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Affiliation |
Faculty of Medicine College Hospital Center for the Community Medical |
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Title |
Assistant Professor |
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Related SDGs |
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NABEKURA Hiroki
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Papers 【 display / non-display 】
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Association between personality traits and glycemic control after inpatient diabetes education Reviewed
上野 浩晶, 清水 浩一郎, 山口 秀樹, Shimoda Kazuya, 内田 泰介, 小永田 綾香, 谷口 宗典, 鍋倉 弘樹, 古郷 芙未子, 長友 雄麻
Metabolism Open 18 100244 2023.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier
application/pdf
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鍋倉 弘樹, イスラム エムディ ヌルル, 迫田 秀之, 張 維東, 中里 雅光
Obesity Facts 16 ( 4 ) 392 - 400 2023.4
Language：English Publishing type：Research paper (scientific journal) Publisher：S. Karger AG
Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a ghrelin receptor antagonist peptide, is a metabolic hormone regulated by VSG. However, it is unknown whether LEAP2 can be used to predict the outcomes of VSG. This study aimed to evaluate LEAP2 as a predictive factor for weight loss and CR-T2DM after VSG.
Methods: This retrospective study included 39 Japanese participants with obesity who underwent VSG. Serum LEAP2, des-acyl ghrelin (DAG), and other metabolic and anthropometric parameters were studied before and at 12 months after VSG. Receiver operating characteristics (ROC) curve was generated to evaluate predictive score for weight loss with cut-off value of >50 percent excess weight loss. ROC curve was also generated to assess CR-T2DM.
Results: Serum LEAP2 levels were significantly higher in participants with body mass index (BMI) 32–50 kg/m2 than in those with normal weight. Participants with BMI >50 kg/m2 had lower serum LEAP2 concentrations than those with BMI 32–50 kg/m2. VSG caused a significant reduction in serum DAG concentrations, but it did not affect serum LEAP2 concentrations in either male or female participants. Preoperative serum LEAP2 concentration of 2.88 pmol/mL was the optimal cutoff value for predicting weight loss after VSG, with sensitivity of 80.0% and specificity of 75.9%. Preoperative serum LEAP2 level higher than 4.67 pmol/mL predicted CR-T2DM after VSG with sensitivity of 100% and specificity of 58.8%.
Conclusion: Preoperative serum LEAP2 could predict weight loss and CR-T2DM as outcomes of VSG. -
Sakai Katsuya, Shiomi Kazutaka, Mochizuki Hitoshi, Islam Md Nurul, Nabekura Hiroki, Tanida Ryota, Sakoda Hideyuki, Nakazato Masamitsu
11 ( 5 ) 2021.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/brb3.2111