膿瘍に至った1例
木下真由、宮本美由貴、杉山崇史、塩見一剛、宮崎泰可
第348回日本内科学会九州地方会
Event date： 2025.1.25
Presentation type：Oral presentation (general)