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所属 |
医学部 附属病院 歯科口腔外科・矯正歯科 |
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職名 |
助教 |
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関連SDGs |
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Baba T., Yamaguma Y., Fukui T., Kaneuji T., Kashima K., Yamashita Y.
Journal of Oral and Maxillofacial Surgery Medicine and Pathology 38 ( 1 ) 140 - 145 2026年1月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Oral and Maxillofacial Surgery Medicine and Pathology
Objectives: Anti-resorptive agents (ARA), such as bisphosphonates and denosumab, are first-line treatments for bone metastases from solid tumors and multiple myeloma. Although these agents effectively inhibit bone resorption, relieve pain associated with bone metastases, and inhibit the growth of bone metastases in malignant diseases, the risk of medication-related osteonecrosis of the jaw (MRONJ) remains a significant concern. In this study, we retrospectively examined patients who received high-dose ARA at our hospital after their initial visit to our department, focusing on their oral condition at the time of the initial visit and at the start of high-dose ARA treatment. Methods: Between 2013 and 2023, 91 patients who received high-dose ARA at our hospital after their initial visit to our department with at least 3 months of follow-up were retrospectively investigated from their medical records. We examined various factors that may increase the risk of MRONJ, but we focused on dental conditions at high-dose ARA administration. Results: Univariate Cox regression analysis showed that sex, steroid use, tooth indicated for extraction at initial visit and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. Furthermore, multivariate Cox regression analysis showed that steroid use and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. (p < 0.05). Conclusion: A pre-treatment dental examination and timely extraction of the indicated tooth prior to high-dose ARA administration may reduce the risk of MRONJ. These findings highlight the importance of early dental intervention in patients receiving high-dose ARA treatment.
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Epithelioid schwannoma in the buccal region: A case report and review of literature 査読あり
Baba T., Baba H., Yamaguma Y., Fukui T., Kaneuji T., Yamashita Y.
Journal of Oral and Maxillofacial Surgery Medicine and Pathology 37 ( 5 ) 1123 - 1130 2025年9月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Oral and Maxillofacial Surgery Medicine and Pathology
Schwannomas are common, benign peripheral nerve sheath tumors that arise from Schwann cells. Several rare morphological variants include ancient, cellular, plexiform, epithelioid, and microcystic/reticular. The epithelioid variant of schwannoma is scarce, with only a few relevant cases reported in the oral and maxillofacial regions. Herein, we report a case of epithelioid schwannoma in the buccal region. A 61-year-old woman was referred to our department from a medical clinic because of a slow-growing nodule in the buccal region, noticed 3 years before presentation. Clinical examination revealed a nodular mass measuring 20 × 20 mm. Computed tomography (CT) and magnetic resonance imaging (MRI) showed an oval lesion with a clear border on the left cheek. The outer margin of the mass exhibited opacities that appeared as multiple microcalcifications. MRI revealed a well-defined mass similar in size to that observed on CT, with low signal intensity on T1-weighted images and mildly high signal intensity on T2-weighted images. The clinical differential diagnosis includes benign tumors such as pleomorphic adenoma. The tumor was surgically excised under general anesthesia. Histopathological examination revealed multilobulated epithelioid cells arranged in nests. The tumor cells showed eosinophilic cytoplasm and uniformly round nuclei. The tumor was diagnosed as an epithelioid schwannoma. Postoperative follow-up was uneventful, and no evidence of recurrence was observed 2 years postoperatively.
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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ECVを用いた口腔癌頸部リンパ節転移に対する診断システムの構築
研究課題/領域番号：25K20424 2025年04月 - 2027年03月
独立行政法人日本学術振興会 科学研究費基金 若手研究
担当区分：研究代表者