YAMAMOTO Kiyotake

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Medical Sciences, Vascular and cellular dynamics

Title

Assistant Professor

Degree 【 display / non-display

  • 博士(薬学) ( 2017.3   徳島大学 )

Research Areas 【 display / non-display

  • Life Science / Pathological biochemistry

  • Life Science / Cell biology

  • Life Science / Pharmacology

  • Life Science / Molecular biology

 

Papers 【 display / non-display

  • Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. Reviewed International journal

    Kiyotake Yamamoto, Haruko Watanabe-Takano, Eri Oguri-Nakamura, Hitomi Matsuno, Daiki Horikami, Tomohiro Ishii, Ryuji Ohashi, Yoshiaki Kubota, Koichi Nishiyama, Takahisa Murata, Naoki Mochizuki, Shigetomo Fukuhara

    FASEB journal   37 ( 12 )   e23310   2023.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fj.202300830RR

    PubMed

  • Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell–Cell Junctions and Vascular Permeability Reviewed

    Kiyotake Yamamoto, Yuki Takagi, Koji Ando, Shigetomo Fukuhara

    Biological and Pharmaceutical Bulletin   44 ( 10 )   1371 - 1379   2021.10

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Pharmaceutical Society of Japan  

    DOI: 10.1248/bpb.b21-00504

  • Protocol for analysis of integrin-mediated cell adhesion of lateral plate mesoderm cells isolated from zebrafish embryos Reviewed

    Seung-Sik Rho, Eri Oguri-Nakamura, Koji Ando, Kiyotake Yamamoto, Yuki Takagi, Shigetomo Fukuhara

    STAR Protocols   2 ( 2 )   100428 - 100428   2021.6

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.xpro.2021.100428

  • Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets Reviewed

    Yamamoto K., Mizuguchi H., Tokashiki N., Kobayashi M., Tamaki M., Sato Y., Fukui H., Yamasuchi A.

    Journal of Medical Investigation   64 ( 1-2 )   122 - 128   2017.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Medical Investigation  

    Accumulating evidence supports the “glucagonocentric hypothesis”, in which antecedent α-cell failure and inhibition of glucagon secretion are responsible for diabetes progression. Protein kinase C (PKC) is involved in glucagon secretion from α-cells, although which PKC isozyme is involved and the mechanism underlying this PKC-regulated glucagon secretion remains unknown. Here, the involvement of PKCδ in the onset and progression of diabetes was elucidated. Immunofluorescence studies revealed that PKCδ was expressed and activated in α-cells of STZ-induced diabetic model mice. Phorbol 12-myristate 13-acetate (PMA) stimulation significantly augmented glucagon secretion from isolated islets. Pre-treatment with quercetin and rottlerin, PKCδ signaling inhibitors, significantly suppressed the PMA-induced elevation of glucagon secretion. While Go6976, a Ca2+ -dependent PKC selective inhibitor did not suppress glucagon secretion. Quercetin suppressed PMA-induced phosphorylation of Tyr311 of PKCδ in isolated islets. However, quercetin itself had no effect on either glucagon secretion or glucagon mRNA expression. Our data suggest that PKCδ signaling inhibitors suppressed glucagon secretion. Elucidation of detailed signaling pathways causing PKCδ activation in the onset and progression of diabetes followed by the augmentation of glucagon secretion could lead to the identification of novel therapeutic target molecules and the development of novel therapeutic drugs for diabetes.

    DOI: 10.2152/jmi.64.122

    Scopus

    PubMed

    CiNii Research

MISC 【 display / non-display

Presentations 【 display / non-display

  • Rap1低分子量Gタンパク質はVE-cadherin接着を増強することで肺の血管バリア機能を維持している

    山本 清威, 渡邊-高野 晴子, 堀上 大貴, 石井 智裕, 久保田 義顕, 村田 幸久, 大橋 隆治, 望月 直樹, 福原 茂朋

    第8回 血管生物医学会 若手研究会  2023.5.27 

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    Event date: 2023.5.26 - 2023.5.27

    Presentation type:Oral presentation (general)  

  • Rap1低分子量Gタンパク質による血管透過性制御とそれを標的とする血管透過性亢進がかかわる疾患の治療戦略

    山本 清威, 渡邊-高野 晴子, 堀上 大貴, 髙木 夕希, 石井 智裕, 大橋 隆治, 久保田 義顕, 村田 幸久, 望月 直樹, 福原 茂朋

    日本薬学会第142年会  2022.3.27 

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    Event date: 2022.3.25 - 2022.3.28

    Presentation type:Oral presentation (general)  

  • Rap1低分子量Gタンパク質は肺における血管透過性制御に必須である

    山本 清威, 渡邊-高野 晴子, 堀上 大貴, 石井 智裕, 久保田 義顕, 村田 幸久, 大橋 隆治, 望月 直樹, 福原 茂朋

    日本薬学会第142年会  2022.3.28 

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    Event date: 2022.3.25 - 2022.3.28

    Presentation type:Oral presentation (general)  

  • ヒト精子運動率関連遺伝子ERBB4をターゲットとした化合物の探索と精子運動率の検討

    伊東 佑星, 小西 麻実, 山本 清威, 佐藤 陽一

    第95回日本生化学大会  2022.11.10 

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    Event date: 2022

    Language:Japanese   Presentation type:Poster presentation  

  • GWASによる精子濃度関連遺伝子座の同定とゲノム創薬研究

    笠原 朱莉, 山本 清威, 佐藤 陽一

    第95回日本生化学大会  2022.11.9 

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    Event date: 2022

    Language:Japanese   Presentation type:Poster presentation  

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Grant-in-Aid for Scientific Research 【 display / non-display

  • 男性不妊症新規原因遺伝子の同定と治療法の開発研究

    Grant number:22K09528  2022.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  • 低分子量G蛋白質Rap1による血管透過性制御とその破綻によるARDSの病態解明

    Grant number:21K15260  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    山本 清威

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    Authorship:Principal investigator