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医学部 附属病院 感染制御部 |
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助教 |
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論文 【 表示 ／ 非表示 】
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Malignant syphilis with presumed multifocal osteomyelitis in a patient with human immunodeficiency virus: A case report 査読あり
Rikitake Y, Kawaguchi T, Iwao C, Fujii T, Kurihara J, Kimura M, Kitamura A, Takajo I, Nakamura E, Miyazaki T
J Infect Chemother. 2026 Jul 21;32(9):103037. doi: 10.1016/j.jiac.2026.103037. Online ahead of print. PMID: 42480840 32 ( 9 ) 103037 2026年7月
掲載種別：研究論文（学術雑誌）
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岩尾 千紘, 梅北 邦彦, 木村 賢俊, 工藤 理紗, 川口 剛, 中井 陸運, 宮崎 泰可
Rheumatology advances in practice 10 ( 2 ) rkag046 2026年4月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Oxford University Press
Objective
To investigate whether human T cell leukaemia virus type 1 (HTLV-1) infection increases the risk of respiratory complications in patients with RA, focusing on high-resolution computed tomography (HRCT) findings and clinical features.
Methods
We retrospectively analysed 30 HTLV-1-positive patients with RA enrolled in the HTLV-1 RA Miyazaki Registry who had undergone chest HRCT. For each patient, three age- and sex-matched HTLV-1-negative RA patients (n = 90) were recruited as controls. We compared pulmonary abnormalities on HRCT, RA disease activity, medication use and systemic complications between the groups. In the HTLV-1-positive group, we also assessed the relationship between HTLV-1 proviral load (PVL) and pulmonary findings.
Results
Although age and disease duration were similar between groups at the time of HRCT, HTLV-1-positive patients had significantly higher disease activity (CDAI: 6.4 vs 3.3, P = 0.01; SDAI: 7.28 vs 3.46, P = 0.01), greater glucocorticoid use (70% vs 36%) and lower biologics use (33% vs 61%). Abnormal pulmonary findings were observed in ≈50% of both groups; however, bronchiolitis was more frequent in HTLV-1-positive patients, while interstitial lung disease patterns were comparable. HTLV-1 PVL did not differ significantly based on the presence or absence of pulmonary lesions.
Conclusion
HTLV-1 infection may link to an increased prevalence of airway lesions, such as bronchiolitis and bronchiectasis, in RA patients. These findings suggest that screening for HTLV-1 should be considered in RA patients, especially those with respiratory symptoms or complications. -
早期に下部消化管病変を合併した抗U3-RNP抗体陽性の全身性硬化症 査読あり
日髙伸彦、岩尾浩昭、和田明香里、工藤理紗、木村賢俊、力武雄幹、岩尾千紘、力武真央、相澤彩子、川口剛、松田基弘、宮内俊一、梅北邦彦.:
九州リウマチ 45 ( 2 ) 64 - 70 2025年9月
掲載種別：研究論文（学術雑誌）
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Successful treatment of disseminated cryptococcosis with liposomal amphotericin B and isavuconazole in an adult living with HIV. 査読あり
Kawaguchi T, Kitamura A, Kimura M, Rikitake Y, Iwao C, Iwao K, Sumiyoshi M, Kariya Y, Matsuda M, Umekita K, Takajo T, Moriguchi-Goto S, Yamashita A, Matsumoto K, Miyazaki T.:
J Infect Chemother. 31 ( 1 ) 102534 2025年1月
掲載種別：研究論文（学術雑誌）
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川口 剛, 北村 瑛子, 木村 賢俊, 力武 雄幹, 岩尾 千紘, 岩尾 浩昭, 住吉 誠, 仮屋 裕美, 松田 基弘, 梅北 邦彦, 高城 一郎, 盛口 清香, 山下 篤, 宮崎 泰可
Journal of Infection and Chemotherapy 31 ( 1 ) 102534 2025年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Elsevier BV
Treating disseminated cryptococcosis in people with human immunodeficiency virus (HIV) is challenging due to the limited availability of effective antifungals. Although isavuconazole has antifungal activity against Cryptococcus neoformans, clinical evidence is sparse because this new drug has not been approved for the treatment of cryptococcosis in the US or Europe. Here, we report a case of HIV-associated cryptococcal meningitis that relapsed during maintenance therapy with fluconazole. A Japanese man in his 20s was diagnosed with HIV-1 infection and cryptococcal meningitis. The patient was intolerant to flucytosine and was treated with liposomal amphotericin B monotherapy for 2 weeks as induction therapy, followed by fluconazole (400 mg/day) for 3 months as consolidation therapy. Four months after starting maintenance therapy with fluconazole (200 mg/day), the patient presented with fever and cough, leading to readmission to our hospital. Biopsies of a nodule in the left lung and a left cervical lymph node led to the diagnosis of disseminated cryptococcosis (pulmonary cryptococcosis and cryptococcal lymphadenitis). Although a combination of fluconazole and liposomal amphotericin B was ineffective, the patient was successfully treated with an induction therapy combining isavuconazole and liposomal amphotericin B, followed by a maintenance therapy with isavuconazole. The patient received isavuconazole orally except for loading doses, achieving stable blood concentration levels. Moreover, we observed that blood levels of amphotericin B increased gradually with repeated administration. Therefore, isavuconazole may have a potential role in the treatment of cryptococcosis, and clinical trials involving larger numbers of cases are needed to confirm its efficacy and safety.
講演・口頭発表等 【 表示 ／ 非表示 】
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ベリムマブが奏効したSLE 関連赤芽球癆の一例
宮田梨緒、小山詩絵、岩尾千紘、栗原 淳、和田明香里、日髙伸彦、工藤理紗、村井優之、木村賢俊、岩尾浩昭、川口 剛、松田基弘、宮内俊一、梅北邦彦
第71回日本リウマチ学会 九州・沖縄支部学術集会
開催年月日： 2026年3月7日 - 2026年3月8日
会議種別：口頭発表（一般）
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麻痺性イレウスを呈しメボリズマブ併用で改善した好酸球性多発血管炎性肉芽腫症の1 例
森梨乃、栗原淳、小山詩絵、日髙伸彦、和田明香里、工藤理紗、木村賢俊、村井優之、岩尾千紘、力武雄幹、岩尾浩昭、川口剛、松田基弘、宮内俊一、梅北邦彦
第71回日本リウマチ学会 九州・沖縄支部学術集会
開催年月日： 2026年3月7日 - 2026年3月8日
会議種別：口頭発表（一般）
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高齢男女に同時期に発症した神経梅毒・梅毒性ぶどう膜炎の症例
藤井智之、岩尾千紘、力武雄幹、川口剛、髙城一郎、宮崎泰可
第36回日本老年医学会九州地方会
開催年月日： 2026年3月7日
会議種別：口頭発表（一般）
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HIV感染症に合併した悪性梅毒の1例
宮田夏月、力武雄幹、岩尾千紘、川口剛、栗原淳、木村賢俊、北村瑛子、高城一郎、中村恵理子、宮崎泰可
第351回日本内科学会九州地方会
開催年月日： 2025年11月30日
会議種別：口頭発表（一般）
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脾臓破裂を来した両心系感染性心内膜炎の1例
熊谷奏実、力武雄幹、栗原淳、木村賢俊、岩尾千紘、北村瑛子、川口剛、髙城一郎、宮崎泰可
第95回日本感染症学会西日本地方会学術集会 第73回日本化学療法西日本支部総会 合同学会
開催年月日： 2025年11月28日 - 2025年11月30日
会議種別：口頭発表（一般）